Mille-feuille-filter removes viruses from water

Press release
18 May 2016

A simple paper sheet made by scientists at Uppsala University can improve the quality of life for millions of people by removing resistant viruses from water. The sheet, made of cellulose nanofibers, is called the mille-feuille filter as it has a unique layered internal architecture resembling that of the French puff pastry mille-feuille (Eng. thousand leaves).

' With a filter material directly from nature, and by using simple production methods, we believe that our filter paper can become the affordable global water filtration solution and help save lives. Our goal is to develop a filter paper that can remove even the toughest viruses from water as easily as brewing coffee', says Albert Mihranyan, Professor of Nanotechnology at Uppsala University, who heads the study.

Access to safe drinking water is among the UN’s Sustainable Development Goals. More than 748 million people lack access to safe drinking water and basic sanitation. Water-borne infections are among the global causes for mortality, especially in children under age of five, and viruses are among the most notorious water-borne infectious microorganisms. They can be both extremely resistant to disinfection and difficult to remove by filtration due to their small size.

Today we heavily rely on chemical disinfectants, such as chlorine, which may produce toxic by-products depending on water quality. Filtration is a very effective, robust, energy-efficient, and inert method of producing drinking water as it physically removes the microorganisms from water rather than inactivates them. But the high price of efficient filters is limiting their use today.

' Safe drinking water is a problem not only in the low-income countries. Massive viral outbreaks have also occurred in Europe in the past, including Sweden, continues Mihranyan referring to the massive viral outbreak in Lilla Edet municipality in Sweden in 2008, when more than 2400 people or almost 20% of the local population got infected with Norovirus due to poor water. '

Cellulose is one of the most common filtering media used in daily life from tea-bags to vacuum cleaners. However, the general-purpose filter paper has too large pores to remove viruses. In 2014, the group has described for the first time a paper filter that can remove large size viruses, such as influenza virus.

Small size viruses have been much harder to get rid of, as they are extremely resistant to physical and chemical inactivation. A successful filter should not only remove viruses but also feature high flow, low fouling, and long life-time, which makes advanced filters very expensive to develop. Now, with the breakthrough achieved using the mille-feuille filter the long awaited shift to affordable advanced filtration solutions may at last become a reality. Another application of the filter includes production of therapeutic proteins and vaccines.

The research was carried out in collaboration with German virologists, and excellent teamwork is behind the success, according to Mihranyan. The other team members include Simon Gustafsson and Pascal Lordat at Uppsala University as well as Tobias Hanrieder, Dr. Marcel Asper, and Dr. Oliver Schaefer from Charles River, Cologne, Germany, who possess some of the world’s best competences, when it comes to validating virus-retentive filters.

Gustafsson S. et al; Mille-feuille paper: a novel type of filter architecture for advanced virus separation applications; Mater. Horiz., 2016, Advance Article, DOI: 10.1039/C6MH00090H

Read about the research in Chemistry World

Professor Albert Mihranyan, Professor of Nanotechnology at Uppsala University, Sweden, email:">, phone +46 70 167 90 37.

Bilder för nedladdning:
The sheet made of cellulose nanofibers in the mille-feuille filter 

Last modified: 2021-01-27