Research at Uppsala University

Research project from 2016-11-01 to 2016-11-30

The 21th Swedish Conference on Macromolecular Structure & Function.Tällberg, June 16-19, 2016Structural biology, Biochemistry, Biophysics & Molecular Biology are strong areas in Swedish research. The Swedish ...

Research project from 2012-01-01 to 2012-12-31

This conference explores how the molecules of life link to the phenotype of the organism. In particular, we focus on the frontiers of the three interconnected topics: developmental biology, neurobiology ...

Research project from 2017-07-01 to 2020-06-30

In this proposal, we aim to explore the uncharted interactions between the heat released from an exothermic enzymatic reaction, and the enzyme’s structure and function. To achieve this goal, we chose pyruvate ...

Research project from 2015-11-01 to 2015-11-30

Conference name and location: Advancing the Frontiers of (Bio)Chemistry with Valence Bond Approaches. Uppsala University, Sweden.Time for the conference (year-month-day): 2016/06/22-24Justification of ...

Research project from 2012-01-01 to 2014-12-31

Fibrillar alpha-synuclein in Lewy bodies is the main hallmark in brains of patients with Parkinson´s disease and some other brain disorders. However, recent studies indicate that oligomers or protofibrils ...

Research project from 2012-01-01 to 2014-12-31

Computer simulation is a tool for better understanding of the reactions between molecules and their diffusion in living cells. There are now experimental data for single molecules to compare with and for ...

Research project from 2017-01-01 to 2022-12-31

Uppsala university has excelled in ribosome research over decades and already has a strong environment in the area of bacterial protein synthesis. We aim here at creating a novel type of ribosome research ...

Research project from 2011-08-22 to 2011-12-31

There is an urgent need to develop sustainable solutions to convert solar energy into energy carriers used in the Society. In addition to present and future solar cells generating electricity there are ...

Research project from 2015-01-01 to 2018-12-31

Generation of architectural polarity impacts all cell types, ranging from epithelial cells to neurons and astrocytes, relates to tissue organization and links to disease development when misregulated. ...

Research project from 2020-08-01 to 2020-12-31

Low molecular-weight heparin (LMWH) has rapidly become a primary drug in treatment of Covid-19 patients. A major rationale is the pulmonary coagulopathy typical of the seriously ill patient. Increasing ...

Research project from 2016-01-01 to 2018-12-31

We propose to study the structure-function relations of the bacterial ribosome. The ribosome is a large (2.5 MD) macromolecular complex that makes peptide chains with amino acid sequences as prescribed ...

Research project from 2013-01-01 to 2015-12-31

The ribosome is a large macromolecular complex of two subunits. It links amino acids into proteins according to the messenger RNA (mRNA) instructions. The twenty amino acids (aa) are covalently coupled ...

Research project from 2012-01-01 to 2014-12-31

Ginseng polysaccharide is a complex mixture of neutral and acidic polysaccharides that has been proven to have anticancer activities. It functions through interactions with a protein called Galectin-3. ...

Research project from 2020-01-01 to 2023-12-31

Protein synthesis has been studied for decades, and we have a detailed picture of the process in vitro. However, when researchers aim to exploit the system, e.g. for recombinant protein production, or ...

Research project from 2021-01-01 to 2023-12-31

In this project we will address the fundamental question of how the genetic information in DNA codes for rates of binding and unbinding, by using p53 - DNA binding as a model system. To answer this question ...

Research project from 2015-01-01 to 2015-12-31

I have previously identified over 40 novel genes that code for new members of the solute carrier family and many of these are likely to be novel transporters for amino acids. A number of these were evolutionary ...

Research project from 2013-01-01 to 2018-12-31

The overall ambition is to make intracellular measurements that bridge the gap between quantitative physical models and biological observations in order to identify and resolve inconsistencies in our current ...

Research project from 2020-01-01 to 2022-12-31

To accelerate CO2 fixation, cyanobacteria encapsulate Rubisco and carbonic anhydrase within a protein organelle called the carboxysome. This provides Rubisco with a high concentration of CO2 and protects ...

Research project from 2020-01-01 to 2023-12-31

To accelerate CO2 fixation, cyanobacteria encapsulate Rubisco and carbonic anhydrase within a protein organelle called the carboxysome. This provides Rubisco with a high concentration of CO2 and protects ...

Research project from 2012-01-01 to 2014-12-31

The aim is to study the structure and function of the CO2-concentration machinery in phytoplankton. Competition between O2 and CO2 at the active site of the CO2-fixing enzyme, Rubisco, reduces the efficiency ...

Research project from 2011-01-01 to 2015-12-31

A grand challenge for the 21st century is to develop a molecular-level understanding of a living cell. A key step in this direction is to obtain structures for individual cell organelles. The structure ...

Research project from 2015-01-01 to 2018-12-31

This project deals with computational studies in the general areas of biological catalysis and molecular recognition. We emphasize what may be called quantitative computational structural biology, where ...

Research project from 2019-01-01 to 2022-12-31

This project deals with the problem of how enzymes can be shaped by evolution to work under extreme conditions. In particular, we will address cold-adapted enzymes that are able to maintain a high catalytic ...

Research project from 2014-01-01 to 2017-12-31

This project is focused on understanding GPCR dimerization and strategies to discover ligands of receptors using structure-based methods. The A2A adenosine (A2AAR) and D2 dopamine (D2DR) receptors form ...

Research project from 2012-01-01 to 2015-12-31

Life processes depend critically on interactions between macromolecules. Many of these interactions involve coupled folding and binding, which lies at the heart of many biologically, medically, and technologically ...

Research project from 2021-01-01 to 2024-12-31

Phosphorylation and ubiquitination are among the most common post-translational modifications (PTMs) and regulate together most cellular processes. The PTMs are catalyzed by more than 500 kinases and 600 ...

Research project from 2017-01-01 to 2019-12-31

Cyanobacteria are photosynthetic microorganisms, capable of growing on water and carbon dioxide captured from the atmosphere, with sunlight as their energy source. This lifestyle makes them eminently suitable ...

Research project from 2021-01-01 to 2024-12-31

Last year marked the emergence of DNA sequencing-based microscopy: methods to produce optics-free microscopic images by encoding spatial information in DNA sequence format prior to recovering that information ...

Research project from 2011-08-01 to 2011-12-31

By using quantitative shotgun proteomics analysis we have found that several of the individual proteins in the protein-families involved in control of reactive oxygen species in the cyanobacterium Nostoc ...

Research project from 2014-01-01 to 2017-12-31

Emotional evaluation of daily environmental and internal stimuli is essential for proper guidance of motivated and goal-directed behaviour. Central in this process is the ventral tegmental area (VTA) with ...