Research at Uppsala University

• Genetics of platelet biogenesis and aggregation in humans and zebrafish, and relationship to cardiovascular disease

  Research project from 2016-07-01 to 2019-06-30

  The overall aim is to understand platelet biogenesis, development and reactivity. The first two years of training will be in the host institute abroad, i.e., Framingham heart study (FHS), National Institutes ...

• 7th European Conference on Marine Natural Products (7ECMNP)http://www.fkog.uu.se/7ECMNP

  Research project from 2011-01-01 to 2011-12-31

  Denna konferens är den 7:e i en serie av möten inom marin naturproduktforskning som anordnas vartannat år av Europeiska forskare. Professor Lars Bohlin med medarbetare har fått hedersuppdraget att för ...

• A double-edged sword? Quantifying tradeoffs in CRISPR immunity

  Research project from 2021-01-01 to 2024-12-31

  CRISPR-Cas-based adaptive immune systems are ubiquitous in bacteria and archaea. Paradoxically, CRISPR-associated endonucleases are remarkably slow at locating target DNA, with search times on the order ...

• A genome wide approach to replication initiation

  Research project from 2018-12-01 to 2021-12-31

  At the core of this project is the question how a cell coordinates growth with DNA replication. We have recently shown that the bacterium E. coli does this by triggering replication initiation at a fixed ...

• Adaptive traits in soil fungal ecology

  Research project from 2013-01-01 to 2016-12-31

  The long-term goal of my research program is to unravel the functional link between soil fungal communities and nutrient and carbon cycling in terrestrial ecosystems. This is achieved by first establishing ...

• An Integrated Environment for Ribosome Research

  Research project from 2017-01-01 to 2022-12-31

  Uppsala university has excelled in ribosome research over decades and already has a strong environment in the area of bacterial protein synthesis. We aim here at creating a novel type of ribosome research ...

• Are new genetic models needed for precision breeding based on genomics information?

  Research project from 2018-01-01 to 2020-12-31

  Providing food for a growing world wide population in a cost-efficient and environmentally friendly manner is a significant challenge in future agriculture. Animal and plant breeding will have a central ...

• Evolution of ascetosporean parasites, an emerging threat in marine environments

  Research project from 2018-01-01 to 2021-12-31

  Each branch of the tree of life includes a myriad of parasitic species but current research does not adequately represent their remarkable diversity. Today, entire parasitic groups have eluded characterization ...

• Basal mechanisms of the ribosome

  Research project from 2013-01-01 to 2015-12-31

  The ribosome is a large macromolecular complex of two subunits. It links amino acids into proteins according to the messenger RNA (mRNA) instructions. The twenty amino acids (aa) are covalently coupled ...

• Finding the hidden GEMS in genome-wide association analyses: Do we need to change the way to model the genetics of quantitative traits?

  Research project from 2018-01-01 to 2021-12-31

  Genotype-to-phenotype mapping is a core feature of genetics. These maps describe how combinations of DNA variants (genotypes) contribute to the appearance (the phenotype) of an individual organism. Staggering ...

• Beyond GWAS of obesity: from genetic association to function

  Research project from 2016-01-01 to 2019-12-31

  Over the next decades, dramatic increases of obesity and type 2 diabetes are expected in the U.S. and throughout the world. As insulin resistance is a usual intermediate step between obesity, type 2 diabetes ...

• Can HIV infection be averted - characterization of the early host response in SIV infected Indian-origin rhesus macaques by RNA sequencing

  Research project from 2013-07-01 to 2016-06-30

  The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...

• Flow sorter for single cell genomics of microorganisms from the environment

  Research project from 2013-01-01 to 2017-12-31

  Microorganisms drive biogeochemical processes and cycling of most biologically active elements in the biosphere. These ecosystem processes are critical for our long-term existence on earth, yet our knowledge ...

• Comparative genomics of domestic animals and wild host populations for studies of virus-host co-evolution

  Research project from 2019-01-01 to 2021-12-31

  The purpose of this project is to generate new knowledge about co-evolution among retroviruses and their hosts by studying natural variation in the endogenous retrovirus (ERV) record within and across ...

• Comparative genomics of host populations for studies of virus-host co-evolution

  Research project from 2019-01-01 to 2021-12-31

  The purpose of this project is to generate new knowledge about co-evolution among retroviruses and their hosts by studying natural variation in the endogenous retrovirus (ERV) record within and across ...

• Crosstalk between phosphorylation and ubiquitination at the level of short linear motifs

  Research project from 2021-01-01 to 2024-12-31

  Phosphorylation and ubiquitination are among the most common post-translational modifications (PTMs) and regulate together most cellular processes. The PTMs are catalyzed by more than 500 kinases and 600 ...

• DNA sequencing-based microscopy for ultra-multiplexed, optics-free, 3D imaging of proteins and genes

  Research project from 2021-01-01 to 2024-12-31

  Last year marked the emergence of DNA sequencing-based microscopy: methods to produce optics-free microscopic images by encoding spatial information in DNA sequence format prior to recovering that information ...

• Development of new strategies for sequence based characterization of RNA and post-transcriptional regulation in human tissues

  Research project from 2013-01-01 to 2015-12-31

  Over the past few years, new sequencing technologies have led to the discovery of novel types of RNA and novel catalytic functions for RNA in the cell. RNA-sequencing has further increased the ability ...

• Development of sequence based strategies for genetic diagnostics to identify genes causing intellectual disability

  Research project from 2013-01-01 to 2016-12-31

  The advent of massively parallel sequencing (MPS) has brought about significant changes genomics research. However, for use of MPS in genetic diagnostics, there are still many unsolved issues including ...

• Dissection of the genetics underlying long-term selection response for immune and production traits

  Research project from 2014-01-01 to 2016-12-31

  Genetics has allowed humans to domesticate animals and plants, and through intense breeding develop breeds and varieties with desirable properties for agricultural production across the globe. Despite ...

• ELIXIR -- the European infrastructure for biological information

  Research project from 2017-01-01 to 2017-12-31

  The main mission of ELIXIR is to build a sustainable European infrastructure for biological information, supporting life-science research and its translation to society, the bio-industries, environment ...

• The origin and diversification of ectomycorrhizal Fungi

  Research project from 2017-01-01 to 2020-12-31

  Most of our timber producing trees are depending on a root associated symbiosis with fungi called ectomycorrhiza (ECM). ECM communities usually containing only a few stand forming trees but hundreds of ...

• Genetic architecture, gene function and genomic prediction for chicken growth evaluated using large advanced intercross populations

  Research project from 2019-01-01 to 2021-12-31

  Genomic selection is a biotechnologically based approach to animal and plant breeding. It is efficient for closely related individuals, but less efficient for distantly related ones. It is therefore less ...

• Enabling Systematic Phenotypic Cell Profiling in Safety Pharmacology

  Research project from 2020-12-01 to 2023-12-31

  Assessing safety of early candidates in drug discovery is currently to a large extent based on animal studies, requiring large amounts of animals every year. The purpose of this project is to validate ...

• Single cell genomics of marine archaea

  Research project from 2013-01-01 to 2015-12-31

  Archaea are present in all ecosystems as important facilitators of global cycling of nutrients. In the deep ocean they are as common as bacteria which make the archaea one of the most numerous groups of ...

• Evolution and Control of Genetic Recombination

  Research project from 2016-01-01 to 2018-12-31

  Genetic recombination is central to evolution that serves as the unifying principle in the biology of higher organisms. This project will investigate how fine-scale recombination rate is controlled and ...

• The evolution of genetic recombination in social insects

  Research project from 2015-01-01 to 2018-12-31

  Sex and recombination are ubiquitous in nature but evolutionary biologists struggle to explain their origins and evolution. Social insects have the highest recombination rates recorded in the animal kingdom ...

• Evolution of cooperative traits in endosymbiotic bacteria

  Research project from 2012-01-01 to 2014-12-31

  The aim of this project is to study the origin, evolution and stability of cooperative traits in endosymbiotic bacteria, such as secreted proteins and gene transfer agents. We will use recent technologies ...

• Evolutionary dynamics of germline-restricted chromosomes in songbirds

  Research project from 2021-01-01 to 2024-12-31

  All cells within a multicellular organism are expected to contain the same genome because they originate from a single cell. However, programmed DNA elimination can remove DNA during germline–soma differentiation ...

• Evolutionary importance and genomic architecture of introgression

  Research project from 2020-12-01 to 2024-12-01

  Introgression is an important evolutionary process that allows the transfer of adaptive genetic variants across species boundaries and facilitates the emergence of biological diversity. Yet, the genomic ...

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