Research at Uppsala University

• The Torrent Ahead: Algorithms for X-ray Lasers to Study Structure, Function and Dynamics

  Research project from 2019-01-01 to 2024-12-31

  A new generation of superluminous X-ray free-electron lasers (XFEL) will deliver billions of exposures per day at intensities up to 100-times higher than intensities available from existing XFELs. The ...

• 21st Swedish Conference on Macromolecular Structure and Function

  Research project from 2016-11-01 to 2016-11-30

  The 21th Swedish Conference on Macromolecular Structure & Function.Tällberg, June 16-19, 2016Structural biology, Biochemistry, Biophysics & Molecular Biology are strong areas in Swedish research. The Swedish ...

• A DNA origami single molecule trap to study self-inflicted heat shocks in enzymes

  Research project from 2017-07-01 to 2020-06-30

  In this proposal, we aim to explore the uncharted interactions between the heat released from an exothermic enzymatic reaction, and the enzyme’s structure and function. To achieve this goal, we chose pyruvate ...

• A double-edged sword? Quantifying tradeoffs in CRISPR immunity

  Research project from 2021-01-01 to 2024-12-31

  CRISPR-Cas-based adaptive immune systems are ubiquitous in bacteria and archaea. Paradoxically, CRISPR-associated endonucleases are remarkably slow at locating target DNA, with search times on the order ...

• A genome wide approach to replication initiation

  Research project from 2018-12-01 to 2021-12-31

  At the core of this project is the question how a cell coordinates growth with DNA replication. We have recently shown that the bacterium E. coli does this by triggering replication initiation at a fixed ...

• En Experimentell Inblick i den Molekylära fasrymden

  Research project from 2018-01-01 to 2021-12-31

  Amyloid fibers are associated with more than \num{20} human diseasesranging from diabetes to Alzheimer´s. Still, the initiation of fiberformation has eluded scientists because of the many rapidconformational ...

• Arrested infection: probing intermediates in viral entry with cell mimetics

  Research project from 2018-01-01 to 2021-12-31

  Enveloped viruses such as influenza, HIV, and Zika enter cells via a process of membrane fusion between the viral envelope and a cellular membrane, mediated by viral fusion proteins.  The non-protein components ...

• Basal mechanisms of the ribosome

  Research project from 2016-01-01 to 2018-12-31

  We propose to study the structure-function relations of the bacterial ribosome. The ribosome is a large (2.5 MD) macromolecular complex that makes peptide chains with amino acid sequences as prescribed ...

• Computations for structural mass spectrometry

  Research project from 2016-01-01 to 2018-12-31

  The structure and dynamics of biomolecules are intimately coupled to biological function, and numerous diseases are rooted in biomolecular structure. Functionally important conformational states are often ...

• Determinants for efficient synthesis, folding, and targeting of proteins in living cells

  Research project from 2020-01-01 to 2023-12-31

  Protein synthesis has been studied for decades, and we have a detailed picture of the process in vitro. However, when researchers aim to exploit the system, e.g. for recombinant protein production, or ...

• Determination of reaction mechanism and specificity in nucleotide sequence recognition

  Research project from 2021-01-01 to 2023-12-31

  In this project we will address the fundamental question of how the genetic information in DNA codes for rates of binding and unbinding, by using p53 - DNA binding as a model system. To answer this question ...

• Biophysics of the Central Dogma in Living Cells

  Research project from 2013-01-01 to 2018-12-31

  The overall ambition is to make intracellular measurements that bridge the gap between quantitative physical models and biological observations in order to identify and resolve inconsistencies in our current ...

• Boosting photosynthesis by mapping the interactome of the cyanobacterial CO2 fixing supercharger – the carboxysome

  Research project from 2020-01-01 to 2023-12-31

  To accelerate CO2 fixation, cyanobacteria encapsulate Rubisco and carbonic anhydrase within a protein organelle called the carboxysome. This provides Rubisco with a high concentration of CO2 and protects ...

• Boosting photosynthesis by mapping the interactome of the cyanobacterial CO2 fixing supercharger – the carboxysome

  Research project from 2020-01-01 to 2022-12-31

  To accelerate CO2 fixation, cyanobacteria encapsulate Rubisco and carbonic anhydrase within a protein organelle called the carboxysome. This provides Rubisco with a high concentration of CO2 and protects ...

• Carboxysomes - structure of a cell organelle

  Research project from 2012-01-01 to 2014-12-31

  The aim is to study the structure and function of the CO2-concentration machinery in phytoplankton. Competition between O2 and CO2 at the active site of the CO2-fixing enzyme, Rubisco, reduces the efficiency ...

• Coherent diffractive imaging and nanocrystallography: Structure of intact carboxysomes and components

  Research project from 2011-01-01 to 2015-12-31

  A grand challenge for the 21st century is to develop a molecular-level understanding of a living cell. A key step in this direction is to obtain structures for individual cell organelles. The structure ...

• Colloids and Surfaces in Biology and Biomaterials

  Research project from 2015-07-01 to 2015-07-31

  Dates: 4-6 November in Uppsala 2015.Web site: www.asmcs.se.Surface and colloid chemistry continues to play an important role in the investigation of biological systems for elucidating basic biological ...

• Conquering 3D Single Particle X-ray Diffraction Imaging

  Research project from 2013-09-01 to 2017-08-31

  The advent of X-ray free-electron lasers has provided users with beams of unprecedented peak brightness, a billion times brighter than previous sources, and briefness with pulse duration on only a few ...

• Coupled folding and binding in protein association processes

  Research project from 2012-01-01 to 2015-12-31

  Life processes depend critically on interactions between macromolecules. Many of these interactions involve coupled folding and binding, which lies at the heart of many biologically, medically, and technologically ...

• Crosstalk between phosphorylation and ubiquitination at the level of short linear motifs

  Research project from 2021-01-01 to 2024-12-31

  Phosphorylation and ubiquitination are among the most common post-translational modifications (PTMs) and regulate together most cellular processes. The PTMs are catalyzed by more than 500 kinases and 600 ...

• Developing biotechnological hydrogen production by combining chemistry and biology.

  Research project from 2015-01-01 to 2017-12-31

  Long-term storage is a key obstacle for further implementation of renewable energy resources in our society. In this context hydrogen gas is often put forward as a future energy vector. Today the progress ...

• The dynamics of biological transport networks

  Research project from 2011-05-01 to 2014-04-30

  We will study the dynamics of transport networks built by the body of the slime mould Physarum. Main objectives: 1. To understand rheological mechanics of transport networks in Physarum. 2. To ...

• Emergence and evolution of interactions between intrinsically disordered and folded proteins

  Research project from 2021-01-01 to 2024-12-31

  Intrinsically disordered proteins (IDPs) are common in all life and involved in the intricate network of protein interactions that govern cell function. We want to understand how such interactions emerge ...

• Exploring hydrogenases and their biotechnological potential through a combination of chemistry and biology

  Research project from 2015-01-01 to 2018-12-31

  Long-term storage is a key obstacle for further implementation of renewable energy resources in our society. In this context hydrogen gas is often put forward as a future energy vector. However, today ...

• Exploring molecular interactions - from protein function and regulation of biological processes to drug design

  Research project from 2014-01-01 to 2016-12-31

  AIMS: To obtain fundamental insights into the molecular basis of protein interactions with metal ions, ligands and other proteins, ultimately related to the chemical principles of regulation of biological ...

• FIXED: Fluorescent Incoherent X-ray Emission and Diffraction to determine protein structures

  Research project from 2020-01-01 to 2023-12-31

  The project studies the feasibility of incoherent diffractive imaging - a brand new method to determine atomic and electronic structure of condensed matter and molecules. It uses ultrashort and intense ...

• TOMORROW´S BIOLOGY AT ADVANCED PHOTON SOURCES

  Research project from 2011-01-01 to 2015-12-31

  This proposal brings together those who developed the scientific case in biology for building X-ray lasers (Uppsala) with the team that leads the world in synchrotron-based X-ray crystallography and the ...

• Folding, binding and disorder in protein-ligand interactions

  Research project from 2013-01-01 to 2016-12-31

  Intrinsically disordered proteins (IDPs) are very common, in particular among signalling proteins. There are several hypotheses explaining why they are so common, but a paucity of experimental data to ...

• Folding, binding and evolution of intrinsically disordered proteins

  Research project from 2017-01-01 to 2020-12-31

  Intrinsically disordered proteins (IDPs) are common in all domains of life and are often crucial for mediating protein-protein interations in for example cell signaling. In the binding process, IDPs undergo ...

• Visualising Photo-induced Structural Dynamics in solution through Ultra-fast X-ray scattering and Femtosecond Spectroscopy

  Research project from 2013-01-01 to 2015-12-31

  In this project we utilize time-resolved X-ray scattering to investigate photo-induced reaction dynamics in various chemical and biological molecular systems both in crystals and in solution. The program ...

Showing 30 of 58 hits