Research at Uppsala University
History of human antibiotic use written in the oral bacteria of wild brown bears
25 August 2021. An international team of researchers used historical museum collections to study the effects of huma ...
How research can encourage us to cycle instead
19 August 2021. How do you get to work in the mornings? Transport currently accounts for 25 per cent of GHG emission ...
Philippine ethnic group has most Denisovan DNA
13 August 2021. The Philippine ethnic group Ayta Magbukon has the highest proportion of genes from our extinct relat ...
Search for research projects
Here you will find all research projects at Uppsala University funded by the main Swedish funding bodies. The search feature is based on the SweCRIS database.
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Your choice produced 57 hits
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A human whole blood loop system for superior characterization of therapeutic antibodies
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Research project from 2013-01-01 to 2014-12-31
This project aims to develop of a novel human ex-vivo whole blood loop system for an improved characterization of therapeutic antibodies in order to avoid irrelevant and unnecessary animal studies. Today ...
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A new targeted radiopharmaceutical for treatment of anaplastic thyroid cancer
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Research project from 2019-07-01 to 2021-12-31
Purpose and goal: There is no cure for Anaplastic Thyroid Cancer (ATC) today. Whereas other forms of thyroid cancer can be successfully treated with radioactive iodine, ATC cells lack the ion pumps required ...
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AI-Driven Large-scale Screening for Oral and Oropharyngeal Cancer
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Research project from 2021-01-01 to 2023-12-31
Purpose and goal: High mortality from cancer of the oral cavity and throat is largely due to late diagnosis. Today´s methods for cancer detection are expensive and painful. Modern AI-techniques make it ...
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Single-cell analysis for precision medicine in acute pediatric leukemia
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Research project from 2020-01-01 to 2023-12-31
The established chemotherapeutic treatment strategies used in pediatric oncology benefit groups of patients with similar clinical manifestations. Relapsed, chemorefractory, and extramedullary disease remain ...
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Evaluation of the use of self-sampling and repeated HPV testing in primary screening for cervical cancer: a randomised study
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Research project from 2014-01-01 to 2015-12-31
Cervical cancer is the second most frequent cancer in women and caused by persistent infection by human papillomavirus (HPV). The organised screening in Sweden has reduced the incidence of cervical cancer ...
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Subpial zone astrocytes as the origin of cortical astrocytomas
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Research project from 2015-01-01 to 2017-06-30
Astrocytes, the most abundant cell population in the brain, show temporal and regional heterogeneity. Astrocytomas, the most common primary malignant brain tumor in adult patients, are often localized ...
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Autonomous phenotypic drug profiling
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Research project from 2020-12-01 to 2024-11-30
The experimental space of biomedical research is vast and in many cases infeasible to cover with conventional methods where experiments are selected and carried out by humans. The purpose of this project ...
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Computational modelling and functional validation platform for personalized colorectal cancer clinical therapy decision support
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Research project from 2021-01-01 to 2023-12-31
More than 150.000 persons within EU- die of colorectal cancer every year (more than 10% cancer-related deaths). For advanced-stages, where surgery is not possible, systemic therapy is used. Although new ...
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Beyond Gleason Grading - Malignancy Grading of Prostate Cancer with Image Analysis
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Research project from 2013-01-01 to 2014-12-31
Prostate cancer is the leading cause of death in men. The diagnosis and prognosis is based on Gleason grading which is the most widely used system for determining the severity of prostate cancer from tissue ...
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Image analysis for reliable and cost effective cancer detection
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Research project from 2016-01-01 to 2018-12-31
A crucial aspect for reliable automated analysis of cell samples for cancer detection is accurate and robust quantification of very subtle changes in the nuclear chromatin distribution through image analysis ...
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Biomarker test for cervical, ovarian or endometrial cancer
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Research project from 2016-07-01 to 2017-07-01
Purpose and goal: The aim of the project is to perform a number of steps towards formulation and marketing of a diagnostic test for gynecological cancer (ovarian cancer, endometrial cancer and cervical ...
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Cancer survival affected by the choice of anaesthetic drugs?
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Research project from 2013-01-01 to 2015-12-31
Background: A recent retrospective analysis of 2,173 patients indicated that 5-year survival may differ up to 5% depending on the choice of anaesthetic. Sevoflurane, an inhalational anaesthetic, is pro-inflammatory ...
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Cell of origin for glioblastoma as a basis for stratification, target identification and drug screening
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Research project from 2013-01-01 to 2015-12-31
Our goal is to, based on cell of origin, stratify glioblastoma (GBM) into novel subclasses of clinical relevance, identify pathways and biomarkers of therapeutic value, and drugs with potency against glioma ...
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Companion Diagnostics Initiative
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Research project from 2009-09-01 to 2015-05-31
Currently not available ...
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Comprehensive molecular characterization of chronic lymphocytic leukemia
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Research project from 2013-01-01 to 2016-12-31
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. The disease is clinically and biologically heterogeneous and remains incurable. The etiology is unknown. Our main goals ...
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Development of a protein biomarker test for preoperative diagnosis of ovarian cancer.
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Research project from 2017-10-11 to 2019-10-10
Purpose and goal: The goal of the project is to improve ovarian cancer diagnostics by developing a biomarker test that can be used to determine if women with a pelvic aberrant ultrasound need to undergo ...
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Development of small molecular immunomodulating anticancer drugs using mebendazol as template
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Research project from 2016-06-17 to 2017-06-16
Purpose and goal: The project goal is to develop a new type of immune activating cancer drug, to be be formulated for oral administration. We observed that mebendazole, now in use for parasitic infections ...
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The EFFIPEC Trial Program (Efficacy of HIPEC): A phase I trial and an open-label randomized phase III trial for treating colorectal cancer with peritoneal metastases
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Research project from 2020-12-01 to 2024-12-31
Background, Population and Aim: To increase the cure rate from colorectal cancer, more effective treatments for metastatic disease are needed. Metastases to the peritoneum is a common and difficult clinical ...
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ESCAPE Cancer - Engineered SCAffold Proteins Engaged for CANCER therapy
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Research project from 2016-12-01 to 2019-06-30
Purpose and goal: This proposal aims to develop next-generation affinity proteins, engineered scaffold proteins (ESPs), as novel cancer drugs. ESPs have proven suitable for targeting applications and ...
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Endocrine tumorigenesis
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Research project from 2012-01-01 to 2014-12-31
This project is a translational project with a twin focus: A/ adrenocortical carcinoma (ACC) and B/ pancreatic endocrine tumors. A/ We have run a phase III randomized, prospective, controlled, open -label ...
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Regulation of TGFbeta signaling and cell differentiation by nuclear enzymes and non-coding RNAs
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Research project from 2013-01-01 to 2017-12-31
Transforming growth factor beta (TGFbeta) family polypeptides are cytokines regulating cell differentiation including the epithelial-mesenchymal transition (EMT). TGFbeta ligands signal via cell surface ...
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Eurostars project INSIGHT E! 6548 Uppsala university
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Research project from 2011-07-01 to 2014-06-30
Purpose and goal: Using established expertise in cancer genetics and a proprietary technology to perform in vitro gene engineering, we will create a new range of predictive human disease models carrying ...
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Systems-scale models of genetic and pharmacological perturbations in cancer
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Research project from 2012-01-01 to 2014-12-31
One of the central problems of cancer systems biology is to understand the complex molecular changes of cancerous cells and tissues, and use this understanding to support the development of new targeted ...
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Targeting mechanisms for IGF-1R dependent and independent epigenetic gene silencing guarding proliferation and survival in multiple myeloma - Implications for biology and therapy
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Research project from 2018-01-01 to 2021-12-31
The overall objective of this proposal is to dissect a disease-specific global epigenetic pattern of clinical importance for multiple myeloma (MM), to increase understanding of how epigenetic abnormalities ...
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Physical training and cancer (Phys-Can) - effects and understanding of mechanisms for minimizing cancer related fatigue, improve quality of life and disease outcome -a multicenter clinical trial
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Research project from 2014-01-01 to 2018-12-31
Cancer Related Fatigue (CRF) is reported in up to 90% of cancer patients. It can arise at any point in the course of the disease and is often very self-limited and persists for years. CRF has serious impact ...
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Improving cancer treatment by combining radio-immunotargeting and p53 therapy
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Research project from 2014-01-01 to 2018-12-31
In this project, we will combine radio-immunotherapy (RIT) with p53 therapy. RIT is a way to deliver a radiation dose to the malignant cells much more specifically than with current external radiation ...
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Parents with Cancer: Development of an e-health intervention targeting psychological distress in parents diagnosed with cancer while caring for young children
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Research project from 2021-01-01 to 2023-12-31
The overall aim is to develop an e-health intervention targeting psychological distress, by providing emotional support and improving parenting efficacy, in individuals diagnosed with cancer who are parents ...
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Global Surgery - Uppsala
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Research project from 2019-01-01 to 2021-12-31
Content of researchLack of surgical healthcare costs lives and money. The burden of surgical disease is highest in sub-Saharan Africa where access to surgery is most limited. This proposal builds on previous ...
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Growth Factors and Cell Transformation
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Research project from 2012-01-01 to 2012-12-31
Målet med symposiet "Growth Factors and Cell Transformation" är att öka förståelsen för tillväxtfaktorer och belysa deras övergripande roll i normal utvecklingsbiologi och vid cancer. Symposiet är öppet ...
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Host-virus interaction in development of cervical cancer
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Research project from 2013-08-01 to 2016-07-31
Cervical cancer is the third most common cancer in women worldwide and is caused by infection by oncogenic types of human papillomavirus (HPV). Only some of the infections lead to cancer, indicating that ...
Showing 30 Of 57 hits
Show more hitsResearch spotlight: The coronavirus
New method for discovery of antiviral drugs
2 August 2021. The current COVID-19 pandemic has highlighted the need for methods to identify new or repurposed dru ...
Helpline important for older people during the pandemic
8 July 2021. For many older individuals, the COVID-19 pandemic has resulted in the loss of daily anonymous contac ...
The national COVID-19 Data Portal turns one year old
3 June 2021. The national Swedish COVID-19 Data Portal was launched one year ago to support researchers in utilis ...
Lectures
Uppsala University’s researchers share their knowledge in public lectures. Every year, the University is visited by leading researchers and influential people from around the world. At Uppsala University, you can hear Nobel laureates, researchers, authors, politicians and many others give lectures. Here we present some of the most prominent, annually occurring lectures at Uppsala University.