Research at Uppsala University

• Immunity in a changing world: the role of migration on the evolution of the immune system of birds

  Research project from 2020-07-01 to 2023-06-30

  Pathogens and parasites exert the strongest selection pressures on earth, shaping the evolution of an effective and efficient immune system. However, the geographic distribution of pathogens is hypothesized ...

• A Swedish Earth Biogenome Project platform: building a pipeline and proof of principle studies

  Research project from 2021-01-01 to 2024-12-31

  A grand challenge for humanity is to maintain biodiversity and ensure food safety for the growing population. There is currently an alarming loss of biodiversity due to loss of natural habitats and human ...

• A genomic map to sex-specific variation in lifespan

  Research project from 2009-09-10 to 2013-12-31

  Virtually all human diseases have a sex specific component, in terms of rate of occurrence, age of onset and/or severity. Understanding the causes to these differences may hold important clues to how many ...

• Population size predicts it all? From conservation genomics to conservation practice

  Research project from 2019-01-01 to 2021-12-31

  Human-induced changes in land use and climate are considered major threats to the long-term survival of numerous species, and recent studies have shown that effects of climate and land use interact and ...

• Understanding motor networks: Non-invasive optogenetic modulation of Dmrt3+ spinal interneurons in zebrafish.

  Research project from 2016-01-01 to 2019-12-31

  The proposed project addresses the formation and function of the spinal locomotor network. This pattern generator operates as an autonomous metronome that creates a rhythmic output to the muscles as well ...

• Anmälan om utnyttjande av återvändarbidrag för beviljade postdoktorstipendier

  Research project from 2014-03-01 to 2015-03-01

  Anmälan om utnyttjande av återvändarbidrag för beviljade postdoktorstipendier ...

• Ansökan från Amy Goldberg inom programmet Graduate Research Opportunity Worldwide

  Research project from 2014-01-01 to 2014-12-31

  Ansökan från Amy Goldberg inom programmet Graduate Research Opportunity Worldwide ...

• Ansökan från Daniel D. Vanderpool inom programmet Graduate Research Opportunities Worldwide

  Research project from 2014-01-01 to 2014-12-31

  Ansökan från Daniel D. Vanderpool inom programmet Graduate Research Opportunities Worldwide ...

• Ansökan från Megan Mayo inom programmet Graduate Research Opportunities Worldwide

  Research project from 2014-01-01 to 2014-12-31

  Ansökan från Megan Mayo inom programmet Graduate Research Opportunities Worldwide ...

• Application for 3rd generation DNA sequencing technology to the Swedish National Infrastructure for Large-Scale DNA sequencing (SNISS)

  Research project from 2011-01-01 to 2015-12-31

  The Swedish National Infrastructure for Large-Scale DNA Sequencing (SNISS) was established by VR-RFI in January 2010 as a national core facility shared between Royal Institute of Technology, Stockholm, ...

• Är framväxten av infektionssjukdomar och klimatförändringar hot mot nordliga amfibier?

  Research project from 2019-01-01 to 2021-12-31

  A lethal fungal pathogen Batrachochytrium dendrobatidis (Bd) has caused extinction of over 100 species of amphibians globally. Our previous studies have shown that it is lethal also to Swedish amphibians ...

• Are new genetic models needed for precision breeding based on genomics information?

  Research project from 2018-01-01 to 2020-12-31

  Providing food for a growing world wide population in a cost-efficient and environmentally friendly manner is a significant challenge in future agriculture. Animal and plant breeding will have a central ...

• Assembly of the gut microbiome from birth to weaning: a cross-species comparison in wild mammals

  Research project from 2020-07-01 to 2023-06-30

  The assembly of the gut microbiome after birth is one of the most important processes for animal development and health. Yet we know extremely little about this process, including whether microbes are ...

• Origins of the Norway spruce breeding population, response to climate change and allocation to breeding zones

  Research project from 2014-01-01 to 2016-12-31

  Norway spruce is one of the main components of the boreal forest and a major source of wood products in Sweden. A large proportion of Central and Southern Sweden spruce stands were created with seeds imported ...

• Bacterial genome dynamics

  Research project from 2013-01-01 to 2016-12-31

  Many genomes are in a dynamic state where genes are continuously being lost, gained and altered by deletions, gene amplification/horizontal gene transfer (HGT) and point mutations. Several processes are ...

• Bacterial microevolution: From codon usage to genome organization

  Research project from 2017-01-01 to 2017-12-31

  The chromosome theory of inheritance, the identification of chromosomes as the carriers of genetic information, is a unifying theory of genetics. According to the chromosome theory the genetic units identified ...

• Bacterial microevolution: genetic and physiological responses to impaired growth potential.

  Research project from 2013-01-01 to 2015-12-31

  This proposal addresses examples of bacterial microevolution, and the genetic and physiological adaptations that occur, in response to impaired growth potential. In one sub-project the evolution and physiological ...

• Finding the hidden GEMS in genome-wide association analyses: Do we need to change the way to model the genetics of quantitative traits?

  Research project from 2018-01-01 to 2021-12-31

  Genotype-to-phenotype mapping is a core feature of genetics. These maps describe how combinations of DNA variants (genotypes) contribute to the appearance (the phenotype) of an individual organism. Staggering ...

• Visit by Evan Koch as part of the GROW program

  Research project from 2016-10-01 to 2016-12-31

  The distribution of fitness effects of new mutations (DFE) is a vital parameter forunderstanding aspects of population genetics such as the polymorphism level, genetic load, and level of backgroundselection ...

• Nuclear interactions in the fungal heterokaryon

  Research project from 2020-01-01 to 2023-12-31

  Heterokaryosis is a genetic system in which genetically different nuclei coexist in the same cytoplasm. It is widespread among eukaryotes, and is particularly common in the fungal kingdom. Knowledge about ...

• Characterising adaptations associated with a shift from a protein to a carbohydrate based diet during dog domestication.

  Research project from 2017-01-01 to 2020-12-31

  Based on low pass whole genome sequencing I recently compared patterns of genetic variation in dog and wolf to provide initial insight into the genetic basis of adaptations during dog domestication. I ...

• Characterization of the genetic basis of migratory behavior in butterflies

  Research project from 2020-01-01 to 2022-12-31

  Human societies are facing one of the greatest environmental emergencies in history, a predicament in many ways shared by all other living organisms. Shifts in animal migratory behavior due to a rapidly ...

• Climate genomics in the Northern krill: the past, present and future of an important marine species

  Research project from 2018-01-01 to 2020-12-31

  Climate change is causing extensive alterations to the planet’s ocean ecosystems and food webs but it is still unclear if genetic adaptation in species is rapid enough to keep pace with these changes. ...

• Mutation bias in adaptive evolution and the adaptive evolution of mutation bias

  Research project from 2020-01-01 to 2023-12-31

  Evolutionary theory typically considers the phenotypic effects of new mutations as independent of past selection, but this view has recently been challenged. If selection does not only discriminate among ...

• De novo optogenetic dissection of parallel neuronal circuitries engaging the ventral tegmental area and guiding motivated behaviour.

  Research project from 2014-01-01 to 2017-12-31

  Emotional evaluation of daily environmental and internal stimuli is essential for proper guidance of motivated and goal-directed behaviour. Central in this process is the ventral tegmental area (VTA) with ...

• The genetics of biodiversity

  Research project from 2018-01-01 to 2027-12-31

  The aim is to explore the relationship between genetic variation and biodiversity by combining genetic screens in non-model organisms (e.g. Atlantic herring and Darwin’s finches) with functional follow ...

• Evolutionary Genomics of Sexual Selection in Lekking Birds

  Research project from 2014-01-01 to 2016-12-31

  Lekking birds have been models for studies of sexual selection for decades. Given that a few males commonly are observed to get most of the matings, this sets the situation for the so-called lek paradox ...

• Development of a Next Generation Sequencing molecular identification system to curb the illegal trade in orchid tubers (Orchidaceae: Orchidoideae) in Iran and Turkmenistan

  Research project from 2014-01-01 to 2016-12-31

  Orchids are collected widely in Asia Minor for use in the traditional product salep. Destructive harvesting and overexploitation of fragile populations has forced traders to tap into new resource areas ...

• Development of new strategies for sequence based characterization of RNA and post-transcriptional regulation in human tissues

  Research project from 2013-01-01 to 2015-12-31

  Over the past few years, new sequencing technologies have led to the discovery of novel types of RNA and novel catalytic functions for RNA in the cell. RNA-sequencing has further increased the ability ...

• Dynamics of gene regulatory networks in response to different stresses in Mycobacteria

  Research project from 2018-01-01 to 2020-12-31

  Gene regulatory networks play important roles in e.g. the cell cycle, signal transduction, cellular differentiation, and adaptation to varying environments. Understanding the dynamics of these networks ...

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