Research at Uppsala University
History of human antibiotic use written in the oral bacteria of wild brown bears
25 August 2021. An international team of researchers used historical museum collections to study the effects of huma ...
How research can encourage us to cycle instead
19 August 2021. How do you get to work in the mornings? Transport currently accounts for 25 per cent of GHG emission ...
Philippine ethnic group has most Denisovan DNA
13 August 2021. The Philippine ethnic group Ayta Magbukon has the highest proportion of genes from our extinct relat ...
Search for research projects
Here you will find all research projects at Uppsala University funded by the main Swedish funding bodies. The search feature is based on the SweCRIS database.
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Your choice produced 13 hits
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Genetics of platelet biogenesis and aggregation in humans and zebrafish, and relationship to cardiovascular disease
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Research project from 2016-07-01 to 2019-06-30
The overall aim is to understand platelet biogenesis, development and reactivity. The first two years of training will be in the host institute abroad, i.e., Framingham heart study (FHS), National Institutes ...
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Single-cell analysis for precision medicine in acute pediatric leukemia
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Research project from 2020-01-01 to 2023-12-31
The established chemotherapeutic treatment strategies used in pediatric oncology benefit groups of patients with similar clinical manifestations. Relapsed, chemorefractory, and extramedullary disease remain ...
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Clonal heterogeneity in acute myeloid leukemia: defining the molecular signature of dominant and dormant clones
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Research project from 2014-07-01 to 2017-06-30
Recent evidence suggests that the leukemia stem cell (LSC) population in acute myeloid leukemia (AML) is diverse, consisting of both dominant and dormant clones. In many cases, dormant clones persist after ...
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Comprehensive molecular characterization of chronic lymphocytic leukemia
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Research project from 2013-01-01 to 2016-12-31
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. The disease is clinically and biologically heterogeneous and remains incurable. The etiology is unknown. Our main goals ...
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DNMT3A in acute myeloid leukemia - exploring mechnisms for leukemogenesis and developing targeted treatment
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Research project from 2019-01-01 to 2022-12-31
In this project, we are developing a novel treatment strategy against acute myeloid leukemia (AML) with mutant DNMT3A. In addition, we will define the mechanisms by which DNMT3A mutations drive leukemogenesis.We ...
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Targeting mechanisms for IGF-1R dependent and independent epigenetic gene silencing guarding proliferation and survival in multiple myeloma - Implications for biology and therapy
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Research project from 2018-01-01 to 2021-12-31
The overall objective of this proposal is to dissect a disease-specific global epigenetic pattern of clinical importance for multiple myeloma (MM), to increase understanding of how epigenetic abnormalities ...
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Mast cells and their progenitors - mechanisms of action and significance in disease
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Research project from 2017-01-01 to 2022-12-31
Purpose and aimIn diseases such as asthma and systemic mastocytosis (SM), mast cells accumulate in the affected tissues and become activated leading to symptoms caused by the released mediators. Our studies ...
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Targeting the IGF-1R signal and mechanisms for epigenetic gene silencing guarding tumor proliferation and survival - Implications for biology and therapy
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Research project from 2015-01-01 to 2017-12-31
Previously accomplished results in our highly relevant model of multiple myeloma (MM) has generated proof-of-principle that the IGF-1R is an attractive target for intervention, and that survival circuits ...
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Targeting the IGF-1R signal and mechanisms for epigenetic gene silencing guarding tumor proliferation and survival - Implications for biology and therapy
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Research project from 2012-01-01 to 2014-12-31
The interest in mapping mechanisms regulating apoptosis has grown in the light of an established role for survival circuits in tumourigenesis and therapeutic targeting. Previously accomplished research ...
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Targets and function of DNA methylation in acute leukemia
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Research project from 2010-01-01 to 2015-12-31
Epigenetic methylation of CpG sites in the human genome may play an imortnat role in disease progression of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Our objective is to identify ...
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Targeting mutated DNMT3A in acute myeloid leukemia
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Research project from 2016-01-01 to 2018-12-31
In this project, we aim to develop a novel treatment strategy against the most common type of acute leukemia: acute myeloid leukemia (AML). The prognosis for AML patients remains grim with less than 20% ...
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Neutrophil Extracellular Traps as Potential Driver of COVID-19
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Research project from 2020-08-01 to 2020-12-31
Neutrophils comprise the first line of defense against pathogens, as they are instrumental for killing the invaders by different means including NETosis (Neutrophil Extracellular Traps). Aberrant NET formation ...
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Tracking clonal evolution in leukemia- one cell at a time.
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Research project from 2020-07-01 to 2023-06-30
Acute lymphoblastic leukemia (ALL) accounts for the greatest number of deaths from childhood cancer overall. Hence there remains an urgent need to devise novel treatment strategies, particularly for the ...
Showing 13 Of 13 hits
Research spotlight: The coronavirus
New method for discovery of antiviral drugs
2 August 2021. The current COVID-19 pandemic has highlighted the need for methods to identify new or repurposed dru ...
Helpline important for older people during the pandemic
8 July 2021. For many older individuals, the COVID-19 pandemic has resulted in the loss of daily anonymous contac ...
The national COVID-19 Data Portal turns one year old
3 June 2021. The national Swedish COVID-19 Data Portal was launched one year ago to support researchers in utilis ...
Lectures
Uppsala University’s researchers share their knowledge in public lectures. Every year, the University is visited by leading researchers and influential people from around the world. At Uppsala University, you can hear Nobel laureates, researchers, authors, politicians and many others give lectures. Here we present some of the most prominent, annually occurring lectures at Uppsala University.