Research at Uppsala University
Access to water – also a future issue in Sweden
24 January 2022. There is enough water on Earth. Just not everywhere – and for everyone. Now researchers at Uppsala U ...
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Strengthening societal responses to natural hazard events
18 January 2022. Our societies generally need to enhance their preparedness for extreme natural hazard events, such a ...
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Previously unknown dinosaur habitat found in Poland
13 January 2022. In summer 2021, in an opencast clay mine in Borkowice, Poland, researchers found what may be Europe’ ...
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Search for research projects
Here you will find all research projects at Uppsala University funded by the main Swedish funding bodies. The search feature is based on the SweCRIS database.
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Your choice produced 13 hits
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Genetics of platelet biogenesis and aggregation in humans and zebrafish, and relationship to cardiovascular disease
Research project from 2016-07-01 to 2019-06-30
The overall aim is to understand platelet biogenesis, development and reactivity. The first two years of training will be in the host institute abroad, i.e., Framingham heart study (FHS), National Institutes ...
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Single-cell analysis for precision medicine in acute pediatric leukemia
Research project from 2020-01-01 to 2023-12-31
The established chemotherapeutic treatment strategies used in pediatric oncology benefit groups of patients with similar clinical manifestations. Relapsed, chemorefractory, and extramedullary disease remain ...
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Clonal heterogeneity in acute myeloid leukemia: defining the molecular signature of dominant and dormant clones
Research project from 2014-07-01 to 2017-06-30
Recent evidence suggests that the leukemia stem cell (LSC) population in acute myeloid leukemia (AML) is diverse, consisting of both dominant and dormant clones. In many cases, dormant clones persist after ...
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Comprehensive molecular characterization of chronic lymphocytic leukemia
Research project from 2013-01-01 to 2016-12-31
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. The disease is clinically and biologically heterogeneous and remains incurable. The etiology is unknown. Our main goals ...
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DNMT3A in acute myeloid leukemia - exploring mechnisms for leukemogenesis and developing targeted treatment
Research project from 2019-01-01 to 2022-12-31
In this project, we are developing a novel treatment strategy against acute myeloid leukemia (AML) with mutant DNMT3A. In addition, we will define the mechanisms by which DNMT3A mutations drive leukemogenesis.We ...
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Targeting mechanisms for IGF-1R dependent and independent epigenetic gene silencing guarding proliferation and survival in multiple myeloma - Implications for biology and therapy
Research project from 2018-01-01 to 2021-12-31
The overall objective of this proposal is to dissect a disease-specific global epigenetic pattern of clinical importance for multiple myeloma (MM), to increase understanding of how epigenetic abnormalities ...
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Mast cells and their progenitors - mechanisms of action and significance in disease
Research project from 2017-01-01 to 2022-12-31
Purpose and aimIn diseases such as asthma and systemic mastocytosis (SM), mast cells accumulate in the affected tissues and become activated leading to symptoms caused by the released mediators. Our studies ...
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Targeting the IGF-1R signal and mechanisms for epigenetic gene silencing guarding tumor proliferation and survival - Implications for biology and therapy
Research project from 2012-01-01 to 2014-12-31
The interest in mapping mechanisms regulating apoptosis has grown in the light of an established role for survival circuits in tumourigenesis and therapeutic targeting. Previously accomplished research ...
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Targeting the IGF-1R signal and mechanisms for epigenetic gene silencing guarding tumor proliferation and survival - Implications for biology and therapy
Research project from 2015-01-01 to 2017-12-31
Previously accomplished results in our highly relevant model of multiple myeloma (MM) has generated proof-of-principle that the IGF-1R is an attractive target for intervention, and that survival circuits ...
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Targets and function of DNA methylation in acute leukemia
Research project from 2010-01-01 to 2015-12-31
Epigenetic methylation of CpG sites in the human genome may play an imortnat role in disease progression of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Our objective is to identify ...
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Targeting mutated DNMT3A in acute myeloid leukemia
Research project from 2016-01-01 to 2018-12-31
In this project, we aim to develop a novel treatment strategy against the most common type of acute leukemia: acute myeloid leukemia (AML). The prognosis for AML patients remains grim with less than 20% ...
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Neutrophil Extracellular Traps as Potential Driver of COVID-19
Research project from 2020-08-01 to 2020-12-31
Neutrophils comprise the first line of defense against pathogens, as they are instrumental for killing the invaders by different means including NETosis (Neutrophil Extracellular Traps). Aberrant NET formation ...
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Tracking clonal evolution in leukemia- one cell at a time.
Research project from 2020-07-01 to 2023-06-30
Acute lymphoblastic leukemia (ALL) accounts for the greatest number of deaths from childhood cancer overall. Hence there remains an urgent need to devise novel treatment strategies, particularly for the ...
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Research spotlight: The coronavirus
Blocking inhibits SARS-CoV-2 infection of human cells
24 November 2021. Viruses invade our cells and turn them into virus factories. Researchers at Uppsala University, toge ...
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New method for discovery of antiviral drugs
2 August 2021. The current COVID-19 pandemic has highlighted the need for methods to identify new or repurposed dru ...
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Helpline important for older people during the pandemic
8 July 2021. For many older individuals, the COVID-19 pandemic has resulted in the loss of daily anonymous contac ...
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Lectures
Uppsala University’s researchers share their knowledge in public lectures. Every year, the University is visited by leading researchers and influential people from around the world. At Uppsala University, you can hear Nobel laureates, researchers, authors, politicians and many others give lectures. Here we present some of the most prominent, annually occurring lectures at Uppsala University.