Research at Uppsala University

Research project from 2013-01-01 to 2014-12-31

This project aims to develop of a novel human ex-vivo whole blood loop system for an improved characterization of therapeutic antibodies in order to avoid irrelevant and unnecessary animal studies. Today ...

Research project from 2019-07-01 to 2021-12-31

Purpose and goal: There is no cure for Anaplastic Thyroid Cancer (ATC) today. Whereas other forms of thyroid cancer can be successfully treated with radioactive iodine, ATC cells lack the ion pumps required ...

Research project from 2021-01-01 to 2023-12-31

Mast cells are currently emerging as major players in a variety of pathologies, but the mechanisms by which they exert such diverse functions remain to be elucidated. A hallmark feature of mast cells is ...

Research project from 2021-01-01 to 2024-12-31

Glioblastomas are aggressive gliomas with a grim prognosis, characterized extreme invasiveness and abnormal vessels. The abnormal vessels can promote tumor progession by providing a route of invasion for ...

Research project from 2019-01-01 to 2021-12-31

Regulatory T cells (Tregs) are immune cells that play a pivotal role in maintaining homeostasis, as well as in autoimmunity, infection and tumor biology. Recent evidence suggests that tissue-specific Tregs ...

Research project from 2013-07-01 to 2016-06-30

The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...

Research project from 2020-01-01 to 2023-12-31

Immunotherapy has revolutionized cancer treatment and checkpoint inhibitors, which act by removing negative signals in already activated T cells, are predicted tobecome first line treatment for many cancer ...

Research project from 2016-01-01 to 2019-12-31

Immunotherapy is currently being established as cancer treatment. Immune checkpoint blockade antibodies that fine-tune T cell activity to attack and kill tumor cells can cure 20-25% of patients with refractory ...

Research project from 2016-01-01 to 2018-12-31

The overall aim of this plan is to improve the treatment of patients with persistent pain and itch by developing novel pharmaceutical strategies and by increasing our knowledge of how itch and pain is ...

Research project from 2015-01-01 to 2017-12-31

Why some persons develop type 1 diabetes mellitus is still largely unknown. The incidence of this disease is increasing worldwide, but the reasons for the onset of the autoimmune process killing the insulin-producing ...

Research project from 2014-01-01 to 2018-12-31

A prominent feature in a number of rheumatic diseases is an increased expression in blood and tissue cells of type I interferon regulated genes (an IFN signature), which activates both the innate and adaptive ...

Research project from 2019-01-01 to 2021-12-31

The over-all purpose of this project is to improve immunotherapy in neurodegenerative diseases by targeting neurotoxic protein aggregates with brain penetrating bispecific antibodies. As antibodies do ...

Research project from 2017-01-01 to 2020-12-31

Animal cells maintain tissue function by secreting regulatory factors to signal their activity and nutrient status, pathogen infections or injury. These regulated vesicle fusion events are typically much ...

Research project from 2016-01-01 to 2018-12-31

Antibodies dramatically up- or downregulate the immune response to the antigen they bind and thus, depending on isotype and antigen, act as natural adjuvants or immunosuppressors. IgG-MEDIATED SUPPRESSION ...

Research project from 2012-01-01 to 2014-12-31

The objectives are to understand how IgM/complement and IgE/the low affinity receptor for IgE (CD23) operate to feedback enhance the immune response and how IgG feedback suppresses antibody responses. ...

Research project from 2019-01-01 to 2021-12-31

The aim is to understand how passively administered or endogenously produced Abs, forming immune complexes (ICs) with their Ag, can completely suppress or enhance Ab responses several 100-fold. Special ...

Research project from 2014-01-01 to 2016-12-31

OBJECTIVE: To study immune complex (IC)-mediated mechanisms in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), with emphasis on how IC and IC-associated autoantibodies regulate production ...

Research project from 2021-01-01 to 2023-12-31

We recently made three discoveries related to acquired Loss Of chromosome Y (LOY) in blood of adult/aging men. LOY is associated with: a) shorter survival and increased mortality from cancer; b) Alzheimer ...

Research project from 2013-01-01 to 2015-12-31

Autoinflammatory disease (AID) is a disease of self, presenting clinically as unprovoked inflammation in the absence of high titre autoantibodies or antigen specific T cells, and resulting from a dysregulation ...

Research project from 2020-01-01 to 2022-12-31

In this four-year project we will expand, develop and refine the way autoimmune serology is used to characterize and understand the pathogenetic mechanisms leading to individual clinical phenotypes of ...

Research project from 2016-01-01 to 2017-12-31

Autoantibodies, immune complex (IC) deposition, and complement are important factors in many autoimmune diseases. IgM antibodies exert their effect through complement or Fc-receptors. The aim of the current ...

Research project from 2015-01-01 to 2018-12-31

Immune cells (leukocytes) have essential roles in many situations in the body and are vital for survival. However, they are also driving detrimental inflammation, contributing to the majority of diseases ...

Research project from 2018-01-01 to 2018-12-31

Immunological research ...

Research project from 2013-01-01 to 2017-12-31

Global mortality among children under the age of 5 approximates 10 million deaths per year, of whom 1.9 million is due to diarrhea and 5 million deaths are associated with malnutrition. A substantial ...

Research project from 2021-01-01 to 2024-12-31

Despite more than 100 million infections annually and extensive scientific efforts to understand disease mechanisms, the clinical course of dengue infection, progression to severe dengue disease, particularly ...

Research project from 2017-01-01 to 2020-12-31

Glioblastomas are highly aggressive brain tumors, characterized by microvascular proliferation and dysfunctional vessels. The abnormal vessels contribute substantially to patient mortality. Still, the ...

Research project from 2012-01-01 to 2014-12-31

Detrimental inflammation contributes to a majority of diseases, and increased knowledge of the mechanisms that regulate leukocyte recruitment is central to limit inflammatory response. We previously established ...

Research project from 2017-01-01 to 2020-12-31

The lymph nodes provide a unique environment for immune activation and regulation, including antitumor responses. They arealso common sites for tumor metastasis. My own and others recent data has shownthat ...

Research project from 2017-01-01 to 2022-12-31

Purpose and aimIn diseases such as asthma and systemic mastocytosis (SM), mast cells accumulate in the affected tissues and become activated leading to symptoms caused by the released mediators. Our studies ...

Research project from 2012-01-01 to 2014-12-31

In lungs of patients with allergic asthma mast cell numbers are increased and they release mediators that contribute to asthma symptoms. The increase in lung mast cells in mouse models of allergic airway ...