Research at Uppsala University
History of human antibiotic use written in the oral bacteria of wild brown bears
25 August 2021. An international team of researchers used historical museum collections to study the effects of huma ...
How research can encourage us to cycle instead
19 August 2021. How do you get to work in the mornings? Transport currently accounts for 25 per cent of GHG emission ...
Philippine ethnic group has most Denisovan DNA
13 August 2021. The Philippine ethnic group Ayta Magbukon has the highest proportion of genes from our extinct relat ...
Search for research projects
Here you will find all research projects at Uppsala University funded by the main Swedish funding bodies. The search feature is based on the SweCRIS database.
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Your choice produced 42 hits
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A human whole blood loop system for superior characterization of therapeutic antibodies
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Research project from 2013-01-01 to 2014-12-31
This project aims to develop of a novel human ex-vivo whole blood loop system for an improved characterization of therapeutic antibodies in order to avoid irrelevant and unnecessary animal studies. Today ...
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A new targeted radiopharmaceutical for treatment of anaplastic thyroid cancer
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Research project from 2019-07-01 to 2021-12-31
Purpose and goal: There is no cure for Anaplastic Thyroid Cancer (ATC) today. Whereas other forms of thyroid cancer can be successfully treated with radioactive iodine, ATC cells lack the ion pumps required ...
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Biological function of mast cell tryptase: cancer and beyond
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Research project from 2021-01-01 to 2023-12-31
Mast cells are currently emerging as major players in a variety of pathologies, but the mechanisms by which they exert such diverse functions remain to be elucidated. A hallmark feature of mast cells is ...
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The vasculature as a target for therapy in brain tumors
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Research project from 2021-01-01 to 2024-12-31
Glioblastomas are aggressive gliomas with a grim prognosis, characterized extreme invasiveness and abnormal vessels. The abnormal vessels can promote tumor progession by providing a route of invasion for ...
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Pancreas-specific regulatory T cells: characterizing their molecular signature by establishing novel tools and investigating their role in pancreatic homeostasis and pathology
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Research project from 2019-01-01 to 2021-12-31
Regulatory T cells (Tregs) are immune cells that play a pivotal role in maintaining homeostasis, as well as in autoimmunity, infection and tumor biology. Recent evidence suggests that tissue-specific Tregs ...
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Can HIV infection be averted - characterization of the early host response in SIV infected Indian-origin rhesus macaques by RNA sequencing
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Research project from 2013-07-01 to 2016-06-30
The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...
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Cancer immunotherapy using next generation oncolytic viruses and CAR T cells
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Research project from 2020-01-01 to 2023-12-31
Immunotherapy has revolutionized cancer treatment and checkpoint inhibitors, which act by removing negative signals in already activated T cells, are predicted tobecome first line treatment for many cancer ...
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Cancer immunotherapy with engineered T cells and viruses
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Research project from 2016-01-01 to 2019-12-31
Immunotherapy is currently being established as cancer treatment. Immune checkpoint blockade antibodies that fine-tune T cell activity to attack and kill tumor cells can cure 20-25% of patients with refractory ...
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Deciphering sensory circuits – central and peripheral regulation of itch and pain
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Research project from 2016-01-01 to 2018-12-31
The overall aim of this plan is to improve the treatment of patients with persistent pain and itch by developing novel pharmaceutical strategies and by increasing our knowledge of how itch and pain is ...
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Diabetes When it Happens: Real-time In Vivo Imaging of Innate and Adaptive Immune Responses in Type 1 Diabetes
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Research project from 2015-01-01 to 2017-12-31
Why some persons develop type 1 diabetes mellitus is still largely unknown. The incidence of this disease is increasing worldwide, but the reasons for the onset of the autoimmune process killing the insulin-producing ...
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Disease mechanisms in autoimmune rheumatic diseases with an interferon signature
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Research project from 2014-01-01 to 2018-12-31
A prominent feature in a number of rheumatic diseases is an increased expression in blood and tissue cells of type I interferon regulated genes (an IFN signature), which activates both the innate and adaptive ...
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Enhanced brain delivery of antibodies for effective treatment of neurodegenerative diseases
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Research project from 2019-01-01 to 2021-12-31
The over-all purpose of this project is to improve immunotherapy in neurodegenerative diseases by targeting neurotoxic protein aggregates with brain penetrating bispecific antibodies. As antibodies do ...
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Exploring How Vesicle Fusion is Regulated by Kinases and GTPases
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Research project from 2017-01-01 to 2020-12-31
Animal cells maintain tissue function by secreting regulatory factors to signal their activity and nutrient status, pathogen infections or injury. These regulated vesicle fusion events are typically much ...
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Feedback regulation of immune responses
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Research project from 2016-01-01 to 2018-12-31
Antibodies dramatically up- or downregulate the immune response to the antigen they bind and thus, depending on isotype and antigen, act as natural adjuvants or immunosuppressors. IgG-MEDIATED SUPPRESSION ...
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Feedback regulation of immune responses
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Research project from 2012-01-01 to 2014-12-31
The objectives are to understand how IgM/complement and IgE/the low affinity receptor for IgE (CD23) operate to feedback enhance the immune response and how IgG feedback suppresses antibody responses. ...
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Feedback regulation of immune responses
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Research project from 2019-01-01 to 2021-12-31
The aim is to understand how passively administered or endogenously produced Abs, forming immune complexes (ICs) with their Ag, can completely suppress or enhance Ab responses several 100-fold. Special ...
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Functional and prognostic impact of immune complexes and immune complex-associated autoantibodies in rheumatic diseases
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Research project from 2014-01-01 to 2016-12-31
OBJECTIVE: To study immune complex (IC)-mediated mechanisms in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), with emphasis on how IC and IC-associated autoantibodies regulate production ...
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Loss of chromosome Y causes defective immune-surveillance, which leads to cancer and Alzheimer’s disease in aging men
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Research project from 2021-01-01 to 2023-12-31
We recently made three discoveries related to acquired Loss Of chromosome Y (LOY) in blood of adult/aging men. LOY is associated with: a) shorter survival and increased mortality from cancer; b) Alzheimer ...
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The characterization of autoinflammatory disease (AID) predisposition and progression through genetic and functional studies
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Research project from 2013-01-01 to 2015-12-31
Autoinflammatory disease (AID) is a disease of self, presenting clinically as unprovoked inflammation in the absence of high titre autoantibodies or antigen specific T cells, and resulting from a dysregulation ...
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How immune complexes and associated autoantibodies determine clinical phenotypes in rheumatic diseases
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Research project from 2020-01-01 to 2022-12-31
In this four-year project we will expand, develop and refine the way autoimmune serology is used to characterize and understand the pathogenetic mechanisms leading to individual clinical phenotypes of ...
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IgM, complement and the IgM Fc-receptor in humoral immune responses and autoimmune diseases
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Research project from 2016-01-01 to 2017-12-31
Autoantibodies, immune complex (IC) deposition, and complement are important factors in many autoimmune diseases. IgM antibodies exert their effect through complement or Fc-receptors. The aim of the current ...
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Targeting Leukocytes in Health and Disease
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Research project from 2015-01-01 to 2018-12-31
Immune cells (leukocytes) have essential roles in many situations in the body and are vital for survival. However, they are also driving detrimental inflammation, contributing to the majority of diseases ...
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Immunological research
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Research project from 2018-01-01 to 2018-12-31
Immunological research ...
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Virulence mechanisms of intestinal protozoa: from arginine starvation to stimulation of co-infections
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Research project from 2013-01-01 to 2017-12-31
Global mortality among children under the age of 5 approximates 10 million deaths per year, of whom 1.9 million is due to diarrhea and 5 million deaths are associated with malnutrition. A substantial ...
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Mapping the virus-host transcriptional landscape for a better understanding of dengue disease
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Research project from 2021-01-01 to 2024-12-31
Despite more than 100 million infections annually and extensive scientific efforts to understand disease mechanisms, the clinical course of dengue infection, progression to severe dengue disease, particularly ...
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The vasculature as a target for therapy in brain tumors
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Research project from 2017-01-01 to 2020-12-31
Glioblastomas are highly aggressive brain tumors, characterized by microvascular proliferation and dysfunctional vessels. The abnormal vessels contribute substantially to patient mortality. Still, the ...
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Leukocyte recruitment during inflammation and angiogenesis
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Research project from 2012-01-01 to 2014-12-31
Detrimental inflammation contributes to a majority of diseases, and increased knowledge of the mechanisms that regulate leukocyte recruitment is central to limit inflammatory response. We previously established ...
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Lymph node vessel specialization and heterogeneity in orchestration of the immune response in cancer
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Research project from 2017-01-01 to 2020-12-31
The lymph nodes provide a unique environment for immune activation and regulation, including antitumor responses. They arealso common sites for tumor metastasis. My own and others recent data has shownthat ...
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Mast cells and their progenitors - mechanisms of action and significance in disease
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Research project from 2017-01-01 to 2022-12-31
Purpose and aimIn diseases such as asthma and systemic mastocytosis (SM), mast cells accumulate in the affected tissues and become activated leading to symptoms caused by the released mediators. Our studies ...
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Mast cells and their progenitors in allergic airway inflammation and respiratory infections
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Research project from 2012-01-01 to 2014-12-31
In lungs of patients with allergic asthma mast cell numbers are increased and they release mediators that contribute to asthma symptoms. The increase in lung mast cells in mouse models of allergic airway ...
Showing 30 Of 42 hits
Show more hitsResearch spotlight: The coronavirus
New method for discovery of antiviral drugs
2 August 2021. The current COVID-19 pandemic has highlighted the need for methods to identify new or repurposed dru ...
Helpline important for older people during the pandemic
8 July 2021. For many older individuals, the COVID-19 pandemic has resulted in the loss of daily anonymous contac ...
The national COVID-19 Data Portal turns one year old
3 June 2021. The national Swedish COVID-19 Data Portal was launched one year ago to support researchers in utilis ...
Lectures
Uppsala University’s researchers share their knowledge in public lectures. Every year, the University is visited by leading researchers and influential people from around the world. At Uppsala University, you can hear Nobel laureates, researchers, authors, politicians and many others give lectures. Here we present some of the most prominent, annually occurring lectures at Uppsala University.