Research at Uppsala University
History of human antibiotic use written in the oral bacteria of wild brown bears
25 August 2021. An international team of researchers used historical museum collections to study the effects of huma ...
How research can encourage us to cycle instead
19 August 2021. How do you get to work in the mornings? Transport currently accounts for 25 per cent of GHG emission ...
Philippine ethnic group has most Denisovan DNA
13 August 2021. The Philippine ethnic group Ayta Magbukon has the highest proportion of genes from our extinct relat ...
Search for research projects
Here you will find all research projects at Uppsala University funded by the main Swedish funding bodies. The search feature is based on the SweCRIS database.
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Your choice produced 36 hits
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3rd Frontiers in Medicinal Chemistry Meeting: Emerging Targets, Novel Candidates and Innovative Strategies
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Research project from 2011-01-01 to 2011-12-31
Undertecknad är "co-chair" av det internationella läkemedelskemimötet ?Frontiers in Medicinal Chemistry?. Detta arrangeras nu för tredje gången och Stockholm har blivit utsedd som värd (19-21/6, 2011). ...
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Frontiers in Antibacterial Drug Discovery
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Research project from 2016-06-01 to 2016-06-30
The Frontiers in Antibiotic Drug Discovery (FiADD) symposium will be held at the Conference Center of the Royal Swedish Academy of Engineering Sciences (IVA) in Stockholm, Sweden, on 14 -15 September, ...
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Antibody-based PET in neurodegenerative diseases
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Research project from 2018-01-01 to 2021-12-31
Aim: To develop antibody (mAb) based Positron Emission Tomography (PET) ligands for use in Alzheimer’s (AD) and Parkinson’s disease (PD) with dynamic and specific properties correlating with disease severity.Current ...
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Antimicrobial peptides from meat production waste as immune-boosting antibiotic agents.
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Research project from 2019-01-01 to 2021-12-31
Antimicrobial peptides are part of the innate immune system of animals where they serve multifunctional purposes including: broad-spectrum bactericidal activity, bacterial toxin inhibition, wound healing ...
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Pushing the boundaries of the nucleophilic aromatic substitution through photochemistry
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Research project from 2017-02-01 to 2018-06-30
Purpose and goal: The project had two goals; (i) to establish longterm research contacts between my research group at UU and AstraZeneca and (ii) to develop the photo-SNAr reaction. Both goals have been ...
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Attenuation of SARS-CoV-2 infectivity and hyperinflammation in Covid-19 by heparin-related polysaccharides
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Research project from 2020-08-01 to 2020-12-31
Low molecular-weight heparin (LMWH) has rapidly become a primary drug in treatment of Covid-19 patients. A major rationale is the pulmonary coagulopathy typical of the seriously ill patient. Increasing ...
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Can enzymes from crop plants be used for the generation of peptide antibiotics? Proof of concept of biocatalysts for green peptide chemistry
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Research project from 2017-01-01 to 2019-12-31
Peptides are rapidly gaining interest for the development of drugs, for use in agriculture, and in biotechnology because their specificity and potency. However, the development is hampered by their lack ...
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Computational design of GPCR drugs from fragments
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Research project from 2017-01-01 to 2017-03-13
G protein-coupled receptors (GPCRs) play important roles in numerous physiological processes and are important drug targets for neurological diseases. Breakthroughs in GPCR structural biology and access ...
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Computational studies of adenosine receptor modulation via orthosteric, allosteric, and indirect allosteric mechanisms
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Research project from 2018-01-01 to 2021-12-31
The project is focused on structure-based strategies for discovery of selective ligands of G protein-coupled receptors (GPCRs) and understanding of GPCR dimerization. The A1 adenosine receptor (A1R) is ...
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Design of chemical tools for drug discovery beyond the ¨rule of 5¨
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Research project from 2017-01-01 to 2020-12-31
Many novel targets, in particular protein-protein interactions (PPIs), cannot be modulated with small drug-like molecules. Instead, compounds in a different chemical space, e.g. macrocycles and peptides ...
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Exchange between academia and industry in the area of drug discovery and development
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Research project from 2016-06-01 to 2017-11-30
Purpose and goal: The aim for this project was to transfer knowledge and methods in drug discovery and development between Uppsala University and AstraZeneca Gothenburg. Specific goals in the project ...
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Exploration of East African Herbal Resources to Control Major Health Challenges
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Research project from 2017-01-01 to 2019-12-31
This study will make use of East African indigenous knowledge for the application of natural resources to control the major health and societal challenges malaria, tuberculosis and bacterial infections.Following ...
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Exploration of East African Medicinal Herbs in the Search for Novel Antibacterial Agents
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Research project from 2020-01-01 to 2022-12-31
Antimicrobial resistance has become a major threat to human health and development. As our currently used antibiotics lose efficiency, we risk rapidly increasing number of untreatable infections leading ...
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Exploring ion channel toxins from the Swedish fauna
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Research project from 2014-01-01 to 2018-12-31
Peptide toxins have a huge potential as pharmacological agents due to high affinity and selectivity for their target receptors. In the current project we will explore a neglected natural resource to find ...
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Exploring physics-based methods for predicting protein-ligand binding
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Research project from 2015-07-01 to 2018-06-30
One important role of computer aided drug design is to guide modifications of ligands to improve binding to the protein target. Free energy perturbation (FEP) is one of the most rigorous methods to calculate ...
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From Oddity to Utility: New and Enabling Synthetic Tools for Molecular Imaging and Chemical Biology
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Research project from 2019-01-01 to 2022-12-31
The invention of new methodology for the synthesis of biologically active compounds is one the most fundamental and important goals in modern organic chemistry. As the demands for new medicines, diagnostic ...
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New Approaches to Target Tuberculosis and Infectious Diseases
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Research project from 2011-01-01 to 2011-12-31
The conference will be a scientific forum for developers of new potent drugs against drug resistant and latent strains of Mycobacterium tuberculosis, and for developers of therapeutics against hospital ...
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Inhibition studies of metallo-beta-lactamases as target proteins of antibiotic resistance
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Research project from 2014-01-01 to 2018-12-31
The appearance of superbugs producing metallo-beta-lactamases have resulted in a clinical crisis. This project intends to express and purify subclasses of metallo-beta-lactamases including NDM-1. Specific ...
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Innovative tools for drug-discovery
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Research project from 2009-11-01 to 2014-04-30
Currently not available ...
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Quantitative Structure-Based Models for Ligand Interactions with G-Protein Coupled Receptors
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Research project from 2014-01-01 to 2018-12-31
This project deals with computational analysis and modelling of key interactions between membrane associated G-protein coupled receptors (GPCRs) of medical importance and endogenous as well as extraneous ...
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Quantitative Structure-Based Models for Ligand Interactions with Membrane Channels and Receptors
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Research project from 2011-01-01 to 2013-12-31
This project deals with computational analysis and modelling of key interactions between membrane associated proteins of medical importance and endogenous as well as extraneous ligands. It is primarily ...
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Mechanisms of protein synthesis and ribosome targeting antibiotic drugs in mycobacteria.
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Research project from 2009-06-01 to 2013-05-31
Purpose and goal: Expected results and effects: Approach and implementation: ...
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New Nucleolytically Stable Antisense/siRNA/miRNA Oligonucleotides For The Target mRNA Degradation
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Research project from 2015-01-01 to 2018-12-31
Our carba-LNA modified antisense oligos and siRNAs are shown (see Scientific report: D) to block gene expression by degrading disease-specific target mRNA with (1) high blood-serum stability, (2) enhanced ...
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Novel cancer chemotherapies targeting loss of heterozygosity
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Research project from 2021-01-01 to 2024-12-31
New cancer therapeutics are sorely needed to extend the treatment options for cancer. Our research aims at development of a new class of individualized cancer therapies that target cells with loss-of-heterozygosity ...
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Open and Free Infrastructure for Predictive Modeling in Drug Discovery and Development
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Research project from 2013-01-01 to 2015-12-31
Today´s pharmacy industry barely develops medicines for neglected diseases. We here propose to implement an open and free chemobioinformatics infrastructure, which can be used by anyone to effectively ...
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PARAMAGNETIC LIGAND TAGGING, A NEW TOOL IN CHEMISTRY AND BIOLOGY
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Research project from 2017-01-01 to 2020-12-31
The chief aim of this project is to develop an exceptionally sensitive technique for detection and characterization of weak interactions in solution, in chemical and biological contexts. To achieve this ...
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PET imaging of soluble amyloid-beta in Alzheimer´s disease
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Research project from 2013-01-01 to 2015-12-31
The over-all purpose of this project is to improve clinical PET imaging of amyloid-beta (Abeta), such that the technique can be used to monitor disease progression and therapeutic efficacy of drug candidates ...
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Paramagnetic ligand tagging, a new tool in drug development
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Research project from 2016-01-01 to 2016-12-31
Access to 3D-structural information on the protein complexes of pharmaceutical screening hits is crucial for their development into lead molecules, i.e. starting points for new drugs. Due to inefficiency ...
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Polypeptide conjugates that recognize proteins
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Research project from 2015-01-01 to 2018-12-31
A chemical strategy for the molecular recognition of proteins based on polypeptide conjugates has been shown to provide dramatically increased affinities and selectivities over those of the small organic ...
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Proximitetsligering som ett nytt verktyg för selektion av kombinationer av reagens för diagnostik och terapi
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Research project from 2012-01-01 to 2016-12-31
Efficient identification of molecules specifically binding proteins is of central importance in future medicine. Accordingly, effective means to construct, select and optimize affinity reagents can enable ...
Showing 30 Of 36 hits
Show more hitsResearch spotlight: The coronavirus
New method for discovery of antiviral drugs
2 August 2021. The current COVID-19 pandemic has highlighted the need for methods to identify new or repurposed dru ...
Helpline important for older people during the pandemic
8 July 2021. For many older individuals, the COVID-19 pandemic has resulted in the loss of daily anonymous contac ...
The national COVID-19 Data Portal turns one year old
3 June 2021. The national Swedish COVID-19 Data Portal was launched one year ago to support researchers in utilis ...
Lectures
Uppsala University’s researchers share their knowledge in public lectures. Every year, the University is visited by leading researchers and influential people from around the world. At Uppsala University, you can hear Nobel laureates, researchers, authors, politicians and many others give lectures. Here we present some of the most prominent, annually occurring lectures at Uppsala University.