Research at Uppsala University

Research project from 2011-01-01 to 2011-12-31

Undertecknad är "co-chair" av det internationella läkemedelskemimötet ?Frontiers in Medicinal Chemistry?. Detta arrangeras nu för tredje gången och Stockholm har blivit utsedd som värd (19-21/6, 2011). ...

Research project from 2011-01-01 to 2011-12-31

Denna konferens är den 7:e i en serie av möten inom marin naturproduktforskning som anordnas vartannat år av Europeiska forskare. Professor Lars Bohlin med medarbetare har fått hedersuppdraget att för ...

Research project from 2018-01-01 to 2020-12-31

The project aims at the development of a novel photochemical process for production of sustainable fossil-free lubricant oils from compounds obtained from Swedish biosources. For a variety of different ...

Research project from 2016-01-01 to 2019-12-31

In project A, we will synthesize bioinorganic model complexes of the [FeFe] and the [Fe] hydrogenase (H2ase) active sites. The role of the second coordination sphere and the protein matrix in [FeFe] H2ases ...

Research project from 2020-01-01 to 2023-12-31

The project fuses low-coordinate phosphorus chemistry and carbonyl olefinations with the aim to develop unprecedented alkene formation reactions from the reductive cross-coupling of two carbonyl compounds ...

Research project from 2017-02-01 to 2018-06-30

Purpose and goal: The project had two goals; (i) to establish longterm research contacts between my research group at UU and AstraZeneca and (ii) to develop the photo-SNAr reaction. Both goals have been ...

Research project from 2017-01-01 to 2019-12-31

This project aims for the development of Li-ion batteries produced primarily from biomass resources, and where lithium can be recycled using low-temperature processing and non-toxic conditions. Such a ...

Research project from 2010-10-01 to 2016-09-30

In project A, we will synthesize bioinorganic model complexes of the [FeFe] and the [Fe] hydrogenase (H2ase) active sites. The design of the [FeFe]-H2ase mimics is guided by functional aspects which will ...

Research project from 2018-01-01 to 2021-12-31

My recent ground-breaking finding (Angew Chem Int Ed., 2016, 55, 12306, Hot Paper) shows that three dimensional organic polymer nano-dots (Pdots) prepared from pristine polymers are a family of efficient ...

Research project from 2012-01-01 to 2014-12-31

When substitution of the hydroxyl group of an alcohol is performed in traditional synthesis, the alcohol is first converted into a more reactive ester or halide in an extra synthetic step. Besides lowering ...

Research project from 2014-01-01 to 2017-12-31

The aim of the proposed work is the development of new fluorescent tools to investigate biological phenomena. First, new, spectroscopically active base analogues, and nucleic acid-compatible lanthanide ...

Research project from 2017-01-01 to 2020-12-31

Many novel targets, in particular protein-protein interactions (PPIs), cannot be modulated with small drug-like molecules. Instead, compounds in a different chemical space, e.g. macrocycles and peptides ...

Research project from 2011-01-01 to 2013-12-31

A unique concept for the molecular recognition of proteins has been developed that dramatically shortens the time for development of powerful binder molecules. It is based on the conjugation of small organic ...

Research project from 2018-01-01 to 2020-12-31

Electrophilic halofunctionalization of alkenes is a fundamental chemical transformation. Nonracemic chiral halogenated molecules, the products of asymmetric halofunctionalization, are amongst the most ...

Research project from 2021-01-01 to 2024-12-31

Electrophilic halofunctionalization of alkenes is a fundamental transformation of organic chemistry. Asymmetric halofunctionalizations would deliver nonracemic chiral halogenated molecules, which are highly ...

Research project from 2020-10-01 to 2022-07-31

Purpose and goal: This project aims to develop effective, GMP-grade siRNA drugs for anticancer therapy via targeted, systemic delivery with Programmable Oligonucleotide Delivery System (PODS), resulting ...

Research project from 2019-08-01 to 2021-07-31

Purpose and goal: The main goal of this project is the development of an exceptional sensitive method for the recognition and 3D characterisation of weak bonding in solution. Therefore the first objective ...

Research project from 2016-01-01 to 2019-12-31

This research proposal is centered on two areas; the first devoted to investigations of excited state aromaticity and antiaromaticity effects (shortly, excited state (anti)aromaticity) or ES(A)A) and the ...

Research project from 2017-01-01 to 2019-12-31

This study will make use of East African indigenous knowledge for the application of natural resources to control the major health and societal challenges malaria, tuberculosis and bacterial infections.Following ...

Research project from 2020-01-01 to 2022-12-31

Antimicrobial resistance has become a major threat to human health and development. As our currently used antibiotics lose efficiency, we risk rapidly increasing number of untreatable infections leading ...

Research project from 2020-01-01 to 2023-12-31

Organic synthesis underpins the modern world, but it also is in constant need of more powerful and sustainable methods to create the medicines, agrochemicals and materials that make this possible.Arynes ...

Research project from 2021-01-01 to 2024-12-31

This project will investigate the excited state reactivity of a recently discovered class of iron complexes featuring unique nanosecond lifetimes and sizable luminescence quantum yields of their charge-transfer ...

Research project from 2019-01-01 to 2022-12-31

The invention of new methodology for the synthesis of biologically active compounds is one the most fundamental and important goals in modern organic chemistry. As the demands for new medicines, diagnostic ...

Research project from 2012-01-01 to 2015-12-31

Heterocycles rank amongst the most important chemical motifs in organic, pharmaceutical and materials chemistry. However, even modern approaches to make 7-9 membered heterocycles are typically wasteful ...

Research project from 2012-01-01 to 2015-12-31

Three projects are proposed; two fall within molecular/organic electronics, two concern conjugation and aromaticity, and two are based on heavy Group 14 element compounds. Molecular electronic structure ...

Research project from 2015-01-01 to 2018-12-31

Direct solar energy conversion into a storable solar fuel is an attractive renewable energy concept. In Sweden this would allow storage of solar energy from summer to winter. Our scientific and technological ...

Research project from 2019-01-01 to 2022-12-31

Oxygen deficiency (hypoxia) is a feature of most cancer tumors that is associated with poor prognosis, chemoresistance and metastatic progression. Thus, the development of imaging agents that target cancer-specific ...

Research project from 2011-01-01 to 2011-12-31

Oskar Widman var den första Professorn i Sverige som ägnade hela sin karriär åt den organiska kemin. Han var den högst renommerade forskaren i Sverige inom detta fält under sin livstid. Vårt främsta mål ...

Research project from 2014-01-01 to 2018-12-31

The appearance of superbugs producing metallo-beta-lactamases have resulted in a clinical crisis. This project intends to express and purify subclasses of metallo-beta-lactamases including NDM-1. Specific ...

Research project from 2018-01-01 to 2020-12-31

Current risk assessment needs place increasing reliance on in vitro and in silico approaches to generate quantitative information based on mechanistic understanding. Despite this, compound-specific variations ...