Research at Uppsala University
New biomarkers can lead to breakthrough in diabetes research
18 February 2021. With the discovery of two new biomarkers, Olof Eriksson, researcher in translational imaging, may le ...
Producing more sustainable hydrogen
12 February 2021. Hydrogen for energy use can be extracted in an environmentally friendly way from water and sunlight, ...
The professor wanting to contribute to peace on Earth
25 January 2021. Isak Svensson is, as he describes it, a product of the Department of Peace and Conflict Research. Si ...
Search for research projects
Here you will find all research projects at Uppsala University funded by the main Swedish funding bodies. The search feature is based on the SweCRIS database.
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Your choice produced 25 hits
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Engineered scaffold proteins for radionuclide tumour targeting
Research project from 2016-01-01 to 2019-12-31
A promising approach to treatment of disseminated cancer is a targeting, i.e. therapy based on specific recognition of cancer-associated molecular alteration in tumour cells. Success of the targeting therapy ...
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A pharmacometric framework for model-based translation of antibiotic effects in vitro to outcomes in patients infected by resistant bacteria
Research project from 2019-01-01 to 2022-12-31
Antibiotic resistance is increasing at an alarming rate. There is consequently an urgent need for new approaches that can define efficient dosing strategies and facilitate development of treatments against ...
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The importance of transporters from the solute carrier family in health and disease
Research project from 2017-01-01 to 2019-12-31
This research plan describes a series of projects with an overall goal to elucidate how the amino acid transporters (SLCs) regulate neurotransmitter levels and energy metabolism in the brain.We usetransgenic ...
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Molecular regulation of vascular abnormalization and its role in tumor progression in glioblastoma
Research project from 2014-01-01 to 2016-12-31
AIM: To understand molecular mechanisms regulating vascular abnormalization in glioblastoma and to identify vascular targets for cancer therapy. BACKGROUND: Glioblastoma are aggressive brain tumors characterized ...
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The genetics of biodiversity
Research project from 2018-01-01 to 2027-12-31
The aim is to explore the relationship between genetic variation and biodiversity by combining genetic screens in non-model organisms (e.g. Atlantic herring and Darwin’s finches) with functional follow ...
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ELIXIR -- the European infrastructure for biological information
Research project from 2017-01-01 to 2017-12-31
The main mission of ELIXIR is to build a sustainable European infrastructure for biological information, supporting life-science research and its translation to society, the bio-industries, environment ...
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ESPRIT: Engineered Scaffold Protein based Radionuclide Imaging and Therapy
Research project from 2020-01-01 to 2023-12-31
The purpose of the project is to investigate factors influencing targeted delivery of radionuclides using engineered scaffold proteins (ESP). The ultimate goal is to provide rationale for molecular design ...
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Establishing a Swedish node in European Advanced Translational Research InfraStructure in Medicine (EATRIS.se)
Research project from 2015-01-01 to 2019-12-31
Sweden has a long and proud tradition in translational medicine, with major pharmaceutical and medical technology companies and many important Swedish research studies with large impact on clinical medicine ...
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Evolution of Influenza A Virus and Antiviral Resistance
Research project from 2014-01-01 to 2016-12-31
Få mikroorganismer har så stor inverkan på människors och djurs hälsa som influensa A virus (IAV). IAV finns hos änder men korsar artbarriärer och infekterar tamfåglar, däggdjur och människa. Fågelvirus ...
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Formulation, Uptake and Anticancer Activity of Thymoquinone Nanoparticles in vitro and in vivo
Research project from 2014-01-01 to 2016-12-31
The plant-derived molecule Thymoquinone (TQ) is promising against cancer and a drug candidate that has recently shown enhanced in vitro efficacy when formulated as nanoparticles (TQ-NPs) compared with ...
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Systems biology of glioblastoma: using patient-derived cells to decipher tumor expansion and evaluate new treatments
Research project from 2019-01-01 to 2021-12-31
In this proposal, we will implement a cross-disciplinary research program to target glioblastoma, the most common form of brain cancer. In the affected patient, a glioblastoma expands gradually through ...
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Functional characterisation of a new causative gene for primary lymphoedema
Research project from 2014-01-01 to 2016-12-31
Lymphatic vasculature constitutes a network of vessels critical for the maintenance of tissue fluid homeostasis. Failure of the lymphatic system leads to chronic swelling, called lymphoedema, but it is ...
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Functional genomic analysis of the kidney glomerulus
Research project from 2013-01-01 to 2017-12-31
This plan describes the continuation of a project, which has been ongoing in the PIs laboratory for the past ten years. The project started as a broad mapping of the glomerular transcriptome and has so ...
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Heparan sulfate - biosynthesis, structure and pathophysiological functions
Research project from 2012-01-01 to 2015-12-31
Heparan sulfate (HS) and the structurally related heparin occur in proteoglycan form at cell surfaces, in the extracellular matrix, and in intracellular vesicles. The heterogeneous polysaccharide chains ...
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Isolation, structure elucidation and synthesis of cytotoxic compound(s) from bee venom as anticancer lead in hepatocellular carcinoma model
Research project from 2017-01-01 to 2019-12-31
For over 40 years, natural products have served us well in combating cancer. The main sources of these successful compounds are microbes and plants from the nature. A major contribution comes from plant ...
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The vasculature as a target for therapy in brain tumors
Research project from 2017-01-01 to 2020-12-31
Glioblastomas are highly aggressive brain tumors, characterized by microvascular proliferation and dysfunctional vessels. The abnormal vessels contribute substantially to patient mortality. Still, the ...
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Lymph node vessel specialization and heterogeneity in orchestration of the immune response in cancer
Research project from 2017-01-01 to 2020-12-31
The lymph nodes provide a unique environment for immune activation and regulation, including antitumor responses. They arealso common sites for tumor metastasis. My own and others recent data has shownthat ...
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Molecular mechanisms of influenza A virus interspecies transmission
Research project from 2017-01-01 to 2020-12-31
This proposal aims at understanding molecular mechanisms of interspecies transmission of influenza A viruses (IAV) from the natural reservoir to poultry. Few viruses have affected humanity as much as IAV ...
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National Bioinformatics Infrastructure Sweden (NBIS)
Research project from 2016-04-01 to 2017-12-31
NBIS is a continuation of BILS (Bioinformatics Infrastructure for Life Sciences) now also including WABI (Wallenberg Advanced Bioinformatics Infrastr.), SILS (Systems Biology Infrastr. for Life Sciences ...
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Organ- and vessel type-specific lymphatic vascular development: implications for vessel function and disease
Research project from 2014-01-01 to 2019-12-31
Lymphatic system is composed of a hierarchy of vessels with specific features serving their unique functions: lymphatic capillaries that absorb interstitial fluid and collecting lymphatic vessels that ...
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Planning of a Swedish node in European Advanced Translational Research InfraStructure in Medicine (EATRIS.se)
Research project from 2014-01-01 to 2014-12-31
Sweden has a long tradition in translational medicine, with major pharmaceutical companies and important Swedish studies with large impact on clinical medicine. However, in the past decade, this landscape ...
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Retinal stem and progenitor cells in regeneration, normal and neoplastic growth
Research project from 2017-01-01 to 2019-12-31
This research proposal is about when generation of cells go wrong in retina. We will study the cancer retinoblastoma and cells that initiate a non-functional regeneration program with proliferation, which ...
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SYSTEMIC EFFECTS OF CANCER - neutrophils and platelets as regulators of tumor-induced organ failure and metastasis
Research project from 2017-01-01 to 2020-12-31
Cancer does not only affect the site where the tumor cells are located, but also the functionality of other organs in the body. Although tumor-induced systemic effects account for the majority of cancer-related ...
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Studies on amyloid toxicity work performed on human mouse and drosophila
Research project from 2013-01-01 to 2015-12-31
With described work we aim to clarify by which mechanisms amyloid harm cells and if amyloid can be prevented or resolved. Amyloid is cell-toxic aggregates and IAPP forms amyloid in beta-cells in type 2 ...
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Theranostics for prostate cancer: Combined targeted radionuclide imaging and therapy
Research project from 2020-01-01 to 2022-12-31
There is a clinical need to improve therapy of disseminated prostate cancer (PCa). My program should provide scientific rationale for the use of theranostics (agents suitable for both diagnostic and therapy ...
Showing 25 Of 25 hits
Research spotlight: The coronavirus
Limited transmission of COVID-19 from open schools but teachers were affected
12 February 2021. Most countries introduced school closures during the spring of 2020 despite uncertainty regarding th ...
New clues to how SARS-CoV-2 infects cells
8 February 2021. The molecular details of how SARS-CoV-2 enters cells and infects them are still not clear. Researche ...
Interdisciplinary collaboration provides new answers about immunity after Covid-19
8 January 2021. Only weeks after the coronavirus reached Sweden, blood samples were taken from more than 2,000 emplo ...
Lectures
Uppsala University’s researchers share their knowledge in public lectures. Every year, the University is visited by leading researchers and influential people from around the world. At Uppsala University, you can hear Nobel laureates, researchers, authors, politicians and many others give lectures. Here we present some of the most prominent, annually occurring lectures at Uppsala University.