Research at Uppsala University

• Engineered scaffold proteins for radionuclide tumour targeting

  Research project from 2016-01-01 to 2019-12-31

  A promising approach to treatment of disseminated cancer is a targeting, i.e. therapy based on specific recognition of cancer-associated molecular alteration in tumour cells. Success of the targeting therapy ...

• A pharmacometric framework for model-based translation of antibiotic effects in vitro to outcomes in patients infected by resistant bacteria

  Research project from 2019-01-01 to 2022-12-31

  Antibiotic resistance is increasing at an alarming rate. There is consequently an urgent need for new approaches that can define efficient dosing strategies and facilitate development of treatments against ...

• The importance of transporters from the solute carrier family in health and disease

  Research project from 2017-01-01 to 2019-12-31

  This research plan describes a series of projects with an overall goal to elucidate how the amino acid transporters (SLCs) regulate neurotransmitter levels and energy metabolism in the brain.We usetransgenic ...

• Molecular regulation of vascular abnormalization and its role in tumor progression in glioblastoma

  Research project from 2014-01-01 to 2016-12-31

  AIM: To understand molecular mechanisms regulating vascular abnormalization in glioblastoma and to identify vascular targets for cancer therapy. BACKGROUND: Glioblastoma are aggressive brain tumors characterized ...

• The genetics of biodiversity

  Research project from 2018-01-01 to 2027-12-31

  The aim is to explore the relationship between genetic variation and biodiversity by combining genetic screens in non-model organisms (e.g. Atlantic herring and Darwin’s finches) with functional follow ...

• ELIXIR -- the European infrastructure for biological information

  Research project from 2017-01-01 to 2017-12-31

  The main mission of ELIXIR is to build a sustainable European infrastructure for biological information, supporting life-science research and its translation to society, the bio-industries, environment ...

• ESPRIT: Engineered Scaffold Protein based Radionuclide Imaging and Therapy

  Research project from 2020-01-01 to 2023-12-31

  The purpose of the project is to investigate factors influencing targeted delivery of radionuclides using engineered scaffold proteins (ESP). The ultimate goal is to provide rationale for molecular design ...

• Establishing a Swedish node in European Advanced Translational Research InfraStructure in Medicine (EATRIS.se)

  Research project from 2015-01-01 to 2019-12-31

  Sweden has a long and proud tradition in translational medicine, with major pharmaceutical and medical technology companies and many important Swedish research studies with large impact on clinical medicine ...

• Evolution of Influenza A Virus and Antiviral Resistance

  Research project from 2014-01-01 to 2016-12-31

  Få mikroorganismer har så stor inverkan på människors och djurs hälsa som influensa A virus (IAV). IAV finns hos änder men korsar artbarriärer och infekterar tamfåglar, däggdjur och människa. Fågelvirus ...

• Formulation, Uptake and Anticancer Activity of Thymoquinone Nanoparticles in vitro and in vivo

  Research project from 2014-01-01 to 2016-12-31

  The plant-derived molecule Thymoquinone (TQ) is promising against cancer and a drug candidate that has recently shown enhanced in vitro efficacy when formulated as nanoparticles (TQ-NPs) compared with ...

• Systems biology of glioblastoma: using patient-derived cells to decipher tumor expansion and evaluate new treatments

  Research project from 2019-01-01 to 2021-12-31

  In this proposal, we will implement a cross-disciplinary research program to target glioblastoma, the most common form of brain cancer. In the affected patient, a glioblastoma expands gradually through ...

• Functional characterisation of a new causative gene for primary lymphoedema

  Research project from 2014-01-01 to 2016-12-31

  Lymphatic vasculature constitutes a network of vessels critical for the maintenance of tissue fluid homeostasis. Failure of the lymphatic system leads to chronic swelling, called lymphoedema, but it is ...

• Functional genomic analysis of the kidney glomerulus

  Research project from 2013-01-01 to 2017-12-31

  This plan describes the continuation of a project, which has been ongoing in the PIs laboratory for the past ten years. The project started as a broad mapping of the glomerular transcriptome and has so ...

• Heparan sulfate - biosynthesis, structure and pathophysiological functions

  Research project from 2012-01-01 to 2015-12-31

  Heparan sulfate (HS) and the structurally related heparin occur in proteoglycan form at cell surfaces, in the extracellular matrix, and in intracellular vesicles. The heterogeneous polysaccharide chains ...

• Isolation, structure elucidation and synthesis of cytotoxic compound(s) from bee venom as anticancer lead in hepatocellular carcinoma model

  Research project from 2017-01-01 to 2019-12-31

  For over 40 years, natural products have served us well in combating cancer. The main sources of these successful compounds are microbes and plants from the nature. A major contribution comes from plant ...

• The vasculature as a target for therapy in brain tumors

  Research project from 2017-01-01 to 2020-12-31

  Glioblastomas are highly aggressive brain tumors, characterized by microvascular proliferation and dysfunctional vessels. The abnormal vessels contribute substantially to patient mortality. Still, the ...

• Lymph node vessel specialization and heterogeneity in orchestration of the immune response in cancer

  Research project from 2017-01-01 to 2020-12-31

  The lymph nodes provide a unique environment for immune activation and regulation, including antitumor responses. They arealso common sites for tumor metastasis. My own and others recent data has shownthat ...

• Molecular mechanisms of influenza A virus interspecies transmission

  Research project from 2017-01-01 to 2020-12-31

  This proposal aims at understanding molecular mechanisms of interspecies transmission of influenza A viruses (IAV) from the natural reservoir to poultry. Few viruses have affected humanity as much as IAV ...

• National Bioinformatics Infrastructure Sweden (NBIS)

  Research project from 2016-04-01 to 2017-12-31

  NBIS is a continuation of BILS (Bioinformatics Infrastructure for Life Sciences) now also including WABI (Wallenberg Advanced Bioinformatics Infrastr.), SILS (Systems Biology Infrastr. for Life Sciences ...

• Organ- and vessel type-specific lymphatic vascular development: implications for vessel function and disease

  Research project from 2014-01-01 to 2019-12-31

  Lymphatic system is composed of a hierarchy of vessels with specific features serving their unique functions: lymphatic capillaries that absorb interstitial fluid and collecting lymphatic vessels that ...

• Planning of a Swedish node in European Advanced Translational Research InfraStructure in Medicine (EATRIS.se)

  Research project from 2014-01-01 to 2014-12-31

  Sweden has a long tradition in translational medicine, with major pharmaceutical companies and important Swedish studies with large impact on clinical medicine. However, in the past decade, this landscape ...

• Retinal stem and progenitor cells in regeneration, normal and neoplastic growth

  Research project from 2017-01-01 to 2019-12-31

  This research proposal is about when generation of cells go wrong in retina. We will study the cancer retinoblastoma and cells that initiate a non-functional regeneration program with proliferation, which ...

• SYSTEMIC EFFECTS OF CANCER - neutrophils and platelets as regulators of tumor-induced organ failure and metastasis

  Research project from 2017-01-01 to 2020-12-31

  Cancer does not only affect the site where the tumor cells are located, but also the functionality of other organs in the body. Although tumor-induced systemic effects account for the majority of cancer-related ...

• Studies on amyloid toxicity work performed on human mouse and drosophila

  Research project from 2013-01-01 to 2015-12-31

  With described work we aim to clarify by which mechanisms amyloid harm cells and if amyloid can be prevented or resolved. Amyloid is cell-toxic aggregates and IAPP forms amyloid in beta-cells in type 2 ...

• Theranostics for prostate cancer: Combined targeted radionuclide imaging and therapy

  Research project from 2020-01-01 to 2022-12-31

  There is a clinical need to improve therapy of disseminated prostate cancer (PCa). My program should provide scientific rationale for the use of theranostics (agents suitable for both diagnostic and therapy ...

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