Research at Uppsala University

• A MOLECULAR UNDERSTANDING OF LIPID BASED DRUG DELIVERY - A BRIDGE FOR POORLY SOLUBLE COMPOUNDS TO REACH PHYSIOLOGICAL TARGETS

  Research project from 2011-01-01 to 2013-12-31

  With 70-90% of the new drug-like molecules synthesised at date showing poor water solubility computational tools that allow predictions of the solubility and give suggestions on how to improve this property ...

• A Swedish infrastructure for chemical safety predictions with focus on human health

  Research project from 2012-01-01 to 2013-12-31

  The field of chemical safety predictions aims at establishing the safety of novel chemical structures in silico, using computational models based on existing in vitro and in vivo data. The field is hampered ...

• A pharmacometric framework for model-based translation of antibiotic effects in vitro to outcomes in patients infected by resistant bacteria

  Research project from 2019-01-01 to 2022-12-31

  Antibiotic resistance is increasing at an alarming rate. There is consequently an urgent need for new approaches that can define efficient dosing strategies and facilitate development of treatments against ...

• A three dimensional in vitro model of the gut to inform on optimal dosage form design for oral drug delivery

  Research project from 2019-01-01 to 2022-12-31

  The vast majority of modern pharmacologically active compounds demands advanced drug delivery systems (ADDSs) to be developed as orally administered medicines. The goal for this project is to design lab ...

• Brain-specific drug delivery by targeting active uptake at the blood-brain barrier

  Research project from 2019-01-01 to 2021-12-31

  Most molecules have limited ability to cross the blood-brain barrier (BBB), heavily restricting the future expansion of neurotherapeutics development. With the current proposal, we aim to evaluate the ...

• An integrated approach to oral drug delivery

  Research project from 2021-01-01 to 2024-12-31

  The purpose of this project is to push the limits for oral drug delivery and disposition with the use of breakthrough methodologies and models for accurate and precise prediction of oral drug delivery ...

• Reconstructing early modern pharmacy: Global trade networks, substances and practices

  Research project from 2015-01-01 to 2017-12-31

  This project will unlock and re-evaluate early modern pharmacy as a field of knowledge by reconstrucing lost pharmaceutical skills concerning trade, handling, and composition of medicines. Where did substances ...

• Biopharmaceutical Mass Spectrometry Imaging Provides Novel Information in Drug Research and Development

  Research project from 2019-01-01 to 2022-12-31

  To understand the complex biochemical interactions between drugs and their targets, it is necessary to identify the molecular entities involved and determine their abundance and spatial distribution in ...

• Counteracting L-DOPA-induced dyskinesias by modifying the bioconversion of opioid peptides in Parkinson´s disease.

  Research project from 2013-01-01 to 2015-12-31

  Recent data from our lab suggest that L-DOPA-induced dyskinesia (LID) in Parkinson´s disease (PD) is associated with abnormal opioid peptide metabolism in the striatum, but not in the projection target ...

• CARE - Visualiserar fördelar med behandling mot hjärt- och kärlsjukdom, för ökad följsamhet med behandling för patienter med diabetes

  Research project from 2019-01-01 to 2022-12-31

  Cardiovascular disease (CV) contributes greatly to high mortality and morbidity in diabetes and thus, treatment focuses on controlling risk factors, e.g. hypertension, hyperlipidemia and obesity. However ...

• Composite score models for efficient use of patient data in decision making for development and usage of drugs

  Research project from 2019-01-01 to 2022-12-31

  The aim of this project is to develop mathematical models, methods and processes that will allow data from composite assessments of patient status to be efficiently utilized with the purpose of improving ...

• DEVELOPMENTAL NEUROEPIGENETICS OF ALCOHOLISM: methylation profiling of human brain and blood DNA

  Research project from 2020-01-01 to 2022-12-31

  We hypothesize that alterations in the epigenome in response to adverse events and / or alcohol binging in early life may be a critical factor contributing to risk and resilience to alcohol use disorders ...

• Developing combinations of CO-ACTIVE antimicrobials and non-antimicrobials

  Research project from 2015-12-01 to 2018-11-30

  The CO-ACTION project aims to develop and provide a framework for evaluating and validating the effectiveness of antibiotic (AB)- and non-antibiotic (NA) combinations (COMs) in the preclinical setting ...

• Utveckla och implementera den allra senaste landvinningarna inom målinriktad och global proteomik för att förstå de aktiva processer som bestämmer läkemedels disposition i kroppen

  Research project from 2014-08-01 to 2018-07-31

  The overall aim of this PhD project is to develop and implement state-of-the-art targeted and global proteomic technologies to understand the role of active processes mediated by transporter proteins and ...

• Development of CNS delivery strategies for therapeutic peptides and proteins: The role of nanocarriers for enhanced uptake at the blood-brain barrier.

  Research project from 2011-01-01 to 2013-12-31

  Peptides and proteins are objects of great interest as potential new medicines for the treatment of central nervous system (CNS) disorders. However, the transport into the brain is minute due to the blood-brain ...

• Emerging strategies in the treatment of advanced hepatocellular carcinoma: the role of targeted drug delivery

  Research project from 2011-01-01 to 2013-12-31

  Cancer is a major public health issue globally and about 25% of all deaths in the EU and USA are due to cancer. Liver cancer, the fifth most common tumor, is often offered a palliative treatment with chemotherapeutic ...

• Towards a computational intestine for formulation assessment: Impact of dilution, digestion and absorption on restructuring of solubilizing lipoidal nanoaggregates

  Research project from 2014-01-01 to 2018-12-31

  A major gap to understand drug performance in the intestine is the poor knowledge of the dynamics of solubilizing lipoidal nanostructures (micelles, vesicles, oil droplets) present in the intestinal fluid ...

• Exchange between academia and industry in the area of drug discovery and development

  Research project from 2016-06-01 to 2017-11-30

  Purpose and goal: The aim for this project was to transfer knowledge and methods in drug discovery and development between Uppsala University and AstraZeneca Gothenburg. Specific goals in the project ...

• Functional neuroproteomic changes associated with L-Dopa-induced dyskinesia in Parkinson´s disease

  Research project from 2014-01-01 to 2017-12-31

  The main objective of the present research is to study functional protein, peptide and neurotransmitter neurochemical processes in Parkinson disease (PD) and specifically L-Dopa-induced dyskinesias (LID ...

• Functional neuroproteomic changes associated with L-Dopa-induced dyskinesia in Parkinson´s disease

  Research project from 2011-01-01 to 2013-12-31

  The main objective of the present research is to study functional protein and peptide neurochemical processes in Parkinson disease (PD) and specifically L-Dopa-induced dyskinesias (LID). No treatment exists ...

• Increased tumor target delivery of functionalized nanoparticles (NPs) loaded with chemotherapeutics and/or new modalities

  Research project from 2019-01-01 to 2022-12-31

  Cancer is a global health issue and about 25% of all deaths in the EU and USA are due to cancer. The primary objective of this cross-disciplinary project is to develop new advanced injectable pharmaceutical ...

• Mass Spectrometry Imaging Infrastructure

  Research project from 2016-01-01 to 2020-12-31

  We propose to upgrade and improve the Mass Spectrometry Imaging (MSI) Infrastructure at Uppsala University. The technology program proposed herein will involve significant development of techniques for ...

• Mass Spectrometry Imaging in Drug Discovery - Targeting drugs, metabolites, peptides and neurotransmitter

  Research project from 2015-01-01 to 2018-12-31

  The project presented here will utilize the full potential of matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI), to provide state-of-the-art molecular tools aiding drug ...

• Model-based development of anti-tuberculosis drug combinations

  Research project from 2011-01-01 to 2013-12-31

  Drug development in tuberculosis (TB) requires new integrated methods to speed the passage of novel agents from the laboratory to the clinic. More effective combination regimens are desperately needed ...

• Novel mechanisms of oxygenation of unsaturated fatty acids and medical importance

  Research project from 2013-01-01 to 2015-12-31

  The proposal focuses on bio-activation of w3 and w6 fatty acids by oxygenases (CYP4, lipoxygenases, cyclooxygenases, dioxygenases). CYP4F8, 4Z1 and 4X1 are expressed in human prostate and breast tumors ...

• Open and Free Infrastructure for Predictive Modeling in Drug Discovery and Development

  Research project from 2013-01-01 to 2015-12-31

  Today´s pharmacy industry barely develops medicines for neglected diseases. We here propose to implement an open and free chemobioinformatics infrastructure, which can be used by anyone to effectively ...

• Precisionsläkemedel för autoimmuna sjukdomar

  Research project from 2019-01-01 to 2022-12-31

  Precision based medicine means that treatment is individualized, based on environmental, lifestyle and genetic conditions. But how do we use precision when these factors are unknown? Or when genetics is ...

• Swedish Drug Delivery Forum

  Research project from 2017-07-01 to 2020-08-31

  Purpose and goal: SDDF´s aim is to form a powerful research environment permeated by close interaction and collaboration between academic researchers and industrial researchers to contribute to the preservation ...

• The Swedish Drug Delivery Center (SweDeliver)

  Research project from 2020-01-01 to 2024-12-31

  Purpose and goal: The Swedish Drug Delivery Center (SweDeliver) is a competence center which consolidates world-class, needs-driven drug delivery science of benefit for pharmaceutical innovation in Sweden ...

• Theranostics for prostate cancer: Combined targeted radionuclide imaging and therapy

  Research project from 2020-01-01 to 2022-12-31

  There is a clinical need to improve therapy of disseminated prostate cancer (PCa). My program should provide scientific rationale for the use of theranostics (agents suitable for both diagnostic and therapy ...

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