Research at Uppsala University

Research project from 2012-01-01 to 2013-12-31

The field of chemical safety predictions aims at establishing the safety of novel chemical structures in silico, using computational models based on existing in vitro and in vivo data. The field is hampered ...

Research project from 2013-01-01 to 2014-12-31

This project aims to develop of a novel human ex-vivo whole blood loop system for an improved characterization of therapeutic antibodies in order to avoid irrelevant and unnecessary animal studies. Today ...

Research project from 2013-01-01 to 2015-12-31

Radionuclide imaging of molecular targets in vivo is a promising way to increase specificity of cancer treatment. Affibody molecules constitute a new type of affinity proteins, which has been developed ...

Research project from 2021-01-01 to 2024-12-31

The purpose of this project is to push the limits for oral drug delivery and disposition with the use of breakthrough methodologies and models for accurate and precise prediction of oral drug delivery ...

Research project from 2013-04-01 to 2014-03-31

Anmälan om utnyttjande av återvändarbidrag för beviljade postdoktorsstipendier inom medicin eller natur- och teknikvetenskap ...

Research project from 2015-01-01 to 2017-06-30

Astrocytes, the most abundant cell population in the brain, show temporal and regional heterogeneity. Astrocytomas, the most common primary malignant brain tumor in adult patients, are often localized ...

Research project from 2012-08-01 to 2012-12-31

The primary aim of this application is firstly to cover the expenses for me and my co-applicant Professor Lars Lind for attending Dioxin 2012 in Cairns Australia, were we both will give oral presentations ...

Research project from 2013-01-01 to 2015-12-31

The AIM of this project is to investigate whether low-dose exposure to bisphenol A (BPA) during early development disturbs the subsequent balance between bone and adipose tissue throughout the life span ...

Research project from 2019-01-01 to 2022-12-31

To understand the complex biochemical interactions between drugs and their targets, it is necessary to identify the molecular entities involved and determine their abundance and spatial distribution in ...

Research project from 2013-01-01 to 2015-12-31

Recent data from our lab suggest that L-DOPA-induced dyskinesia (LID) in Parkinson´s disease (PD) is associated with abnormal opioid peptide metabolism in the striatum, but not in the projection target ...

Research project from 2015-01-01 to 2017-12-31

Anabolic androgenic steroids (AAS) have been shown to increase aggression and also to affect the brain reward system. Behavioral tests demonstrate that AAS increase intake and response to other drugs of ...

Research project from 2012-01-01 to 2014-12-31

Background: Adverse drug reactions (ADRs) impose a huge health and economic burden on society. They are a common cause of admission to hospital and as costly as drug treatment itself. We are a national ...

Research project from 2015-12-01 to 2018-11-30

The CO-ACTION project aims to develop and provide a framework for evaluating and validating the effectiveness of antibiotic (AB)- and non-antibiotic (NA) combinations (COMs) in the preclinical setting ...

Research project from 2011-01-01 to 2013-12-31

Peptides and proteins are objects of great interest as potential new medicines for the treatment of central nervous system (CNS) disorders. However, the transport into the brain is minute due to the blood-brain ...

Research project from 2018-01-01 to 2021-12-31

Toxicology testing is one of the main reasons for using experimental animals. We set up a very productive fly (Drosophila) lab, with a range of methodologies, enabling detailed molecular, physiological ...

Research project from 2020-12-01 to 2024-12-31

Background, Population and Aim: To increase the cure rate from colorectal cancer, more effective treatments for metastatic disease are needed. Metastases to the peritoneum is a common and difficult clinical ...

Research project from 2020-01-01 to 2023-12-31

The purpose of the project is to investigate factors influencing targeted delivery of radionuclides using engineered scaffold proteins (ESP). The ultimate goal is to provide rationale for molecular design ...

Research project from 2012-08-01 to 2012-12-31

A growing scientific literature has raised concerns about the health effects of human exposure to bisphenol A (BPA). Humans are continuously exposed to BPA and epidemiological evidence suggest that high ...

Research project from 2020-12-01 to 2023-12-31

Assessing safety of early candidates in drug discovery is currently to a large extent based on animal studies, requiring large amounts of animals every year. The purpose of this project is to validate ...

Research project from 2014-01-01 to 2017-12-31

Growing evidence supports the developmental origins of health and disease hypothesis, in which environmental compound and nutritional exposures early in development influences chronic disease outcomes ...

Research project from 2014-01-01 to 2018-12-31

Peptide toxins have a huge potential as pharmacological agents due to high affinity and selectivity for their target receptors. In the current project we will explore a neglected natural resource to find ...

Research project from 2019-01-01 to 2021-12-31

The overall aim of this project is to explore toxicity mechanisms and pathways of environmental contaminants with intelligent data generation, using an automated lab controlled by an AI system. Current ...

Research project from 2013-01-01 to 2015-12-31

There is a clinical need to improve both diagnostics and therapy of prostate cancer (PC). I propose to use molecular imaging based on radionuclide targeting against proteins associated with disease progression ...

Research project from 2013-01-01 to 2015-12-31

GABA (gamma-aminobutyric acid) is a small molecule with the highest concentration in our brains where it is the main neurotransmitter that reduces neuronal and neuronal networks excitability. All neurons ...

Research project from 2015-01-01 to 2017-12-31

Engineered nanoparticles are a group of materials produced artificially, which have a size below 100 nm. These materials are becoming widely used in consumer products such as sunscreens and in turn an ...

Research project from 2018-01-01 to 2020-12-31

Evidence is accumulating that developmental exposure to endocrine disrupting chemicals (EDCs) affects brain development and increases the risks for neurodevelopmental disorders. The etiology of neurodevelopmental ...

Research project from 2019-01-01 to 2021-12-31

Our overall aim is to develop new insecticides to effectively fight insect pests without damaging the surrounding environment or humans, for sustainable agriculture and domestic use. Recently, we discovered ...

Research project from 2014-01-01 to 2016-12-31

BACKGROUND: A number of environmental contaminants have been associated with negative health effects, but the mechanisms of actions are sparsely known for the majority of the contaminants, especially in ...

Research project from 2020-01-01 to 2023-12-31

My research program aims to translate robust associations from large-scale genome-wide association studies for coronary artery disease into functional understanding and novel treatments.Candidate genes ...

Research project from 2009-11-01 to 2014-04-30

Currently not available ...