Research at Uppsala University
History of human antibiotic use written in the oral bacteria of wild brown bears
25 August 2021. An international team of researchers used historical museum collections to study the effects of huma ...
How research can encourage us to cycle instead
19 August 2021. How do you get to work in the mornings? Transport currently accounts for 25 per cent of GHG emission ...
Philippine ethnic group has most Denisovan DNA
13 August 2021. The Philippine ethnic group Ayta Magbukon has the highest proportion of genes from our extinct relat ...
Search for research projects
Here you will find all research projects at Uppsala University funded by the main Swedish funding bodies. The search feature is based on the SweCRIS database.
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Your choice produced 48 hits
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A Swedish infrastructure for chemical safety predictions with focus on human health
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Research project from 2012-01-01 to 2013-12-31
The field of chemical safety predictions aims at establishing the safety of novel chemical structures in silico, using computational models based on existing in vitro and in vivo data. The field is hampered ...
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A human whole blood loop system for superior characterization of therapeutic antibodies
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Research project from 2013-01-01 to 2014-12-31
This project aims to develop of a novel human ex-vivo whole blood loop system for an improved characterization of therapeutic antibodies in order to avoid irrelevant and unnecessary animal studies. Today ...
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Affibody molecules, a new class of tracers for molecular imaging. Molecular design of targeting properties of anti-tumour Affibody molecules.
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Research project from 2013-01-01 to 2015-12-31
Radionuclide imaging of molecular targets in vivo is a promising way to increase specificity of cancer treatment. Affibody molecules constitute a new type of affinity proteins, which has been developed ...
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An integrated approach to oral drug delivery
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Research project from 2021-01-01 to 2024-12-31
The purpose of this project is to push the limits for oral drug delivery and disposition with the use of breakthrough methodologies and models for accurate and precise prediction of oral drug delivery ...
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Anmälan om utnyttjande av återvändarbidrag för beviljade postdoktorsstipendier inom medicin eller natur- och teknikvetenskap
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Research project from 2013-04-01 to 2014-03-31
Anmälan om utnyttjande av återvändarbidrag för beviljade postdoktorsstipendier inom medicin eller natur- och teknikvetenskap ...
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Subpial zone astrocytes as the origin of cortical astrocytomas
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Research project from 2015-01-01 to 2017-06-30
Astrocytes, the most abundant cell population in the brain, show temporal and regional heterogeneity. Astrocytomas, the most common primary malignant brain tumor in adult patients, are often localized ...
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Attending Dioxin 2012, 26-31 August 2012, Cairns, Australia
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Research project from 2012-08-01 to 2012-12-31
The primary aim of this application is firstly to cover the expenses for me and my co-applicant Professor Lars Lind for attending Dioxin 2012 in Cairns Australia, were we both will give oral presentations ...
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Does Developmental exposure to Bisphenol A induce bone and adipose tissue disturbances?
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Research project from 2013-01-01 to 2015-12-31
The AIM of this project is to investigate whether low-dose exposure to bisphenol A (BPA) during early development disturbs the subsequent balance between bone and adipose tissue throughout the life span ...
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Biopharmaceutical Mass Spectrometry Imaging Provides Novel Information in Drug Research and Development
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Research project from 2019-01-01 to 2022-12-31
To understand the complex biochemical interactions between drugs and their targets, it is necessary to identify the molecular entities involved and determine their abundance and spatial distribution in ...
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Counteracting L-DOPA-induced dyskinesias by modifying the bioconversion of opioid peptides in Parkinson´s disease.
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Research project from 2013-01-01 to 2015-12-31
Recent data from our lab suggest that L-DOPA-induced dyskinesia (LID) in Parkinson´s disease (PD) is associated with abnormal opioid peptide metabolism in the striatum, but not in the projection target ...
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Central mechanisms in drug addiction and development of rational strategies for treatment and restoration of drug-induced brain damages
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Research project from 2015-01-01 to 2017-12-31
Anabolic androgenic steroids (AAS) have been shown to increase aggression and also to affect the brain reward system. Behavioral tests demonstrate that AAS increase intake and response to other drugs of ...
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Detection and use of pharmacogenomic biomarkers for personalised treatment
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Research project from 2012-01-01 to 2014-12-31
Background: Adverse drug reactions (ADRs) impose a huge health and economic burden on society. They are a common cause of admission to hospital and as costly as drug treatment itself. We are a national ...
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Developing combinations of CO-ACTIVE antimicrobials and non-antimicrobials
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Research project from 2015-12-01 to 2018-11-30
The CO-ACTION project aims to develop and provide a framework for evaluating and validating the effectiveness of antibiotic (AB)- and non-antibiotic (NA) combinations (COMs) in the preclinical setting ...
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Development of CNS delivery strategies for therapeutic peptides and proteins: The role of nanocarriers for enhanced uptake at the blood-brain barrier.
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Research project from 2011-01-01 to 2013-12-31
Peptides and proteins are objects of great interest as potential new medicines for the treatment of central nervous system (CNS) disorders. However, the transport into the brain is minute due to the blood-brain ...
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Development of a Drosophila replacement model to determine short and long term effects of environmental toxin mixtures
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Research project from 2018-01-01 to 2021-12-31
Toxicology testing is one of the main reasons for using experimental animals. We set up a very productive fly (Drosophila) lab, with a range of methodologies, enabling detailed molecular, physiological ...
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The EFFIPEC Trial Program (Efficacy of HIPEC): A phase I trial and an open-label randomized phase III trial for treating colorectal cancer with peritoneal metastases
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Research project from 2020-12-01 to 2024-12-31
Background, Population and Aim: To increase the cure rate from colorectal cancer, more effective treatments for metastatic disease are needed. Metastases to the peritoneum is a common and difficult clinical ...
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ESPRIT: Engineered Scaffold Protein based Radionuclide Imaging and Therapy
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Research project from 2020-01-01 to 2023-12-31
The purpose of the project is to investigate factors influencing targeted delivery of radionuclides using engineered scaffold proteins (ESP). The ultimate goal is to provide rationale for molecular design ...
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Effects of bisphenol A in cardiovascular cells and tissues in vivo and in vitro
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Research project from 2012-08-01 to 2012-12-31
A growing scientific literature has raised concerns about the health effects of human exposure to bisphenol A (BPA). Humans are continuously exposed to BPA and epidemiological evidence suggest that high ...
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Enabling Systematic Phenotypic Cell Profiling in Safety Pharmacology
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Research project from 2020-12-01 to 2023-12-31
Assessing safety of early candidates in drug discovery is currently to a large extent based on animal studies, requiring large amounts of animals every year. The purpose of this project is to validate ...
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Epigenetic responses following developmental exposure to low levels of environmental compounds
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Research project from 2014-01-01 to 2017-12-31
Growing evidence supports the developmental origins of health and disease hypothesis, in which environmental compound and nutritional exposures early in development influences chronic disease outcomes ...
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Exploring ion channel toxins from the Swedish fauna
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Research project from 2014-01-01 to 2018-12-31
Peptide toxins have a huge potential as pharmacological agents due to high affinity and selectivity for their target receptors. In the current project we will explore a neglected natural resource to find ...
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Exploring toxicity mechanisms for environmental contaminants using an AI-controlled automated laboratory
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Research project from 2019-01-01 to 2021-12-31
The overall aim of this project is to explore toxicity mechanisms and pathways of environmental contaminants with intelligent data generation, using an automated lab controlled by an AI system. Current ...
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Improvement of diagnostics and personalised treatment of prostate cancer by radionuclide molecular imaging
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Research project from 2013-01-01 to 2015-12-31
There is a clinical need to improve both diagnostics and therapy of prostate cancer (PC). I propose to use molecular imaging based on radionuclide targeting against proteins associated with disease progression ...
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GABA, not just a neurotransmitter molecule!
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Research project from 2013-01-01 to 2015-12-31
GABA (gamma-aminobutyric acid) is a small molecule with the highest concentration in our brains where it is the main neurotransmitter that reduces neuronal and neuronal networks excitability. All neurons ...
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HARVEST: Microsystem for blood-brain barrier nanotoxicology studies
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Research project from 2015-01-01 to 2017-12-31
Engineered nanoparticles are a group of materials produced artificially, which have a size below 100 nm. These materials are becoming widely used in consumer products such as sunscreens and in turn an ...
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Opening up for disease: The role of environmental chemicals for blood-brain barrier function
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Research project from 2018-01-01 to 2020-12-31
Evidence is accumulating that developmental exposure to endocrine disrupting chemicals (EDCs) affects brain development and increases the risks for neurodevelopmental disorders. The etiology of neurodevelopmental ...
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Sustainable bioinsecticides from marine toxins
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Research project from 2019-01-01 to 2021-12-31
Our overall aim is to develop new insecticides to effectively fight insect pests without damaging the surrounding environment or humans, for sustainable agriculture and domestic use. Recently, we discovered ...
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INVESTIGATION OF MECHANISMS OF ACTIONS OF ENVIRONMENTAL CONTAMINANTS IN HUMANS USING AN "-OMICS"-BASED APPROACH
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Research project from 2014-01-01 to 2016-12-31
BACKGROUND: A number of environmental contaminants have been associated with negative health effects, but the mechanisms of actions are sparsely known for the majority of the contaminants, especially in ...
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Identifying and characterising new targets, drugs, and small molecules for prevention and treatment of coronary artery disease
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Research project from 2020-01-01 to 2023-12-31
My research program aims to translate robust associations from large-scale genome-wide association studies for coronary artery disease into functional understanding and novel treatments.Candidate genes ...
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Innovative tools for drug-discovery
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Research project from 2009-11-01 to 2014-04-30
Currently not available ...
Showing 30 Of 48 hits
Show more hitsResearch spotlight: The coronavirus
New method for discovery of antiviral drugs
2 August 2021. The current COVID-19 pandemic has highlighted the need for methods to identify new or repurposed dru ...
Helpline important for older people during the pandemic
8 July 2021. For many older individuals, the COVID-19 pandemic has resulted in the loss of daily anonymous contac ...
The national COVID-19 Data Portal turns one year old
3 June 2021. The national Swedish COVID-19 Data Portal was launched one year ago to support researchers in utilis ...
Lectures
Uppsala University’s researchers share their knowledge in public lectures. Every year, the University is visited by leading researchers and influential people from around the world. At Uppsala University, you can hear Nobel laureates, researchers, authors, politicians and many others give lectures. Here we present some of the most prominent, annually occurring lectures at Uppsala University.