Research at Uppsala University

Research project from 2015-01-01 to 2020-12-31

Acute kidney injury - mechanisms and novel therapeutic targets in large animal models ...

Research project from 2012-01-01 to 2014-12-31

Acute kidney injury (AKI) is a major clinical problem with no effective treatment and poorly defined pathogenesis. Our preliminary data using unique large animal models indicate that septic AKI is independent ...

Research project from 2015-01-01 to 2017-12-31

Acute kidney injury (AKI) is a major clinical problem with no effective treatment and poorly defined pathogenesis. Our preliminary data using unique large animal models indicate that septic AKI is independent ...

Research project from 2013-01-01 to 2015-12-31

Angiopoietin-1 (Angpt1) and Angiopoietin-2 (Angpt2) bind to the tyrosine kinase receptor, Tek, found on endothelial cells. Angpt1 is a Tek agonist and promotes endothelial cell stabilization, whereas Angpt2 ...

Research project from 2012-01-01 to 2014-12-31

The pancreatic islets are a complex micro-organ containing many cell types. The importance of interactions between these cells, particularly islet vasculature, for normal islet endocrine function has lately ...

Research project from 2015-01-01 to 2017-12-31

Factors influencing body fat accumulation are poorly understood. Individuals that deposit fat in the liver, muscle and pancreas (ectopic fat) without increasing lean tissue (sarcopenic obesity) are prone ...

Research project from 2017-01-01 to 2019-12-31

We aim to study the molecular mechanisms of food intake and reward functions, considering genetic background and cognitive functions. We plan to combine fly, mouse and human genetic models to unravel modes ...

Research project from 2013-01-01 to 2015-12-31

Genome-wide association studies (GWAS) have provided insight into the genetic architecture of many chronic diseases, but translation of this knowledge into clinical practice has been limited. One reason ...

Research project from 2016-01-01 to 2018-12-31

The small molecule γ-aminobutyric acid (GABA) is made and released by neurons, the insulin secreting β-cells and some immune cells. GABA is an extracellular signal molecule and a Master Regulator of physiological ...

Research project from 2014-07-01 to 2017-06-30

Recent work shows that growth factor receptor signalling continues in endosomes, turning the endosomal network into a signalling platform. Different growth factors modulate the endosomal network and features ...

Research project from 2015-01-01 to 2017-12-31

Why some persons develop type 1 diabetes mellitus is still largely unknown. The incidence of this disease is increasing worldwide, but the reasons for the onset of the autoimmune process killing the insulin-producing ...

Research project from 2013-01-01 to 2017-12-31

Transforming growth factor beta (TGFbeta) family polypeptides are cytokines regulating cell differentiation including the epithelial-mesenchymal transition (EMT). TGFbeta ligands signal via cell surface ...

Research project from 2012-01-01 to 2014-12-31

DA-regulated processes, which range from motor control to emotional control and also involves the ability to experience pleasure, are vital for brain function. Disorders of the DA system, including addiction ...

Research project from 2013-01-01 to 2017-12-31

This plan describes the continuation of a project, which has been ongoing in the PIs laboratory for the past ten years. The project started as a broad mapping of the glomerular transcriptome and has so ...

Research project from 2013-01-01 to 2015-12-31

GABA (gamma-aminobutyric acid) is a small molecule with the highest concentration in our brains where it is the main neurotransmitter that reduces neuronal and neuronal networks excitability. All neurons ...

Research project from 2016-01-01 to 2019-12-31

Hypoxia is a common finding in chronic kidney injury and shifts in cellular oxygen metabolism generate specific signals that modulate cellular differentiation and function, cell-cell interactions and inflammation ...

Research project from 2014-01-01 to 2016-12-31

BACKGROUND: A number of environmental contaminants have been associated with negative health effects, but the mechanisms of actions are sparsely known for the majority of the contaminants, especially in ...

Research project from 2015-01-01 to 2018-12-31

Immune cells (leukocytes) have essential roles in many situations in the body and are vital for survival. However, they are also driving detrimental inflammation, contributing to the majority of diseases ...

Research project from 2013-01-01 to 2013-12-31

Frisättningen av insulin och glukagon från de Langerhanska öarnas beta- respektive alfaceller är avgörande för blodsockerregleringen. Störd frisättning av insulin uppfattas idag som orsak till de flesta ...

Research project from 2012-01-01 to 2014-12-31

Cardiovascular disease is a dominant cause for invalidity and mortality. The research proposal use rats, genetically modified mice, human kidney tissue and renomedullary interstitial cells in integrative ...

Research project from 2014-01-01 to 2019-12-31

Kidney disease is a major cause for premature mortality in diabetic patients. The focus has recently shifted from a glomerulocentric to a predominantly tubulocentric view of mechanisms initiating the development ...

Research project from 2014-01-01 to 2016-12-31

Arterial hypertension is an important health problems and we need a better understanding of the disease to find new principles for treatment. Nitric Oxide (NO) is a potent vasodilator and a blockade of ...

Research project from 2012-01-01 to 2014-12-31

Detrimental inflammation contributes to a majority of diseases, and increased knowledge of the mechanisms that regulate leukocyte recruitment is central to limit inflammatory response. We previously established ...

Research project from 2021-01-01 to 2024-12-31

Lymphatic vessels within different organs have diverse developmental origins and exhibit remarkable tissue-specific specialisation. We hypothesise that uncovering organ-specific features and functions ...

Research project from 2013-01-01 to 2017-12-31

Possibilities to prevent pancreatic beta-cell death and restore beta-cell numbers are crucial for optimal treatment of type 1 diabetes (T1D). Moreover, non-invasive monitoring of beta-cell mass would be ...

Research project from 2012-01-01 to 2014-12-31

Moderate overweight is common, but still are the metabolic implications of moderate weight gain poorly explored in humans. For unknown reasons, some individuals, but not others, deposit excess calories ...

Research project from 2020-01-01 to 2023-12-31

Chronic kidney disease (CKD) is associated with abnormal mitochondrial metabolism. Key players in CKD development are FOXD1 stroma-derived interstitial cells, which give rise to extracellular matrix-producing ...

Research project from 2021-01-01 to 2023-12-31

We will use a multi-pronged approach for two aims: early identification of individuals at risk of developing chronic obstructive pulmonary disease (COPD) and identification of subjects with an established ...

Research project from 2020-01-01 to 2023-12-31

Kidney disease is a major cause for premature mortality in diabetic patients. Recently, the focus has shifted from a glomerulocentric to a predominantly tubulocentric view of mechanisms initiating the ...

Research project from 2019-01-01 to 2021-12-31

The interaction between the nervous system, hormones and the immune system is dynamic and altered in diabetes.Type 2 diabetes (T2D) is associated with impaired β-cell function and insulin resistance, while ...