Research at Uppsala University
Focus of financial reporting can influence business cycles
27 December 2021. Editorial choices can impact the amplitude of business cycles even if the information that is report ...
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Protein biomarkers protect against disease development
10 December 2021. A comprehensive study from Uppsala University shows that several disease-associated protein biomarke ...
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Leadership – a key to achieving climate goals
10 December 2021. Everyone needs to be on board if climate goals are to be reached in time. Yet, the countries of the ...
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Search for research projects
Here you will find all research projects at Uppsala University funded by the main Swedish funding bodies. The search feature is based on the SweCRIS database.
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Your choice produced 36 hits
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Acute kidney injury - mechanisms and novel therapeutic targets in large animal models
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Research project from 2012-01-01 to 2014-12-31
Acute kidney injury (AKI) is a major clinical problem with no effective treatment and poorly defined pathogenesis. Our preliminary data using unique large animal models indicate that septic AKI is independent ...
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Acute kidney injury - mechanisms and novel therapeutic targets in large animal models
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Research project from 2015-01-01 to 2017-12-31
Acute kidney injury (AKI) is a major clinical problem with no effective treatment and poorly defined pathogenesis. Our preliminary data using unique large animal models indicate that septic AKI is independent ...
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Acute kidney injury - mechanisms and novel therapeutic targets in large animal models
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Research project from 2015-01-01 to 2020-12-31
Acute kidney injury - mechanisms and novel therapeutic targets in large animal models ...
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The Angiopoietin/Tek System in Health and Disease
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Research project from 2013-01-01 to 2015-12-31
Angiopoietin-1 (Angpt1) and Angiopoietin-2 (Angpt2) bind to the tyrosine kinase receptor, Tek, found on endothelial cells. Angpt1 is a Tek agonist and promotes endothelial cell stabilization, whereas Angpt2 ...
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Pancreatic islet vascular function; implications for the pathogenesis of type 2 diabetes.
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Research project from 2012-01-01 to 2014-12-31
The pancreatic islets are a complex micro-organ containing many cell types. The importance of interactions between these cells, particularly islet vasculature, for normal islet endocrine function has lately ...
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Role of fatty acids in ectopic fat accumulation and skeletal muscle hypertrophy during overfeeding: metabolic and molecular studies
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Research project from 2015-01-01 to 2017-12-31
Factors influencing body fat accumulation are poorly understood. Individuals that deposit fat in the liver, muscle and pancreas (ectopic fat) without increasing lean tissue (sarcopenic obesity) are prone ...
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Central regulation of food intake and reward; Molecular mechanisms and human pathologies
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Research project from 2017-01-01 to 2019-12-31
We aim to study the molecular mechanisms of food intake and reward functions, considering genetic background and cognitive functions. We plan to combine fly, mouse and human genetic models to unravel modes ...
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Genetic architecture of human quantitative clinical traits: Contribution of rare and common genetic variants to the missing heritability
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Research project from 2013-01-01 to 2015-12-31
Genome-wide association studies (GWAS) have provided insight into the genetic architecture of many chronic diseases, but translation of this knowledge into clinical practice has been limited. One reason ...
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The vital GABA signalling in brain, pancreatic islets and immune cells.
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Research project from 2016-01-01 to 2018-12-31
The small molecule γ-aminobutyric acid (GABA) is made and released by neurons, the insulin secreting β-cells and some immune cells. GABA is an extracellular signal molecule and a Master Regulator of physiological ...
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The endosomal network as signalling platform in regenerating liver
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Research project from 2014-07-01 to 2017-06-30
Recent work shows that growth factor receptor signalling continues in endosomes, turning the endosomal network into a signalling platform. Different growth factors modulate the endosomal network and features ...
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Diabetes When it Happens: Real-time In Vivo Imaging of Innate and Adaptive Immune Responses in Type 1 Diabetes
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Research project from 2015-01-01 to 2017-12-31
Why some persons develop type 1 diabetes mellitus is still largely unknown. The incidence of this disease is increasing worldwide, but the reasons for the onset of the autoimmune process killing the insulin-producing ...
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Regulation of TGFbeta signaling and cell differentiation by nuclear enzymes and non-coding RNAs
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Research project from 2013-01-01 to 2017-12-31
Transforming growth factor beta (TGFbeta) family polypeptides are cytokines regulating cell differentiation including the epithelial-mesenchymal transition (EMT). TGFbeta ligands signal via cell surface ...
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Functional analyses of the glutamate cophenotype of dopamine neurons - Relevance for neurological and neuropsychiatric disorders
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Research project from 2012-01-01 to 2014-12-31
DA-regulated processes, which range from motor control to emotional control and also involves the ability to experience pleasure, are vital for brain function. Disorders of the DA system, including addiction ...
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Functional genomic analysis of the kidney glomerulus
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Research project from 2013-01-01 to 2017-12-31
This plan describes the continuation of a project, which has been ongoing in the PIs laboratory for the past ten years. The project started as a broad mapping of the glomerular transcriptome and has so ...
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GABA, not just a neurotransmitter molecule!
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Research project from 2013-01-01 to 2015-12-31
GABA (gamma-aminobutyric acid) is a small molecule with the highest concentration in our brains where it is the main neurotransmitter that reduces neuronal and neuronal networks excitability. All neurons ...
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Hypoxic signalling in renal interstitial cells and its impact on the pathogenesis of kidney disease
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Research project from 2016-01-01 to 2019-12-31
Hypoxia is a common finding in chronic kidney injury and shifts in cellular oxygen metabolism generate specific signals that modulate cellular differentiation and function, cell-cell interactions and inflammation ...
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INVESTIGATION OF MECHANISMS OF ACTIONS OF ENVIRONMENTAL CONTAMINANTS IN HUMANS USING AN "-OMICS"-BASED APPROACH
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Research project from 2014-01-01 to 2016-12-31
BACKGROUND: A number of environmental contaminants have been associated with negative health effects, but the mechanisms of actions are sparsely known for the majority of the contaminants, especially in ...
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Targeting Leukocytes in Health and Disease
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Research project from 2015-01-01 to 2018-12-31
Immune cells (leukocytes) have essential roles in many situations in the body and are vital for survival. However, they are also driving detrimental inflammation, contributing to the majority of diseases ...
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The enigmatic alpha-cell - role in glucose homeostasis and diabetes.
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Research project from 2013-01-01 to 2013-12-31
Frisättningen av insulin och glukagon från de Langerhanska öarnas beta- respektive alfaceller är avgörande för blodsockerregleringen. Störd frisättning av insulin uppfattas idag som orsak till de flesta ...
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Renal Interstitial Hyaluronan in the Regulation of Fluid Handling. Regulatory Aspects During Physiological and Pathophysiological Conditions.
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Research project from 2012-01-01 to 2014-12-31
Cardiovascular disease is a dominant cause for invalidity and mortality. The research proposal use rats, genetically modified mice, human kidney tissue and renomedullary interstitial cells in integrative ...
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Kidney hypoxia and diabetic nephropathy
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Research project from 2014-01-01 to 2019-12-31
Kidney disease is a major cause for premature mortality in diabetic patients. The focus has recently shifted from a glomerulocentric to a predominantly tubulocentric view of mechanisms initiating the development ...
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The role of nitric oxide in kidney function and development of arterial hypertension
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Research project from 2014-01-01 to 2016-12-31
Arterial hypertension is an important health problems and we need a better understanding of the disease to find new principles for treatment. Nitric Oxide (NO) is a potent vasodilator and a blockade of ...
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Leukocyte recruitment during inflammation and angiogenesis
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Research project from 2012-01-01 to 2014-12-31
Detrimental inflammation contributes to a majority of diseases, and increased knowledge of the mechanisms that regulate leukocyte recruitment is central to limit inflammatory response. We previously established ...
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Organ-specific origins, regulation and functions of lymphatic vessels in development and disease
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Research project from 2021-01-01 to 2024-12-31
Lymphatic vessels within different organs have diverse developmental origins and exhibit remarkable tissue-specific specialisation. We hypothesise that uncovering organ-specific features and functions ...
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Means to monitor, preserve and restore beta-cell mass in type 1 diabetes mellitus
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Research project from 2013-01-01 to 2017-12-31
Possibilities to prevent pancreatic beta-cell death and restore beta-cell numbers are crucial for optimal treatment of type 1 diabetes (T1D). Moreover, non-invasive monitoring of beta-cell mass would be ...
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Metabolic and genetic response to moderate weight gain: role of dietary fat composition
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Research project from 2012-01-01 to 2014-12-31
Moderate overweight is common, but still are the metabolic implications of moderate weight gain poorly explored in humans. For unknown reasons, some individuals, but not others, deposit excess calories ...
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Metabolic control of renal interstitial cell function
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Research project from 2020-01-01 to 2023-12-31
Chronic kidney disease (CKD) is associated with abnormal mitochondrial metabolism. Key players in CKD development are FOXD1 stroma-derived interstitial cells, which give rise to extracellular matrix-producing ...
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Multi-pronged approach for early diagnosis and prognosis of COPD
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Research project from 2021-01-01 to 2023-12-31
We will use a multi-pronged approach for two aims: early identification of individuals at risk of developing chronic obstructive pulmonary disease (COPD) and identification of subjects with an established ...
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Renal oxygen metabolism and diabetic kidney disease
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Research project from 2020-01-01 to 2023-12-31
Kidney disease is a major cause for premature mortality in diabetic patients. Recently, the focus has shifted from a glomerulocentric to a predominantly tubulocentric view of mechanisms initiating the ...
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Normal GABA signaling and how it is altered in diabetes mellitus.
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Research project from 2019-01-01 to 2021-12-31
The interaction between the nervous system, hormones and the immune system is dynamic and altered in diabetes.Type 2 diabetes (T2D) is associated with impaired β-cell function and insulin resistance, while ...
Showing 30 Of 36 hits
Show more hitsResearch spotlight: The coronavirus
Blocking inhibits SARS-CoV-2 infection of human cells
24 November 2021. Viruses invade our cells and turn them into virus factories. Researchers at Uppsala University, toge ...
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New method for discovery of antiviral drugs
2 August 2021. The current COVID-19 pandemic has highlighted the need for methods to identify new or repurposed dru ...
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Helpline important for older people during the pandemic
8 July 2021. For many older individuals, the COVID-19 pandemic has resulted in the loss of daily anonymous contac ...
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Lectures
Uppsala University’s researchers share their knowledge in public lectures. Every year, the University is visited by leading researchers and influential people from around the world. At Uppsala University, you can hear Nobel laureates, researchers, authors, politicians and many others give lectures. Here we present some of the most prominent, annually occurring lectures at Uppsala University.