Research at Uppsala University

• The Torrent Ahead: Algorithms for X-ray Lasers to Study Structure, Function and Dynamics

  Research project from 2019-01-01 to 2024-12-31

  A new generation of superluminous X-ray free-electron lasers (XFEL) will deliver billions of exposures per day at intensities up to 100-times higher than intensities available from existing XFELs. The ...

• 21st Swedish Conference on Macromolecular Structure and Function

  Research project from 2016-11-01 to 2016-11-30

  The 21th Swedish Conference on Macromolecular Structure & Function.Tällberg, June 16-19, 2016Structural biology, Biochemistry, Biophysics & Molecular Biology are strong areas in Swedish research. The Swedish ...

• An Integrated Environment for Ribosome Research

  Research project from 2017-01-01 to 2022-12-31

  Uppsala university has excelled in ribosome research over decades and already has a strong environment in the area of bacterial protein synthesis. We aim here at creating a novel type of ribosome research ...

• Atomistic studies of functional mechanisms used by human membrane transporter proteins

  Research project from 2013-12-01 to 2017-10-30

  Purpose and goal: The purpose of this research project is to further our understanding of how human chloride ion channels and transporters work. One specific goal is to explain and visualize the molecular ...

• Computations for interrogating protein complex architecture

  Research project from 2021-01-01 to 2024-12-31

  How can we study inherently dynamic and heterogeneous architectures of protein complexes? Most techniques struggle with heterogeneous systems, especially when lowly populated states are crucial for the ...

• Elucidating the molecular mechanisms of anticancer activities in natural polysaccharides from Ginseng

  Research project from 2012-01-01 to 2014-12-31

  Ginseng polysaccharide is a complex mixture of neutral and acidic polysaccharides that has been proven to have anticancer activities. It functions through interactions with a protein called Galectin-3. ...

• Discovery of bioactive compounds with potential pharmaceutical applications from Sri Lankan medicinal plants

  Research project from 2014-01-01 to 2016-12-31

  The overall objective of this project is to evaluate the potential of traditional Sri Lankan medicinal plants as a source of novel biolgically active molecules that can be used as leads or tools for medical ...

• Biodiversity and chemodiversity of Sri Lankan marine sponges: an opportunity to explore new pharmaceutical applications

  Research project from 2018-01-01 to 2020-12-31

  Sponges (phylum Porifera) are unquestionably the most promising source of new marine compounds and yet, they are quite often neglected in the field of natural products research because of the extreme difficulty ...

• Carboxysomes - Compartmentalised Carbon Fixation In Photosynthetic Microorganisms

  Research project from 2016-01-01 to 2018-12-31

  Background and aim: Our aim is to study the structure and function of the CO2-concentration machinery in phytoplankton and autotrophic bacteria. Competition between O2 and CO2 at the active site of the ...

• Carboxysomes - structure of a cell organelle

  Research project from 2012-01-01 to 2014-12-31

  The aim is to study the structure and function of the CO2-concentration machinery in phytoplankton. Competition between O2 and CO2 at the active site of the CO2-fixing enzyme, Rubisco, reduces the efficiency ...

• Coherent diffractive imaging and nanocrystallography: Structure of intact carboxysomes and components

  Research project from 2011-01-01 to 2015-12-31

  A grand challenge for the 21st century is to develop a molecular-level understanding of a living cell. A key step in this direction is to obtain structures for individual cell organelles. The structure ...

• Computational Studies of Biological Catalysis and Molecular Recognition

  Research project from 2015-01-01 to 2018-12-31

  This project deals with computational studies in the general areas of biological catalysis and molecular recognition. We emphasize what may be called quantitative computational structural biology, where ...

• Computational analysis of enzyme adaptation to extreme environments

  Research project from 2019-01-01 to 2022-12-31

  This project deals with the problem of how enzymes can be shaped by evolution to work under extreme conditions. In particular, we will address cold-adapted enzymes that are able to maintain a high catalytic ...

• Computational design of GPCR drugs from fragments

  Research project from 2017-01-01 to 2017-03-13

  G protein-coupled receptors (GPCRs) play important roles in numerous physiological processes and are important drug targets for neurological diseases. Breakthroughs in GPCR structural biology and access ...

• Computational studies of adenosine receptor modulation via orthosteric, allosteric, and indirect allosteric mechanisms

  Research project from 2018-01-01 to 2021-12-31

  The project is focused on structure-based strategies for discovery of selective ligands of G protein-coupled receptors (GPCRs) and understanding of GPCR dimerization. The A1 adenosine receptor (A1R) is ...

• Computational studies of the structural and chemical biology of A2A adenosine and D2 dopamine receptor signaling

  Research project from 2014-01-01 to 2017-12-31

  This project is focused on understanding GPCR dimerization and strategies to discover ligands of receptors using structure-based methods. The A2A adenosine (A2AAR) and D2 dopamine (D2DR) receptors form ...

• Coupled folding and binding in protein association processes

  Research project from 2012-01-01 to 2015-12-31

  Life processes depend critically on interactions between macromolecules. Many of these interactions involve coupled folding and binding, which lies at the heart of many biologically, medically, and technologically ...

• TOMORROW´S BIOLOGY AT ADVANCED PHOTON SOURCES

  Research project from 2011-01-01 to 2015-12-31

  This proposal brings together those who developed the scientific case in biology for building X-ray lasers (Uppsala) with the team that leads the world in synchrotron-based X-ray crystallography and the ...

• Folding, binding and disorder in protein-ligand interactions

  Research project from 2013-01-01 to 2016-12-31

  Intrinsically disordered proteins (IDPs) are very common, in particular among signalling proteins. There are several hypotheses explaining why they are so common, but a paucity of experimental data to ...

• Function and regulation of an oncogenic remodeler

  Research project from 2020-01-01 to 2023-12-31

  The packaging of DNA into chromatin regulates a wide range of vital processes. One key class of enzymes that can regulate chromatin structure is the ATP-dependent chromatin remodeling enzymes (remodelers ...

• Functional and Structural Studies on Ribosomal Stalk Proteins and Translational GTPases

  Research project from 2015-01-01 to 2018-12-31

  Despite significant progress in understanding of bacterial protein synthesis several questions remained unanswered. In this project we aim to address some of the unanswered questions. The large subunit ...

• Fundamental functions of S-adenosyl methionine in bacterial physiology and resistance

  Research project from 2018-01-01 to 2021-12-31

  S-adenosyl methionine (SAM) is an essential co-substrate in methylation and a regulatory molecule in bacteria. In bacterial protein synthesis, methylation of rRNA by house-keeping site-specific SAM-dependent ...

• Structural acquisitions of capsid functions in icosahedral dsRNA viruses: three hypothesis

  Research project from 2019-01-01 to 2022-12-31

  Non-enveloped icosahedral dsRNA viruses that infect unicellular hosts are transmitted intracellularly. However, phylogenetically closely-related viruses found in multicellular hosts (metazoa) have acquired ...

• Hur allosteriska mutationer hos HIV-1 proteas leder till resistens mot läkemedel: Nya strategier för läkemedelsdesign

  Research project from 2017-01-01 to 2018-12-31

  Allosteric regulation is fundamental to protein function. HIV-1 protease from drug-treated patients acquires multiple allosteric mutations that resist drugs profoundly with little impact on enzymatic activity ...

• Regulation of ATP-dependent chromatin remodelers by their accessory domains and subunits

  Research project from 2016-01-01 to 2019-12-31

  The packaging of DNA as chromatin regulates many important cellular processes that require access to the cell’s genetic material. One major class of enzymes responsible for regulating the structure of ...

• IN-KIND CONTRIBUTION TO THE EUROPEAN XFEL

  Research project from 2012-01-01 to 2017-12-31

  The Laboratory of Molecular Biophysics at Uppsala University will provide parts of the bio-imaging instrumentation as a Swedish in-kind contribution to the European XFEL GmbH. This project has been approved ...

• Inhibition studies of metallo-beta-lactamases as target proteins of antibiotic resistance

  Research project from 2014-01-01 to 2018-12-31

  The appearance of superbugs producing metallo-beta-lactamases have resulted in a clinical crisis. This project intends to express and purify subclasses of metallo-beta-lactamases including NDM-1. Specific ...

• Structural and functional characterisation of metalloregulators in an actinomycete model organism – key players at the heart of metal homeostasis and the oxidative stress response

  Research project from 2017-01-01 to 2020-12-31

  Metal ions are essential for life, as structural components of the cellular machinery and catalysts of chemical reactions, yet are toxic at high concentrations. Metal homeostasis is therefore tightly controlled ...

• Life-and-death dynamics of the algal blooms: Studies on the host-specific marine algal viruses.

  Research project from 2019-01-01 to 2021-12-31

  Algal blooms greatly impact the marine ecosystem, human activities such as fishery and seaside recreation, and human health. Monitoring of algal blooms is one of the important governmental programs for ...

• MASS SPECTROMETER AND CELL SORTER FOR BIOLOGY INFRASTRUCTURE AT XFEL

  Research project from 2013-01-01 to 2013-12-31

  High flux coherent X-ray pulses can revolutionise the way we visualise biological events, bimolecular dynamics, and processes. Recent results show that free-electron lasers can potentially unlock the structure ...

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