From molecular design to immune modulation: hyaluronan-based strategies for musculoskeletal regeneration

You are warmly invited to attend the seminar:

Beurling Room, Ångström Laboratory, March 19 at 11:00-12:00.
https://link.mazemap.com/ooJjfIRv

Seminar title: From molecular design to immune modulation: hyaluronan-based strategies for musculoskeletal regeneration

Abstract:
Hyaluronan and its derivatives, combined with matrix proteins, represent key building blocks for advanced functional polymers in biomedical applications.

This talk will explore semisynthetic derivatives of hyaluronic acid and their composites, beginning with the underlying chemistry of derivatization. A range of biofabrication applications will be presented, with a particular focus on cartilage, bone, and intervertebral disc models and regeneration. Examples will highlight strategies for modulating microscopic architecture and integrating gene-activated matrices to enhance bioactivity and cell-instructive properties.

Finally, the talk will explore emerging approaches to uncover how biomaterials influence and modulate immune responses, with the vision of leveraging this knowledge to design next-generation materials for improved tissue regeneration.

Short bio:
Dr. Matteo D’Este holds an MSc (2002) and PhD (2006) in Physical Chemistry from the University of Padova, Italy. After the PhD, he has worked in the pharmaceutical and medical devices industry on biopolymers and their derivatives. He joined the AO Research Institute Davos in 2011, where his current position is Principal Investigator and Head of Biomedical Materials. Dr D’ Este has wide expertise in biopolymers chemical modification for the development of molecular networks to be used for fundamental and translational research. His research interests embrace biofabrication, immunomodulatory biomaterials, and drug delivery. Dr. D'Este is also actively committed to the growth of the biomaterial community and rising of the research level in areas previously penalized by geopolitical situation and lack of infrastructures. Dr. D’Este has authored 6 patents and over 80 papers. He is adjunct professor at the Laval University, Canada, and he has served as Chair of the 2023 European Society for Biomaterials Conference.

You are of course also welcome to the defense of Christos, on the 20th March at 13:15 in Häggsalen, Ångström lab. Thesis title: “Quantitative Design and Additive Manufacturing of Resorbable Composite Biomaterial for Bone Regeneration