Master projects in the Competence Centre

MASTER PROJECTS WITHIN WP3: Additive manufacturing of materials for implants

PROJECT: Zn-alloy system development for biodegradable implants

Background: Zinc is a promising biodegradable material because of its non-toxicity and inherent benefits to the human body. In contrast to degradable Mg alloys, Zn alloys display improved degradation properties, but their mechanical properties are inferior to those of Mg alloys. Additive manufacturing is a viable technique for developing degradable Zn alloys implants, particularly in regards to porous scaffolds for bone grafting. The aim of this research is to develop initial PBF-L processing parameters for a Zn alloy system with the aim of improving mechanical properties while maintaining good degradation resistance.

Possible objectives:

  • Design of Zn alloy system
  • PBF-LB process optimization for simple cubes and scaffolds
  • Mechanical and degradation testing

Your application should include:

  • A brief letter of interest describing yourself and why you are interested in the project
  • A CV (max. 2 pages)

Please send your application and interest to Franchesco D'Elia 

Master projects within WP5 : Printing for medication

PROJECT 1: Master thesis project in Nanotechnology - Additive Manufacturing (AM) of Medications 

Additive Manufacturing (AM) of Medications at the Division of Nanotechnology and Functional Materials, Department of Material Sciences and Engineering, The Ångström Laboratory

The Division of Nanotechnology and Functional Materials (NFM) is part of the Department of Materials Science and Engineering at the Ångström Laboratory. Researchers at NFM have extensive experience in research into organic energy storage, additive manufacturing, biocompatibility and nanosafety as well as development of functional porous materials.

Project description:  At the Division of Nanotechnology and Functional Materials we have, in a joint effort with the Department of Pharmacy and Uppsala Academic Hospital, developed additive manufacturing methods to produce drug loaded dosage forms.

We intend to expand this area of research focusing on additive manufacturing of drug loaded polymeric materials, which will include development of novel additive manufacturing procedures and of novel dosage forms.

Work duties: The work tasks in the research project involve developing additive manufacturing processes for production of drug loaded dosage forms from polymeric materials. The use of additive manufacturing for producing dosage forms will require some experience or strong interest in powder bed AM techniques, polymer chemistry and computer-aided design (CAD).

Instructions for application:

Your application should include the following:

1) A brief personal letter where you briefly describe yourself

2) A CV/résume (max 2 pages)


PROJECT 2: Master thesis project in Nanotechnology – Additive Manufacturing (AM) of Biomaterials

Additive Manufacturing (AM) of Biomaterials at the Division of Nanotechnology and Functional Materials, Department of Material Sciences and Engineering, The Ångström Laboratory

The Division of Nanotechnology and Functional Materials (NFM) is part of the Department of Materials Science and Engineering at the Ångström Laboratory. Researchers at NFM have extensive experience in research into organic energy storage, additive manufacturing, biocompatibility and nanosafety as well as development of functional porous materials.

Project description:  At the Division of Nanotechnology and Functional Materials we have developed additive manufacturing methods to produce bio-structures.

We intend to expand this area of research focusing on additive manufacturing of hydrogels with following crosslinking process in order to study structures stability and cytotoxicity with respect to loaded stem cells.

Work duties: The work tasks in the research project involve developing additive manufacturing processes, material preparation and structure analysis. The use of additive manufacturing process will require some experience or strong interest in fused deposition modelling (FDM) techniques, programming (mostly G-code) and computer-aided design (CAD).

Instructions for application:

Your application should include the following:

1) A brief personal letter where you briefly describe yourself

2) A CV/résume (max 2 pages)

Starting date: Spring 2022 or by appointment.

For further information about the position please contact Dr Jonas Lindh, jonas.lindh@angstrom.uu.se

Master projects within WP6: Implementation and business models

In Work Package 6 we see a large potential in combining the research performed in Industrial Technology, with the resources within the local innovation system (UU Innovation, UIC etc.). We also see a need for better pre-operative models, produced by AM in collaboration with the clinics. Implementation of e.g. additively manufactured implants in the clinics is not a straight-forward matter. Implants manufactured in a traditional manner are already subject to new, tougher regulations from 2020 through the new Medical Device Regulation, and by using AM several additional issues need to be considered, such as operator effects, ensuring certain material and implant properties for each product, etc. Furthermore, the completely new way of manufacturing also requires companies to consider new business models.

Below we list master thesis projects where we can offer possibilities for master thesis students to write their thesis. If you are interested or need more information please e-mail WP6 leader: anders.brantnell@angstrom.uu.se

Please notice that the project information is preliminary and there might be changes to the content. The master students also have great possibility to influence objectives, methods, data collection and analysis of findings.


Project 1. AM in orthopedics

Competence centre partners: OssDsign, Uppsala universitet

OssDsign: OssDsign AB manufactures patient specific implant for repair of large bone defects in the skull bone. The implants consist of a unique combination of titanium and calcium phosphate. The company was founded in 2011 and is a spin-off from research performed at Uppsala University and the Karolinska Institute.

Background: AM in clinical applications is spreading to different areas and AM in healthcare is considered as one of the cornerstones in cybernetic revolution. Despite this actual use and clinical implementation is not understood in detail. AM in orthopedics can be used to produce tailored implants for instance for spine, hips or knees.

Possible objectives:

  • To explore views and opinions on AM in orthopedics in Sweden (eg., threat or possibility, what to print)
  • To explore access to AM implants (in house production or external)
  • To explore understanding and knowledge of the regulatory requirements for AM implants, in particular when produced in house.

Methods: Interviews (Zoom or IRL) with orthopedists in Sweden (some access points will be provided, interviews can be conducted both in Swedish and English)


Project 2. AM in dentistry (focus on dentistry companies)

Competence centre partners: Region Uppsala (Academic hospital), Uppsala universitet

Region Uppsala: Region Uppsala exists to serve the people of Uppsala County. Our goal is to create conditions for good health and sustainability and development for everyone living and working here. Region Uppsala aims to promote health and improve the quality of life of the people who live in the county. We provide equal health, medical and dental care services characterised by high quality, good accessibility and good treatment. We aim to create good opportunities for healthy, safe and sustainable living and working environments through innovative approaches.

Background: AM in clinical applications is spreading to different areas and AM in healthcare is considered as one of the cornerstones in cybernetic revolution. AM in dentistry has the biggest market share (around 34%) among all clinical AM applications. Since AM in dentistry is a mature market, we could assume that several companies have started to work with AM in production. However, whether this is the case and how AM in that case has influenced dentistry companies is not well-known. In general, little knowledge on how AM is transforming the business and clinical landscape exist.

Possible objectives:

  • To explore views and opinions of dentistry companies on AM in production (eg., threat or possibility, what to print)
  • To explore what type of companies are investing in AM and why (eg., value proposition)
  • To explore how AM influences the business model of dentistry companies

Methods: Interviews (Zoom or IRL) with a set of dentistry companies in Sweden (both those that use AM and those that do not). A list of possible companies with contact information will be provided. Data collection is facilitated by a quantitative overview. (Interviews can be conducted both in Swedish and English)


Project 3. AM in dentistry (focus on dentists)

Competence centre partners: Region Uppsala (Academic hospital), Uppsala universitet

Region Uppsala: Region Uppsala exists to serve the people of Uppsala County. Our goal is to create conditions for good health and sustainability and development for everyone living and working here. Region Uppsala aims to promote health and improve the quality of life of the people who live in the county. We provide equal health, medical and dental care services characterised by high quality, good accessibility and good treatment. We aim to create good opportunities for healthy, safe and sustainable living and working environments through innovative approaches.

Background: AM in clinical applications is spreading to different areas and AM in healthcare is considered as one of the cornerstones in cybernetic revolution. AM in dentistry has the biggest market share (around 34%) among all clinical AM applications. Since AM in dentistry is a mature market, we could assume that several dentists have started to work with and offer AM applications. However, whether this is the case and how AM in that case is used and implemented is not well-known. In general, little knowledge on how AM is transforming the clinical landscape exist.

Possible objectives:

  • To explore views and opinions of dentists on AM applications in their work (eg., possibility, challenge, use areas)
  • To explore motivations behind dentists’ use of AM in their work (eg., added value)
  • To explore how AM influences the work of dentists

Methods: Interviews (Zoom or IRL) with dentists in Sweden (both those that use AM and those that do not). Some access points will be provided. Interviews can be conducted both in Swedish and English.

Last modified: 2022-01-10