Time period: 2012-01-01 to 2017-12-31

Project leader: Janos Hajdu

Funder: Swedish Research Council

Type of award: Project grant

Total fundning: 1 825 000 SEK

The Laboratory of Molecular Biophysics at Uppsala University will provide parts of the bio-imaging instrumentation as a Swedish in-kind contribution to the European XFEL GmbH. This project has been approved by VR/XFEL, and Phase I of the project has already received funding. The present application asks for funds to complete Phase II. The instrumentation will permit ultra-fast coherent diffraction studies on non-crystalline objects, such as single virus particles or biomolecules. This concept was invented by us. Initial experiments at the FLASH free-electron laser and at the Linac Coherent Light Source (LCLS) demonstrated the feasibility of the approach. The contribution builds on the technical developments that have enabled these successes. The project will be guided by an appropriate R&D effort, including tests of prototypes at FLASH and at the LCLS. Items of bio-imaging instrumentation fall into two main categories: Instruments for sample injection and guidance, and instruments to provide information about the interaction of XFEL pulses with sample particles. The instrumentation can be interfaced with various instruments at the European XFEL, in particular the SPB and SQS instruments. The project at its completion will provide the following bio-imaging instrumentation for the European XFEL: a. Sample injector and catcher system with laser-based injector, b. Probes to record plasma emission at the interaction point.