The EXPRESS study. Follow-up at 11 years of extremely preterm infants in Sweden.
Time period: 2015-01-01 to 2018-12-31
Project leader: Fredrik Serenius
Other personnel: Karin Källen, Karin Källén, Ulrika Ådén, Lisa Berlin Thorell, Lisa Thorell, Aijaz Farooqi
Funder: Swedish Research Council
Type of award: Project grant
Total fundning: 4 000 000 SEK
Progress in perinatal care has resulted in an increase in the survival of extremely preterm infants creating a new population with an increased risk for later disabilities. Our study population comprise a cohort of all infants born in Sweden at <27 wks in 3 years, 2004-2007 (liveborns, n=707; stillbirths, n =303: the EXPRESS cohort). The aim is to assess short- and long term outcomes in relation background factors. Short term outcomes include gestational age specific survival and neonatal morbidities. Long term outcomes include the presence of neurosensory impairments, physical and mental impairments and behaviour at age 2.5 years (corrected), at 6.5 years and at age 11. Long term assessments are performed by pediatric neurologists, psychologists and ophthalmologists and include a term controlgroup. The survival rate was high (JAMA 2010), the neonatal morbidity rates (Acta Paediatrica 2010) similar to recent studies and the 2.5 year follow-up (n= 456) showed similar or lower disability rates (JAMA 2013) compared with these studies. Results from the 6.5 year follow-up are being analyzed. The proposed study at age 11 is a multidisciplinary project which will comprehensively assess the somatic and mental health and wellbeing, and school performance to allow a total view of the EXPRESS cohort within the context of the family, school peers and health care system. This will enable us to create successful interventions as these children face new challenges when they grow up.