General provisions

Corresponds to the earlier course Medicinal Chemistry (3FK022). 1.5 credits (hp) correspond to 1 credit point (p) according to earlier study regulation.

Entry requirements

Attendance of all earlier courses within the pharmacy programme and of which 60 credits/40 credit points of term 1-3 should be passed. For single subject course 45 credits/30 credit points of which at least 22.5 credits/15 credit points chemistry including 7.5 credits/5 credit points organic chemistry and at least 7.5 credits/5 credit points pharmacology is required.

Learning outcomes

On completion of the course the student should be able to: – Apply the basic reasoning of structure-effect relationships within the most important groups of pharmacologically active compounds. – Assess the general chemical properties of pharmaceutical substances and pharmacological effects from their chemical structure. – Apply the basic ideas and methods for analysing quantitative structure-effect relationships of biologically active substances. – Account for the principles of modern drug design. – Translate rational chemical names to structural formulas.

Content

The course focuses on the organic-chemical perspective of drugs. Strong emphasis is put on structure-effect relationships, especially stereochemical factors influencing the drug-receptor interaction. Furthermore, the influence of physico-chemical properties on the bioavailability of drugs is dealt with. Drug nomenclature and chemical aspects on drug stability and metabolism are dealt with.

Instruction

The teaching is given as lectures and seminars.

Compulsory parts of the course:

Course introduction.

Assessment

Examination is given at the end of the course. To pass the course, a passed examination is required. Each student has the right to in all six examinations i.e. one examination and five re-examinations.