General provisions

The course is a direct continuation of the basic course Pharmacokinetics 7.5 credits (3FB605).

Entry requirements

Master of Science in Pharmacy Programme: 60 credits is required from semester 1-3 and the student has followed all earlier courses within the programme.

Learning outcomes

After having completed the course, the student should be able to:

- calculate and evaluate pharmacokinetic data obtained from experiments in various animal species.

- evaluate data from studies of drug metabolism in vitro.

- use allometric scaling to predict pharmacokinetic properties of a candidate drug in humans.

- evaluate pharmacodynamic data and estimate therapeutic plasma drug concentrations in patients.

- evaluate pharmacokinetic and pharmacodynamic data from a drug industry perspective and make a reasoned choice of candidate drug to bring forward to clinical trial.

Content

The course deals with different methods used within preclinical drug research to evaluate the pharmacokinetic and pharmacodynamic properties of new substances. It also discusses which properties are desirable for new candidate drugs.

Instruction

Teaching is provided through lectures and an individual assignment involving computer work.

Course introduction, some lectures according to the schedule and oral examination are compulsory.

Assessment

Examination is arranged at the end of the course. In order to pass the course, the student must provide a satisfactory account of completion of the task, both in writing and during oral examination.