General provisions

Corresponds to earlier course 3FK013 Organic Pharmaceutical Chemistry.

Entry requirements

Attendance of all earlier courses within the pharmacy programme For single subject course, General Pharmaceutical Chemistry 7.5 credits or equivalent is required.

Learning outcomes

On completion of the course the students should be able to:

• Explain and apply the safety precautions that are essential in organic chemistry laboratory work, keep adequate records in the lab book and make a risk analysis
• plan and carry out syntheses of simple pharmaceutical substances, as well as orally and in writing account for the theoretical and practical results
• interpret rational chemical names and name simple organic molecules
• explain the reactivity of the most common substance classes in organic chemistry and, when relevant, explain their relative acid-base strength
• define the three-dimensional structure of organic molecules and explain their stereochemical relationships
• describe organic molecules basic reactions and the corresponding reaction mechanisms and apply this on drug molecules
• interpret spectra (IR, MS and NMR) of simple organic molecules

Content

The course focuses on the, in pharmaceutical contexts, most important substance classes in organic chemistry (e.g. haloalkanes, alcohols, amines, alkenes, alkynes, aromatics, aldehydes, ketones, carboxylic acids and carboxylic acid derivatives) with respect to their structure and their chemical properties. The interplay between structure and function are discussed for a greater understanding of chemical reactions and processes that take place in our environment. Further, organic-chemical reactions (e.g. substitution, elimination, addition to the alkene and the alkyne, electrophilic aromatic substitution, carbonyl group reactions, carboxylic acid derivatives reactions, oxidation and reduction) are discussed together with the associated reaction mechanisms. Naming by means of rational chemical nomenclature (IUPAC), including some common names, are an important part of the course. Relative acid strength, base strength and reactivity are discussed based on concepts such as nucleophilicity, electrophilicity, inductive effect, resonance, resonance effect, solvation and steric effects. Stereochemistry and how isomers relate to each other are also discussed during the course. Characterisations of molecules using spectroscopic techniques (IR, MS and NMR) are included, both in theory and in practice. The laboratory part includes organic synthesis, organic reaction theory, as well as purification and identification of organic compounds. The laboratory exercises are presented both orally and in a laboratory report.

Instruction

Compulsory parts of the course: Compulsory parts of the course: all parts related to laboratory sessions. Laboratory sessions may be held in the evenings.

Assessment

To pass the whole course a passed laboratory course and a passed written, individual examination are required, as well as attendance during all compulsory parts of the course. The laboratory sessions are examined orally and in writing. A chance to complete a failed laboratory course can be given only at the next occasion at which the course is given and only in case of a vacancy.