Forskning vid Uppsala universitet

Forskningsprojekt från 2013-01-01 till 2014-12-31

This project aims to develop of a novel human ex-vivo whole blood loop system for an improved characterization of therapeutic antibodies in order to avoid irrelevant and unnecessary animal studies. Today ...

Forskningsprojekt från 2019-07-01 till 2021-12-31

Syfte och mål: Anaplastisk sköldkörtelcancer (ASC) har idag en mycket dålig prognos, och bristen på kurativa behandlingsalternativ för ASC är ett stort problem. Andra typer av sköldkörtelcancer kan framgångsrikt ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

Mast cells are currently emerging as major players in a variety of pathologies, but the mechanisms by which they exert such diverse functions remain to be elucidated. A hallmark feature of mast cells is ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Glioblastomas are aggressive gliomas with a grim prognosis, characterized extreme invasiveness and abnormal vessels. The abnormal vessels can promote tumor progession by providing a route of invasion for ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Regulatory T cells (Tregs) are immune cells that play a pivotal role in maintaining homeostasis, as well as in autoimmunity, infection and tumor biology. Recent evidence suggests that tissue-specific Tregs ...

Forskningsprojekt från 2013-07-01 till 2016-06-30

The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

Immunotherapy has revolutionized cancer treatment and checkpoint inhibitors, which act by removing negative signals in already activated T cells, are predicted tobecome first line treatment for many cancer ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Immunotherapy is currently being established as cancer treatment. Immune checkpoint blockade antibodies that fine-tune T cell activity to attack and kill tumor cells can cure 20-25% of patients with refractory ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

The overall aim of this plan is to improve the treatment of patients with persistent pain and itch by developing novel pharmaceutical strategies and by increasing our knowledge of how itch and pain is ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Why some persons develop type 1 diabetes mellitus is still largely unknown. The incidence of this disease is increasing worldwide, but the reasons for the onset of the autoimmune process killing the insulin-producing ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

A prominent feature in a number of rheumatic diseases is an increased expression in blood and tissue cells of type I interferon regulated genes (an IFN signature), which activates both the innate and adaptive ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

The over-all purpose of this project is to improve immunotherapy in neurodegenerative diseases by targeting neurotoxic protein aggregates with brain penetrating bispecific antibodies. As antibodies do ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Animal cells maintain tissue function by secreting regulatory factors to signal their activity and nutrient status, pathogen infections or injury. These regulated vesicle fusion events are typically much ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Antibodies dramatically up- or downregulate the immune response to the antigen they bind and thus, depending on isotype and antigen, act as natural adjuvants or immunosuppressors. IgG-MEDIATED SUPPRESSION ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The objectives are to understand how IgM/complement and IgE/the low affinity receptor for IgE (CD23) operate to feedback enhance the immune response and how IgG feedback suppresses antibody responses. ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

The aim is to understand how passively administered or endogenously produced Abs, forming immune complexes (ICs) with their Ag, can completely suppress or enhance Ab responses several 100-fold. Special ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

OBJECTIVE: To study immune complex (IC)-mediated mechanisms in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), with emphasis on how IC and IC-associated autoantibodies regulate production ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

We recently made three discoveries related to acquired Loss Of chromosome Y (LOY) in blood of adult/aging men. LOY is associated with: a) shorter survival and increased mortality from cancer; b) Alzheimer ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Autoinflammatoriska sjukdomar (AID) karakteriseras av en felreglering av det primära immunförsvaret. Den kliniska bilden utgörs av inflammation utan infektiös eller autoimmun bakomliggande orsak. AID är ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

In this four-year project we will expand, develop and refine the way autoimmune serology is used to characterize and understand the pathogenetic mechanisms leading to individual clinical phenotypes of ...

Forskningsprojekt från 2016-01-01 till 2017-12-31

Autoantibodies, immune complex (IC) deposition, and complement are important factors in many autoimmune diseases. IgM antibodies exert their effect through complement or Fc-receptors. The aim of the current ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Immune cells (leukocytes) have essential roles in many situations in the body and are vital for survival. However, they are also driving detrimental inflammation, contributing to the majority of diseases ...

Forskningsprojekt från 2018-01-01 till 2018-12-31

Immunological research ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

Global mortality among children under the age of 5 approximates 10 million deaths per year, of whom 1.9 million is due to diarrhea and 5 million deaths are associated with malnutrition. A substantial ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Despite more than 100 million infections annually and extensive scientific efforts to understand disease mechanisms, the clinical course of dengue infection, progression to severe dengue disease, particularly ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Glioblastomas are highly aggressive brain tumors, characterized by microvascular proliferation and dysfunctional vessels. The abnormal vessels contribute substantially to patient mortality. Still, the ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Detrimental inflammation contributes to a majority of diseases, and increased knowledge of the mechanisms that regulate leukocyte recruitment is central to limit inflammatory response. We previously established ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

The lymph nodes provide a unique environment for immune activation and regulation, including antitumor responses. They arealso common sites for tumor metastasis. My own and others recent data has shownthat ...

Forskningsprojekt från 2017-01-01 till 2022-12-31

Purpose and aimIn diseases such as asthma and systemic mastocytosis (SM), mast cells accumulate in the affected tissues and become activated leading to symptoms caused by the released mediators. Our studies ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

In lungs of patients with allergic asthma mast cell numbers are increased and they release mediators that contribute to asthma symptoms. The increase in lung mast cells in mouse models of allergic airway ...