Användningen av självprovtagning och repeterat HPV test i den gynekologiska hälsokontrollen för att reducera förekomsten av livmoderhalscancer: en randomiserad studie

Tidsperiod: 2014-01-01 till 2015-12-31

Projektledare: Ulf Gyllensten

Medarbetare: Erik Wilander, Matts Olovsson

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 2 600 000 SEK

Cervical cancer is the second most frequent cancer in women and caused by persistent infection by human papillomavirus (HPV). The organised screening in Sweden has reduced the incidence of cervical cancer by 50 %. A further reduction may be achieved by using HPV as a primary test and a screening system where women can take the samples at their own convenience (at home) to increase the population coverage. At present there are no studies using self-sampling and repeated HPV testing in primary screening. This project will fill this knowledge-gap by performning a randomised study in Uppsala County. The study aims are to determine: A) The efficiency of using self-collected samples and repeated HPV testing as compared to screening using Pap-smear for identification of women with cervical cancer prestages (moderate to severe dysplasia). B) The health-economic benefits of using self-collected samples and repeated HPV testing as compared to conventional cytology. The outcome of the project will be implemented smoothly into the regular screening routine. This project was initiated in 2012 by a VR grant and presently over 10 000 women have been invited and are at different project steps. This application it to fund the remaining part of invitations, laboratory and clinical analysis, in order to complete the study.