Högupplöst positronemissionstomografi med scintillatorer pixelerade med laser-inducerade optiska barriärer
Tidsperiod: 2015-01-01 till 2017-12-31
Projektledare: Lisa Bläckberg
Budget: 3 150 000 SEK
This research aims to develop scintillator detector arrays for high resolution PET imaging, using the recently emerging technique of Laser-Induced Optical Barriers (LIOB). LIOB allows for a flexible and cost-effective production of pixelated scintillator crystals, compared to current fabrication methods which are cumbersome, expensive, and involves sub-optimal tradeoff between key performance metrics of the detectors. The proposed project will involve simulations and experimental characterization of the reflectivity of the optical barriers, which are created by locally altering the crystal structure within scintillators using an internally focused laser beam. The understanding of the barrier behaviour will be used to optimize the detectors in terms of spatial resolution. Optimized detector arrays will finally be integrated in a small animal PET scanner and characterized in terms of image quality. The work will be conducted at the Center for Advanced Medical Imaging at Harvard Medical School where world-class research in the field of medical imaging, in particular PET, is performed. The end result of the project is scintillator detector blocks with high spatial resolution and depth of interaction capability, produced using the LIOB technique. The proposed technique may drastically reduce the cost and and increase the flexibility in the fabrication of high resolution scintillator arrays, and thus have the potential to shift the paradigm in PET detector instrumentation.