Role of the brain in the development of type 2 diabetes

Would you like to describe the project in short?

"We examine the brain's various neural networks, especially those with dopamine as a signalling substance, and their involvement in the development of type 2 diabetes. This can also lead to new 'precision medicines' or other tailor-made measures, such as those concerning lifestyle, to prevent and treat diabetes."

What are the cross-disciplinary aspects of this project?

"We collaborate locally within UU and SLU, but also internationally. Several scientific disciplines are involved, such as endocrinology, neurophysiology, neuroradiology, and pharmacology."

How was the project and collaboration born?

"We have found that obesity surgery, which counteracts type 2 diabetes, exerts part of the effect through a neuroendocrine adjustment based in the brain. This leads to decreased activity in blood sugar raising systems, such as insulin antagonistic hormones. This in turn has led to a hypothesis that the reverse event, such as elevated insulin antagonistic hormones, contributes to the development of type 2 diabetes and that the brain plays an important role. In addition, the findings provide suggestions for possible new treatment methods to counteract type 2 diabetes and associated complications."

How can UDC be of help in your research?

"Creating contact interfaces for both senior researchers and doctoral students through symposia, research retreat and more."

What can UDC do to make the PhD students feel like they belong to the centre?

"In addition to the mentioned contact interfaces, various educational activities are of great value. For example, research school and joint courses that should also be open to other PhD students."

Which UDC activities will be meaningful for this project?

"Symposia, research retreat, research school and joint courses."

Jan Eriksson

Professor at Department of Medical Sciences, Clinical diabetology and metabolism

Email:
jan.eriksson[AT-sign]medsci.uu.se
Telephone:
+4618-6114419
Mobile phone:
+46 73 8681133
Last modified: 2022-04-05