Postdoc position in Computational biology/Bioinformatics
Postdoc position in Computational biology/Bioinformatics focusing on
eukaryotic RNA biology/RNA regulation/microRNAs at Uppsala University, Sweden.
We are looking for a new member of the Söderbom research group to analyze gene regulation by non-coding RNAs and how this affects evolution of multicellularity. Specific focus is on microRNAs, both their role in the transition from uni- to multicellular life, but also how and when microRNA appeared during evolution. Apart from microRNAs, the lab is studying a new non-coding RNA that we have demonstrated to be important for early development in the social amoeba Dictyostelium discoideum. In the group, we combine experimental wet-lab approaches with computational analysis. We are now seeking a highly motivated and enthusiastic postdoc to join the Söderbom research group in our research efforts.
For our studies we have mainly used social amoebae, which allow for both computational and experimental studies of how gene regulation contribute to multicellular development. We have recently extended our studies to other organisms to better understand the evolution of non-coding RNAs and their effect of organism complexity. More information about our research can be found at
Recent publications describing our computational approaches:
Edelbroek et al. (2024). Evolution of microRNAs in Amoebozoa and implication for the origin of multicellularity. Nucleic Acids Research.
Edelbroek et al. (2024). Chromosome-level genome assembly and annotation of the social amoeba Dictyostelium firmibasis. Scientific Data.
Edelbroek et al. (2024). Multi-omics analysis of aggregative multicellularity (2024). iScience.
Kjellin et al. (2021). Abundantly expressed class of non-coding RNAs conserved through the multicellular evolution of dictyostelid social amoebas. Genome Research.
Qualifications
The successful candidate will have a strong interest in computational and RNA biology, with a PhD degree in bioinformatics, biology, molecular biology or equivalent. Very good knowledge and proven substantial experience in computational analyses of e.g. high-throughput sequencing data is a requirement. Programming skills, using for example R and Python, are also required. Important for the position is to be able to work independently but good skills in working in a team and collaborating with other researchers are also essential. Excellent communication skills (written and spoken English) are required. Assessment of personal suitability will be an important aspect in the selection. The applicant must have received his/her PhD degree within the last six years.
Additional qualification that is considered an asset:
Experience in: analysis of small RNA-seq and mRNA-seq data; analysis of genome sequencing data and genome annotation; analysis of protein expression by mass-spec data; and multi-omics analysis.
Position
The project is funded by a tax-free 2-year scholarship (Carl Trygger’s Foundation) at the Program of Microbiology and Immunology at the Department of Cell and Molecular Biology, Uppsala University.
How to apply
Please send your application (in English) to fredrik.soderbom@icm.uu.se with the subject heading ‘Postdoc application’. The application must include the following documents combined into a single pdf file in the following order:
- CV (max 3 pages)
- Publication list
- A cover letter describing your interest and suitability for the position (max 1 page)
- Contact details of two to three references
Applications will be evaluated continuously until the position is filled.
Questions
For further information about the position, please contact: Professor Fredrik Söderbom, fredrik.soderbom@icm.uu.se