Institutionen för farmaci

A charged tail on anti-α-Synuclein antibodies does not enhance their affinity to α-Synuclein fibrils

Petersen, Inga; Godec, Ana; Ranjbarian, Farahnaz; Hofer, Anders et al.

Ingår i PLOS ONE, 2024

• DOI för A charged tail on anti-α-Synuclein antibodies does not enhance their affinity to α-Synuclein fibrils
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Advancing opioid stewardship in low-middle-income countries: challenges and opportunities

Jadhari, Rojita; Pathak, Nabin; Shrestha, Rajeev; Shrestha, Sunil et al.

Ingår i JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE, 2024

• DOI för Advancing opioid stewardship in low-middle-income countries: challenges and opportunities
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AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1

Díaz-Holguin, Alejandro; Saarinen, Marcus; Vo, Duc Duy; Sturchio, Andrea et al.

Ingår i Science Advances, 2024

• DOI för AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
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Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches

Zhuo, Xuezhi; Foderà, Vito; Larsson, Per; Schaal, Zarah et al.

Ingår i European Journal of Pharmaceutical Sciences, 2024

• DOI för Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches
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Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Hu, Yang; Girdenyte, Milda; Roest, Lieke; Liukkonen, Iida et al.

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy
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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI för Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
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Assessment of enhancing curcumin's solubility versus uptake on its anti-cancer efficacy

Rawas-Qalaji, Mutasem; Jagal, Jayalakshmi; Sadik, Sefeera; Said, Zafar et al.

Ingår i Colloids and Surfaces B, 2024

• DOI för Assessment of enhancing curcumin's solubility versus uptake on its anti-cancer efficacy

Benefits of combining supersaturating and solubilizing formulations - Is two better than one?

Alvebratt, Caroline; Karlén, Filip; Åhlén, Michelle; Edueng, Khadijah et al.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Benefits of combining supersaturating and solubilizing formulations - Is two better than one?

Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model

Ibrahim, Eman I. K.; Ellingsen, Espen B.; Mangsbo, Sara M.; Friberg, Lena

Ingår i International Immunopharmacology, 2024

• DOI för Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model
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Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach

Brekkan, Ari; Lledo-Garcia, Rocio; Lacroix, Brigitte; Jonsson, Siv et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 65-75, 2024

• DOI för Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach
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Comparison of Two Methods for Determining Item Characteristic Functions and Latent Variable Time-Course for Pharmacometric Item Response Models

Arrington, Leticia; Karlsson, Mats

Ingår i AAPS Journal, 2024

• DOI för Comparison of Two Methods for Determining Item Characteristic Functions and Latent Variable Time-Course for Pharmacometric Item Response Models
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Conjugated hyperbilirubinemia associated with accidental rifapentine overdose

Yohane, M.; Naufal, F.; Endoza-Ticona, A. M.; Svensson, Elin M. et al.

Ingår i The International Journal of Tuberculosis and Lung Disease, s. 354-356, 2024

• DOI för Conjugated hyperbilirubinemia associated with accidental rifapentine overdose

Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Soukarieh, Fadi; Mashabi, Alaa; Richardson, William; Oton, Eduard Vico et al.

Ingår i Journal of Medicinal Chemistry, s. 1008-1023, 2024

• DOI för Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections
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Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay

Schulzen, Arne; Andreadis, Ioannis I.; Bergström, Christel A. S.; Quodbach, Julian

Ingår i European Journal of Pharmaceutical Sciences, 2024

• DOI för Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay
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Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood

Schouten, Wietse M.; Roseboom, Ignace C.; Lucas, Luc; Tshiongo, Japhet Kabalu et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2024

• DOI för Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood
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Development of a canine artificial colonic mucus model for drug diffusion studies

Barmpatsalou, Vicky; Tjakra, Marco; Li, Lingxiao; Dubbelboer, Ilse R. et al.

Ingår i European Journal of Pharmaceutical Sciences, 2024

• DOI för Development of a canine artificial colonic mucus model for drug diffusion studies
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Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals

Kvitne, Kine Eide; Hovd, Markus; Johnson, Line Kristin; Wegler, Christine et al.

Ingår i Clinical Pharmacokinetics, s. 109-120, 2024

• DOI för Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals
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Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations

Parrow, Albin; Kabedev, Aleksei; Larsson, Per; Johansson, Pernilla et al.

Ingår i Journal of Controlled Release, 2024

• DOI för Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations
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Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App^NL-F Mouse Model of Alzheimer's Disease

Portal, Benjamin; Södergren, Moa; Parés i Borrell, Teo; Giraud, Romain et al.

Ingår i Journal of Alzheimer's Disease, s. 1017-1037, 2024

• DOI för Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App^NL-F Mouse Model of Alzheimer's Disease
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Effect of Interindividual Variability in Metabolic Clearance and Relative Bioavailability on Rifampicin Exposure in Tuberculosis Patients with and without HIV Co-Infection: Does Formulation Quality Matter?

Nardotto, Glauco Henrique Balthazar; Svensson, Elin; Bollela, Valdes Roberto; Rocha, Adriana et al.

Ingår i Pharmaceutics, 2024

• DOI för Effect of Interindividual Variability in Metabolic Clearance and Relative Bioavailability on Rifampicin Exposure in Tuberculosis Patients with and without HIV Co-Infection: Does Formulation Quality Matter?
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Engineering and characterization of a hydrogel mimicking subcutaneous interstitial space

Rodler, Agnes; Samanta, Ayan; Goh, Wen-Jun; Hilborn, Jöns et al.

Ingår i European Polymer Journal, 2024

• DOI för Engineering and characterization of a hydrogel mimicking subcutaneous interstitial space
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Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units

Damgaard, Tobias; Woksepp, Hanna; Brudin, Lars; Bonnedahl, Jonas et al.

Ingår i Infectious Diseases, s. 451-459, 2024

• DOI för Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units
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Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics

Sinko, Patrick D.; Parker, Louis; Prahl Wittberg, Lisa; Bergström, Christel A. S.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics
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Evaluation of covariate effects in item response theory models

Wellhagen, Gustaf; Yassen, Ashraf; Garmann, Dirk; Broeker, Astrid et al.

Ingår i CPT, s. 812-822, 2024

• DOI för Evaluation of covariate effects in item response theory models
• Ladda ner fulltext (pdf) av Evaluation of covariate effects in item response theory models

Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL-6 levels following administration of the T-cell bispecific engager glofitamab

Djebli, Nassim; Parrott, Neil; Jaminion, Felix; O'Jeanson, Amaury et al.

Ingår i CPT, s. 396-409, 2024

• DOI för Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL-6 levels following administration of the T-cell bispecific engager glofitamab
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Experiences and Translatability of In Vitro and In Vivo Models to Evaluate Caprate as a Permeation Enhancer

Emeh, Prosper; Breitholtz, Katarina; Berg, Staffan; Vedin, Charlotta et al.

Ingår i Molecular Pharmaceutics, s. 313-324, 2024

• DOI för Experiences and Translatability of In Vitro and In Vivo Models to Evaluate Caprate as a Permeation Enhancer

Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

de Waal, Tom; Handin, Niklas; Brouwers, Joachim; Miserez, Marc et al.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Cam, Henrik; Gillespie, Ulrika; Kälvemark Sporrong, Sofia; Nielsen, Elisabet I. et al.

Ingår i Research in Social and Administrative Pharmacy, s. 216-217, 2024

• DOI för Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam, Thua-Phong; Tran, Ngoc-Vi Nguyen; Pham, Long-Hung Dinh; Lai, Nghia Vo-Trong et al.

Ingår i NATURAL PRODUCTS AND BIOPROSPECTING, 2024

• DOI för Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies
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Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

Yee, Sook Wah; Ferrández-Peral, Luis; Alentorn-Moron, Pol; Fontsere, Claudia et al.

Ingår i Nature Communications, 2024

• DOI för Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates
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Impact of continuous-infusion meropenem degradation and infusion bag changes on bacterial killing of Pseudomonas aeruginosa based on model-informed translation

Minichmayr, Iris; Friberg, Lena

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för Impact of continuous-infusion meropenem degradation and infusion bag changes on bacterial killing of Pseudomonas aeruginosa based on model-informed translation
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Integration of individual preclinical and clinical anti-infective PKPD data to predict clinical study outcomes

Aranzana-Climent, Vincent; van Os, Wisse; Nutman, Amir; Lellouche, Jonathan et al.

Ingår i Clinical and Translational Science, 2024

• DOI för Integration of individual preclinical and clinical anti-infective PKPD data to predict clinical study outcomes
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Integration of the Butina algorithm and ensemble learning strategies for the advancement of a pharmacophore ligand-based model: an in silico investigation of apelin agonists

Tran, Xuan-Truc Dinh; Phan, Tieu-Long; To, Van-Thinh; Tran, Ngoc-Vi Nguyen et al.

Ingår i Frontiers in Chemistry, 2024

• DOI för Integration of the Butina algorithm and ensemble learning strategies for the advancement of a pharmacophore ligand-based model: an in silico investigation of apelin agonists
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Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model

Verrest, Luka; Monnerat, Severine; Musa, Ahmed M.; Mbui, Jane et al.

Ingår i PLoS Neglected Tropical Diseases, 2024

• DOI för Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model
• Ladda ner fulltext (pdf) av Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model

Linking Inner Context and Innovation Factors: Examining a pharmacy-based intervention through the eyes of pharmacy staff

Watterson, Taylor L.; Moon, Jukrin; Stone, Jamie A.; Gilson, Aaron M. et al.

Ingår i Exploratory Research in Clinical and Social Pharmacy, 2024

• DOI för Linking Inner Context and Innovation Factors: Examining a pharmacy-based intervention through the eyes of pharmacy staff
• Ladda ner fulltext (pdf) av Linking Inner Context and Innovation Factors: Examining a pharmacy-based intervention through the eyes of pharmacy staff

MALT1 inhibition suppresses antigen-specific T cell responses

Kerzeli, Iliana K.; Nasi, Aikaterini; Fletcher, Erika; Chourlia, Aikaterini et al.

Ingår i Cellular Immunology, 2024

• DOI för MALT1 inhibition suppresses antigen-specific T cell responses
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Model-Informed Precision Dosing to Reduce Vincristine-Induced Peripheral Neuropathy in Pediatric Patients: A Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis

Centanni, Maddalena; van de Velde, Mirjam E.; Uittenboogaard, Aniek; Kaspers, Gertjan J. L. et al.

Ingår i Clinical Pharmacokinetics, s. 197-209, 2024

• DOI för Model-Informed Precision Dosing to Reduce Vincristine-Induced Peripheral Neuropathy in Pediatric Patients: A Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis
• Ladda ner fulltext (pdf) av Model-Informed Precision Dosing to Reduce Vincristine-Induced Peripheral Neuropathy in Pediatric Patients: A Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis

Molecular dynamics study on micelle-small molecule interactions: developing a strategy for an extensive comparison

Kabedev, Aleksei; Bergström, Christel A. S.; Larsson, Per

Ingår i Journal of Computer-Aided Molecular Design, 2024

• DOI för Molecular dynamics study on micelle-small molecule interactions: developing a strategy for an extensive comparison
• Ladda ner fulltext (pdf) av Molecular dynamics study on micelle-small molecule interactions: developing a strategy for an extensive comparison

Multistate modeling for survival analysis in critically ill patients treated with meropenem

Peng, Yaru; Minichmayr, Iris; Liu, Han; Xie, Feifan et al.

Ingår i CPT, s. 222-233, 2024

• DOI för Multistate modeling for survival analysis in critically ill patients treated with meropenem
• Ladda ner fulltext (pdf) av Multistate modeling for survival analysis in critically ill patients treated with meropenem

N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands

Wannberg, Johan; Gising, Johan; Henriksson, Martin; Vo, Duc Duy et al.

Ingår i European Journal of Medicinal Chemistry, 2024

• DOI för N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Ingår i Scientific Reports, 2024

• DOI för OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
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Optimizing designs in clinical trials with an application in treatment of Epidermolysis bullosa simplex, a rare genetic skin disease

Nyberg, Joakim; Hooker, Andrew; Zimmermann, Georg; Verbeeck, Johan et al.

Ingår i Computational Statistics & Data Analysis, 2024

• DOI för Optimizing designs in clinical trials with an application in treatment of Epidermolysis bullosa simplex, a rare genetic skin disease
• Ladda ner fulltext (pdf) av Optimizing designs in clinical trials with an application in treatment of Epidermolysis bullosa simplex, a rare genetic skin disease

Optimizing the design of a pharmacokinetic trial to evaluate the dosing scheme of a novel tuberculosis drug in children living with or without HIV

Montepiedra, Grace; Svensson, Elin M.; Wong, Weng Kee; Hooker, Andrew C.

Ingår i CPT, s. 270-280, 2024

• DOI för Optimizing the design of a pharmacokinetic trial to evaluate the dosing scheme of a novel tuberculosis drug in children living with or without HIV

Potential for pharmacist prescribing in primary care: A Dutch citizen perspective

Kempen, Thomas G. H.; van Dijk, Liset; Floor-Schreudering, Annemieke; Kohli, Aradhana et al.

Ingår i Exploratory Research in Clinical and Social Pharmacy, 2024

• DOI för Potential for pharmacist prescribing in primary care: A Dutch citizen perspective
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Power to identify exposure-response relationships in phase IIa pulmonary tuberculosis trials with multi-dimensional bacterial load modeling

Koele, Simon E; Dorlo, Thomas P. C.; Upton, Caryn M; Aarnoutse, Rob E et al.

Ingår i CPT, s. 374-385, 2024

• DOI för Power to identify exposure-response relationships in phase IIa pulmonary tuberculosis trials with multi-dimensional bacterial load modeling
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Predictability of human exposure by human-CYP3A4-transgenic mouse models: A meta-analysis

Damoiseaux, David; Schinkel, Alfred H.; Beijnen, Jos H.; Huitema, Alwin D. R. et al.

Ingår i Clinical and Translational Science, 2024

• DOI för Predictability of human exposure by human-CYP3A4-transgenic mouse models: A meta-analysis

Predicting the Long-Term Effects of Therapeutic Neutralization of Oncostatin M on Human Hematopoiesis

Thorsted, Anders; Zecchin, Chiara; Berges, Alienor; Karlsson, Mats O. et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 703-715, 2024

• DOI för Predicting the Long-Term Effects of Therapeutic Neutralization of Oncostatin M on Human Hematopoiesis
• Ladda ner fulltext (pdf) av Predicting the Long-Term Effects of Therapeutic Neutralization of Oncostatin M on Human Hematopoiesis

Properties of the full random-effect modeling approach with missing covariate data

Nyberg, Joakim; Jonsson, E. Niclas; Karlsson, Mats O.; Häggström, Jonas

Ingår i Statistics in Medicine, s. 935-952, 2024

• DOI för Properties of the full random-effect modeling approach with missing covariate data
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Proteomic workflows for deep phenotypic profiling of 3D organotypic liver models

Koutsilieri, Stefania; Mickols, Evgeniya; Vegvari, Akos; Lauschke, Volker M.

Ingår i Biotechnology Journal, 2024

• DOI för Proteomic workflows for deep phenotypic profiling of 3D organotypic liver models
• Ladda ner fulltext (pdf) av Proteomic workflows for deep phenotypic profiling of 3D organotypic liver models