Institutionen för farmaci

A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice

Mebrahtu, Aman; Laurén, Ida; Veerman, Rosanne; Güclüler Akpinar, Gözde et al.

Ingår i Nature Communications, 2024

• DOI för A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice
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A charged tail on anti-α-Synuclein antibodies does not enhance their affinity to α-Synuclein fibrils

Petersen, Inga; Godec, Ana; Ranjbarian, Farahnaz; Hofer, Anders et al.

Ingår i PLOS ONE, 2024

• DOI för A charged tail on anti-α-Synuclein antibodies does not enhance their affinity to α-Synuclein fibrils
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Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Bällgren, Frida; Bergfast, Tilda; Ginosyan, Aghavni; Mahajan, Jessica et al.

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Active CNS delivery of oxycodone in healthy and endotoxemic pigs
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Advancing opioid stewardship in low-middle-income countries: challenges and opportunities

Jadhari, Rojita; Pathak, Nabin; Shrestha, Rajeev; Shrestha, Sunil et al.

Ingår i JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE, 2024

• DOI för Advancing opioid stewardship in low-middle-income countries: challenges and opportunities
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AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1

Díaz-Holguin, Alejandro; Saarinen, Marcus; Vo, Duc Duy; Sturchio, Andrea et al.

Ingår i Science Advances, 2024

• DOI för AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
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Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches

Zhuo, Xuezhi; Foderà, Vito; Larsson, Per; Schaal, Zarah et al.

Ingår i European Journal of Pharmaceutical Sciences, 2024

• DOI för Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches
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Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Hu, Yang; Girdenyte, Milda; Roest, Lieke; Liukkonen, Iida et al.

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy
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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI för Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
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Assessment of enhancing curcumin's solubility versus uptake on its anti-cancer efficacy

Rawas-Qalaji, Mutasem; Jagal, Jayalakshmi; Sadik, Sefeera; Said, Zafar et al.

Ingår i Colloids and Surfaces B, 2024

• DOI för Assessment of enhancing curcumin's solubility versus uptake on its anti-cancer efficacy

Benefits of combining supersaturating and solubilizing formulations - Is two better than one?

Alvebratt, Caroline; Karlén, Filip; Åhlén, Michelle; Edueng, Khadijah et al.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Benefits of combining supersaturating and solubilizing formulations - Is two better than one?

Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model

Ibrahim, Eman I. K.; Ellingsen, Espen B.; Mangsbo, Sara M.; Friberg, Lena

Ingår i International Immunopharmacology, 2024

• DOI för Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model
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Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach

Brekkan, Ari; Lledo-Garcia, Rocio; Lacroix, Brigitte; Jonsson, Siv et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 65-75, 2024

• DOI för Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach
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Clofazimine as a substitute for rifampicin improves efficacy of Mycobacterium avium pulmonary disease treatment in the hollow-fiber model

Salillas, Sandra; Raaijmakers, Jelmer; Aarnoutse, Rob E.; Svensson, Elin et al.

Ingår i Antimicrobial Agents and Chemotherapy, 2024

• DOI för Clofazimine as a substitute for rifampicin improves efficacy of Mycobacterium avium pulmonary disease treatment in the hollow-fiber model
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Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

Sanchez, Javier; Claus, Christina; McIntyre, Christine; Tanos, Tamara et al.

Ingår i Frontiers in Pharmacology, 2024

• DOI för Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL
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Comparison of Two Methods for Determining Item Characteristic Functions and Latent Variable Time-Course for Pharmacometric Item Response Models

Arrington, Leticia; Karlsson, Mats

Ingår i AAPS Journal, 2024

• DOI för Comparison of Two Methods for Determining Item Characteristic Functions and Latent Variable Time-Course for Pharmacometric Item Response Models
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Conjugated hyperbilirubinemia associated with accidental rifapentine overdose

Yohane, M.; Naufal, F.; Endoza-Ticona, A. M.; Svensson, Elin M. et al.

Ingår i The International Journal of Tuberculosis and Lung Disease, s. 354-356, 2024

• DOI för Conjugated hyperbilirubinemia associated with accidental rifapentine overdose

Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Soukarieh, Fadi; Mashabi, Alaa; Richardson, William; Oton, Eduard Vico et al.

Ingår i Journal of Medicinal Chemistry, s. 1008-1023, 2024

• DOI för Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections
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Determining tissue distribution of the oral antileishmanial agent miltefosine: a physiologically-based pharmacokinetic modeling approach

Ramisetty, Bhargavi Srija; Yang, Sihyung; Dorlo, Thomas P.C.; Wang, Michael Zhuo

Ingår i Antimicrobial Agents and Chemotherapy, 2024

• DOI för Determining tissue distribution of the oral antileishmanial agent miltefosine: a physiologically-based pharmacokinetic modeling approach

Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay

Schulzen, Arne; Andreadis, Ioannis I.; Bergström, Christel A. S.; Quodbach, Julian

Ingår i European Journal of Pharmaceutical Sciences, 2024

• DOI för Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay
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Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood

Schouten, Wietse M.; Roseboom, Ignace C.; Lucas, Luc; Tshiongo, Japhet Kabalu et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2024

• DOI för Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood
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Development of a canine artificial colonic mucus model for drug diffusion studies

Barmpatsalou, Vicky; Tjakra, Marco; Li, Lingxiao; Dubbelboer, Ilse R. et al.

Ingår i European Journal of Pharmaceutical Sciences, 2024

• DOI för Development of a canine artificial colonic mucus model for drug diffusion studies
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Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals

Kvitne, Kine Eide; Hovd, Markus; Johnson, Line Kristin; Wegler, Christine et al.

Ingår i Clinical Pharmacokinetics, s. 109-120, 2024

• DOI för Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals
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Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations

Parrow, Albin; Kabedev, Aleksei; Larsson, Per; Johansson, Pernilla et al.

Ingår i Journal of Controlled Release, 2024

• DOI för Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations
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Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App^NL-F Mouse Model of Alzheimer's Disease

Portal, Benjamin; Södergren, Moa; Parés i Borrell, Teo; Giraud, Romain et al.

Ingår i Journal of Alzheimer's Disease, s. 1017-1037, 2024

• DOI för Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App^NL-F Mouse Model of Alzheimer's Disease
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Early Prediction and Impact Assessment of CYP3A4-Related Drug-Drug Interactions for Small-Molecule Anticancer Drugs Using Human-CYP3A4-Transgenic Mouse Models

Damoiseaux, David; Beijnen, Jos H.; Huitema, Alwin D. R.; Dorlo, Thomas P. C.

Ingår i Drug Metabolism And Disposition, s. 1217-1223, 2024

• DOI för Early Prediction and Impact Assessment of CYP3A4-Related Drug-Drug Interactions for Small-Molecule Anticancer Drugs Using Human-CYP3A4-Transgenic Mouse Models
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Effect of Interindividual Variability in Metabolic Clearance and Relative Bioavailability on Rifampicin Exposure in Tuberculosis Patients with and without HIV Co-Infection: Does Formulation Quality Matter?

Nardotto, Glauco Henrique Balthazar; Svensson, Elin; Bollela, Valdes Roberto; Rocha, Adriana et al.

Ingår i Pharmaceutics, 2024

• DOI för Effect of Interindividual Variability in Metabolic Clearance and Relative Bioavailability on Rifampicin Exposure in Tuberculosis Patients with and without HIV Co-Infection: Does Formulation Quality Matter?
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Efficiency of multivariate tests in trials in progressive supranuclear palsy

Yousefi, Elham; Gewily, Mohamed; Koenig, Franz; Hoeglinger, Guenter et al.

Ingår i Scientific Reports, 2024

• DOI för Efficiency of multivariate tests in trials in progressive supranuclear palsy
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Engineering and characterization of a hydrogel mimicking subcutaneous interstitial space

Rodler, Agnes; Samanta, Ayan; Goh, Wen-Jun; Hilborn, Jöns et al.

Ingår i European Polymer Journal, 2024

• DOI för Engineering and characterization of a hydrogel mimicking subcutaneous interstitial space
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Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units

Damgaard, Tobias; Woksepp, Hanna; Brudin, Lars; Bonnedahl, Jonas et al.

Ingår i Infectious Diseases, s. 451-459, 2024

• DOI för Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units
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Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics

Sinko, Patrick D.; Parker, Louis; Prahl Wittberg, Lisa; Bergström, Christel A. S.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics
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Evaluation of covariate effects in item response theory models

Wellhagen, Gustaf; Yassen, Ashraf; Garmann, Dirk; Broeker, Astrid et al.

Ingår i CPT, s. 812-822, 2024

• DOI för Evaluation of covariate effects in item response theory models
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Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL-6 levels following administration of the T-cell bispecific engager glofitamab

Djebli, Nassim; Parrott, Neil; Jaminion, Felix; O'Jeanson, Amaury et al.

Ingår i CPT, s. 396-409, 2024

• DOI för Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL-6 levels following administration of the T-cell bispecific engager glofitamab
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Experiences and Translatability of In Vitro and In Vivo Models to Evaluate Caprate as a Permeation Enhancer

Emeh, Prosper; Breitholtz, Katarina; Berg, Staffan; Vedin, Charlotta et al.

Ingår i Molecular Pharmaceutics, s. 313-324, 2024

• DOI för Experiences and Translatability of In Vitro and In Vivo Models to Evaluate Caprate as a Permeation Enhancer

Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

de Waal, Tom; Handin, Niklas; Brouwers, Joachim; Miserez, Marc et al.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Cam, Henrik; Gillespie, Ulrika; Kälvemark Sporrong, Sofia; Nielsen, Elisabet I. et al.

Ingår i Research in Social and Administrative Pharmacy, s. 216-217, 2024

• DOI för Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam, Thua-Phong; Tran, Ngoc-Vi Nguyen; Pham, Long-Hung Dinh; Lai, Nghia Vo-Trong et al.

Ingår i NATURAL PRODUCTS AND BIOPROSPECTING, 2024

• DOI för Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies
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Forced randomization: the what, why, and how

Carter, Kerstine; Kuznetsova, Olga; Anisimov, Volodymyr; Krisam, Johannes et al.

Ingår i BMC Medical Research Methodology, 2024

• DOI för Forced randomization: the what, why, and how
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Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

Girdenytė, Milda; Hu, Yang; Ginosyan, Aghavni; Hammarlund-Udenaes, Margareta et al.

Ingår i Frontiers in Pharmacology, 2024

• DOI för Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy
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Identifying and presenting key country-specific indicators related to medication adherence: a comprehensive study across European countries

Agh, Tamas; Garuoliene, Kristina; Granas, Anne Gerd; Gregorio, Joao et al.

Ingår i Frontiers in Pharmacology, 2024

• DOI för Identifying and presenting key country-specific indicators related to medication adherence: a comprehensive study across European countries
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Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

Yee, Sook Wah; Ferrández-Peral, Luis; Alentorn-Moron, Pol; Fontsere, Claudia et al.

Ingår i Nature Communications, 2024

• DOI för Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates
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Impact of continuous-infusion meropenem degradation and infusion bag changes on bacterial killing of Pseudomonas aeruginosa based on model-informed translation

Minichmayr, Iris; Friberg, Lena

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för Impact of continuous-infusion meropenem degradation and infusion bag changes on bacterial killing of Pseudomonas aeruginosa based on model-informed translation
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Impact of the COVID-19 pandemic on initiation of antihypertensive drugs in Sweden: an interrupted time series study

Tomas, Ana; Wettermark, Björn; Nyberg, Fredrik; Hajiebrahimi, Mohammadhossein

Ingår i BMJ Open, 2024

• DOI för Impact of the COVID-19 pandemic on initiation of antihypertensive drugs in Sweden: an interrupted time series study
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Impact of the early COVID-19 pandemic on adult mental health-related dispensed medications, hospitalizations and specialist outpatient visits in Norway and Sweden: Interrupted time series analysis

Moreno-Martos, David; Zhao, Jing; Li, Huiqi; Nyberg, Fredrik et al.

Ingår i British Journal of Clinical Pharmacology, s. 1627-1636, 2024

• DOI för Impact of the early COVID-19 pandemic on adult mental health-related dispensed medications, hospitalizations and specialist outpatient visits in Norway and Sweden: Interrupted time series analysis
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Integration of individual preclinical and clinical anti-infective PKPD data to predict clinical study outcomes

Aranzana-Climent, Vincent; van Os, Wisse; Nutman, Amir; Lellouche, Jonathan et al.

Ingår i Clinical and Translational Science, 2024

• DOI för Integration of individual preclinical and clinical anti-infective PKPD data to predict clinical study outcomes
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Integration of the Butina algorithm and ensemble learning strategies for the advancement of a pharmacophore ligand-based model: an in silico investigation of apelin agonists

Tran, Xuan-Truc Dinh; Phan, Tieu-Long; To, Van-Thinh; Tran, Ngoc-Vi Nguyen et al.

Ingår i Frontiers in Chemistry, 2024

• DOI för Integration of the Butina algorithm and ensemble learning strategies for the advancement of a pharmacophore ligand-based model: an in silico investigation of apelin agonists
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Investigating the treatment shortening potential of a combination of bedaquiline, delamanid and moxifloxacin with and without sutezolid, in a murine tuberculosis model with confirmed drug exposures

Walter, Kerstin; te Brake, Lindsey H. M.; Lemm, Ann-Kathrin; Hoelscher, Michael et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 2607-2610, 2024

• DOI för Investigating the treatment shortening potential of a combination of bedaquiline, delamanid and moxifloxacin with and without sutezolid, in a murine tuberculosis model with confirmed drug exposures
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Item performance of the scale for the assessment and rating of ataxia in rare and ultra-rare genetic ataxias

Hamdan, Alzahra; Hooker, Andrew C.; Chen, Xiaomei; Traschütz, Andreas et al.

Ingår i CPT, s. 1327-1340, 2024

• DOI för Item performance of the scale for the assessment and rating of ataxia in rare and ultra-rare genetic ataxias
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Item response theory analysis of daytime sleepiness as a symptom of obstructive sleep apnea

Wellhagen, Gustaf; Karlsson, Mats O.; Kjellsson, Maria C.; Garmann, Dirk et al.

Ingår i CPT, s. 880-890, 2024

• DOI för Item response theory analysis of daytime sleepiness as a symptom of obstructive sleep apnea
• Ladda ner fulltext (pdf) av Item response theory analysis of daytime sleepiness as a symptom of obstructive sleep apnea

Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model

Verrest, Luka; Monnerat, Severine; Musa, Ahmed M.; Mbui, Jane et al.

Ingår i PLoS Neglected Tropical Diseases, 2024

• DOI för Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model
• Ladda ner fulltext (pdf) av Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model