Rudbeckseminarium - Ning Xu Landén

Dr. Ning Xu Landén is a Senior Lecturer in the Dermatology and Venereology Division at Karolinska Institutet. Since 2014, she has led a dynamic research group (www.xulandenlab.com) that bridges molecular biology and clinical medicine to advance understanding of human skin wound healing and to develop innovative therapies for chronic ulcers and tissue repair. She has received numerous competitive grants and honors, including the Ragnar Söderberg Fellowship in Medicine (2015) and the global LEO Foundation Award (2020) for her seminal contributions to wound biology. She has led large-scale gene expression studies of human wounds, identified key molecular pathways, discovered novel regulatory RNAs essential for tissue repair, and established proof-of-concept for miRNA-based wound therapies. More recently, her research has expanded to investigate the molecular and cellular mechanisms driving long-term radiotherapy-induced toxicity in cancer survivors. Her team’s latest work revealed that dermal fibroblasts in irradiated skin retain an epigenetic “memory” of radiation, which compromises healing capacity. Her long-term goal is to develop innovative therapies targeting radiation memory to prevent or reverse radiotherapy-related skin damage.

Selected publications from Xu Landén group:

Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors.

Bian X, Piipponen M, Liu Z, Luo L, Geara J, Chen Y, Sangsuwan T, Maselli M, Diaz C, Bain CA, Eenjes E., Genander M., Crichton M, Cash JL, Archambault L, Haghdoost S, Fradette J, Sommar P, Halle M, Xu Landén N. Nature Communications 2024 Oct 28;15(1):9286. PMID: 39468077

Spatiotemporal Single-Cell Roadmap of Human Skin Wound Healing.

Liu Z, Bian X, Luo L, Björklund AK, Li L, Zhang L, Chen Y, Guo L, Gao J, Cao C, Wang J, He W, Xiao Y, Zhu L, Annusver K, Gopee H, Bennett CL, Kasper M, Haniffa M, Sommar P, Li D, Xu Landén N. Cell Stem Cell 2024 Dec 18:S1934-5909(24)00412-0. PMID: 39729995

Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair.

1. Niu, M. A. Toma, J. Geara, X. Bian, Y. Chen, L. Luo, Q. Wang, Y. Xiao, M. Vij, M. Piipponen, Z. Liu, S. Oasa, L. Zhang, D. Schlesinger, Á. Végvári, D. Li, A. Wang, V. Vukojević, S. J. Elsässer, P. Sommar, N. Xu Landén, Advanced Science 2025, 25:e2416784. PMID: 40279507

The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing.

Li D, Liu Z, Zhang L, Bian X, Wu J, Li L, Chen Y, Luo L, Pan L, Kong L, Xiao Y, Wang J, Zhang X, Wang W, Toma M, Piipponen M, Sommar P, Xu Landén N. Nature Communications 2024 Oct 5;15(1):8637. PMID: 39366968

Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport.

Zhang L, Piipponen M, Liu Z, Li D, Bian X, Toma M, Sommar P, Xu Landén N. Cell Death and Differentiation 2023 May;30(5):1334-1348. PMID: 36869179.