Lanekoffs grupp

Innovativa analytiska verktyg för att fastställa kemin bakom biologiska processer med masspektrometri
Funktionen av biologiska system beror på invecklade kemiska interaktioner där av molekylstrukturen är avgörande. I vår grupp utvecklar vi innovativa masspektrometriska verktyg som möjliggör karakterisering av små molekyler med isomerisk precision - från biologiska vävnader ner till enskilda celler. Våra verktyg inkluderar pneumatiskt assisterad nanospray desorption elektrospray jonisering (PA nano-DESI) för avbildning av tunna vävnadssnitt, en direktinfusion-probe (DIP) för molekylär profilering av små (µL) provvolymer, en miniprobe för PA nano-DESI för global kemisk analys av enskilda celler och kapillärelektrofores för spatial metabolomik med isomerisk upplösning. Dessutom utvecklar vi datahanteringsverktyg för att visualisera och utvärdera våra unika dataformat. Vi använder också kreativa och strategiska tillvägagångssätt för att kvantifiera detekterade analyter, optimera lösningsmedel och att driva masspektrometerns prestanda bortom den senaste tekniken.
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Gruppmedlemmar
Publikationer
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Ingår i Talanta, 2026
- DOI för Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
- Ladda ner fulltext (pdf) av Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
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Ingår i Angewandte Chemie International Edition, 2026
- DOI för Multiplexed tandem mass spectrometry imaging enables large-scale isomer mapping and annotation in tissues
- Ladda ner fulltext (pdf) av Multiplexed tandem mass spectrometry imaging enables large-scale isomer mapping and annotation in tissues
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Ingår i eBioMedicine, 2026
- DOI för Metabolomic signatures of SSRI exposure during neural differentiation and correlation of lysophosphatidylcholines with early symptoms of neurodevelopmental disorders
- Ladda ner fulltext (pdf) av Metabolomic signatures of SSRI exposure during neural differentiation and correlation of lysophosphatidylcholines with early symptoms of neurodevelopmental disorders
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Ingår i Talanta, 2025
- DOI för Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
- Ladda ner fulltext (pdf) av Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
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Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
Ingår i Acta Neuropathologica, 2025
- DOI för Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
- Ladda ner fulltext (pdf) av Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
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Ingår i Analytica Chimica Acta, 2025
- DOI för Multimodal mass spectrometry - Raman imaging reveals solvent dependent structural and chemical tissue alterations
- Ladda ner fulltext (pdf) av Multimodal mass spectrometry - Raman imaging reveals solvent dependent structural and chemical tissue alterations
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Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
Ingår i Analytical Chemistry, s. 11572-11580, 2025
- DOI för Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
- Ladda ner fulltext (pdf) av Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
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Ingår i Metabolites, 2024
- DOI för Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
- Ladda ner fulltext (pdf) av Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
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Ingår i International Journal of Molecular Sciences, 2024
- DOI för Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
- Ladda ner fulltext (pdf) av Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
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Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
Ingår i Talanta Open, 2024
- DOI för Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
- Ladda ner fulltext (pdf) av Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
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Ingår i Analytical Chemistry, s. 11589-11595, 2023
- DOI för Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
- Ladda ner fulltext (pdf) av Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
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Ingår i Journal of the American Society for Mass Spectrometry, s. 2341-2349, 2023
- DOI för Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization
- Ladda ner fulltext (pdf) av Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization
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Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
Ingår i Metabolites, 2023
- DOI för Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
- Ladda ner fulltext (pdf) av Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
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Ingår i Scientific Reports, 2023
- DOI för Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
- Ladda ner fulltext (pdf) av Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
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Ingår i Journal of the American Society for Mass Spectrometry, s. 2518-2524, 2023
- DOI för Global and Spatial Metabolomics of Individual Cells Using a Tapered Pneumatically Assisted nano-DESI Probe
- Ladda ner fulltext (pdf) av Global and Spatial Metabolomics of Individual Cells Using a Tapered Pneumatically Assisted nano-DESI Probe
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Ingår i Analytical Chemistry, s. 17843-17850, 2023
- DOI för Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging
- Ladda ner fulltext (pdf) av Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging
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Matrix Effects Free Imaging of Thin Tissue Sections Using Pneumatically Assisted Nano-DESI MSI
Ingår i Imaging Mass Spectrometry, s. 107-121, Humana Press, 2023
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Ingår i Electrophoresis, s. 387-394, 2023
- DOI för Surface sampling capillary electrophoresis–mass spectrometry for a direct chemical characterization of tissue and blood samples
- Ladda ner fulltext (pdf) av Surface sampling capillary electrophoresis–mass spectrometry for a direct chemical characterization of tissue and blood samples
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Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
Ingår i Analytical and Bioanalytical Chemistry, s. 7473-7482, 2022
- DOI för Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
- Ladda ner fulltext (pdf) av Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
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Ingår i Vietnam Journal of Food Control, s. 89-103, 2022
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Ingår i Analytical Chemistry, s. 2391-2398, 2022
- DOI för Host-Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
- Ladda ner fulltext (pdf) av Host-Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
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Ingår i Environmental Science and Technology, s. 3096-3105, 2022
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A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
Ingår i Analytical Chemistry, s. 12875-12883, 2022
- DOI för A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
- Ladda ner fulltext (pdf) av A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
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Single-cell metabolomics: where are we and where are we going?
Ingår i Current Opinion in Biotechnology, 2022
- DOI för Single-cell metabolomics: where are we and where are we going?
- Ladda ner fulltext (pdf) av Single-cell metabolomics: where are we and where are we going?
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Single cell metabolism: current and future trends
Ingår i Metabolomics, 2022
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Ingår i Analytical and Bioanalytical Chemistry, s. 2735-2745, 2021
- DOI för CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
- Ladda ner fulltext (pdf) av CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
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Ingår i Communications Biology, 2021
- DOI för In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
- Ladda ner fulltext (pdf) av In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
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Ingår i Advanced Mass Spectrometry-Based Analytical Separation Techniques for Probing the Polar Metabolome, s. 125-164, Royal Society of Chemistry, 2021
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PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Ingår i Organs-on-a-Chip, 2020
- DOI för PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
- Ladda ner fulltext (pdf) av PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
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Ingår i Journal of the American Society for Mass Spectrometry, s. 2479-2487, 2020
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Advances in mass spectrometry based single-cell metabolomics
Ingår i The Analyst, s. 782-793, 2019
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Ingår i International Journal of Mass Spectrometry, s. 49-57, 2019
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Spatially Defined Surface Sampling Capillary Electrophoresis Mass Spectrometry
Ingår i Analytical Chemistry, s. 7819-7827, 2019
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Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
Ingår i Analytical and Bioanalytical Chemistry, s. 2809-2816, 2019
- DOI för Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
- Ladda ner fulltext (pdf) av Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
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Ingår i Encyclopedia of Analytical Chemistry, Wiley-VCH Verlagsgesellschaft, 2018
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Improving the biocompatibility of PDMS by improving its curing time and temperature
2018
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Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
Ingår i Advances In Chromatography, Vol 54, s. 43-72, CRC Press, 2018
- DOI för Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
- Ladda ner fulltext (pdf) av Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
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Oversampling To Improve Spatial Resolution for Liquid Extraction Mass Spectrometry Imaging
Ingår i Analytical Chemistry, s. 2451-2455, 2018
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Tailoring the biocompatibility of the elastomer PDMS for on-chip applications
2018
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Ingår i Analytical Chemistry, s. 7246-7252, 2018
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Profiling and quantifying endogenous molecules in single cells using nano-DESI MS
Ingår i The Analyst, s. 3639-3647, 2017
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Ingår i The Analyst, s. 3424-3431, 2017
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Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS
Ingår i Journal of Analytical Methods in Chemistry, 2016
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Ingår i The Analyst, s. 3686-3695, 2016
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Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques
Ingår i Analytical Chemistry, s. 52-73, 2016
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Ingår i Scientific Reports, 2016
- DOI för Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
- Ladda ner fulltext (pdf) av Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
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PACAP suppresses dry eye signs by stimulating tear secretion
Ingår i Nature Communications, 2016
- DOI för PACAP suppresses dry eye signs by stimulating tear secretion
- Ladda ner fulltext (pdf) av PACAP suppresses dry eye signs by stimulating tear secretion
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Ingår i Analytical and Bioanalytical Chemistry, s. 2063-2071, 2015
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Towards Adaptive, Streaming Analysis of X-ray Tomography Data
Ingår i Synchrotron Radiation News, s. 10-14, 2015
- DOI för Towards Adaptive, Streaming Analysis of X-ray Tomography Data
- Ladda ner fulltext (pdf) av Towards Adaptive, Streaming Analysis of X-ray Tomography Data
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Ingår i Methods in molecular biology, s. 99-106, Springer, 2015