Lanekoffs grupp

Innovativa analytiska verktyg för att fastställa kemin bakom biologiska processer med masspektrometri
Funktionen av biologiska system beror på invecklade kemiska interaktioner där av molekylstrukturen är avgörande. I vår grupp utvecklar vi innovativa masspektrometriska verktyg som möjliggör karakterisering av små molekyler med isomerisk precision - från biologiska vävnader ner till enskilda celler. Våra verktyg inkluderar pneumatiskt assisterad nanospray desorption elektrospray jonisering (PA nano-DESI) för avbildning av tunna vävnadssnitt, en direkt infusion probe (DIP) för molekylär profilering av små (µL) provvolymer, en miniprobe för PA nano-DESI för global kemisk analys av enskilda celler och kapillärelektrofores för spatial metabolomik med isomerisk upplösning. Dessutom utvecklar vi datahanteringsverktyg för att visualisera och utvärdera våra unika dataformat. Vi använder också kreativa och strategiska tillvägagångssätt för att kvantifiera detekterade analyter, optimera lösningsmedel och att driva masspektrometerns prestanda bortom den senaste tekniken.
Gruppmedlemmar
Publikationer
Ingår i Talanta, 2026
- DOI för Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
- Ladda ner fulltext (pdf) av Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
Ingår i Talanta, 2025
- DOI för Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
- Ladda ner fulltext (pdf) av Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
Ingår i Acta Neuropathologica, 2025
- DOI för Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
- Ladda ner fulltext (pdf) av Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
Ingår i Analytica Chimica Acta, 2025
- DOI för Multimodal mass spectrometry - Raman imaging reveals solvent dependent structural and chemical tissue alterations
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Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
Ingår i Analytical Chemistry, s. 11572-11580, 2025
- DOI för Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
- Ladda ner fulltext (pdf) av Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
Ingår i Metabolites, 2024
- DOI för Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
- Ladda ner fulltext (pdf) av Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
Ingår i International Journal of Molecular Sciences, 2024
- DOI för Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
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Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
Ingår i Talanta Open, 2024
- DOI för Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
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Ingår i Electrophoresis, s. 387-394, 2023
- DOI för Surface sampling capillary electrophoresis–mass spectrometry for a direct chemical characterization of tissue and blood samples
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Ingår i Analytical Chemistry, s. 11589-11595, 2023
- DOI för Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
- Ladda ner fulltext (pdf) av Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
Ingår i Journal of the American Society for Mass Spectrometry, s. 2341-2349, 2023
- DOI för Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization
- Ladda ner fulltext (pdf) av Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization
Ingår i Analytical Chemistry, s. 17843-17850, 2023
- DOI för Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging
- Ladda ner fulltext (pdf) av Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging
Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
Ingår i Metabolites, 2023
- DOI för Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
- Ladda ner fulltext (pdf) av Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
Ingår i Scientific Reports, 2023
- DOI för Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
- Ladda ner fulltext (pdf) av Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
Ingår i Journal of the American Society for Mass Spectrometry, s. 2518-2524, 2023
- DOI för Global and Spatial Metabolomics of Individual Cells Using a Tapered Pneumatically Assisted nano-DESI Probe
- Ladda ner fulltext (pdf) av Global and Spatial Metabolomics of Individual Cells Using a Tapered Pneumatically Assisted nano-DESI Probe
Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
Ingår i Analytical and Bioanalytical Chemistry, s. 7473-7482, 2022
- DOI för Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
- Ladda ner fulltext (pdf) av Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
Ingår i Vietnam Journal of Food Control, s. 89-103, 2022
Ingår i Analytical Chemistry, s. 2391-2398, 2022
- DOI för Host-Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
- Ladda ner fulltext (pdf) av Host-Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
Ingår i Environmental Science and Technology, s. 3096-3105, 2022
A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
Ingår i Analytical Chemistry, s. 12875-12883, 2022
- DOI för A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
- Ladda ner fulltext (pdf) av A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
Single-cell metabolomics: where are we and where are we going?
Ingår i Current Opinion in Biotechnology, 2022
- DOI för Single-cell metabolomics: where are we and where are we going?
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Single cell metabolism: current and future trends
Ingår i Metabolomics, 2022
Ingår i Analytical and Bioanalytical Chemistry, s. 2735-2745, 2021
- DOI för CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
- Ladda ner fulltext (pdf) av CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
Ingår i Communications Biology, 2021
- DOI för In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
- Ladda ner fulltext (pdf) av In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
Ingår i Advanced Mass Spectrometry-Based Analytical Separation Techniques for Probing the Polar Metabolome, s. 125-164, Royal Society of Chemistry, 2021
PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Ingår i Organs-on-a-Chip, 2020
- DOI för PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
- Ladda ner fulltext (pdf) av PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Ingår i Journal of the American Society for Mass Spectrometry, s. 2479-2487, 2020
Advances in mass spectrometry based single-cell metabolomics
Ingår i The Analyst, s. 782-793, 2019
Ingår i International Journal of Mass Spectrometry, s. 49-57, 2019
Spatially Defined Surface Sampling Capillary Electrophoresis Mass Spectrometry
Ingår i Analytical Chemistry, s. 7819-7827, 2019
Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
Ingår i Analytical and Bioanalytical Chemistry, s. 2809-2816, 2019
- DOI för Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
- Ladda ner fulltext (pdf) av Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
Ingår i Encyclopedia of Analytical Chemistry, Wiley-VCH Verlagsgesellschaft, 2018
Improving the biocompatibility of PDMS by improving its curing time and temperature
2018
Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
Ingår i Advances In Chromatography, Vol 54, s. 43-72, CRC Press, 2018
- DOI för Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
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Oversampling To Improve Spatial Resolution for Liquid Extraction Mass Spectrometry Imaging
Ingår i Analytical Chemistry, s. 2451-2455, 2018
Tailoring the biocompatibility of the elastomer PDMS for on-chip applications
2018
Ingår i Analytical Chemistry, s. 7246-7252, 2018
Profiling and quantifying endogenous molecules in single cells using nano-DESI MS
Ingår i The Analyst, s. 3639-3647, 2017
Ingår i The Analyst, s. 3424-3431, 2017
Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS
Ingår i Journal of Analytical Methods in Chemistry, 2016
Ingår i The Analyst, s. 3686-3695, 2016
Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques
Ingår i Analytical Chemistry, s. 52-73, 2016
Ingår i Scientific Reports, 2016
- DOI för Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
- Ladda ner fulltext (pdf) av Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
PACAP suppresses dry eye signs by stimulating tear secretion
Ingår i Nature Communications, 2016
- DOI för PACAP suppresses dry eye signs by stimulating tear secretion
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Ingår i Analytical and Bioanalytical Chemistry, s. 2063-2071, 2015
Towards Adaptive, Streaming Analysis of X-ray Tomography Data
Ingår i Synchrotron Radiation News, s. 10-14, 2015
- DOI för Towards Adaptive, Streaming Analysis of X-ray Tomography Data
- Ladda ner fulltext (pdf) av Towards Adaptive, Streaming Analysis of X-ray Tomography Data
Ingår i Methods in molecular biology, s. 99-106, Springer, 2015
Ingår i Analytical Chemistry, s. 1872-80, 2014
Matrix effects in biological mass spectrometry imaging: identification and compensation
Ingår i The Analyst, s. 3528-3532, 2014
Ingår i Analytical Chemistry, s. 9596-9603, 2013