Molekyär avbildning och medicinsk fysik

Gruppens forskning täcker hela perspektivet från substansscreening, via radiokemi och preklinisk validering, till klinisk implementering.

Forskning inom nuklearmedicin och PET är främst inriktad på utveckling av nya PET-tracers och kliniska PET-metoder, för att möta kliniska krav och underlätta klinisk forskning, samt på diagnos och behandling av neuroendokrina tumörer.

Gruppens forskning täcker hela perspektivet från substansscreening, via radiokemi och preklinisk validering, till klinisk implementering ("bench to bedside"). Deras kliniska forskning fokuserar på användningen av PET för att skapa förutsättningar för individanpassad medicin, till exempel i samband med molekylär strålbehandling och andra kostsamma cancerterapier. Dessutom syftar deras forskning till att öka förståelsen för molekylära processer i samband med olika sjukdomar, t.ex. utvecklingen av multimodal avbildning med PET-MRI i samband med metaboliska sjukdomar och cancer. För att kunna erbjuda en komplett plattform för användning av PET och PET-MRI inom klinisk forskning och läkemedelsutveckling, har PET-gruppen vid Uppsala universitet och Akademiska sjukhuset en hög kompetens inom alla aspekter av PET-metodik: kemi, fysik, dataanalys, etc.

Samarbete

Forskningen inom gruppen för nuklearmedicin och PET vid institutionen för kirurgiska vetenskaper utförs i nära samarbete med PET-MRI-gruppen, den prekliniska PET-plattformen vid institutionen för läkemedelskemi, sektionen för biomedicinsk strålningsvetenskap vid institutionen för genetik och patologi, PET-centrum vid Akademiska sjukhuset i Uppsala samt ett antal kliniska forskargrupper vid Uppsala universitet och Akademiska sjukhuset i Uppsala.

Porträttfoto av Mark Lubberink

Mark Lubberink

Publikationer

Whole-body tumor segmentation from FDG-PET/CT: Leveraging a segmentation prior from tissue-wise projections.

Tarai, Sambit; Lundström, Elin; Ahmad, Nouman; Strand, Robin et al.

Ingår i Heliyon, 2025
- DOI för Whole-body tumor segmentation from FDG-PET/CT: Leveraging a segmentation prior from tissue-wise projections.
Non-invasive [¹⁵O]H₂O PET measurements of cerebral perfusion and cerebrovascular reactivity using an additional heart scan.

Bach, Mathias Jacobsen; Larsen, Mia E; Kellberg, Amanda O; Henriksen, Alexander C et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, 2025
- DOI för Non-invasive [¹⁵O]H₂O PET measurements of cerebral perfusion and cerebrovascular reactivity using an additional heart scan.
Efficacy and safety of the PHIL embolic agent in the treatment of intracranial dural arteriovenous fistulas: results of the PHIL-dAVF study.

Marnat, Gaultier; Barreau, Xavier; Januel, Anne-Christine; Spelle, Laurent et al.

Ingår i Journal of neurointerventional surgery, 2025
- DOI för Efficacy and safety of the PHIL embolic agent in the treatment of intracranial dural arteriovenous fistulas: results of the PHIL-dAVF study.
Jämförelse mellan T2 HASTE med deep learning och andningshållning versus respiratorisk triggning för pankreas MRT vid 3 Tesla

Lönnberg, Isak

2025
- Ladda ner fulltext (pdf) av Jämförelse mellan T2 HASTE med deep learning och andningshållning versus respiratorisk triggning för pankreas MRT vid 3 Tesla
Implementering av IRIS en diffusionsviktad MR-sekvens för tumördetektion vid rektal- och analcancer: Påverkan på röntgensjuksköterskors självständighet i arbetsflöde

Hassan Bagheri, Raheleh

2025
- Ladda ner fulltext (pdf) av Implementering av IRIS en diffusionsviktad MR-sekvens för tumördetektion vid rektal- och analcancer: Påverkan på röntgensjuksköterskors självständighet i arbetsflöde
Safety of CT-guided percutaneous cryoablation in patients treated for clinical T1 renal cell carcinoma with the need for pre-procedural ureteral stenting: an international cohort study

Junker, T.; Tivell, Ludvig; Rønnegaard, A. E.; Duus, L. A. et al.

Ingår i Clinical Radiology, 2025
- DOI för Safety of CT-guided percutaneous cryoablation in patients treated for clinical T1 renal cell carcinoma with the need for pre-procedural ureteral stenting: an international cohort study
- Ladda ner fulltext (pdf) av Safety of CT-guided percutaneous cryoablation in patients treated for clinical T1 renal cell carcinoma with the need for pre-procedural ureteral stenting: an international cohort study
Regional Metabolic Abnormalities in Autoimmune Encephalitis: A Meta-analysis of 498 Cases With Brain FDG PET.

Kosek, Sonja; Kilsved, Ellen; Danfors, Torsten; Cunningham, Janet L et al.

Ingår i Clinical Nuclear Medicine, s. 208-213, 2025
- DOI för Regional Metabolic Abnormalities in Autoimmune Encephalitis: A Meta-analysis of 498 Cases With Brain FDG PET.
Plasma expansion and renal perfusion in critical COVID-19 with AKI: a prospective case control study

Luther, Tomas; Eckerbom, Per; Cox, Eleanor; Lipcsey, Miklós et al.

Ingår i Acta Anaesthesiologica Scandinavica, 2025
- DOI för Plasma expansion and renal perfusion in critical COVID-19 with AKI: a prospective case control study
- Ladda ner fulltext (pdf) av Plasma expansion and renal perfusion in critical COVID-19 with AKI: a prospective case control study
Automated whole-body PET/CT lesion tracking for lesion-wise response evaluation in metastatic breast cancer

Jönsson, Hanna; Korenyushkin, Alexander; van Geel, Jasper J.L.; Eisses, Bertha et al.

Ingår i Proceedings of 2024 International Conference on Medical Imaging and Computer-Aided Diagnosis (MICAD 2024), 2025
- DOI för Automated whole-body PET/CT lesion tracking for lesion-wise response evaluation in metastatic breast cancer
Is ¹⁸F-fluoride PET/CT an Accurate Tool to Diagnose Loosening After Total Joint Arthroplasty?

Sköld, Caroline; Sörensen, Jens; Brüggemann, Anders; Hailer, Nils P.

Ingår i Clinical Orthopaedics and Related Research, s. 415-428, 2025
- DOI för Is ¹⁸F-fluoride PET/CT an Accurate Tool to Diagnose Loosening After Total Joint Arthroplasty?
- Ladda ner fulltext (pdf) av Is ¹⁸F-fluoride PET/CT an Accurate Tool to Diagnose Loosening After Total Joint Arthroplasty?
Behandling av tromboembolisk pumlonell hypertension

Andersen, Kasper; Larsson, Bertil; Björklund, Erik; Bergman, Eva-Mathilda et al.

Ingår i Läkartidningen, s. 148-151, 2025
The value of whole-body MRI instead of only brain MRI in addition to 18 F-FDG PET/CT in the staging of advanced non-small-cell lung cancer

Holmstrand, Hanna; Lindskog, Magnus; Sundin, Anders; Hansen, Tomas

Ingår i Cancer Imaging, 2025
- DOI för The value of whole-body MRI instead of only brain MRI in addition to 18 F-FDG PET/CT in the staging of advanced non-small-cell lung cancer
- Ladda ner fulltext (pdf) av The value of whole-body MRI instead of only brain MRI in addition to 18 F-FDG PET/CT in the staging of advanced non-small-cell lung cancer
Enhanced glomerular thrombosis in pronated animals with ARDS

Marchesi, Silvia; Lundström, Elin; Lindström, Elin; Ödmark, Jonas et al.

Ingår i Intensive Care Medicine Experimental, 2025
- DOI för Enhanced glomerular thrombosis in pronated animals with ARDS
- Ladda ner fulltext (pdf) av Enhanced glomerular thrombosis in pronated animals with ARDS
Whole-body PET/CT image registration and analysis in cancer

Jönsson, Hanna

2025
- Ladda ner fulltext (pdf) av Whole-body PET/CT image registration and analysis in cancer
Soft tissue tumor imaging in adults: whole-body staging in sarcoma, non-malignant entities requiring special algorithms, pitfalls and special imaging aspects. Guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR)

Noebauer-Huhmann, Iris-Melanie; Vanhoenacker, Filip M.; Vilanova, Joan C.; Tagliafico, Alberto S. et al.

Ingår i European Radiology, s. 351-359, 2025
- DOI för Soft tissue tumor imaging in adults: whole-body staging in sarcoma, non-malignant entities requiring special algorithms, pitfalls and special imaging aspects. Guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR)
- Ladda ner fulltext (pdf) av Soft tissue tumor imaging in adults: whole-body staging in sarcoma, non-malignant entities requiring special algorithms, pitfalls and special imaging aspects. Guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR)
Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system

Sousa, Joao M.; Appel, Lieuwe; Engstrom, Mathias; Nyholm, Dag et al.

Ingår i Physica medica (Testo stampato), 2024
- DOI för Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system
- Ladda ner fulltext (pdf) av Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system
Massive Chylous Ascites in a 9-Year-Old Girl with Malrotation-A Case Report

Winberg, Hans; Gerwins, Pär; Hagelsteen, Kristine

Ingår i EUROPEAN JOURNAL OF PEDIATRIC SURGERY REPORTS, 2024
- DOI för Massive Chylous Ascites in a 9-Year-Old Girl with Malrotation-A Case Report
- Ladda ner fulltext (pdf) av Massive Chylous Ascites in a 9-Year-Old Girl with Malrotation-A Case Report
Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Ingår i Molecular Metabolism, 2024
- DOI för Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
- Ladda ner fulltext (pdf) av Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
Dual-Layer computed tomography of the brain: May virtually monoenergetic images provide better diagnosis?

Ghalamkari, Odett

2024
Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls

Ivashchenko, Oleksandra V.; O'Doherty, Jim; Hardiansyah, Deni; Cremonesi, Marta et al.

Ingår i Physica medica (Testo stampato), 2024
- DOI för Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls
- Ladda ner fulltext (pdf) av Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls
Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor

Khalil, Amina; Hakhverdyan, Sona; Cheung, Pierre; Bossart, Martin et al.

Ingår i Nuclear Medicine and Biology, 2024
- DOI för Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor
- Ladda ner fulltext (pdf) av Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor
Gadoliniumretention, dess inverkan på människokroppen samt vilka förebyggande åtgärder röntgensjuksköterskan kan behöva implementera: En litteraturstudie

Ahlkvist, Malin; Lidell, Tilda

2024
- Ladda ner fulltext (pdf) av Gadoliniumretention, dess inverkan på människokroppen samt vilka förebyggande åtgärder röntgensjuksköterskan kan behöva implementera: En litteraturstudie
Deep learning segmentation of low-resolution images for prostate magnetic resonance-guided radiotherpy

Fransson, Samuel; Tilly, David; Strand, Robin

2024
Absolute and relative GFR and contrast medium dose/GFR ratio: cornerstones when predicting the risk of acute kidney injury.

Nyman, Ulf; Leander, Peter; Liss, Per; Sterner, Gunnar et al.

Ingår i European Radiology, s. 612-621, 2024
- DOI för Absolute and relative GFR and contrast medium dose/GFR ratio: cornerstones when predicting the risk of acute kidney injury.
Patienters upplevelse av information i samband med en ¹⁸F-FDG PET/DT-undersökning: En kvantitativ enkätstudie

Arcos Qvarnström, Ronja; Bonde Kalén, Matilda

2024
- Ladda ner fulltext (pdf) av Patienters upplevelse av information i samband med en ¹⁸F-FDG PET/DT-undersökning: En kvantitativ enkätstudie
Optimizing diagnostics and follow-up of patients with ureterolithiasis

Sahlén, Klara

2024
- Ladda ner fulltext (pdf) av Optimizing diagnostics and follow-up of patients with ureterolithiasis
Can AI Predict the Need for Surgery in Traumatic Brain Injury?

Haller, Sven

Ingår i Radiology: Artificial Intelligence, 2024
- DOI för Can AI Predict the Need for Surgery in Traumatic Brain Injury?
Machine Learning in Magnetic Resonance-Guided Adaptive Radiotherapy

Fransson, Samuel

2024
- Ladda ner fulltext (pdf) av Machine Learning in Magnetic Resonance-Guided Adaptive Radiotherapy
Patienters upplevelser kring information inför en ¹⁸F-FDG- PET/DT-undersökning: En enkätstudie

Carlsson, Elina; Chen Sagrén, Maja

2024
- Ladda ner fulltext (pdf) av Patienters upplevelser kring information inför en ¹⁸F-FDG- PET/DT-undersökning: En enkätstudie
A scoping review of person-centred care strategies used in diagnostic Nuclear Medicine

Champendal, M.; Grima, K. Borg; Costa, P.; Andersson, Camilla et al.

Ingår i Radiography, s. 448-456, 2024
- DOI för A scoping review of person-centred care strategies used in diagnostic Nuclear Medicine
Determining Hemodynamically Significant Coronary Artery Disease: Patient-Specific Cutoffs in Quantitative Myocardial Blood Flow Using [¹⁵O]H₂O PET Imaging

Hoek, Roel; van Diemen, Pepijn A.; Raijmakers, Pieter G.; Driessen, Roel S. et al.

Ingår i Journal of Nuclear Medicine, s. 1113-1121, 2024
- DOI för Determining Hemodynamically Significant Coronary Artery Disease: Patient-Specific Cutoffs in Quantitative Myocardial Blood Flow Using [¹⁵O]H₂O PET Imaging
Functional MRI Neurofeedback Outperforms Cognitive Behavioral Therapy for Reducing Tinnitus Distress: A Prospective Randomized Clinical Trial

Gninenko, Nicolas; Trznadel, Stéphanie; Daskalou, Dimitrios; Gramatica, Luca et al.

Ingår i Radiology, 2024
- DOI för Functional MRI Neurofeedback Outperforms Cognitive Behavioral Therapy for Reducing Tinnitus Distress: A Prospective Randomized Clinical Trial
Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial

Rosqvist, Fredrik; Cedernaes, Jonathan; Martínez Mora, Andrés; Fridén, Michael et al.

Ingår i American Journal of Clinical Nutrition, s. 121-128, 2024
- DOI för Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial
- Ladda ner fulltext (pdf) av Overfeeding polyunsaturated fat compared to saturated fat does not differentially influence lean tissue accumulation in overweight individuals: a randomized controlled trial
Body mass index is associated with pulmonary gas and blood distribution mismatch in COVID-19 acute respiratory failure: A physiological study

Bjarnadóttir, Kristín J.; Perchiazzi, Gaetano; Sidenbladh, Caroline Lördal; Larina, Aleksandra et al.

Ingår i Frontiers in Physiology, 2024
- DOI för Body mass index is associated with pulmonary gas and blood distribution mismatch in COVID-19 acute respiratory failure: A physiological study
- Ladda ner fulltext (pdf) av Body mass index is associated with pulmonary gas and blood distribution mismatch in COVID-19 acute respiratory failure: A physiological study
Consensus Guidelines of Irreversible Electroporation for Pancreatic Tumors: Protocol Standardization Using the Modified Delphi Technique

Vos, Danielle J. W.; Ruarus, Alette H.; Timmer, Florentine E. F.; Geboers, Bart et al.

Ingår i Seminars in interventional radiology, s. 176-219, 2024
- DOI för Consensus Guidelines of Irreversible Electroporation for Pancreatic Tumors: Protocol Standardization Using the Modified Delphi Technique
Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications

Engström, G.; Lampa, Erik; Dekkers, Koen; Lin, Yi-Ting et al.

Ingår i European Journal of Epidemiology, s. 35-49, 2024
- DOI för Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
- Ladda ner fulltext (pdf) av Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
Evaluation of Diffusion Tensor Imaging Analysis Along the Perivascular Space as a Marker of the Glymphatic System

Haller, Sven; Moy, Linda; Anzai, Yoshimi

Ingår i Radiology, 2024
- DOI för Evaluation of Diffusion Tensor Imaging Analysis Along the Perivascular Space as a Marker of the Glymphatic System
Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia

Lorenzini, Luigi; Maranzano, Alessio; Ingala, Silvia; Collij, Lyduine E. et al.

Ingår i Neurology, 2024
- DOI för Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia
- Ladda ner fulltext (pdf) av Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia
Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer

Hammarström, Klara; Nunes, Luís; Mathot, Lucy; Mezheyeuski, Artur et al.

Ingår i International Journal of Cancer, s. 40-53, 2024
- DOI för Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer
- Ladda ner fulltext (pdf) av Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer
Anatomical and subcortical invasiveness in diffuse low-grade astrocytomas differ between IDH status and provide prognostic information

Zetterling, Maria; Fahlström, Markus; Latini, Francesco

Ingår i Upsala Journal of Medical Sciences, 2024
- DOI för Anatomical and subcortical invasiveness in diffuse low-grade astrocytomas differ between IDH status and provide prognostic information
- Ladda ner fulltext (pdf) av Anatomical and subcortical invasiveness in diffuse low-grade astrocytomas differ between IDH status and provide prognostic information
Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure

Tranfa, Mario; Lorenzini, Luigi; Collij, Lyduine E.; Vallez Garcia, David et al.

Ingår i Annals of Clinical and Translational Neurology, s. 1541-1556, 2024
- DOI för Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure
- Ladda ner fulltext (pdf) av Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure
Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study

Fryk, Emanuel; Silva, Vagner Ramon Rodrigues; Strindberg, Lena; Strand, Robin et al.

Ingår i International Journal of Obesity, s. 1180-1189, 2024
- DOI för Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
- Ladda ner fulltext (pdf) av Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
Prediction of Total Metabolic Tumor Volume from Tissue-Wise FDG-PET/CT Projections, Interpreted Using Cohort Saliency Analysis

Tarai, Sambit; Lundström, Elin; Öfverstedt, Johan; Jönsson, Hanna et al.

Ingår i Medical Image Understanding and Analysis, s. 242-255, 2024
- DOI för Prediction of Total Metabolic Tumor Volume from Tissue-Wise FDG-PET/CT Projections, Interpreted Using Cohort Saliency Analysis
Developing Communication Support Material for Sharing Information with Patients Undergoing an 18 F-FDG PET/CT Examination

Andersson, Camilla; Moller-Christensen, Berit

Ingår i Journal of Nuclear Medicine Technology, s. 234-238, 2024
- DOI för Developing Communication Support Material for Sharing Information with Patients Undergoing an 18 F-FDG PET/CT Examination
A detailed analysis of body composition in relation to cardiopulmonary exercise test indices.

Karlsson, Per; Strand, Robin; Kullberg, Joel; Michaëlsson, Karl et al.

Ingår i Scientific Reports, s. 21633, 2024
- DOI för A detailed analysis of body composition in relation to cardiopulmonary exercise test indices.
- Ladda ner fulltext (pdf) av A detailed analysis of body composition in relation to cardiopulmonary exercise test indices.
Wearing a KN95/FFP2 facemask has no measureable effect on functional activity in a challenging working memory n-back task

Montandon, Marie-Louise; Haller, Sven; Rodriguez, Cristelle; Herrmann, Francois R. et al.

Ingår i Frontiers in Human Neuroscience, 2024
- DOI för Wearing a KN95/FFP2 facemask has no measureable effect on functional activity in a challenging working memory n-back task
- Ladda ner fulltext (pdf) av Wearing a KN95/FFP2 facemask has no measureable effect on functional activity in a challenging working memory n-back task
Correction to: Absolute and relative GFR and contrast medium dose/GFR ratio

Nyman, Ulf; Leander, Peter; Liss, Per; Sterner, Gunnar et al.

Ingår i European Radiology, s. 3526, 2024
- DOI för Correction to: Absolute and relative GFR and contrast medium dose/GFR ratio
Correction: Absolute and relative GFR and contrast medium dose/GFR ratio

Nyman, Ulf; Leander, Peter; Liss, Per; Sterner, Gunnar et al.

Ingår i European Radiology, s. 2123-2124, 2024
- DOI för Correction: Absolute and relative GFR and contrast medium dose/GFR ratio
A Rare Case of Angiofibroma Presenting as an Endolymphatic Sac Tumor

Elfstrand, Erika; Löfvenberg, Christian; Lundman, Lars; Wikström, Johan

Ingår i The Laryngoscope, s. 1897-1900, 2024
- DOI för A Rare Case of Angiofibroma Presenting as an Endolymphatic Sac Tumor
Short-term effects of obesity surgery versus low-energy diet on body composition and tissue-specific glucose uptake: a randomised clinical study using whole-body integrated ¹⁸F-FDG-PET/MRI.

Eriksson, Jan W; Pereira, Maria J; Kagios, Christakis; Kvernby, Sofia et al.

Ingår i Diabetologia, s. 1399-1412, 2024
- DOI för Short-term effects of obesity surgery versus low-energy diet on body composition and tissue-specific glucose uptake: a randomised clinical study using whole-body integrated ¹⁸F-FDG-PET/MRI.