Daniel Globisch
Professor vid Institutionen för kemi - BMC; Analytisk kemi; Globisch grupp
- Telefon:
- 070-425 01 39, 018-471 36 30
- E-post:
- daniel.globisch@kemi.uu.se
- Besöksadress:
- Husargatan 3 (D5)
752 37 Uppsala - Postadress:
- Box 599
75124 Uppsala
- ORCID:
- 0000-0002-4526-5788
Kort presentation
Professor with focus on Biomarker Discovery using techniques at the interface of Chemistry and Biology including Chemical Biology, Organic Chemistry, mass spectrometry-based investigation of human samples, and metabolomics-methodologies. Former SciLifeLab Fellow.
- My research group: https://www.globischlab.org/
Nyckelord
- mass spectrometry
- biomarker discovery
- metabolomics
- bioorganic chemistry
- organic chemistry
- chemical biology
- gut microbiota
- microbiome
Biografi
- 11/23 – present Uppsala University, Sweden; Professor
- 12/20 – 10/23 Uppsala University, Sweden; Associate Professor (tenured)
- 04/17 – 12/20 Uppsala University, Sweden; Associate Professor
- 08/15 – 04/17 Uppsala University, Sweden; Assistant Professor
- 04/11 – 08/15 The Scripps Research Institute, La Jolla, USA; PostDoc with Professor Kim D. Janda, Ph.D.
- 03/07 – 03/11 Ludwig-Maximilians-University Munich, Germany; PhD student with Professor Dr. Thomas Carell
- 04/06 – 01/07 & 04/05 – 07/05 University of Southern Denmark
- 10/01 – 03/06 Technical University Kaiserslautern, Germany
Publikationer
Urval av publikationer
The protective role of commensal gut microbes and their metabolites against bacterial pathogens
Ingår i Gut microbes, 2024
- DOI för The protective role of commensal gut microbes and their metabolites against bacterial pathogens
- Ladda ner fulltext (pdf) av The protective role of commensal gut microbes and their metabolites against bacterial pathogens
Ingår i Angewandte Chemie International Edition, 2024
- DOI för Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
- Ladda ner fulltext (pdf) av Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
Ingår i Analytical Chemistry, s. 12565-12571, 2023
- DOI för Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
- Ladda ner fulltext (pdf) av Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
Ingår i Chemical Science, s. 5291-5301, 2023
- DOI för Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
- Ladda ner fulltext (pdf) av Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
Ingår i Food Chemistry, 2023
- DOI för Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
- Ladda ner fulltext (pdf) av Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
Ingår i Angewandte Chemie International Edition, s. 23232-23240, 2021
- DOI för Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
- Ladda ner fulltext (pdf) av Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
DNA surface exploration and operator bypassing during target search
Ingår i Nature, s. 858-+, 2020
- DOI för DNA surface exploration and operator bypassing during target search
- Ladda ner fulltext (pdf) av DNA surface exploration and operator bypassing during target search
Ingår i The Analyst, s. 3822-3831, 2020
- DOI för Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
- Ladda ner fulltext (pdf) av Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
Ingår i Chemical Communications, s. 9080-9083, 2019
- DOI för Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
- Ladda ner fulltext (pdf) av Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
Ingår i Chemical Science, s. 6233-6239, 2018
- DOI för New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
- Ladda ner fulltext (pdf) av New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
Ingår i Angewandte Chemie International Edition, s. 13805-13809, 2018
Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Ingår i ACS - Infectious Diseases, s. 1423-1431, 2018
- DOI för Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
- Ladda ner fulltext (pdf) av Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Senaste publikationer
NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
Ingår i Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025
- DOI för NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
- Ladda ner fulltext (pdf) av NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
Ingår i EBioMedicine, 2024
- DOI för Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
- Ladda ner fulltext (pdf) av Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
Ingår i European Journal of Pharmaceutical Sciences, 2024
- DOI för Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug
- Ladda ner fulltext (pdf) av Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug
The protective role of commensal gut microbes and their metabolites against bacterial pathogens
Ingår i Gut microbes, 2024
- DOI för The protective role of commensal gut microbes and their metabolites against bacterial pathogens
- Ladda ner fulltext (pdf) av The protective role of commensal gut microbes and their metabolites against bacterial pathogens
Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
Ingår i ACS Chemical Neuroscience, s. 1335-1341, 2024
- DOI för Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
- Ladda ner fulltext (pdf) av Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
Alla publikationer
Artiklar i tidskrift
NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
Ingår i Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025
- DOI för NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
- Ladda ner fulltext (pdf) av NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
Ingår i EBioMedicine, 2024
- DOI för Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
- Ladda ner fulltext (pdf) av Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
Ingår i European Journal of Pharmaceutical Sciences, 2024
- DOI för Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug
- Ladda ner fulltext (pdf) av Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug
The protective role of commensal gut microbes and their metabolites against bacterial pathogens
Ingår i Gut microbes, 2024
- DOI för The protective role of commensal gut microbes and their metabolites against bacterial pathogens
- Ladda ner fulltext (pdf) av The protective role of commensal gut microbes and their metabolites against bacterial pathogens
Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
Ingår i ACS Chemical Neuroscience, s. 1335-1341, 2024
- DOI för Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
- Ladda ner fulltext (pdf) av Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
Ingår i Angewandte Chemie International Edition, 2024
- DOI för Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
- Ladda ner fulltext (pdf) av Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
Ingår i Chemical Communications, s. 5843-5846, 2023
Ingår i Analytical Chemistry, s. 12565-12571, 2023
- DOI för Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
- Ladda ner fulltext (pdf) av Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
Ingår i Journal of Crohn's & Colitis, s. 418-432, 2023
- DOI för Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers
- Ladda ner fulltext (pdf) av Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers
Ingår i Chemical Science, s. 5291-5301, 2023
- DOI för Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
- Ladda ner fulltext (pdf) av Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
Ingår i Food Chemistry, 2023
- DOI för Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
- Ladda ner fulltext (pdf) av Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
Ingår i PLOS Genetics, 2023
- DOI för A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
- Ladda ner fulltext (pdf) av A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
Ingår i Biochemical Pharmacology, 2022
- DOI för Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
- Ladda ner fulltext (pdf) av Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle
Ingår i Metabolites, 2022
- DOI för Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle
- Ladda ner fulltext (pdf) av Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle
Ingår i Microbiology Spectrum, 2022
- DOI för Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors
- Ladda ner fulltext (pdf) av Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors
Ingår i RSC Advances, s. 34788-34794, 2021
- DOI för Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency
- Ladda ner fulltext (pdf) av Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency
Ingår i Journal of Pharmaceutical and Biomedical Analysis, 2021
- DOI för Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites
- Ladda ner fulltext (pdf) av Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites
Ingår i Journal of Experimental & Clinical Cancer Research, 2021
- DOI för Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
- Ladda ner fulltext (pdf) av Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
Ingår i Angewandte Chemie International Edition, s. 23232-23240, 2021
- DOI för Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
- Ladda ner fulltext (pdf) av Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 3324-3338, 2021
- DOI för Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
- Ladda ner fulltext (pdf) av Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
Ingår i RSC CHEMICAL BIOLOGY, s. 1479-1483, 2021
- DOI för Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines
- Ladda ner fulltext (pdf) av Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines
DNA surface exploration and operator bypassing during target search
Ingår i Nature, s. 858-+, 2020
- DOI för DNA surface exploration and operator bypassing during target search
- Ladda ner fulltext (pdf) av DNA surface exploration and operator bypassing during target search
Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples
Ingår i Metabolites, 2020
- DOI för Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples
- Ladda ner fulltext (pdf) av Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples
Ingår i The Analyst, s. 3822-3831, 2020
- DOI för Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
- Ladda ner fulltext (pdf) av Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World
Ingår i Chemistry - A European Journal, s. 14856-14860, 2020
- DOI för Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World
- Ladda ner fulltext (pdf) av Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World
Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
Ingår i Angewandte Chemie International Edition, s. 14342-14346, 2020
- DOI för Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
- Ladda ner fulltext (pdf) av Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
Ingår i Free Radical Biology & Medicine, s. 745-754, 2020
- DOI för Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host
- Ladda ner fulltext (pdf) av Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host
Ingår i Bioorganic & Medicinal Chemistry, s. 955-962, 2019
Ingår i Chemical Communications, s. 9080-9083, 2019
- DOI för Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
- Ladda ner fulltext (pdf) av Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
Ingår i ChemBioChem, s. 1678-1683, 2019
Ingår i Chemical Science, s. 6233-6239, 2018
- DOI för New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
- Ladda ner fulltext (pdf) av New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
Ingår i Angewandte Chemie International Edition, s. 13805-13809, 2018
Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Ingår i ACS - Infectious Diseases, s. 1423-1431, 2018
- DOI för Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
- Ladda ner fulltext (pdf) av Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Ingår i Organic and biomolecular chemistry, s. 698-702, 2018
Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)
Ingår i Bioorganic & Medicinal Chemistry Letters, s. 3436-3440, 2017