Mark Richards

KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation

Arce, Maximiliano; Erzar, Iza; Yang, Fan; Senthilkumar, Neeharika et al.

Ingår i Cell Reports, 2025

• DOI för KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation
• Ladda ner fulltext (pdf) av KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation

Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions

Pal, Sagnik; Su, Yangyang; Nwadozi, Emmanuel; Claesson-Welsh, Lena et al.

Ingår i Angiogenesis, 2025

• DOI för Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
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VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis

Sáinz-Jaspeado, Miguel; Ring, Sarah; Proulx, Steven T.; Richards, Mark et al.

Ingår i Life Science Alliance, 2024

• DOI för VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis
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Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src

Sjöberg, Elin; Melssen, Marit; Richards, Mark; Ding, Yindi et al.

Ingår i Journal of Clinical Investigation, 2023

• DOI för Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src
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Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis

Jin, Yi; Ding, Yindi; Richards, Mark; Kaakinen, Mika et al.

Ingår i Nature Cardiovascular Research, s. 1156-1173, 2022

• DOI för Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis
• Ladda ner fulltext (pdf) av Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis

KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation

Arce, Maximiliano; Erzar, Iza; Yang, Fan; Senthilkumar, Neeharika et al.

Ingår i Cell Reports, 2025

• DOI för KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation
• Ladda ner fulltext (pdf) av KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation

Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions

Pal, Sagnik; Su, Yangyang; Nwadozi, Emmanuel; Claesson-Welsh, Lena et al.

Ingår i Angiogenesis, 2025

• DOI för Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
• Ladda ner fulltext (pdf) av Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions

VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis

Sáinz-Jaspeado, Miguel; Ring, Sarah; Proulx, Steven T.; Richards, Mark et al.

Ingår i Life Science Alliance, 2024

• DOI för VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis
• Ladda ner fulltext (pdf) av VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis

Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src

Sjöberg, Elin; Melssen, Marit; Richards, Mark; Ding, Yindi et al.

Ingår i Journal of Clinical Investigation, 2023

• DOI för Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src
• Ladda ner fulltext (pdf) av Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src

Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis

Jin, Yi; Ding, Yindi; Richards, Mark; Kaakinen, Mika et al.

Ingår i Nature Cardiovascular Research, s. 1156-1173, 2022

• DOI för Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis
• Ladda ner fulltext (pdf) av Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis

Targeting VEGF-induced vascular permeability

Richards, Mark; Claesson-Welsh, Lena

Ingår i Nature Cardiovascular Research, s. 413-414, 2022

• DOI för Targeting VEGF-induced vascular permeability

Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner

Richards, Mark; Nwadozi, Emmanuel; Pal, Sagnik; Martinsson, Pernilla et al.

Ingår i eLIFE, 2022

• DOI för Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner
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Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin alpha 5

Richards, Mark; Pal, Sagnik; Sjöberg, Elin; Martinsson, Pernilla et al.

Ingår i Cell Reports, 2021

• DOI för Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin alpha 5

c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly

Schimmel, Lilian; Fukuhara, Daisuke; Richards, Mark; Jin, Yi et al.

Ingår i Development, 2020

• DOI för c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly
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House retinal cell behaviour in space and time using light sheet fluorescence microscopy

Prahst, Claudia; Ashrafzadeh, Parham; Mead, Thomas; Figueiredo, Ana et al.

Ingår i eLIFE, 2020

• DOI för House retinal cell behaviour in space and time using light sheet fluorescence microscopy
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Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events

Honkura, Naoki; Richards, Mark; Laviña, Bàrbara; Sainz-Jaspeado, Miguel et al.

Ingår i Nature Communications, 2018

• DOI för Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events
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Endothelial-specific phosphatase VEPTP negatively regulates VEGF receptor-2 activity

Pal, Sagnik; Oliveira, Filipa; Su, Yangyang; Olsen, Signe et al.