Canan Yilmaz UGUR
Forskare vid Institutionen för farmaci; Translationell PKPD
- E-post:
- canan.yilmaz@farmaci.uu.se
- Besöksadress:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postadress:
- Box 580
751 23 UPPSALA
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Kort presentation
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Currently, working on different ongoing projects with national and International (IM2PACT) teams. The common focus of the projects is transportation of the large molecules through the blood-brain barrier under the pathological conditions to cure the related neurodegenerative diseases and potential treatment options/ways with biological or small molecule drugs.
Also, defining new transporters on BBB is another aim to increase the opportunity to have treatment chance for brain related diseases
Nyckelord
- animal models
- blood brain barrier
- drug delivery
- immunotherapy
- neuroinflammation
- protein drug
- resistant epilepsy
- temporal lobe epilepsy
Publikationer
Senaste publikationer
- Standardized Preclinical In Vitro Blood-Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways (2023)
- Targeting the blood-brain barrier disruption in hypertension by ALK5/ TGF-? (2022)
- Changes in the Expression of c-fos and AQP4 in the Hippocampus and Amygdala Regions of Rats with Kainic Acid-Induced Temporal Lobe Epilepsy and Their Role in the Pathogenesis of Disease (2022)
- Blood-brain barrier targeted delivery of lacosamide-conjugated gold nanoparticles (2022)
- Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain (2021)
Alla publikationer
Artiklar
- Standardized Preclinical In Vitro Blood-Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways (2023)
- Targeting the blood-brain barrier disruption in hypertension by ALK5/ TGF-? (2022)
- Changes in the Expression of c-fos and AQP4 in the Hippocampus and Amygdala Regions of Rats with Kainic Acid-Induced Temporal Lobe Epilepsy and Their Role in the Pathogenesis of Disease (2022)
- Blood-brain barrier targeted delivery of lacosamide-conjugated gold nanoparticles (2022)
- Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain (2021)
- Targeted delivery of lacosamide-conjugated gold nanoparticles into the brain in temporal lobe epilepsy in rats (2020)
- Effects of methyl-beta-cyclodextrin on blood-brain barrier permeability in angiotensin II-induced hypertensive rats (2019)
- The Effects of Lipopolysaccharide on the Disrupted Blood-Brain Barrier in a Rat Model of Preeclampsia (2018)
- Blood-Brain Barrier Dynamics Of Nanotechnological Drug Carriers In Animal Model Of Temporal Lobe Epilepsy (2018)
Konferenser
