Maria Kjellsson

Blood-glucose Profile Evaluation with a Model-based Approach using Continuous Glucose Monitoring Data

Kunina, Hanna; Chien, Jenny Y.; Garhyan, Parag; Geiser, Jeanne S. et al.

Ingår i AAPS Journal, 2026

• DOI för Blood-glucose Profile Evaluation with a Model-based Approach using Continuous Glucose Monitoring Data
• Ladda ner fulltext (pdf) av Blood-glucose Profile Evaluation with a Model-based Approach using Continuous Glucose Monitoring Data

Learning Covariate Relations in Disease Progression Models Using Symbolic Neural Networks

Sundell, Jesper; Wahlquist, Ylva; Kjellsson, Maria C.; Karlsson, Mats O. et al.

Ingår i CPT, 2026

• DOI för Learning Covariate Relations in Disease Progression Models Using Symbolic Neural Networks
• Ladda ner fulltext (pdf) av Learning Covariate Relations in Disease Progression Models Using Symbolic Neural Networks

Glucose-dependent dynamics of glucagon, cortisol and adrenocorticotropic hormone before and after gastric bypass

Chronopoulos, Vasileios; Kjellsson, Maria C.; Lundqvist, Martin H.

Ingår i Journal of the Endocrine Society, 2026

• DOI för Glucose-dependent dynamics of glucagon, cortisol and adrenocorticotropic hormone before and after gastric bypass
• Ladda ner fulltext (pdf) av Glucose-dependent dynamics of glucagon, cortisol and adrenocorticotropic hormone before and after gastric bypass

Modeling of Disease Progression of Type 2 Diabetes Using Real-World Data: Quantifying Competing Risks of Morbidity and Mortality

Kunina, Hanna; Franzen, Stefan; Kjellsson, Maria C.

Ingår i CPT, s. 606-615, 2025

• DOI för Modeling of Disease Progression of Type 2 Diabetes Using Real-World Data: Quantifying Competing Risks of Morbidity and Mortality
• Ladda ner fulltext (pdf) av Modeling of Disease Progression of Type 2 Diabetes Using Real-World Data: Quantifying Competing Risks of Morbidity and Mortality

Response to "Enhance Multistate Models With Clinically Meaningful Graphs"

Ibrahim, Moustafa M. A.; Kjellsson, Maria C.; Karlsson, Mats O.

Ingår i CPT, s. 1899-1899, 2025

• DOI för Response to "Enhance Multistate Models With Clinically Meaningful Graphs"
• Ladda ner fulltext (pdf) av Response to "Enhance Multistate Models With Clinically Meaningful Graphs"

Blood-glucose Profile Evaluation with a Model-based Approach using Continuous Glucose Monitoring Data

Kunina, Hanna; Chien, Jenny Y.; Garhyan, Parag; Geiser, Jeanne S. et al.

Ingår i AAPS Journal, 2026

• DOI för Blood-glucose Profile Evaluation with a Model-based Approach using Continuous Glucose Monitoring Data
• Ladda ner fulltext (pdf) av Blood-glucose Profile Evaluation with a Model-based Approach using Continuous Glucose Monitoring Data

Learning Covariate Relations in Disease Progression Models Using Symbolic Neural Networks

Sundell, Jesper; Wahlquist, Ylva; Kjellsson, Maria C.; Karlsson, Mats O. et al.

Ingår i CPT, 2026

• DOI för Learning Covariate Relations in Disease Progression Models Using Symbolic Neural Networks
• Ladda ner fulltext (pdf) av Learning Covariate Relations in Disease Progression Models Using Symbolic Neural Networks

Glucose-dependent dynamics of glucagon, cortisol and adrenocorticotropic hormone before and after gastric bypass

Chronopoulos, Vasileios; Kjellsson, Maria C.; Lundqvist, Martin H.

Ingår i Journal of the Endocrine Society, 2026

• DOI för Glucose-dependent dynamics of glucagon, cortisol and adrenocorticotropic hormone before and after gastric bypass
• Ladda ner fulltext (pdf) av Glucose-dependent dynamics of glucagon, cortisol and adrenocorticotropic hormone before and after gastric bypass

Modeling of Disease Progression of Type 2 Diabetes Using Real-World Data: Quantifying Competing Risks of Morbidity and Mortality

Kunina, Hanna; Franzen, Stefan; Kjellsson, Maria C.

Ingår i CPT, s. 606-615, 2025

• DOI för Modeling of Disease Progression of Type 2 Diabetes Using Real-World Data: Quantifying Competing Risks of Morbidity and Mortality
• Ladda ner fulltext (pdf) av Modeling of Disease Progression of Type 2 Diabetes Using Real-World Data: Quantifying Competing Risks of Morbidity and Mortality

Response to "Enhance Multistate Models With Clinically Meaningful Graphs"

Ibrahim, Moustafa M. A.; Kjellsson, Maria C.; Karlsson, Mats O.

Ingår i CPT, s. 1899-1899, 2025

• DOI för Response to "Enhance Multistate Models With Clinically Meaningful Graphs"
• Ladda ner fulltext (pdf) av Response to "Enhance Multistate Models With Clinically Meaningful Graphs"

Population pharmacokinetics of tacrolimus whole blood and peripheral blood mononuclear cell concentrations in stable kidney‐transplanted patients

Agergaard, Katrine; Thiesson, Helle C.; Carstens, Jan; Staatz, Christine E. et al.

Ingår i British Journal of Clinical Pharmacology, s. 761-773, 2025

• DOI för Population pharmacokinetics of tacrolimus whole blood and peripheral blood mononuclear cell concentrations in stable kidney‐transplanted patients
• Ladda ner fulltext (pdf) av Population pharmacokinetics of tacrolimus whole blood and peripheral blood mononuclear cell concentrations in stable kidney‐transplanted patients

Competing Risks Analysis of the Finnish Diabetes Prevention Study

Ibrahim, Moustafa M. A.; Uusitupa, Matti; Tuomilehto, Jaakko; Lindström, Jaana et al.

Ingår i CPT, s. 1459-1469, 2025

• DOI för Competing Risks Analysis of the Finnish Diabetes Prevention Study
• Ladda ner fulltext (pdf) av Competing Risks Analysis of the Finnish Diabetes Prevention Study

Limited Sampling Strategies to Predict Mycophenolic Acid and Tacrolimus Area Under the Concentration - Time Curve in Steroid-Free Kidney Transplant Patients

Agergaard, Katrine; Thiesson, Helle C.; Carstens, Jan; Staatz, Christine E. et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, 2025

• DOI för Limited Sampling Strategies to Predict Mycophenolic Acid and Tacrolimus Area Under the Concentration - Time Curve in Steroid-Free Kidney Transplant Patients
• Ladda ner fulltext (pdf) av Limited Sampling Strategies to Predict Mycophenolic Acid and Tacrolimus Area Under the Concentration - Time Curve in Steroid-Free Kidney Transplant Patients

Item response theory analysis of daytime sleepiness as a symptom of obstructive sleep apnea

Wellhagen, Gustaf; Karlsson, Mats O.; Kjellsson, Maria C.; Garmann, Dirk et al.

Ingår i CPT, s. 880-890, 2024

• DOI för Item response theory analysis of daytime sleepiness as a symptom of obstructive sleep apnea
• Ladda ner fulltext (pdf) av Item response theory analysis of daytime sleepiness as a symptom of obstructive sleep apnea

Evaluation of covariate effects in item response theory models

Wellhagen, Gustaf; Yassen, Ashraf; Garmann, Dirk; Broeker, Astrid et al.

Ingår i CPT, s. 812-822, 2024

• DOI för Evaluation of covariate effects in item response theory models
• Ladda ner fulltext (pdf) av Evaluation of covariate effects in item response theory models

Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP-1

Leohr, Jennifer; Kjellsson, Maria C.

Ingår i CPT, s. 1529-1540, 2023

• DOI för Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP-1
• Ladda ner fulltext (pdf) av Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP-1

Optimal dosing of gliclazide-A model-based approach

Mim, Sabiha R.; Hussein, Haneen; Vidadi, Samira; Leisegang, Rory et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 59-72, 2023

• DOI för Optimal dosing of gliclazide-A model-based approach
• Ladda ner fulltext (pdf) av Optimal dosing of gliclazide-A model-based approach

Altered glucose-dependent secretion of glucagon and ACTH is associated with insulin resistance, assessed by population analysis

Eriksson, Jan; Emad, Reem A.; Lundqvist, Martin H.; Abrahamsson, Niclas et al.

Ingår i Endocrine Connections, 2023

• DOI för Altered glucose-dependent secretion of glucagon and ACTH is associated with insulin resistance, assessed by population analysis
• Ladda ner fulltext (pdf) av Altered glucose-dependent secretion of glucagon and ACTH is associated with insulin resistance, assessed by population analysis

Pharmacometric modeling of drug adverse effects: an application of mixture models in schizophrenia spectrum disorder patients treated with clozapine

Albitar, Orwa; Ghadzi, Siti Maisharah Sheikh; Harun, Sabariah Noor; Ahmad, Siti Nor Aizah et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 21-31, 2023

• DOI för Pharmacometric modeling of drug adverse effects: an application of mixture models in schizophrenia spectrum disorder patients treated with clozapine

Optimization of trial duration to predict long-term HbA1c change with therapy: A pharmacometrics simulation-based evaluation

Kunina, Hanna; Al-Mashat, Alex; Chien, Jenny Y.; Garhyan, Parag et al.

Ingår i CPT, s. 1443-1457, 2022

• DOI för Optimization of trial duration to predict long-term HbA1c change with therapy: A pharmacometrics simulation-based evaluation
• Ladda ner fulltext (pdf) av Optimization of trial duration to predict long-term HbA1c change with therapy: A pharmacometrics simulation-based evaluation

Impact of Obesity on Postprandial Triglyceride Contribution to Glucose Homeostasis, Assessed with a Semimechanistic Model

Leohr, Jennifer; Kjellsson, Maria C.

Ingår i Clinical Pharmacology and Therapeutics, s. 112-124, 2022

• DOI för Impact of Obesity on Postprandial Triglyceride Contribution to Glucose Homeostasis, Assessed with a Semimechanistic Model
• Ladda ner fulltext (pdf) av Impact of Obesity on Postprandial Triglyceride Contribution to Glucose Homeostasis, Assessed with a Semimechanistic Model

Linking categorical models for prediction of pleasantness score using individual predictions of sweetness and creaminess: An advancement of categorical modeling

Leohr, Jennifer; Kjellsson, Maria C.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 815-823, 2021

• DOI för Linking categorical models for prediction of pleasantness score using individual predictions of sweetness and creaminess: An advancement of categorical modeling
• Ladda ner fulltext (pdf) av Linking categorical models for prediction of pleasantness score using individual predictions of sweetness and creaminess: An advancement of categorical modeling

An Item Response Theory-Informed Strategy to Model Total Score Data from Composite Scales

Wellhagen, Gustaf; Ueckert, Sebastian; Kjellsson, Maria C.; Karlsson, Mats

Ingår i AAPS Journal, 2021

• DOI för An Item Response Theory-Informed Strategy to Model Total Score Data from Composite Scales
• Ladda ner fulltext (pdf) av An Item Response Theory-Informed Strategy to Model Total Score Data from Composite Scales

Optimal Designs for Model-Based Assessment of Insulin Sensitivity and Glucose Effectiveness.

Ibrahim, Moustafa M. A.; Redestad, Erik; Kjellsson, Maria C.

Ingår i Journal of clinical pharmacology, s. 116-124, 2021

• DOI för Optimal Designs for Model-Based Assessment of Insulin Sensitivity and Glucose Effectiveness.
• Ladda ner fulltext (pdf) av Optimal Designs for Model-Based Assessment of Insulin Sensitivity and Glucose Effectiveness.

Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data

Wellhagen, Gustaf J.; Karlsson, Mats O.; Kjellsson, Maria C.

Ingår i AAPS Journal, 2021

• DOI för Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data
• Ladda ner fulltext (pdf) av Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data

A Time-to-Event Model Relating Integrated Craving to Risk of Smoking Relapse Across Different Nicotine Replacement Therapy Formulations

Germovsek, Eva; Hansson, Anna; Karlsson, Mats O.; Westin, Ake et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 416-423, 2021

• DOI för A Time-to-Event Model Relating Integrated Craving to Risk of Smoking Relapse Across Different Nicotine Replacement Therapy Formulations

Postprandial triglyceride reduction following acute treatment of a selective 5-hydroxytryptamine-2c agonist and characterization using a semi-physiological model

Leohr, Jennifer; Heathman, Michael; Kjellsson, Maria C.

Ingår i Diabetes, obesity and metabolism, s. 1001-1010, 2021

• DOI för Postprandial triglyceride reduction following acute treatment of a selective 5-hydroxytryptamine-2c agonist and characterization using a semi-physiological model
• Ladda ner fulltext (pdf) av Postprandial triglyceride reduction following acute treatment of a selective 5-hydroxytryptamine-2c agonist and characterization using a semi-physiological model

Dose-Response Mixed Models for Repeated Measures – a New Method for Assessment of Dose-Response

Wellhagen, Gustaf J.; Hamren, Bengt; Kjellsson, Maria C.; Astrand, Magnus

Ingår i Pharmaceutical research, 2020

• DOI för Dose-Response Mixed Models for Repeated Measures – a New Method for Assessment of Dose-Response
• Ladda ner fulltext (pdf) av Dose-Response Mixed Models for Repeated Measures – a New Method for Assessment of Dose-Response

Sweet/Fat Preference Taste in Subjects who are Lean, Obese and Very Obese

Leohr, Jennifer; Kjellsson, Maria C.

Ingår i Pharmaceutical research, 2020

• DOI för Sweet/Fat Preference Taste in Subjects who are Lean, Obese and Very Obese
• Ladda ner fulltext (pdf) av Sweet/Fat Preference Taste in Subjects who are Lean, Obese and Very Obese

Relating Nicotine Plasma Concentration to Momentary Craving Across Four Nicotine Replacement Therapy Formulations

Germovsek, Eva; Hansson, Anna; Kjellsson, Maria C.; Perez Ruixo, Juan Jose et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 238-245, 2020

• DOI för Relating Nicotine Plasma Concentration to Momentary Craving Across Four Nicotine Replacement Therapy Formulations

Variability Attribution for Automated Model Building

Ibrahim, Moustafa M. A.; Nordgren, Rikard; Kjellsson, Maria C.; Karlsson, Mats O.

Ingår i AAPS Journal, 2019

• DOI för Variability Attribution for Automated Model Building
• Ladda ner fulltext (pdf) av Variability Attribution for Automated Model Building

A Bounded Integer Model for Rating and Composite Scale Data

Wellhagen, Gustaf J.; Kjellsson, Maria C.; Karlsson, Mats O.

Ingår i AAPS Journal, 2019

• DOI för A Bounded Integer Model for Rating and Composite Scale Data
• Ladda ner fulltext (pdf) av A Bounded Integer Model for Rating and Composite Scale Data

Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment

Ibrahim, Moustafa M. A.; Ueckert, Sebastian; Freiberga, Svetlana; Kjellsson, Maria C. et al.

Ingår i AAPS Journal, 2019

• DOI för Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment
• Ladda ner fulltext (pdf) av Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment

The Integrated Glucose Insulin Minimal Model: An improved version

Ibrahim, Moustafa M. A.; Largajolli, Anna; Karlsson, Mats; Kjellsson, Maria C.

Ingår i European Journal of Pharmaceutical Sciences, s. 7-19, 2019

• DOI för The Integrated Glucose Insulin Minimal Model: An improved version

Translation between two models; Application with integrated glucose homeostasis models

Ibrahim, Moustafa M. A.; Largajolli, Anna; Kjellsson, Maria C.; Karlsson, Mats

Ingår i Pharmaceutical research, 2019

• DOI för Translation between two models; Application with integrated glucose homeostasis models
• Ladda ner fulltext (pdf) av Translation between two models; Application with integrated glucose homeostasis models

Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics

Stage, Tore Bjerregaard; Wellhagen, Gustaf; Christensen, Mette Marie Hougaard; Guiastrennec, Benjamin et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 105-114, 2019

• DOI för Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics

Model-Based Residual Post-Processing for Residual Model Identification

Ibrahim, Moustafa M. A.; Nordgren, Rikard; Kjellsson, Maria C.; Karlsson, Mats O

Ingår i AAPS Journal, 2018

• DOI för Model-Based Residual Post-Processing for Residual Model Identification
• Ladda ner fulltext (pdf) av Model-Based Residual Post-Processing for Residual Model Identification

Comparison of Power, Prognosis, and Extrapolation Properties of Four Population Pharmacodynamic Models of HbA1c for Type 2 Diabetes

Wellhagen, Gustaf J.; Karlsson, Mats O.; Kjellsson, Maria C.

Ingår i CPT, s. 331-341, 2018

• DOI för Comparison of Power, Prognosis, and Extrapolation Properties of Four Population Pharmacodynamic Models of HbA1c for Type 2 Diabetes

A Semi-physiological Model of Postprandial Triglyceride Response in Lean, Obese and Very obese Subjects Following a high-fat meal

Leohr, Jennifer; Heathman, Michael; Kjellsson, Maria C.

Ingår i Diabetes, obesity and metabolism, s. 660-666, 2018

• DOI för A Semi-physiological Model of Postprandial Triglyceride Response in Lean, Obese and Very obese Subjects Following a high-fat meal

Study Design Selection in Early Clinical Anti-Hyperglycemic Drug Development: A Simulation Study of Glucose Tolerance Tests

Ibrahim, Moustafa M. A.; Ghadzi, Siti Maisharah Sheikh; Kjellsson, Maria C.; Karlsson, Mats O.

Ingår i CPT, s. 432-441, 2018

• DOI för Study Design Selection in Early Clinical Anti-Hyperglycemic Drug Development: A Simulation Study of Glucose Tolerance Tests
• Ladda ner fulltext (pdf) av Study Design Selection in Early Clinical Anti-Hyperglycemic Drug Development: A Simulation Study of Glucose Tolerance Tests

Evidence-Based Design of Fixed-Dose Combinations: Principles and Application to Pediatric Anti-Tuberculosis Therapy

Svensson, Elin; Yngman, Gunnar; Denti, Paolo; McIlleron, Helen et al.

Ingår i Clinical Pharmacokinetics, s. 591-599, 2018

• DOI för Evidence-Based Design of Fixed-Dose Combinations: Principles and Application to Pediatric Anti-Tuberculosis Therapy
• Ladda ner fulltext (pdf) av Evidence-Based Design of Fixed-Dose Combinations: Principles and Application to Pediatric Anti-Tuberculosis Therapy

An exposure-response (ER) model relating nicotine plasma concentration to momentary craving across different nicotine replacement therapy (NRT) formulations

Germovsek, Eva; Hansson, Anna; Kjellsson, Maria C.; Ruixo, Juan Jose Perez et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, 2018

Implications for Drug Characterization in Glucose Tolerance Tests Without Insulin: Simulation Study of Power and Predictions Using Model-Based Analysis

Ghadzi, Siti Maisharah Sheikh; Karlsson, Mats O; Kjellsson, Maria C.

Ingår i CPT, s. 686-694, 2017

• DOI för Implications for Drug Characterization in Glucose Tolerance Tests Without Insulin: Simulation Study of Power and Predictions Using Model-Based Analysis

Model-Based Interspecies Scaling of Glucose Homeostasis

Alskär, Oskar; Karlsson, Mats O.; Kjellsson, Maria C.

Ingår i CPT, s. 778-786, 2017

• DOI för Model-Based Interspecies Scaling of Glucose Homeostasis
• Ladda ner fulltext (pdf) av Model-Based Interspecies Scaling of Glucose Homeostasis

Evidence-based design of fixed-dose combinations: principles and application to pediatric anti-tuberculosis therapy

Svensson, Elin M.; Yngman, Gunnar; Denti, Paolo; McIlleron, Helen et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, 2017

• DOI för Evidence-based design of fixed-dose combinations: principles and application to pediatric anti-tuberculosis therapy

Comparison of diagnostics using model-based post-processing for fast automated model building

Ibrahim, Moustafa M. A.; Nordgren, Rikard; Kjellsson, Maria C.; Karlsson, Mats O

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, 2017

Impact of demographics and disease progression on the relationship between glucose and HbA1c

Claussen, Anetta; Möller, Jonas B.; Kristensen, Niels R.; Klim, Sören et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 417-423, 2017

• DOI för Impact of demographics and disease progression on the relationship between glucose and HbA1c

Modeling the Disease Progression from Healthy to Overt Diabetes in ZDSD Rats

Choy, Steve; de Winter, Willem; Karlsson, Mats O.; Kjellsson, Maria C.

Ingår i AAPS Journal, s. 1203-1212, 2016

• DOI för Modeling the Disease Progression from Healthy to Overt Diabetes in ZDSD Rats

Weight-HbA1c-Insulin-Glucose Model for Describing Disease Progression of Type 2 Diabetes

Choy, Steve; Kjellsson, Maria; Karlsson, Mats; de Winter, Willem

Ingår i CPT, s. 11-19, 2016

• DOI för Weight-HbA1c-Insulin-Glucose Model for Describing Disease Progression of Type 2 Diabetes
• Ladda ner fulltext (pdf) av Weight-HbA1c-Insulin-Glucose Model for Describing Disease Progression of Type 2 Diabetes

Methods for Predicting Diabetes Phase III Efficacy Outcome From Early Data: Superior Performance Obtained Using Longitudinal Approaches.

Møller, J B; Kristensen, N R; Klim, S; Karlsson, Mats O. et al.

Ingår i CPT, s. 388-9, 2016

• DOI för Methods for Predicting Diabetes Phase III Efficacy Outcome From Early Data: Superior Performance Obtained Using Longitudinal Approaches.

Semi-mechanistic model describing gastric emptying and glucose absorption in healthy subjects and patients with type 2 diabetes

Alskär, Oskar; Bagger, Jonatan I; Røge, Rikke M; Knop, Filip K et al.

Ingår i Journal of clinical pharmacology, s. 340-348, 2016

• DOI för Semi-mechanistic model describing gastric emptying and glucose absorption in healthy subjects and patients with type 2 diabetes

Mechanistic modeling of hepatic pitavastatin disposition: a proteomics-informed bottom-up approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 56-57, 2016

Application of the integrated glucose-insulin model for cross-study characterization of T2DM patients on metformin background treatment

Parkinson, Joanna; Hamren, Bengt; Kjellsson, Maria C.; Skrtic, Stanko

Ingår i British Journal of Clinical Pharmacology, s. 1613-1624, 2016

• DOI för Application of the integrated glucose-insulin model for cross-study characterization of T2DM patients on metformin background treatment

A proof-of-principle example for identifying drug effect from a mechanistic model with a more parsimonious model

Wang, Shijun; Karlsson, Kristin E.; Kjellsson, Maria; Karlsson, Mats O. et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, 2016

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Ingår i Drug Metabolism And Disposition, s. 505-516, 2016

• DOI för Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Nonlinear mixed-effects modelling for single cell estimation: when, why, and how to use it

Karlsson, Markus; Janzen, David L. I.; Durrieu, Lucia; Colman-Lerner, Alejandro et al.

Ingår i BMC Systems Biology, 2015

• DOI för Nonlinear mixed-effects modelling for single cell estimation: when, why, and how to use it
• Ladda ner fulltext (pdf) av Nonlinear mixed-effects modelling for single cell estimation: when, why, and how to use it

The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes Mellitus Quantified by an Integrated Glucose Insulin Model

Røge, Rikke M; Klim, Søren; Ingwersen, Steen H; Kjellsson, Maria C et al.

Ingår i CPT, s. 1-9, 2015

• DOI för The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes Mellitus Quantified by an Integrated Glucose Insulin Model
• Ladda ner fulltext (pdf) av The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes Mellitus Quantified by an Integrated Glucose Insulin Model

Interspecies scaling of dynamic glucose and insulin using a mathematical model approach

Alskar, Oskar; Karlsson, Mats O.; Kjellsson, Maria C.

Ingår i Diabetologia, 2015

A mathematical disease progression model for the effect of diet and exercise in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study (FDPS)

Ghadzi, Siti Maisharah Sheikh; Karlsson, Mats O.; de Mello, V. D.; Uusitupa, M. et al.

Ingår i Diabetologia, 2015

Methods for Predicting Diabetes Phase III Efficacy Outcome From Early Data: Superior Performance Obtained Using Longitudinal Approaches

Møller, J B; Kristensen, N R; Klim, S; Karlsson, Mats O et al.

Ingår i CPT, 2014

• DOI för Methods for Predicting Diabetes Phase III Efficacy Outcome From Early Data: Superior Performance Obtained Using Longitudinal Approaches

Modeling of 24-Hour Glucose and Insulin Profiles in Patients With Type 2 Diabetes Mellitus Treated With Biphasic Insulin Aspart

Røge, Rikke M; Klim, Søren; Kristensen, Niels R; Ingwersen, Steen H et al.

Ingår i Journal of clinical pharmacology, s. 809-817, 2014

• DOI för Modeling of 24-Hour Glucose and Insulin Profiles in Patients With Type 2 Diabetes Mellitus Treated With Biphasic Insulin Aspart

Longitudinal Modeling of the Relationship Between Mean Plasma Glucose and HbA1c Following Antidiabetic Treatments

Møller, J B; Overgaard, R V; Kjellsson, Maria C; Kristensen, N R et al.

Ingår i CPT, 2013

• DOI för Longitudinal Modeling of the Relationship Between Mean Plasma Glucose and HbA1c Following Antidiabetic Treatments

Identification of the primary mechanism of action of an insulin secretagogue from meal test data in healthy volunteers based on an integrated glucose-insulin model

Choy, Steve; Henin, Emilie; van der Walt, Jan-Stefan; Kjellsson, Maria et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 1-10, 2013

• DOI för Identification of the primary mechanism of action of an insulin secretagogue from meal test data in healthy volunteers based on an integrated glucose-insulin model

A Model-Based Approach to Predict Longitudinal HbA1c, Using Early Phase Glucose Data From Type 2 Diabetes Mellitus Patients After Anti-Diabetic Treatment

Kjellsson, Maria C.; Cosson, Valerie F.; Mazer, Norman A.; Frey, Nicolas et al.

Ingår i Journal of clinical pharmacology, s. 589-600, 2013

• DOI för A Model-Based Approach to Predict Longitudinal HbA1c, Using Early Phase Glucose Data From Type 2 Diabetes Mellitus Patients After Anti-Diabetic Treatment

ADOPT (A Dynamic HbA(1c) EndpOint Prediction Tool): A framework for Predicting Primary Endpoint in Phase 3 Diabetes Trials

Moller, Jonas B.; Overgaard, Rune V.; Kjellsson, Maria C.; Kristensen, Niels R. et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, 2013

Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions

Kjellsson, Maria C.; Via, Laura E.; Goh, Anne; Weiner, Danielle et al.

Ingår i Antimicrobial Agents and Chemotherapy, s. 446-457, 2012

• DOI för Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions

Abscess penetration of cefpirome: concentrations and simulated pharmacokinetic profiles in pus

Sauermann, Robert; Feurstein, Thomas; Karch, Rudolf; Kjellsson, Maria C et al.

Ingår i European Journal of Clinical Pharmacology, s. 1419-1423, 2012

• DOI för Abscess penetration of cefpirome: concentrations and simulated pharmacokinetic profiles in pus

Good penetration of moxifloxacin into human abscesses

Sauermann, Robert; Karch, Rudolf; Kjellsson, Maria C; Feurstein, Thomas et al.

Ingår i Pharmacology, s. 146-150, 2012

• DOI för Good penetration of moxifloxacin into human abscesses

Modeling sleep data for a new drug in development using Markov mixed-effects models

Kjellsson, Maria C.; Ouellet, Daniele; Corrigan, Brian; Karlsson, Mats O.

Ingår i Pharmaceutical research, s. 2610-2627, 2011

• DOI för Modeling sleep data for a new drug in development using Markov mixed-effects models

The impact of misspecification of residual error or correlation structure on the type I error rate for covariate inclusion

Silber, Hanna E; Kjellsson, Maria C; Karlsson, Mats O

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 81-99, 2009

• DOI för The impact of misspecification of residual error or correlation structure on the type I error rate for covariate inclusion

Evaluation of the Nonparametric Estimation Method in NONMEM VI

Savic, Radojka M.; Kjellsson, Maria C.; Karlsson, Mats O.

Ingår i European Journal of Pharmaceutical Sciences, s. 27-35, 2009

• DOI för Evaluation of the Nonparametric Estimation Method in NONMEM VI

Comparison of proportional odds and differential odds models for mixed-effects analysis of categorical data

Kjellsson, Maria C.; Zingmark, Per-Henrik; Jonsson, E. Niclas; Karlsson, Mats O.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 483-501, 2008

• DOI för Comparison of proportional odds and differential odds models for mixed-effects analysis of categorical data

Estimating bias in population parameters for some models for repeated measures ordinal data using NONMEM or NLMIXED

Jönsson, Siv; Kjellsson, Maria C.; Karlsson, Mats O.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 299-320, 2004

• DOI för Estimating bias in population parameters for some models for repeated measures ordinal data using NONMEM or NLMIXED

The effects of dose staggering on metabolic drug-drug interactions

Yang, Jiansong; Kjellsson, Maria; Rostami-Hodjegan, Amin; Tucker, Geoffrey T

Ingår i European Journal of Pharmaceutical Sciences, s. 223-232, 2003

• DOI för The effects of dose staggering on metabolic drug-drug interactions

Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes

Nyman, Elin; Rozendaal, Yvonne J. W.; Helmlinger, Gabriel; Hamren, Bengt et al.

Ingår i Interface Focus, 2016

• DOI för Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes

Methodological Studies on Models and Methods for Mixed-Effects Categorical Data Analysis

Kjellsson, Maria C.

2008

• Ladda ner fulltext (pdf) av Methodological Studies on Models and Methods for Mixed-Effects Categorical Data Analysis

Impulsive Feedback Modeling of Levodopa Pharmacokinetics Subject to Intermittently Interrupted Gastric Emptying

Runvik, Håkan; Medvedev, Alexander; Kjellsson, Maria C.

Ingår i 2020 American Control Conference (ACC), s. 1323-1328, 2020

• DOI för Impulsive Feedback Modeling of Levodopa Pharmacokinetics Subject to Intermittently Interrupted Gastric Emptying

The metformin intervention (MINT) study – a randomized trial for the treatment of pediatric obesity

Ciba, Iris; Manell, Hannes; Andersson, Kerstin; Aydin, Banu K. et al.