Linus Sandegren
Gästprofessor vid Institutionen för cell- och molekylärbiologi; Mikrobiologi och immunologi
- E-post:
- linus.sandegren@imbim.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
751 24 Uppsala
Professor vid Institutionen för medicinsk biokemi och mikrobiologi; Administration
- E-post:
- linus.sandegren@imbim.uu.se
- Besöksadress:
- BMC
Husargatan 3
752 37 UPPSALA - Postadress:
- Box 582
751 23 UPPSALA
Professor vid Institutionen för medicinsk biokemi och mikrobiologi; Infektioner och Immunitet; Linus Sandegren
- Telefon:
- 018-471 43 65
- E-post:
- Linus.Sandegren@imbim.uu.se
- Besöksadress:
- BMC
Husargatan 3
752 37 UPPSALA - Postadress:
- Box 582
751 23 UPPSALA
Projektkoordinator vid Uppsala antibiotikacentrum
- E-post:
- linus.sandegren@imbim.uu.se
- Besöksadress:
- BMC, SciLifeLab Entrance C11, Room E10:4210
752 37 Uppsala - Postadress:
- BMC, Box 582, Husargatan 3
751 23 Uppsala
Ladda ned kontaktuppgifter för Linus Sandegren vid Uppsala antibiotikacentrum
- Akademiska meriter:
- PhD
Kort presentation
We study fundamental aspects of how resistance plasmids are maintained and disseminated between pathogenic bacteria and how they serve as platforms for evolution of antibiotic resistance. The main focus is to understand how factors such as stability, mobility, positive selection and fitness costs influence the evolutionary success of plasmids.
More info can be found at: https://www.imbim.uu.se/forskargrupper/infektion-och-immunitet/Sandegren_Linus/
Nyckelord
- bioinformatics
- microbiology
- antibiotic resistance
- molecular evolution
- experimental evolution
- antibiotic
- bacterial genetics
- infection biology
- bacteriology
- bacterial evolution
- uppsala antibiotic center

Publikationer
Senaste publikationer
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A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes
Ingår i Scientific Reports, 2025
- DOI för A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes
- Ladda ner fulltext (pdf) av A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes
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Strain-Level Typing of Streptococcus pyogenes Using Optical DNA Mapping
Ingår i ACS - Infectious Diseases, s. 3085-3092, 2025
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DOGMA: de novo assembly of densely labelled optical DNA maps using a matrix profile approach
Ingår i PLOS ONE, 2025
- DOI för DOGMA: de novo assembly of densely labelled optical DNA maps using a matrix profile approach
- Ladda ner fulltext (pdf) av DOGMA: de novo assembly of densely labelled optical DNA maps using a matrix profile approach
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Ingår i JAC - Antimicrobial Resistance, 2025
- DOI för Evaluation of ceftazidime/avibactam in combination with colistin against KPC-2-producing Klebsiella pneumoniae in static and dynamic time-kill experiments
- Ladda ner fulltext (pdf) av Evaluation of ceftazidime/avibactam in combination with colistin against KPC-2-producing Klebsiella pneumoniae in static and dynamic time-kill experiments
-
Ingår i Biosensors and Bioelectronics: X, 2024
- DOI för Reduced amplification by phi29 DNA polymerase in the presence of unbound oligos during reaction in RCA
- Ladda ner fulltext (pdf) av Reduced amplification by phi29 DNA polymerase in the presence of unbound oligos during reaction in RCA
Alla publikationer
Artiklar i tidskrift
-
A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes
Ingår i Scientific Reports, 2025
- DOI för A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes
- Ladda ner fulltext (pdf) av A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes
-
Strain-Level Typing of Streptococcus pyogenes Using Optical DNA Mapping
Ingår i ACS - Infectious Diseases, s. 3085-3092, 2025
-
DOGMA: de novo assembly of densely labelled optical DNA maps using a matrix profile approach
Ingår i PLOS ONE, 2025
- DOI för DOGMA: de novo assembly of densely labelled optical DNA maps using a matrix profile approach
- Ladda ner fulltext (pdf) av DOGMA: de novo assembly of densely labelled optical DNA maps using a matrix profile approach
-
Ingår i JAC - Antimicrobial Resistance, 2025
- DOI för Evaluation of ceftazidime/avibactam in combination with colistin against KPC-2-producing Klebsiella pneumoniae in static and dynamic time-kill experiments
- Ladda ner fulltext (pdf) av Evaluation of ceftazidime/avibactam in combination with colistin against KPC-2-producing Klebsiella pneumoniae in static and dynamic time-kill experiments
-
Ingår i Biosensors and Bioelectronics: X, 2024
- DOI för Reduced amplification by phi29 DNA polymerase in the presence of unbound oligos during reaction in RCA
- Ladda ner fulltext (pdf) av Reduced amplification by phi29 DNA polymerase in the presence of unbound oligos during reaction in RCA
-
Ingår i Antimicrobial Agents and Chemotherapy, 2024
- DOI för Impact of porin deficiency on the synergistic potential of colistin in combination with β-lactam/β-lactamase inhibitors against ESBL- and carbapenemase-producing Klebsiella pneumoniae
- Ladda ner fulltext (pdf) av Impact of porin deficiency on the synergistic potential of colistin in combination with β-lactam/β-lactamase inhibitors against ESBL- and carbapenemase-producing Klebsiella pneumoniae
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Ingår i Microbiology Spectrum, s. 1-14, 2024
- DOI för Molecular characteristics, fitness, and virulence of high-risk and non-high-risk clones of carbapenemase-producing Klebsiella pneumoniae
- Ladda ner fulltext (pdf) av Molecular characteristics, fitness, and virulence of high-risk and non-high-risk clones of carbapenemase-producing Klebsiella pneumoniae
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Ingår i Applied and Environmental Microbiology, 2023
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Strain-level bacterial typing directly from patient samples using optical DNA mapping
Ingår i Communications Medicine, 2023
- DOI för Strain-level bacterial typing directly from patient samples using optical DNA mapping
- Ladda ner fulltext (pdf) av Strain-level bacterial typing directly from patient samples using optical DNA mapping
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Ingår i Journal of Infectious Diseases, s. 1011-1020, 2022
- DOI för Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment
- Ladda ner fulltext (pdf) av Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment
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Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters
Ingår i ACS Omega, s. 4550-4562, 2022
- DOI för Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters
- Ladda ner fulltext (pdf) av Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters
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Ingår i Antimicrobial Agents and Chemotherapy, 2022
-
Ingår i Antibiotics, 2022
- DOI för Evaluation of In Vitro Activity of Double-Carbapenem Combinations against KPC-2-, OXA-48-and NDM-Producing Escherichia coli and Klebsiella pneumoniae
- Ladda ner fulltext (pdf) av Evaluation of In Vitro Activity of Double-Carbapenem Combinations against KPC-2-, OXA-48-and NDM-Producing Escherichia coli and Klebsiella pneumoniae
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The Role of Antibiotic Resistance Genes in the Fitness Cost of Multiresistance Plasmids
Ingår i mBio, 2022
- DOI för The Role of Antibiotic Resistance Genes in the Fitness Cost of Multiresistance Plasmids
- Ladda ner fulltext (pdf) av The Role of Antibiotic Resistance Genes in the Fitness Cost of Multiresistance Plasmids
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Ingår i Biosensors and Bioelectronics: X, 2022
- DOI för Naked-eye detection of antibiotic resistance gene sul1 based on aggregation of magnetic nanoparticles and DNA amplification products
- Ladda ner fulltext (pdf) av Naked-eye detection of antibiotic resistance gene sul1 based on aggregation of magnetic nanoparticles and DNA amplification products
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Ingår i Science of the Total Environment, 2022
- DOI för Genomically diverse carbapenem resistant Enterobacteriaceae fromwild birds provide insight into global patterns of spatiotemporal dissemination
- Ladda ner fulltext (pdf) av Genomically diverse carbapenem resistant Enterobacteriaceae fromwild birds provide insight into global patterns of spatiotemporal dissemination
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Modular 3D-Printed Peg Biofilm Device for Flexible Setup of Surface-Related Biofilm Studies
Ingår i Frontiers in Cellular and Infection Microbiology, 2022
- DOI för Modular 3D-Printed Peg Biofilm Device for Flexible Setup of Surface-Related Biofilm Studies
- Ladda ner fulltext (pdf) av Modular 3D-Printed Peg Biofilm Device for Flexible Setup of Surface-Related Biofilm Studies
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Ingår i Scientific Reports, 2022
- DOI för A simple cut and stretch assay to detect antimicrobial resistance genes on bacterial plasmids by single-molecule fluorescence microscopy
- Ladda ner fulltext (pdf) av A simple cut and stretch assay to detect antimicrobial resistance genes on bacterial plasmids by single-molecule fluorescence microscopy
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A Parallelized Nanofluidic Device for High-Throughput Optical DNA Mapping of Bacterial Plasmids
Ingår i Micromachines, 2021
- DOI för A Parallelized Nanofluidic Device for High-Throughput Optical DNA Mapping of Bacterial Plasmids
- Ladda ner fulltext (pdf) av A Parallelized Nanofluidic Device for High-Throughput Optical DNA Mapping of Bacterial Plasmids
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Ingår i PLOS ONE, 2021
- DOI för Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach
- Ladda ner fulltext (pdf) av Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach
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Ingår i Antimicrobial Agents and Chemotherapy, 2021
-
Cultivation-Free Typing of Bacteria Using Optical DNA Mapping
Ingår i ACS - Infectious Diseases, s. 1076-1084, 2020
- DOI för Cultivation-Free Typing of Bacteria Using Optical DNA Mapping
- Ladda ner fulltext (pdf) av Cultivation-Free Typing of Bacteria Using Optical DNA Mapping
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Ingår i Antimicrobial Agents and Chemotherapy, 2020
- DOI för Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments
- Ladda ner fulltext (pdf) av Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments
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Low sub-minimal inhibitory concentrations of antibiotics generate new types of resistance
Ingår i Sustainable Chemistry and Pharmacy, s. 46-48, 2019
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Ingår i Scientific Reports, 2019
- DOI för Genome and plasmid diversity of Extended-Spectrum beta-Lactamase-producing Escherichia coli ST131-tracking phylogenetic trajectories with Bayesian inference
- Ladda ner fulltext (pdf) av Genome and plasmid diversity of Extended-Spectrum beta-Lactamase-producing Escherichia coli ST131-tracking phylogenetic trajectories with Bayesian inference
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Ingår i mBio, 2019
- DOI för Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak
- Ladda ner fulltext (pdf) av Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak
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Ingår i Antimicrobial Agents and Chemotherapy, 2019
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Ingår i Environmental Microbiology Reports, s. 576-582, 2018
- DOI för Long-term carriage and rapid transmission of extended spectrum beta-lactamase-producing E. coli within a flock of Mallards in the absence of antibiotic selection
- Ladda ner fulltext (pdf) av Long-term carriage and rapid transmission of extended spectrum beta-lactamase-producing E. coli within a flock of Mallards in the absence of antibiotic selection
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Ingår i PLOS ONE, 2018
- DOI för Facilitated sequence assembly using densely labeled optical DNA barcodes: A combinatorial auction approach
- Ladda ner fulltext (pdf) av Facilitated sequence assembly using densely labeled optical DNA barcodes: A combinatorial auction approach
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Ingår i PLOS ONE, 2017
- DOI för A bla(OXA-181)-harbouring multi-resistant ST147 Klebsiella pneumoniae isolate from Pakistan that represent an intermediate stage towards pan-drug resistance
- Ladda ner fulltext (pdf) av A bla(OXA-181)-harbouring multi-resistant ST147 Klebsiella pneumoniae isolate from Pakistan that represent an intermediate stage towards pan-drug resistance
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Ingår i Journal of Antimicrobial Chemotherapy, s. 1188-1198, 2016
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Ingår i Scientific Reports, 2016
- DOI för Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules
- Ladda ner fulltext (pdf) av Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules
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Ingår i Scientific Reports, 2016
- DOI för Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping
- Ladda ner fulltext (pdf) av Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping
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Ingår i Journal of Antimicrobial Chemotherapy, s. 2521-2533, 2016
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Fitness of Escherichia coli mutants with reduced susceptibility to tigecycline
Ingår i Journal of Antimicrobial Chemotherapy, s. 1307-1313, 2016
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Potential of tetracycline resistance proteins to evolve tigecycline resistance
Ingår i Antimicrobial Agents and Chemotherapy, s. 789-796, 2016
- DOI för Potential of tetracycline resistance proteins to evolve tigecycline resistance
- Ladda ner fulltext (pdf) av Potential of tetracycline resistance proteins to evolve tigecycline resistance
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Fast size-determination of intact bacterial plasmids using nanofluidic channels
Ingår i Lab on a Chip, s. 2739-2743, 2015
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Ingår i Molecular biology and evolution, s. 1526-1535, 2014
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Selection of Orphan Rhs Toxin Expression in Evolved Salmonella enterica Serovar Typhimurium
Ingår i PLOS Genetics, 2014
- DOI för Selection of Orphan Rhs Toxin Expression in Evolved Salmonella enterica Serovar Typhimurium
- Ladda ner fulltext (pdf) av Selection of Orphan Rhs Toxin Expression in Evolved Salmonella enterica Serovar Typhimurium
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Ingår i Microbial Drug Resistance, s. 466-471, 2014
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Silver resistance genes are overrepresented among Escherichia coli isolates with CTX-M production
Ingår i Applied and Environmental Microbiology, s. 6863-6869, 2014
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Selection of a multidrug resistance plasmid by sublethal levels of antibiotics and heavy metals
Ingår i mBio, 2014
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Ingår i Lab on a Chip, s. 3409-3418, 2014
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Pathoadaptive Mutations in Salmonella enterica Isolated after Serial Passage in Mice
Ingår i PLOS ONE, 2013
- DOI för Pathoadaptive Mutations in Salmonella enterica Isolated after Serial Passage in Mice
- Ladda ner fulltext (pdf) av Pathoadaptive Mutations in Salmonella enterica Isolated after Serial Passage in Mice
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Ingår i PLOS ONE, 2013
- DOI för Plasmidome-Analysis of ESBL-Producing Escherichia coli Using Conventional Typing and High-Throughput Sequencing
- Ladda ner fulltext (pdf) av Plasmidome-Analysis of ESBL-Producing Escherichia coli Using Conventional Typing and High-Throughput Sequencing
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Ingår i Journal of Antimicrobial Chemotherapy, s. 51-59, 2013
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Ingår i Journal of Antimicrobial Chemotherapy, s. 1319-1326, 2013
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Mechanisms and fitness costs of tigecycline resistance in Escherichia coli
Ingår i Journal of Antimicrobial Chemotherapy, s. 2809-2819, 2013
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Ingår i Journal of Antimicrobial Chemotherapy, s. 74-83, 2012
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Antimicrobial Drug-Resistant Escherichia coli in Wild Birds and Free-range Poultry, Bangladesh
Ingår i Emerging Infectious Diseases, s. 2055-2058, 2012
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Selection of Resistant Bacteria at Very Low Antibiotic Concentrations
Ingår i PLoS pathogens, 2011
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Ingår i PLoS ONE, 2011
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Ingår i Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), s. 302-8, 2008
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Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli
Ingår i Journal of Antimicrobial Chemotherapy, s. 495-503, 2008
Artiklar, forskningsöversikt
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Characterization of ESBL disseminating plasmids
Ingår i INFECTIOUS DISEASES, s. 18-25, 2016
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Selection of antibiotic resistance at very low antibiotic concentrations
Ingår i Upsala Journal of Medical Sciences, s. 103-107, 2014
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Bacterial gene amplification: implications for the evolution of antibiotic resistance
Ingår i Nature Reviews Microbiology, s. 578-588, 2009
Konferensbidrag
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Circle to circle amplification for detection of antibiotic resistance genes
Ingår i Uppsala Antibiotic Days: a multidisciplinary conference, s. 37, 2022
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A microfluidic approach for dynamic investigation of the antibiotic susceptibility of bacteria
Ingår i MME 2013 24th Micromechanics and Microsystems Europe Conference, 2013