Malin Gingnell
Universitetslektor vid Institutionen för psykologi; Avdelningen för Emotionspsykologi
- Telefon:
- 018-471 21 56
- E-post:
- Malin.Gingnell@psyk.uu.se
- Besöksadress:
- Von Kraemers allé 1A och 1C
752 37 Uppsala - Postadress:
- Box 1225
751 42 UPPSALA
Forskare vid Institutionen för medicinska vetenskaper; Psykiatri
- E-post:
- malin.gingnell@neuro.uu.se
- Besöksadress:
- Akademiska sjukhuset, ingång 10
- Postadress:
- Akademiska sjukhuset, ingång 10, plan
751 85 UPPSALA
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Forskning
Experimental Cognitive and Affective Neuroscience –Lab
ECAN
With a background in neuroimaging, one foot in psychology and the other in medicine, the research within our group focuses on various aspects of neural processing in relation to affective stimuli as well as during cognitive tasks, both in one individual at a time and simultaneously during social interaction. This involves both studying healthy participants and clinical cohorts, in the lab or in more natural settings, as well as performing various treatment studies. Our methods include fMRI, PET, EEG, fNIRS and psychophysiological measurements.
The interplay between emotions and ovarian steroid hormones has been in particular focus, such as how the changes in sex hormone levels during puberty interacts with levels of anxiety.
In addition to this, we look at how profound changes in physiology (such as during hypoglycemia or after a sudden decrease in blood flow), as well as more subtle manipulations (such as the intake of caffeine) affect affective symptoms and brain function. Another research trajectory includes the mechanisms underlying treatment effects, both regarding pharmaceutical treatments such as SSRI, but also applying brain stimulating techniques such as ECT and TMS as well as therapeutic interventions such as CBT. In relation to the later, we do in-depth studies of especially the learning process during extinction, using conditioning as a proxy for mechanisms activated during exposure therapy or fear learning. We also conducted studies that explore the mechanisms behind the placebo effect, both in more general terms and in relation to affective disorders and the neurobiological features of curiosity and grief.
Data collection is performed in collaboration with several research groups at Uppsala University as well as together with international groups. As an example, the group is part of RE-MEND and UPIC and collaborates with the research centers WOMHER, CIRCUS and CMH. The team members also coordinate activity in anxiety - an interdisciplinary research network.
Lab leaders:
Malin Gingnell & Andreas Frick
Post docs:
Lykke Silfverbrand
PhD-students:
Magdalena Wlad
Ebba Widegren
Ashika Roy
Patricia Gil Paterna
Barry Karlsson
Carolina Knihs de Camargo
Carl Brandt
Sara Chergia
Kristina Stenström
Lab manager:
Hampus Berg
Lab assistants:
Vanessa Messinger
Felicia Pohl
Previously associated:
Matilda Frick, post doc (now at Stockholm University, Sweden)
Wiebke Struckmann, PhD (now at Stanford, USA)
Publikationer
Senaste publikationer
- A Japanese translation of the Swedish Universities Scales of Personality (2024)
- Directed causal effect with PCMCI in hyperscanning EEG time series (2024)
- Allopregnanolone and progesterone in relation to a single electroconvulsive therapy seizure and subsequent clinical outcome (2024)
- The influence of anterior cingulate GABA+ and glutamate on emotion regulation and reactivity in adolescents and adults (2024)
- Blinding integrity of dorsomedial prefrontal intermittent theta burst stimulation in depression (2023)
Alla publikationer
Artiklar
- A Japanese translation of the Swedish Universities Scales of Personality (2024)
- Directed causal effect with PCMCI in hyperscanning EEG time series (2024)
- Allopregnanolone and progesterone in relation to a single electroconvulsive therapy seizure and subsequent clinical outcome (2024)
- The influence of anterior cingulate GABA+ and glutamate on emotion regulation and reactivity in adolescents and adults (2024)
- Blinding integrity of dorsomedial prefrontal intermittent theta burst stimulation in depression (2023)
- Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents (2023)
- Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial (2023)
- Intercorrelation of physiological seizure parameters and hormonal changes in electroconvulsive therapy (2023)
- Dorsal anterior cingulate cortex activity during cognitive challenge in social anxiety disorder (2023)
- Serotonin and dopamine transporter availability in social anxiety disorder after combined treatment with escitalopram and cognitive-behavioral therapy (2022)
- Internet-delivered approach-avoidance conflict task shows temporal stability and relation to trait anxiety (2022)
- An fMRI-study of leading and following using rhythmic tapping (2022)
- Modulation of dorsolateral prefrontal cortex functional connectivity after intermittent theta-burst stimulation in depression (2022)
- Effects of Gastric Bypass Surgery on the Brain (2021)
- Expectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder (2021)
- Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder (2021)
- Gray matter increases within subregions of the hippocampal complex after pregnancy (2021)
- Significant increases of the amygdala between immediate and late postpartum (2021)
- Postpartum Gray Matter Changes in the Auditory Cortex (2021)
- Inhibitory and excitatory neurotransmitter systems in depressed and healthy (2021)
- Unchanged cognitive performance and concurrent prefrontal blood oxygenation after accelerated intermittent theta-burst stimulation in depression (2021)
- Modulation of the prefrontal blood oxygenation response to intermittent theta-burst stimulation in depression (2021)
- Autonomic modulation networks in schizophrenia (2020)
- Higher- and lower-order personality traits and cluster subtypes in social anxiety disorder (2020)
- Neuroimaging, genetic, clinical, and demographic predictors of treatment response in patients with social anxiety disorder (2020)
- From baby brain to mommy brain (2020)
- Intermittent theta burst stimulation over the dorsomedial prefrontal cortex modulates resting-state connectivity in depressive patients (2020)
- Transcranial magnetic intermittent theta-burst stimulation for depression in pregnancy - A case series (2020)
- Hormonal Cycle and Contraceptive Effects on Amygdala and Salience Resting-State Networks in Women with Previous Affective Side Effects on the Pill. (2018)
- Anterior cingulate cortex activity as a candidate biomarker for treatment selection in social anxiety disorder (2018)
- Potential Brain Age Reversal after Pregnancy (2018)
- Different patterns of attentional bias in antenatal and postpartum depression (2017)
- Do You Believe It? Verbal Suggestions Influence the Clinical and Neural Effects of Escitalopram in Social Anxiety Disorder (2017)
- Emotional anticipation after delivery - a longitudinal neuroimaging study of the postpartum period (2017)
- Within-session effect of repeated stress exposure on extinction circuitry function in social anxiety disorder (2017)
- The effect of combined hormonal contraceptives use on brain reactivity during response inhibition (2016)
- Combining escitalopram and cognitive-behavioural therapy for social anxiety disorder (2016)
- Amygdala Resting State Functional Connectivity is Affected by Oral Contraceptives and Menstrual Cycle Phase (2015)
- Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women (2015)
- Personality and risk for postpartum depressive symptoms (2015)
- Emotional fronto-cingulate cortex activation and brain derived neurotrophic factor polymorphism in premenstrual dysphoric disorder (2014)
- Enlargement of visual processing regions in social anxiety disorder is related to symptom severity (2014)
- Predicting Outcome of Combined CBT and SSRI Treatment for Social Anxiety Disorder Using a Machine Learning Approach (2014)
- Classifying social anxiety disorder using multivoxel pattern analyses of brain function and structure (2014)
- Social stimulation and corticolimbic reactivity in premenstrual dysphoric disorder (2014)
- Classifying Social Anxiety Disorder Using Multivoxel Pattern Analyses of Brain Function and Structure (2014)
- Menstrual cycle influence on cognitive function and emotion processing-from a reproductive perspective (2014)
- Emotional and cognitive functional imaging of estrogen and progesterone effects in the female human brain (2014)
- Symptom Improvement in Social Anxiety Disorder is Associated with Reduced Amygdala Reactivity to Emotional Faces (2013)
- Prefrontal activity during response inhibition decreases over time in the postpartum period (2013)
- Altered Amygdala but not Default Mode Network Functional Connectivity in Social Anxiety Disorder (2013)
- Regional Gray Matter Volume of the Lingual Gyrus is Related to Symptom Severity in Patients with Social Anxiety Disorder (2013)
- Premenstrual dysphoric disorder and prefrontal reactivity during anticipation of emotional stimuli (2013)
- Trait Anxiety Affects Amygdala Reactivity in the Follicular Phase for Women with Previous Emotional Side Effcts of Oral Contraceptices (2013)
- Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill (2013)
- The effect of premenstrual dysphoric disorder and menstrual cycle phase on brain activity during response inhibition (2012)
- Acute Sleep Deprivation Enhances the Brain's Response to Hedonic Food Stimuli (2012)
- Menstrual cycle effects on amygdala reactivity to emotional stimulation in premenstrual dysphoric disorder (2012)
- Patients with polycystic ovary syndrome have lower levels of IgM anti-phosphorylcholine antibodies than healthy women (2011)
- Neuroticism-related personality traits are related to symptom severity in patients with premenstrual dysphoric disorder and to the serotonin transporter gene-linked polymorphism 5-HTTPLPR (2010)
- Habituation of regional cerebral blood flow to repeated symptom provocation in individuals with generalized and non-generalized social phobia. (2009)
- Changes in serotonin and dopamine transporter availability after combined treatment with escitalopram and cognitive-behavioral therapy in patients with social anxiety disorder
- Response expectancies shape the effect of SSRI treatment on serotonin and dopamine transporters in patients with social anxiety disorder
- Directed causal networks for leading and following in hyperscanning EEG
Böcker
Konferenser
- Amygdala and Default Mode Network Resting-State Functional Connectivity in Social Anxiety Disorder (2014)
- Predicting Outcome of Combined CBT and SSRI Treatment for Social Anxiety Disorder Using a Machine Learning Approach (2014)
- Classifying social anxiety disorder using multivoxel pattern analyses of brain function and structure (2014)