Per Jemth

Kort presentation

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Nyckelord

• biophysics
• hpv
• human papillomavirus
• intrinsically disordered proteins
• kinetics
• molecular evolution
• protein
• protein folding
• protein-ligand interactions

Publikationer

Senaste publikationer

• Gustavson syndrome is caused by an in-frame deletion in RBMX associated with potentially disturbed SH3 domain interactions (2024)
• Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes (2024)
• Folded Alpha Helical Putative New Proteins from Apilactobacillus kunkeei (2024)
• Rescue of Escherichia coli auxotrophy by de novo small proteins (2023)
• Allostery Frustrates the Experimentalist (2023)

Alla publikationer

Artiklar

• Gustavson syndrome is caused by an in-frame deletion in RBMX associated with potentially disturbed SH3 domain interactions (2024)
• Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes (2024)
• Folded Alpha Helical Putative New Proteins from Apilactobacillus kunkeei (2024)
• Rescue of Escherichia coli auxotrophy by de novo small proteins (2023)
• Allostery Frustrates the Experimentalist (2023)
• Intrinsically Disordered Flanking Regions Increase the Affinity of a Transcriptional Coactivator Interaction across Vertebrates (2023)
• Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions (2023)
• Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets (2023)
• Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs (2023)
• Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif-mediated interactions (2023)
• Proteome-scale mapping of binding sites in the unstructured regions of the human proteome (2022)
• Disordered Regions Flanking the Binding Interface Modulate Affinity between CBP and NCOA (2022)
• The dynamic properties of a nuclear coactivator binding domain are evolutionarily conserved (2022)
• Determinants of affinity, specificity, and phase separation in a supramodule from Post-synaptic density protein 95 (2022)
• A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses (2022)
• Monoclonal antibodies binding data for SARS-CoV-2 proteins (2022)
• Development of Monoclonal Antibodies to Detect for SARS-CoV-2 Proteins (2022)
• Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly (2021)
• CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells (2021)
• Molecular Details of a Coupled Binding and Folding Reaction between the Amyloid Precursor Protein and a Folded Domain (2021)
• Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities (2021)
• Dissecting Inter-domain Cooperativity in the Folding of a Multi Domain Protein (2021)
• Divergent evolution of a protein-protein interaction revealed through ancestral sequence reconstruction and resurrection (2021)
• Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery (2021)
• An Early Association between the α-Helix of the TEAD Binding Domain of YAP and TEAD Drives the Formation of the YAP:TEAD Complex (2020)
• Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring (2020)
• High affinity between CREBBP/p300 and NCOA evolved in vertebrates (2020)
• Mapping the transition state for a binding reaction between ancient intrinsically disordered proteins (2020)
• Functional interplay between protein domains in a supramodular structure involving the postsynaptic density protein PSD-95 (2020)
• Supertertiary protein structure affects an allosteric network (2020)
• Templated folding of intrinsically disordered proteins (2020)
• Affinity versus specificity in coupled binding and folding reactions (2019)
• Editorial overview (2019)
• Affinity and specificity of motif-based protein-protein interactions (2019)
• A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins (2019)
• Coupled Binding and Helix Formation Monitored by Synchrotron-Radiation Circular Dichroism (2019)
• Seeking allosteric networks in PDZ domains (2018)
• Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins (2018)
• Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations (2018)
• Binding Kinetics of the Intrinsically Disordered p53 Family Transactivation Domains and MDM2 (2018)
• Addressing the role of the alpha-helical extension in the folding of the third PDZ domain from PSD-95 (2017)
• How Fast Is Protein-Ligand Association? (2017)
• Emergence and evolution of an interaction between intrinsically disordered proteins (2017)
• The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A (2017)
• Understanding the role of phosphorylation in the binding mechanism of a PDZ domain (2017)
• Evolution of the p53-MDM2 pathway (2017)
• Activation Barrier-Limited Folding and Conformational Sampling of a Dynamic Protein Domain (2016)
• Coupled binding and folding of intrinsically disordered proteins (2016)
• Protein folding (2016)
• Improved affinity at the cost of decreased specificity (2016)
• Ligand binding to the PDZ domains of postsynaptic density protein 95 (2016)
• Binding Rate Constants Reveal Distinct Features of Disordered Protein Domains (2015)
• Rigidified Clicked Dimeric Ligands for Studying the Dynamics of the PDZ1-2 Supramodule of PSD-95 (2015)
• Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus (2015)
• Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation (2015)
• Targeting Protein-Protein Interactions with Trimeric Ligands (2015)
• The binding mechanisms of intrinsically disordered proteins (2014)
• Only kinetics can prove conformational selection (2014)
• Nonequilibrium Capture Rates Induce Protein Accumulation and Enhanced Adsorption to Solid-State Nanopores (2014)
• Deciphering the mechanisms of binding induced folding at nearly atomic resolution (2014)
• Distinguishing induced fit from conformational selection (2014)
• Conserved nucleation sites reinforce the significance of phi analysis in proteinfolding studies (2014)
• Helical Propensity in an Intrinsically Disordered Protein Accelerates Ligand Binding (2014)
• A Frustrated Binding Interface for Intrinsically Disordered Proteins (2014)
• Thermodynamic Aspects of cAMP Dependent Protein Kinase Catalytic Subunit Allostery (2014)
• The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain (2014)
• Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations (2014)
• The transition state structure for coupled binding and folding of disordered protein domains (2013)
• Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations (2013)
• Single molecule unfolding and stretching of protein domains inside a solid-state nanopore by electric field (2013)
• Energetic pathway sampling in a protein interaction domain (2013)
• Single-Molecule Studies of Intrinsically Disordered Proteins Using Solid-State Nanopores (2013)
• Kinetics of Acrylodan-Labelled cAMP-Dependent Protein Kinase Catalytic Subunit Denaturation (2013)
• A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage (2012)
• Ligand binding by PDZ domains (2012)
• Interactions outside the boundaries of the canonical binding groove of a pdz domain influence ligand binding (2012)
• Fast Association and Slow Transitions in the Interaction between Two Intrinsically Disordered Protein Domains (2012)
• Characterization of the endopeptidase activity of tripeptidyl-peptidase II (2012)
• Folding pathways of proteins with increasing degree of sequence identities but different structure and function (2012)
• Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains (2012)
• An expanded view of the protein folding landscape of PDZ domains (2012)
• Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain (2012)
• The Transition State of Coupled Folding and Binding for a Flexible beta-Finger (2012)
• Biophysical Characterization of the Complex between Human Papillomavirus E6 Protein and Synapse-associated Protein 97 (2011)
• Chemical, Thermal, and Electric Field Induced Unfolding of Single Protein Molecules Studied Using Nanopores (2011)
• Sequence-specific Long Range networks in PSD-95/Discs Large/ZO-1 (PDZ) Domains Tune Their Binding Selectivity (2011)
• Deciphering the kinetic binding mechanism of dimeric ligands, using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example (2010)
• Structural and functional characterization of CcmG from Pseudomonas aeruginosa, a key component of the bacterial cytochrome c maturation apparatus (2010)
• The plastic energy landscape of protein folding (2010)
• Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction (2009)
• A sequential binding mechanism in a PDZ domain (2009)
• Distinguishing between smooth and rough free energy barriers in protein folding (2009)
• Investigating the structural plasticity of a cytochrome P450 (2009)
• Folding and stability of globular proteins and implications for function (2009)
• Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. (2008)
• Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins (2008)
• Reassessing a sparse energetic network within a single protein domain (2008)
• Demonstration by burst-phase analysis of a robust folding intermediate in the FF domain (2008)
• A conserved folding mechanism for PDZ domains (2007)
• A PDZ domain recapitulates a unifying mechanism for protein folding (2007)
• Identification and characterization of protein folding intermediates (2007)
• An on-pathway intermediate in the folding of a PDZ domain (2007)
• PDZ domains (2007)
• Two conserved residues govern the salt and pH dependencies of the binding reaction of a PDZ domain (2006)
• Demonstration of long-range interactions in a PDZ domain by NMR, kinetics, and protein engineering (2006)
• Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1 alpha interactions (2006)
• The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism (2005)
• The structure of the major transition state for folding of an FF domain from experiment and simulation. (2005)
• Fibroblast growth factors share binding sites in heparan sulphate. (2005)
• Simulation and experiment conspire to reveal cryptic intermediates and a slide from the nucleation-condensation to framework mechanism of folding. (2005)
• Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation. (2004)
• Processing of macromolecular heparin by heparanase (2003)
• Oligosaccharide library-based assessment of heparan sulfate6-O-sulfotransferase substrate specificity. (2003)
• Oligosaccharide Library-based Assessment of Heparan Sulfate 6-O-Sulfotransferase Substrate Specificity (2003)
• An ensemble of Theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes (2002)
• Biosynthetic oligosaccharide libraries for identification of protein-binding heparan sulfate motifs (2002)
• A semisyntetic glutathione peroxidase with high catalytic efficiency: Selenoglutathione transferase (2002)
• Role of the glutamyl alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione transferase A1-1 (2001)
• The active-site residue Tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives (2000)
• Conformational change and non-canonical interactions in the complex between human papillomavirus E6 protein and Synapse-Associated Protein 97
• Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions
• Low-density lipoprotein receptor-related protein (LRP)-2/megalin plays a role as a receptor for retinol-binding protein on retina pigment epithelial cells of the eye.
• Dissecting inter-domain cooperativity in the folding of amulti domain protein
• Loss-of-affinity mutations and new interaction motifs underlie a dynamic evolution of the p53/MDM2 interaction in teleosts
• Analysis of AtZDP substrate specificity
• The 3'-DNA phosphatase AtZDP is present in a high molecular weight protein complex, able to repair gapped DNA with a 3' phosphate group
• Evolution of binding affinity between p53 and MDM2 across the animal kingdom

Kapitel

• Nitrocellulose filter binding to assess binding of glycosaminoglycans to proteins (2003)