Molecular Recognition in Biological Systems

15 credits

Course, Master's level, 1KB425

Spring 2024 Spring 2024, Uppsala, 100%, On-campus, English

Spring 2024 Spring 2024, Uppsala, 100%, On-campus, English For exchange students

Spring 2025 Spring 2025, Uppsala, 100%, On-campus, English

Spring 2025 Spring 2025, Uppsala, 100%, On-campus, English For exchange students

About the course

  • Molecular interaction mechanisms and forces between molecules: selectivity, affinity, kinetics and thermodynamics. The effect of the environment on interactions
  • Structure and dynamics of biomacromolecules and their complexes: selectivity, multivalency, avidity. Various types of biomolecular interactions: protein-ligand, protein-protein, DNA-protein, RNA-protein. Inhibition of interactions
  • Applications: design of ligands, modification of proteins and nucleic acids to alter their interactions with other macromolecules or ligands
  • Biological, biochemical and biophysical methods for the identification and characterisation of molecular interactions
  • Modelling of interactions by molecular graphics and structural information
  • Examples of how biological systems can be described in terms of the molecular interactions involved
  • Application of molecular interaction analysis in life science research, drug discovery and diagnostics

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