Entry requirements

Chemical Reactions, 10 credits or Organic Chemistry, 5 credits or equivalent.

Learning outcomes

After the course, the student should be able to

• describe stereochemical problems in relation to chemical transformations
• describe synthetically the processes relevant organic-chemical reactions and be able to discuss the mechanism of these reactions
• correlate the chemical structure of biomolecules to reactivity: Functional groups, acid-base properties, Biochemical as well as synthetic routes
• discuss similarities and differences between transformations of biomolecules in living systems (aquatic environment) and in vitro, e.g. industrial synthesis
• describe how some course concepts are applied within the biomolecular - and pharmaceutical fields
• give examples of how chemical properties and reactivity can influence environmental and economical descicions
• plan and carry out fundamental organic transformations of significance for organic synthes, carry out simpler risk assessment, in-session laboratory documentation and oral/written presentation of the contents and results of laboratory sessions.

Content

Organic-chemical reactions of industrially and biochemically relevant compound classes: Arenes, esters, alcohols, aldols, carbohydrates, lipids, amino acids, peptides and nucleic acids. Reaction mechanisms to build/degrade carbon compounds. Examples for common reagent within synthetic chemistry (oxidation, reduction, Lewis acids and Lewis bases, Grignard reagents, organolithium reagents). Mechanisms for catalytic reactions: acid-base catalysis, enzymatic catalysis, metal catalysis (also in biological systems). Organic-chemical reactions in water. Comparison between synthesis in biological systems and industrial synthesis. Overview of spectroscopic methods in organic chemistry (UV, IR, MS, NMR).

Instruction

Lectures, problem solving sessions and laboratory work.

Assessment

Written examinations are organised at the end of the course and/or during the course and corresponds to 3 credits. The laboratory sessions correspond 2 credits. To pass final grades it is required that all parts have been assessed passed. The final grade is based on a joining of the results of the written examination and the laboratory sessions