Entry requirements

120 credits with 60 credits in Chemistry including Organic Chemistry I, 10 credits or Physical Chemistry, 10 credits or equivalent.

Learning outcomes

After successful completion of the course, the participant should have the ability to:

• use spectroscopic equipment such as MS, IR, NMR spectrometers.
• identify organic compounds by analysis and interpretation of spectral data.
• explain common terms in NMR spectroscopy such as chemical shift, coupling constant, and anisotropy and describe how they are affected by molecular structure
• analyse and interpret 1D and 2D NMR spectra.
• the ability to investigate and determine the structure of typical organic chemical compounds (molecular weight up to ca. 500 Da) using suitable nuclear magnetic resonance experiments
• perform the most commonly used NMR experiments, and to interpret and document their results

Content

Spectroscopic methods for structure analysis such as mass spectrometry, nuclear magnetic resonance spectroscopy, infrared spectroscopy, and ultraviolet spectroscopy. Fundamentals of the NMR phenomenon, relationship between NMR spectra and molecular structure. Recording of routine spectra (1H and 13C), esssentials of data processing (e.g., weighting functions). 1D NMR techniques: Decoupling, DEPT, relaxation measurement, magnetisation transfer, NOE difference spectra. 2D NMRtechniques: Homo- and heteronuclear correlation (COSY, TOCSY, HSQC, HMBC), measurement of the nuclear Overhauser effect (NOESY, ROESY). Emphasis is on learning the practical use of NMR equipment

Instruction

Lectures, seminars, and laboratory work. Exercises in oral and written presentation. Laboratory work and related presentations are mandatory.

Assessment

Written examination is arranged at the end of the course. The laboratory work must also

be passed. The written examination corresponds to 3 HE credits. The laboratory exercises

including written and oral presentations are valued as 4.5 HE credits.