Entry requirements

NMR Spectroscopy I, 5 credits or Organic Chemistry II, 15 credits including practical use of NMR equipment.

Learning outcomes

After successful completion of the course, the participant should have the ability to:

• describe the basic function of some common pulse sequences
• optimise the key parameters in these pulse sequences and be able to perform simple parameter calibrations
• quantify the composition of mixtures
• independently plan and carry out structural determination of more complex organic compounds (molecular weight up to approx. 500 Da) using appropriate NMR experiments efficiently
• discuss the impact of dynamics in organic and organometallic compounds on their NMR spectra
• plan and implement experiments relevant for the course, interpret and document their results

Content

The vector model and its relation to pulse sequences. Function of pulse sequences. Parameter calibration and optimisation. Structural determination of a series of organic molecules of increasing complexity. Spectra of organometallic compounds, fluxionality. Molecular interaction and its effect on NMR spectra.

Instruction

Tutorials and laboratory exercises. Laboratory work and related tutorials and presentations are compulsory.

Assessment

Written examination at the end of the course, laboratory exercises and related written reports and oral presentations. The examination and oral presentations are equivalent to 2 credits. The laboratory exercises and related reports are equivalent to 3 credits.