Research at Department of Pharmaceutical Biosciences

Development of Future Medicines

Our research encompasses everything from fundamental questions about how drugs affect the living cell and how they are metabolized in the body, to the search for new models to describe drug effects. The overarching goal of the institution's research groups is to improve understanding of drug uptake, pharmacokinetics, metabolism, effects, and side effects.

We place great emphasis on collaboration with the surrounding community, and research projects are often conducted in close collaboration with national and international laboratories and pharmaceutical industries. Research collaboration with the international pharmaceutical industry and other parts of the healthcare sector ensures high quality. We also have extensive doctoral education within the various research groups.

Research groups

Anders Backlund	Pharmacognosy
Björn Hellman	Toxicology
Christian Benedict	Pharmacology Sleep Research
Erik Jansson	Medical Mass Spectrometry
Göran Alderborn	Läkemedelsteknik
Göran Frenning	Pharmaceutical Physics
Hans Lennernäs	Translational Drug Discovery and Development
Johan Lennartsson	Pharmaceutical Cell Biology & Biotechnology
Maria Norlin	Steroid biochemistry
Mathias Hallberg	Biological research on drug dependence
Ola Spjuth	Pharmaceutical Bioinformatics
Ola Söderberg	Pharmaceutical Cell Biology & Biotechnology
Per Andrén	Medical Mass Spectrometry
Robert Fredriksson	Molecular Neuropharmacology
Ulf Göransson	Pharmacognosy
Ulrika Simonsson	Translational Drug Discovery and Development

Research areas

Björn Hellman	Drug Safety & Toxicology
Göran Alderborn	Pharmaceutical Technology
Göran Frenning	Pharmaceutical Physics
Hans Lennernäs	Biopharmaceutics
Mathias Hallberg	Neuropharmacology and Biological Addiction Research
Ola Spjuth	Pharmaceutical Bioinformatics
Ola Söderberg	Pharmaceutical cellbiology
Per Andrén	Spatial Mass Spectrometry
Robert Fredriksson	Pharmacology
Ulf Göransson	Pharmacognosy

Our contributors

AbbVie Inc

Akademiska sjukhuset

Astra Zeneca

Barncancerfonden

Bergvalls stiftelse

Cancerfonden

Dicot AB

EU-komm, Horizon (H2020)

EU-komm, Horizon Europe

EU-komm, övriga EU-medel

Faciasstiftelsen

FORMAS

Galderma

Gc Biopharma

Gustavianska stiftelsen (RF)

Hiertas Minne

Hjärnfonden

Kammarkollegiet

Karolinska institutet

Kjell och Märta Beijers Stift.

Kungliga tekniska högskolan

NovoNordiskfonden

Sagens stiftelse

SIDA-Styr.f.intern.utv.samarb

Socialstyrelsen

Stift för strategisk forskn

STINT

Svenska spel AB

Sveriges lantbruksuniversitet

Umeå universitet

Uppsala Akademiförvaltning

Vetenskapsrådet

VINNOVA

Åhlénstiftelsen

Åke Wibergs stiftelse

Publications

Aktuella publikationer

Data management of scientific applications in a reinforcement learning-based hierarchical storage system
Zhang, Tianru; Gupta, Ankit; Francisco Rodríguez, María Andreína et al., 2024
Evaluation of 6 years of eHealth data in the alcohol use disorder field indicates improved efficacy of care
Wallden, Mats; Dahlberg, Gunnar; Månflod, Johan et al., 2024
Obstructive sleep apnea during rapid eye movement sleep and cognitive performance in adults
Tan, Xiao; Ljunggren, Mirjam; Kilander, Lena et al., 2024
Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar et al., 2024
Estimation bias and agreement limits between two common self-report methods of habitual sleep duration in epidemiological surveys.
Korman, Maria; Zarina, Daria; Tkachev, Vadim et al., 2024
Coiled-coil scallops (Chlamys farreri) peptide hydrogel with metal ionic and temperature tunable assembly
Wu, Di; Wu, Chao; Ma, Wuchao et al., 2024
Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa
Kosgahakumbura, Lakmini; Gamage, Jayani; Robertson, Luke et al., 2024
Ulva lactuca polysaccharide inhibits hepatocellular carcinoma growth by induces the expression of CD5L and activates complement cascade
Xu, Jingxiang; Liao, Wei; Yang, Shuxin et al., 2024
Pharmacometric models to inform dose selection and study design: Applied in hemophilia and tuberculosis
Faraj, Alan, 2024
Nightmare frequency is a risk factor for suicidal ideation during the COVID-19 pandemic.
Bolstad, Courtney J; Holzinger, Brigitte; Scarpelli, Serena et al., 2024
Serum metallomics reveals insights into the associations of elements with the progression of preleukemic diseases toward acute leukemia
Siddiqui, Amna Jabbar; Khan, Noman; Fatima, Kauser et al., 2024
Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy
Hu, Yang; Girdenyte, Milda; Roest, Lieke et al., 2024
Integrative Approaches in Shotgun Proteomics: From sample preparation to multifaceted data analysis
Nezhyva, Mariya, 2024
Inquiry-based Learning of Proteomics and Metabolomics
Nezhyva, Mariya; Aerts, Jordan; Sandbaumhüter, Friederike A. et al., 2024
Single-particle fabric tensors for assemblies of spherical particles
Frenning, Göran, 2024
Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation
Engen, Karin; Lundbäck, Thomas; Yadav, Anubha et al., 2024
Subcutaneous Marzeptacog Alfa (Activated) for On‐Demand Treatment of Bleeding Events in Subjects With Hemophilia A or B With Inhibitors
Faraj, Alan; Nyberg, Joakim; Blouse, Grant E. et al., 2024
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
Selvin, Tove; Berglund, Malin; Lenhammar, Lena et al., 2024
From caves to seamounts: the hidden diversity of tetractinellid sponges from the Balearic Islands, with the description of eight new species
Díaz, Julio A.; Ordines, Francesc; Massutí, Enric et al., 2024
Risk Factors for COVID-19 and Respiratory Tract Infections during the Coronavirus Pandemic
Mockeliunas, Laurynas; Van Wijk, Rob C; Upton, Caryn M. et al., 2024
Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes
Al-Sabri, Mohamed H.; Ammar, Nourhane; Korzh, Stanislava et al., 2024
Tableting performance of dry granulated particles: Significance and assessment of compression mechanical properties
Tofiq, Maryam, 2024
Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
Nôga, Diana Aline; de Mello e Souza Meth, Elisa; Pekkola Pacheco, André et al., 2024
Pharmacometric tools to support translational drug development
Ayoun Alsoud, Rami, 2024
The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat
Zelleroth, Sofia; Stam, Frida; Nylander, Erik et al., 2024
Comparative study of Vis/NIR reflectance and transmittance method for on-line detection of strawberry SSC
Guo, Zhiming; Zhai, Lixiang; Zou, Yan et al., 2024
The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
Gising, Johan; Honarnejad, Saman; Bras, Maaike et al., 2024
From pixels to phenotypes: Integrating image-based profiling with cell health data as BioMorph features improves interpretability
Seal, Srijit; Carreras-Puigvert, Jordi; Singh, Shantanu et al., 2024
Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID
Berezin, Linor; Waseem, Rida; Merikanto, Ilona et al., 2024
Melatonin: is it really a cardiovascular wonder pill for shift workers?
Xue, Pei; Noga Morais Ferreira, Diana; Benedict, Christian, 2024
Visualizing DNA single- and double-strand breaks in the Flash comet assay by DNA polymerase-assisted end-labelling
Bivehed, Erik; Hellman, Björn; Wenson, Leonie et al., 2024
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Wannberg, Johan; Gising, Johan; Henriksson, Martin et al., 2024
A multiomic characterization of the leukemia cell line REH using short- and long-read sequencing
Lysenkova, Mariya; Arvidsson, Gustav; Bunikis, Ignas et al., 2024
Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
Vallianatou, Theodosia; de Souza Anselmo, Carina; Tsiara, Ioanna et al., 2024
DNA methylation at DLGAP2 and risk for relapse in alcohol dependence during acamprosate treatment
Özel, Fatih; Di Criscio, Michela; Lupu, Diana Ioana et al., 2024
Effects of microgravity on neural crest stem cells
Han, Yilin; Barasa, Povilas; Zeger, Lukas et al., 2024
Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach
Brekkan, Ari; Lledo-Garcia, Rocio; Lacroix, Brigitte et al., 2024
Method development for the analysis of protein interactions
Kermpatsou, Despoina, 2023
Novel mesoporous silica surface loaded gold nanocomposites SERS aptasensor for sensitive detection of zearalenone
Guo, Zhiming; Gao, Lingbo; Yin, Limei et al., 2023
Sappanin-type homoisoflavonoids from Scilla bisotunensis Speta.: Cytotoxicity, molecular docking, and chemotaxonomic significance
Ghoran, Salar Hafez; Firuzi, Omidreza; Pirhadi, Somayeh et al., 2023
Characterization and recognition of citrus fruit spoilage fungi using Raman scattering spectroscopic imaging
Cai, Jianrong; Zou, Caixia; Yin, Limei et al., 2023
Effective friction in adhesive mixtures intended for inhalation: Simulation of oblique impact of adhesive units
Sarangi, Sohan; Frenning, Göran, 2023
Finding improved drug strategies for schizophrenia: Preclinical studies on lumateperone and sodium nitroprusside
Titulaer, Joep, 2023
A new modelling approach for dissolution of polydisperse powders
van der Zwaan, Ires; Frenning, Göran, 2023
Translational Tumor Drug Delivery: Doxorubicin formulation performance, intracellular uptake and molecular diffusion
Degerstedt, Oliver, 2023
Open field behavior in the house cricket (Acheta domesticus): effect of illumination, sex differences and individual consistency
Vossen, L. E.; Nilsson, E.; Jansson, A. et al., 2023
Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads
Muhammad, Taj; Strömstedt, Adam A.; Gunasekera, Sunithi et al., 2023
Dysregulation of metalloproteins in ischemic heart disease patients with systolic dysfunction
Khan, Noman; Ullah, Junaid; Hashmi, Satwat et al., 2023
Characterisation of an in vitro dissolution method for assessment of novel pulmonary drug delivery systems: With a focus on controlled release systems
van der Zwaan, Irès, 2023
Analysis of PDGF receptor internalization and signaling using proximity ligation assays
Sander, Marie Rubin, 2023

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