Pilarski Group

21-9

Synthetic methodology, catalysis and green chemistry

Organic molecules underpin huge areas of modern life, from pharmaceuticals to functional materials and beyond. However, making the molecules society needs can be enormously challenging, inefficient and expensive. New methods in organic synthesis are needed all the time.

Our group invents and develops new methods to build organic molecules in ever faster, cheaper and more environmentally sustainable ways. We use several strategies to achieve this. These include:

Catalytic C-H functionalisation
Aryne Chemistry
Mechanochemistry

Read more about our research

Group members

Research leader: Lukasz Pilarski

Group members: Matic Hribersek, Manoj Patil

Publications

Solventless Catalytic C-H and C-X Functionalization without Ball Milling

Mendez-Galvez, Carolina; Barnå, Fredrik; Olsthoorn, Boris; Rosich, David Estebanez et al.

Part of Journal of Organic Chemistry, p. 8846-8856, 2025
- DOI for Solventless Catalytic C-H and C-X Functionalization without Ball Milling
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Access to long-lived room temperature phosphorescence through auration of 2,1,3-benzothiadiazole

Posada Urrutia, Mauricio; Kaul, Nidhi; Kaper, Tobias; Hurrell, Dustin et al.

Part of Dalton Transactions, p. 5658-5664, 2024
- DOI for Access to long-lived room temperature phosphorescence through auration of 2,1,3-benzothiadiazole
- Download full text (pdf) of Access to long-lived room temperature phosphorescence through auration of 2,1,3-benzothiadiazole
Derivatization of 2,1,3-Benzothiadiazole via Regioselective C–H Functionalization and Aryne Reactivity

Kunz, Susanna; Barnå, Fredrik; Posada Urrutia, Mauricio; Ingner, Fredric J. L. et al.

Part of Journal of Organic Chemistry, p. 6138-6148, 2024
- DOI for Derivatization of 2,1,3-Benzothiadiazole via Regioselective C–H Functionalization and Aryne Reactivity
- Download full text (pdf) of Derivatization of 2,1,3-Benzothiadiazole via Regioselective C–H Functionalization and Aryne Reactivity
Synthesis and crystal structures of boryl ortho-silylaryl trifluoromethanesulfonates

Barnå, Fredrik; Hribersek, Matic; Orthaber, Andreas; Pilarski, Lukasz T.

Part of Acta Crystallographica Section E, p. 143-147, 2024
- DOI for Synthesis and crystal structures of boryl ortho-silylaryl trifluoromethanesulfonates
- Download full text (pdf) of Synthesis and crystal structures of boryl ortho-silylaryl trifluoromethanesulfonates
Solvent-free and ball mill-free catalytic C–H methylation

Hribersek, Matic; Méndez-Gálvez, Carolina; Huber, Martin; Gates, Paul J. et al.

Part of Green Chemistry, p. 9138-9145, 2023
- DOI for Solvent-free and ball mill-free catalytic C–H methylation
- Download full text (pdf) of Solvent-free and ball mill-free catalytic C–H methylation
Mechanochemical Solvent-Free Catalytic C-H Methylation

Ni, Shengjun; Hribersek, Matic; Baddigam, Swarna K.; Ingner, Fredric J. L. et al.

Part of Angewandte Chemie International Edition, p. 6660-6666, 2021
- DOI for Mechanochemical Solvent-Free Catalytic C-H Methylation
- Download full text (pdf) of Mechanochemical Solvent-Free Catalytic C-H Methylation
Mechanochemical synthesis of (hetero)aryl Au(i) complexes

Ingner, Fredric; Giustra, Zachary X.; Novosedlik, Sebastian; Orthaber, Andreas et al.

Part of Green Chemistry, p. 5648-5655, 2020
- DOI for Mechanochemical synthesis of (hetero)aryl Au(i) complexes
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Mild and Efficient Synthesis of Diverse Organo-Au-I-L Complexes in Green Solvents

Ingner, Fredric; Schmitt, Ann-Cathrin; Orthaber, Andreas; Gates, Paul J. et al.

Part of ChemSusChem, p. 2032-2037, 2020
- DOI for Mild and Efficient Synthesis of Diverse Organo-Au-I-L Complexes in Green Solvents
Arynes and Their Precursors from Arylboronic Acids via Catalytic C-H Silylation

Devaraj, Karthik; Ingner, Fredric; Sollert, Carina; Gates, Paul J. et al.

Part of Journal of Organic Chemistry, p. 5863-5871, 2019
- DOI for Arynes and Their Precursors from Arylboronic Acids via Catalytic C-H Silylation
Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations

Kalepu, Jagadeesh; Pilarski, Lukasz T.

Part of Molecules, 2019
- DOI for Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations
- Download full text (pdf) of Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations
C4-H indole functionalisation: precedent and prospects

Kalepu, Jagadeesh; Gandeepan, Parthasarathy; Ackermann, Lutz; Pilarski, Lukasz T.

Part of Chemical Science, p. 4203-4216, 2018
- DOI for C4-H indole functionalisation: precedent and prospects
- Download full text (pdf) of C4-H indole functionalisation: precedent and prospects
Young Career Focus: Dr. Lukasz T. Pilarski (Uppsala University, Sweden)

Pilarski, Lukasz T.

Part of Synlett, 2017
- DOI for Young Career Focus: Dr. Lukasz T. Pilarski (Uppsala University, Sweden)
Ru-Catalysed C-H Silylation of Gramines, Tryptamines and their Congeners

Devaraj, Karthik; Sollert, Carina; Gates, P. J.; Pilarski, Lukasz

Part of Chemical Communications, p. 5868-5871, 2016
- DOI for Ru-Catalysed C-H Silylation of Gramines, Tryptamines and their Congeners
Selective Activation of Arylboronate or Aryne Reactivity as a Versatile Postfunctionalization Strateg

Larsson, Johanna; Demory, Emilien; Devaraj, Karthik; Sollert, Carina et al.

Part of Synlett, p. 969-976, 2016
- DOI for Selective Activation of Arylboronate or Aryne Reactivity as a Versatile Postfunctionalization Strateg
Selective Activation of Arylboronate or Aryne Reactivity as a Versatile Postfunctionalization Strategy

Larsson, Johanna; Demory, Emilien; Devaraj, Karthik; Sollert, Carina et al.

Part of Synlett, p. 969-976, 2016
- DOI for Selective Activation of Arylboronate or Aryne Reactivity as a Versatile Postfunctionalization Strategy
Boryl (Hetero)aryne Precursors as Versatile Arylation Reagents: Synthesis through C-H Activation and Orthogonal Reactivity

Demory, Emilien; Devaraj, Karthik; Orthaber, Andreas; Gates, Paul J. et al.

Part of Angewandte Chemie International Edition, p. 11765-11769, 2015
- DOI for Boryl (Hetero)aryne Precursors as Versatile Arylation Reagents: Synthesis through C-H Activation and Orthogonal Reactivity
- Download full text (pdf) of Boryl (Hetero)aryne Precursors as Versatile Arylation Reagents: Synthesis through C-H Activation and Orthogonal Reactivity
Ru-Catalysed C-H Arylation of Indoles and Pyrroles with Boronic Acids: Scope and Mechanistic Studies

Sollert, Carina; Devaraj, Karthik; Orthaber, Andreas; Gates, Paul J. et al.

Part of Chemistry - A European Journal, p. 5380-5386, 2015
- DOI for Ru-Catalysed C-H Arylation of Indoles and Pyrroles with Boronic Acids: Scope and Mechanistic Studies
Crystal structure of acetonitrile[eta(6)-1-methyl-4-(1-methylethyl)benzene][1-(pyrimidin-2-yl )-3H-indol-1-ium-2-yl-kappa N-2,C]ruthenium(II) bis-(hexafluoridoantimonate)

Sollert, Carina; Orthaber, Andreas; Pilarski, Lukasz T.

Part of Acta Crystallographica Section E, p. 1190-+, 2015
- DOI for Crystal structure of acetonitrile[eta(6)-1-methyl-4-(1-methylethyl)benzene][1-(pyrimidin-2-yl )-3H-indol-1-ium-2-yl-kappa N-2,C]ruthenium(II) bis-(hexafluoridoantimonate)
- Download full text (pdf) of Crystal structure of acetonitrile[eta(6)-1-methyl-4-(1-methylethyl)benzene][1-(pyrimidin-2-yl )-3H-indol-1-ium-2-yl-kappa N-2,C]ruthenium(II) bis-(hexafluoridoantimonate)
Synthesis of aryne precursors via transition metal-catalyzed C-H silylation

Devaraj, Karthik; Sollert, Carina; Gates, Paul; Pilarski, Lukasz

Part of Abstracts of Papers of the American Chemical Society, 2014
Ruthenium(II)-catalyzed C2-arylation of indoles and pyrroles with boronic acids: Scope and mechanistic insights

Sollert, Carina; Devaraj, Karthik; Orthaber, Andreas; Gates, Paul et al.

Part of Abstracts of Papers of the American Chemical Society, 2014
Benchmarking computational methods for the optimisation of aryne and cycloalkyne geometries

Barnå, Fredrik; Pilarski, Lukasz T.

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Elucidating structure-distortion relationships in arynes and cycloalkynes

Barnå, Fredrik; Pilarski, Lukasz T.

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Aryne Capture Regiocontrol via Fluoroboronate-induced Distortion

Barnå, Fredrik; Sollert, Carina; Hribersek, Matic; Gates, Paul J. et al.

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Chemo- and Regioselective Generation of the 1,3-Benzdiyne Synthon

Barnå, Fredrik; Patil, Manoj D.; Ingner, Fredric; Gates, Paul J. et al.

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