Conspiracy theories characterise views in and about Europe
03 maj 2021
Conspiratorial narratives of internal disintegration and external threats affect views in the European Union and Europe to an increasing extent. Our trust in society is put to the test in crises such as COVID-19 when various groups are singled out as the villains. In extreme cases, this can inspire acts of terror. Researchers from Uppsala University are among those demonstrating this in the new book Europe: Continent of Conspiracies. Conspirac...
Decrease in prostate cancer diagnoses due to pandemic
29 april 2021
During the first wave of the corona pandemic, 36 per cent fewer men were diagnosed with prostate cancer in Sweden than in previous years. On the other hand, the number of patients receiving curative treatment for prostate cancer was unaffected. This is shown by a new register study led by Uppsala University researchers, whose results are published in the Scandinavian Journal of Urology.
Molecular biologists travel back in time 3 billion years
29 april 2021
A research group working at Uppsala University has succeeded in studying ‘translation factors’ – important components of a cell’s protein synthesis machinery – that are several billion years old. By studying these ancient ‘resurrected’ factors, the researchers were able to establish that they had much broader specificities than their present-day, more specialised counterparts.
Socioeconomic deprivation modifies genetic influence on higher education
27 april 2021
A comprehensive study from Uppsala University demonstrates that socioeconomic deprivation modifies genetic effects on higher education and abstract reasoning. The paper illustrates how genes play a greater role in educational attainment in more socioeconomically deprived regions of the United Kingdom. The study was recently published in the American Journal of Psychiatry.
Newly discovered immune cell function vital to healing
22 april 2021
Cardiovascular disease, the most common cause of death, is the result of oxygen deprivation as blood perfusion to affected tissue is prevented. To halt the development of the disease and to promote healing, re-establishment of blood flow is crucial. Researchers at Uppsala University have now discovered that one of the most common immune cells in the human body, macrophages, play an important role in re-establishing and controlling blood flow, ...
David D. Laitin is awarded the Johan Skytte Prize in Political Science
15 april 2021
David D. Laitin, Stanford University, is this year’s recipient of the Johan Skytte Prize, known by many as the ‘Nobel Prize in Political Science’. Professor Laitin is awarded the prize for his “original and objective explanation of how politics shapes cultural strategies in heterogeneous societies.”
Gut epithelium muscles up against infection
12 april 2021
To maximise absorption of nutrients from the diet, the intestinal mucous membrane has a large surface area. However, this also makes it vulnerable to attack from aggressive gut microbes. A new study by Uppsala University researchers now shows that the surface layer of the mucosa, known as the epithelium, can rapidly contract when it recognises a bacterial attack. The results are published in the journal PNAS.
Genome sequencing reveals a new species of bumblebee
07 april 2021
While studying genetic diversity in bumblebees in the Rocky Mountains, USA, researchers from Uppsala University discovered a new species. They named it Bombus incognitus and present their findings in the journal Molecular Biology and Evolution.
Largest-ever DNA mapping study of the Philippines
23 mars 2021
Over 50 millennia, at least five major immigration waves have successively populated the Philippines, the most comprehensive survey of genetic variations in the country to date shows. This Uppsala University study, published in the scientific journal PNAS, comprises 2.3 million DNA markers from some 1,000 individuals.
Mutations in the neurochondrin gene linked to epilepsy
15 mars 2021
Mutations in the neurochondrin (NCDN) gene can cause epilepsy, neurodevelopmental delay and intellectual disability. The gene mutation significantly impairs contacts and signalling between neurons in the brain. This is the conclusion of a study led from Uppsala University and published in the American Journal of Human Genetics.
Unmarried people given less intensive treatment for mantle cell lymphoma
12 mars 2021
Mantle cell lymphoma is a malignant disease in which intensive treatment can prolong life. In a new study, scientists from Uppsala University and other Swedish universities show that people with mantle cell lymphoma who were unmarried, and those who had low educational attainment, were less often treated with a stem-cell transplantation, which may result in poorer survival. The findings have been published in the scientific journal Blood Adva...
Release of serotonin from mast cells contribute to airway hyperresposivness in asthma
12 mars 2021
In asthma, the airways become hyperresponsive. Researchers from Uppsala University have found a new mechanism that contributes to, and explains, airway hyperresponsiveness. The results are published in the scientific journal Allergy.
Behaviour change and antimicrobial resistance in focus at Uppsala Health Summit
09 mars 2021
Antimicrobial resistance is an urgent global threat to human and animal health. This year’s Uppsala Health Summit, which will take place online on 15–18 March, will discuss how behaviour change across various sectors of society can slow down this worrying trend.
Dried blood spots – simple and efficient sample collection for analyses of protein biomarkers
05 mars 2021
Recent results from Uppsala University and Karolinska Institutet demonstrate that self-collected blood in the form of dried blood spots works well in analyses of protein biomarkers for cardiovascular disease. Using these types of samples would mean simpler and efficient blood collection that could be done by the individuals themselves.
New model can predict how bacteria develop antibiotic resistance
04 mars 2021
Using theoretical models of bacterial metabolism and reproduction, scientists can predict the type of resistance that bacteria will develop when they are exposed to antibiotics. This has now been shown by an Uppsala University research team, in collaboration with colleagues in Cologne, Germany. The study is published in the journal Nature Ecology and Evolution.
New light shed on the early evolution of limb bone marrow
02 mars 2021
When and how bone marrow first originated in the limbs of early four-legged animals is disputed in evolutionary biology. With the help of powerful X-ray technology, an international research team, led by Uppsala University, has now discovered that this evolutionary adaptation most likely took place after the first tetrapods stepped ashore. The study is published in the scientific journal eLife.
Sound-frequency map for inner ear created with advanced X-ray technology
24 februari 2021
Researchers at Uppsala University have created the first 3D map of the hearing nerve showing where the various sound frequencies are captured. Using what is known as synchrotron X-ray imaging, they were able to trace the fine nerve threads and the vibrating auditory organ, the cochlea, and find out exactly how the frequencies of incoming sound are distributed. The study is published in Scientific Reports.
Beta blockers can repair malformed blood vessels in the brain
23 februari 2021
Propranolol, a drug that is efficacious against infantile haemangiomas (“strawberry naevi”, resembling birthmarks), can also be used to treat cerebral cavernous malformations, a condition characterised by misshapen blood vessels in the brain and elsewhere. This has been shown by researchers at Uppsala University in a new study published in the scientific journal Stroke.
Innate immune system worsens the situation in severe COVID-19
23 februari 2021
In patients with severe COVID-19, the innate immune system overreacts. This overreaction may underlie the formation of blood clots (thrombi) and deterioration in oxygen saturation that affect the patients. This is shown in an Uppsala University study published in the journal Frontiers in Immunology.
Multigenerational effects of environmental toxins
16 februari 2021
The effects of the endocrine disruptor linuron on frogs are not limited to those exposed, but are passed on to their offspring and grand-offspring. First generation offspring have reduced body weight and decreased fertility, while second generation offspring have increased body weight and a disrupted metabolism. This is demonstrated by a new study conducted by researchers at Uppsala University and Stockholm University that has now been publish...
Metabolic response behind reduced cancer cell growth
12 februari 2021
Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells’ metabolism. These changes can be used as markers to discriminate whether a patient would respond to treatment by EZH2 inhibition. The study has been published in the journal Cell Death & Disease.
Producing more sustainable hydrogen with composite polymer dots
12 februari 2021
Hydrogen for energy use can be extracted in an environmentally friendly way from water and sunlight, using photocatalytic composite polymer nanoparticles developed by researchers at Uppsala University. In laboratory tests, these “polymer dots” showed promising performance and stability alike. The study has been published in the Journal of the American Chemical Society.
New improved dog reference genome will aid a new generation of investigation
10 februari 2021
Researchers at Uppsala University and the Swedish University of Agricultural Sciences have used new methods for DNA sequencing and annotation to build a new, and more complete, dog reference genome. This tool will serve as the foundation for a new era of research, helping scientists to better understand the link between DNA and disease, in dogs and in their human friends. The research is presented in the journal Communications Biology.
- Higher blood pressure at night than in daytime may increase Alzheimer’s disease risk 08 februari 2021
New clues to how SARS-CoV-2 infects cells
08 februari 2021
peer review/experimental study
Stefania Barca the new visiting Zennström climate professor
08 februari 2021
Stefania Barca, from the University of Coimbra in Portugal, is to be Uppsala University’s fourth Zennström Professor of Climate Change Leadership. In her research, she focuses particularly on issues of justice connected with environmental and climate change.
Intensity not paramount for physical training during cancer therapy
03 februari 2021
People receiving treatment for cancer are known to feel better with physical training. But does it make any difference how vigorously they exercise? A new study by researchers at Uppsala University shows that whether the training is intensive or rather less strenuous, its effect is roughly the same. The results are published in the journal Scandinavian Journal of Medicine and Science in Sports.
Warmer climate may make new mutations more harmful
03 februari 2021
A warmer global climate can cause mutations to have more severe consequences for the health of organisms through their detrimental effect on protein function. This may have major repercussions on organisms’ ability to adapt to, and survive in, the altered habitats of the future. This is shown in a new Uppsala University research study now published in the scientific journal Proceedings of the Royal Society B.
Uppsala University Joins Wellcome Leap Global Network
29 januari 2021
Uppsala University has joined the Leap Health Breakthrough Network, a global group of 21 leading academic and research institutions, representing a network of over 150,000 researchers across six continents, committed to solving the world’s most serious health challenges — such as cancer and infectious diseases — at record speed. Wellcome Leap is a US-based non-profit organisation founded by the Wellcome Trust to accelerate innovations that ben...
Ions in molten salts can go “against the flow”
27 januari 2021
In a new article published in the scientific journal Communications Chemistry, a research group at Uppsala University show, using computer simulations, that ions do not always behave as expected. In their research on molten salts, they were able to see that, in some cases, the ions in the salt mixture they were studying affect one another so much that they may even move in the “wrong” direction – that is, towards an electrode with the same cha...
Tough childhood damages life prospects
21 januari 2021
An adverse upbringing often impairs people’s circumstances and health in their adult years, especially for couples who have both had similar experiences. This is shown by a new study, carried out by Uppsala University researchers, in which 818 mothers and their partners filled in a questionnaire one year after having a child together. The study is now published in the scientific journal PLOS ONE.
Natural hazard events and national risk reduction measures unconnected
20 januari 2021
Countries where massive natural hazard events occur frequently are not more likely than others to make changes to reduce risks from future disasters. This is shown in an interdisciplinary Uppsala University study now published in Nature Communications.
European eels – one gene pool fits all
20 januari 2021
European eels spawn in the subtropical Sargasso Sea but spend most of their adult life in a range of fresh- and brackish waters, across Europe and Northern Africa. How eels adapt to such diverse environments has long puzzled biologists. Using whole-genome analysis, a team of scientists led from Uppsala University provides conclusive evidence that all European eels belong to a single panmictic population irrespective of where they spend their a...
Disrupted immune cell navigation in lymph nodes of breast cancer patients
13 januari 2021
In breast cancer, tumours of different types have divergent effects on the functioning of the lymph nodes. In patients with invasive breast cancer, the blood vessels and supporting tissue of the lymph nodes change, but this does not occur in patients with a non-invasive form of breast cancer (ductal carcinoma in situ). This is shown in a new study from Uppsala University, now published online in the scientific journal Cancers.
Antibiotic resistance from random DNA sequences
08 januari 2021
An important and still unanswered question is how new genes that cause antibiotic resistance arise. In a new study, Swedish and American researchers have shown how new genes that produce resistance can arise from completely random DNA sequences. The results have been published in the journal PLOS Genetics.
Faulty metabolism of Parkinson’s medication in the brain linked to severe side effects
07 januari 2021
Until now, the reason why the drug levodopa (L-Dopa), which reduces the motor symptoms of Parkinson’s disease, declines in efficacy after a few years’ use has been unknown. A side effect that then often occur is involuntary movements. A Swedish–French collaboration, led from Uppsala University, has now been able to connect the problems with defective metabolism of L-Dopa in the brain. The study is published in Science Advances.
Parents’ finances differently affected by having a child diagnosed with cancer
04 januari 2021
Mothers and fathers of children diagnosed with cancer are affected financially in different ways. While mothers’ incomes fall in the short term and then rise, the adverse financial repercussions on fathers occur later. Researchers at Uppsala University have investigated the socioeconomic impact on parents of having a child diagnosed with cancer. The study is published in the International Journal of Cancer.
New Centre for Nuclear Disarmament for Uppsala University
22 december 2020
Today, the Swedish Government decided to assign to Uppsala University the task of setting up a new national knowledge centre for research on nuclear disarmament. With an interdisciplinary approach and researchers in fields including peace and conflict research, nuclear physics, artificial intelligence (AI) and political science, the incipient Alva Myrdal Centre will conduct research with the goal of contributing to a safer world for humankind.
Archives crucial for Freemasons’ identity
22 december 2020
The Order of Freemasons’ meticulous archives are fundamental to their identity. The unique structure of the masonic archives reinforces the secrecy and mystique of the self-image that has been fashioned by the Order — and characterises it in the eyes of others. This is shown in a recent thesis from Uppsala University, which focuses on the Masons’ archives in the 18th and 19th centuries.
Parlour games 400 years ago – almost like today
17 december 2020
In a new thesis from Uppsala University, art historian Greger Sundin studied 16th and 17th century games that have been preserved in princely collections for example. Right at the end of his work on the thesis, he and a colleague were able to solve an over 300 year old riddle about a game in the Augsburg Art Cabinet.
Oral contraceptive pills protect against ovarian and endometrial cancer
17 december 2020
A comprehensive study from Uppsala University, involving more than 250,000 women, shows that oral contraceptive use protects against ovarian and endometrial cancer. The protective effect remains for several decades after discontinuing the use. The study is published in the journal Cancer Research.
Genome sequencing paves the way for more sustainable herring fishery
15 december 2020
An international team of Swedish, Norwegian, Danish and Irish scientists has used whole genome sequencing to characterise 53 herring populations from the Atlantic Ocean and the Baltic Sea. They have developed genetic markers that make it possible to better monitor herring populations and avoid overfishing. The study is published in the journal eLife.
New analysis method for predicting the risks and effects of immunotherapy
11 december 2020
In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphocytic leukaemia. This has awakened hopes that this analysis method could pave the way for important breakthroughs in immunotherapy research and treatment.
Diabetes in dogs may indicate elevated risk of type 2 diabetes in their owners
11 december 2020
Owners of a dog with diabetes are more likely to develop type 2 diabetes than owners of a dog without diabetes. No shared risk of diabetes could be detected for cat owners and their cats. These novel findings, from a register-based study conducted at Uppsala University in collaboration with three other universities, have now been published in The BMJ.
Promising treatment for premenstrual dysphoric disorder, PMDD
10 december 2020
The mental symptoms of premenstrual dysphoric disorder improve following treatment with a progesterone receptor modulator, as demonstrated by SciLifeLab researcher Erika Comasco and Professor Inger Sundström-Poromaa, Uppsala University. The mechanism of action of the study drug provides insights into the potential molecular mechanisms underlying this psychiatric disorder and its treatment.
Rare species of small cats inadequately protected
20 november 2020
The Indian subcontinent is a hotspot for wild felines. A new study headed by Uppsala University now shows that only 6–11 per cent of the areas where three rare cat species have their habitat are protected. Lack of knowledge about these species has been an obstacle to understanding their needs for reserves. The research is presented in the journal Scientific Reports.
New semiconductor coating may pave way for future green fuels
18 november 2020
Hydrogen gas and methanol for fuel cells or as raw materials for the chemicals industry, for example, could be produced more sustainably using sunlight, a new Uppsala University study shows. In this study, researchers have developed a new coating material for semiconductors that may create new opportunities to produce fuels in processes that combine direct sunlight with electricity. The study is published in Nature Communications.
240 mammals help us understand the human genome
11 november 2020
A large international consortium led by scientists at Uppsala University and the Broad Institute of MIT and Harvard has sequenced the genome of 130 mammals and analysed the data together with 110 existing genomes to allow scientist to identify which are the important positions in the DNA. This new information can help both research on disease mutations in humans and how best to preserve endangered species. The study is published in Nature.
Chronic stress causes genetic changes in chickens
10 november 2020
How can stress in animals be measured? Scientists from Uppsala University and elsewhere have now found that what are known as epigenetic biomarkers could be used to detect long-term exposure to stress in commercially raised chickens. This may, in time, lead to improved conditions in animal rearing. The study has been published in the journal Frontiers in Genetics.
Swedish, Finnish and Russian wolves closely related
10 november 2020
The Scandinavian wolf originally came from Finland and Russia, and unlike many other European wolf populations its genetic constitution is virtually free from dog admixture. In addition, individuals have migrated into and out of Scandinavia. These findings have emerged from new research at Uppsala University in which genetic material from more than 200 wolves was analysed. The study is published in the journal Evolutionary Applications.