Several new publications by SweDeliver's junior researchers
SweDeliver's PhD students and postdocs continue to conduct studies of very high quality. In the autumn of 2021, Vicky Barmpatsalou, Staffan Berg, Vahid Forooqi Motlaq and Irès van der Zwaan have all presented interesting publications.
(Image removed) Vicky Barmpatsalou, Staffan Berg, Vahid Forooqi Motlaq and Irès van der Zwaan, SweDeliver
Vahid Forooqi Motlaq, PhD student in SweDeliver work package Parenteral Drug Delivery has published the article Investigation of the enhanced ability of bile salt surfactants to solubilize phospholipid bilayers and form mixed micelles in journal Soft Matter, issue 33, 2021.
In this study, Vahid Forooqi Motlaq et al. investigated the bile salt–phospholipid system NaDC–DMPC in physiological saline solution using a combination of the experimental techniques SLS, DLS, SAXS and cryo-TEM. In accordance, the team observed small ellipsoidal micelles that form spontaneously at high fractions of NaDC (XPL ≤ 0.5) and grow in size as the fraction of DMPC is increased.
Vicky Barmpatsalou, postdoc in SweDeliver work package Oral Drug Delivery has published the article Physiological properties, composition and structural profiling of porcine gastrointestinal mucus in journal European journal of pharmaceutics and biopharmaceutics, Vol. 169, 2021.
(Image removed)
In this study, Vicky Barmpatsalou et al. used a larger animal species, the pig model, to characterize the mucus throughout the length of the gastrointestinal tract. This is the first report of the physiological properties (physical appearance, pH and water content), composition (protein, lipid and metabolite content) and structural profiling (rheology and gel network) of the porcine gastrointestinal mucus.
Staffan Berg, PhD student in SweDeliver work package Oral Drug Delivery has published the article In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery in journal Journal of Pharmaceutical Sciences, Vol. 110, 2021.
(Image removed) 3D printer with modified printhead for 3D printing
of rigid filaments & Schematic drawing of the
pressure sensitive capsule.
In this study, Staffan Berg et al. have evaluated a 3D printed capsule – designed to break from the physiological pressures in the antropyloric region – for its ability to deliver the synthetic octapeptide octreotide in beagle dogs when co-formulated with the permeation enhancer sodium caprate. The pressure sensitive capsules were compared to traditional enteric coated hard gelatin capsules and enteric coated tablets. Paracetamol, which is completely absorbed in dogs, was included in the formulations and used as an absorption marker to give information about the in vivo performance of the dosage forms.
Irès van der Zwaan, PhD student in SweDeliver work package Pulmonary Drug Delivery, has published the article Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery – A Particle Engineering Approach in journal Pharmaceutics, issue 13, 2021.
In this study, Irès van der Zwaan et al. shows the feasibility of using spray drying to produce inhalation powders from hyaluronic acid hydrogels for possible controlled release pulmonary drug delivery. To this end, microparticles were prepared by spray drying from crosslinked as well as native HA. The obtained microparticles were subjected to extensive characterization, including chemical composition, particle morphology and size analysis, surface zeta potential, swelling, in vitro biodegradation and aerosolization performance.
More information
CONTACT
(Image removed) Christel Bergström, Professor
Department of Pharmacy, Uppsala University
Christel.Bergstrom@farmaci.uu.se
text: Magnus Alsne, photo: Mikael Wallerstedt, SweDeliver