Maris Lapins

A host-centric morphological profiling approach to identify repurposed antiviral drugs

Asp, Elin; Rietdijk, Jonne; Tampere, Marianna; Axelsson, Hanna et al.

Part of iScience, 2026

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Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Porebski, Bartlomiej; Christ, Wanda; Corman, Alba; Haraldsson, Martin et al.

Part of Molecular Therapy, p. 3012-3024, 2024

• DOI for Discovery of a novel inhibitor of macropinocytosis with antiviral activity
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Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects

Rietdijk, Jonne; Aggarwal, Tanya; Georgiev, Polina; Lapins, Maris et al.

Part of Science of the Total Environment, 2022

• DOI for Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects
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A phenomics approach for antiviral drug discovery

Rietdijk, Jonne; Tampere, Marianna; Pettke, Aleksandra; Georgiev, Polina et al.

Part of BMC Biology, 2021

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A confidence predictor for logD using conformal regression and a support-vector machine

Lapins, Maris; Arvidsson, Staffan; Lampa, Samuel; Berg, Arvid et al.

Part of Journal of Cheminformatics, 2018

• DOI for A confidence predictor for logD using conformal regression and a support-vector machine
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A host-centric morphological profiling approach to identify repurposed antiviral drugs

Asp, Elin; Rietdijk, Jonne; Tampere, Marianna; Axelsson, Hanna et al.

Part of iScience, 2026

• DOI for A host-centric morphological profiling approach to identify repurposed antiviral drugs
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Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Porebski, Bartlomiej; Christ, Wanda; Corman, Alba; Haraldsson, Martin et al.

Part of Molecular Therapy, p. 3012-3024, 2024

• DOI for Discovery of a novel inhibitor of macropinocytosis with antiviral activity
• Download full text (pdf) of Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects

Rietdijk, Jonne; Aggarwal, Tanya; Georgiev, Polina; Lapins, Maris et al.

Part of Science of the Total Environment, 2022

• DOI for Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects
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A phenomics approach for antiviral drug discovery

Rietdijk, Jonne; Tampere, Marianna; Pettke, Aleksandra; Georgiev, Polina et al.

Part of BMC Biology, 2021

• DOI for A phenomics approach for antiviral drug discovery
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A confidence predictor for logD using conformal regression and a support-vector machine

Lapins, Maris; Arvidsson, Staffan; Lampa, Samuel; Berg, Arvid et al.

Part of Journal of Cheminformatics, 2018

• DOI for A confidence predictor for logD using conformal regression and a support-vector machine
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Origin of aromatase inhibitory activity via proteochemometric modeling

Simeon, Saw; Spjuth, Ola; Lapins, Maris; Nabu, Sunanta et al.

Part of PeerJ, 2016

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Extending proteochemometric modeling for unraveling the sorption behavior of compound-soil interaction

Shoombuatong, Watshara; Nabu, Sunanta; Simeon, Saw; Prachayasittikul, Virapong et al.

Part of Chemometrics and Intelligent Laboratory Systems, p. 219-227, 2016

• DOI for Extending proteochemometric modeling for unraveling the sorption behavior of compound-soil interaction

Proteochemometric model for predicting the inhibition of penicillin-binding proteins

Nabu, Sunanta; Nantasenamat, Chanin; Owasirikul, Wiwat; Lawung, Ratana et al.

Part of Journal of Computer-Aided Molecular Design, p. 127-141, 2015

• DOI for Proteochemometric model for predicting the inhibition of penicillin-binding proteins

A Unified Proteochemometric Model for Prediction of Inhibition of Cytochrome P450 Isoforms

Lapins, Maris; Worachartcheewan, Apilak; Spjuth, Ola; Georgiev, Valentin et al.

Part of PLOS ONE, 2013

• DOI for A Unified Proteochemometric Model for Prediction of Inhibition of Cytochrome P450 Isoforms
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Design and evaluation of substrate-based octapeptide and non substrate-based tetrapeptide inhibitors of dengue virus NS2B-NS3 proteases

Prusis, Peteris; Junaid, Muhammad; Petrovska, Ramona; Yahorava, Sviatlana et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 767-772, 2013

• DOI for Design and evaluation of substrate-based octapeptide and non substrate-based tetrapeptide inhibitors of dengue virus NS2B-NS3 proteases
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Melanocortin 4 receptor in silico mutagenesis and docking studies

Shutava, Iryna; Lapinsh, Maris; Wikberg, Jarl

Part of European Biophysics Journal, 2013

­­­­­­­­Enzymatic Analysis of Recombinant Japanese Encephalitis Virus NS2B(H)-NS3pro Protease with Fluorogenic Model Peptide Substrates

Junaid, Muhammad; Chalayut, Chakard; Sehgelmeble Torrejon, Anna; Angsuthanasombat, Chanan et al.

Part of PLOS ONE, 2012

• DOI for ­­­­­­­­Enzymatic Analysis of Recombinant Japanese Encephalitis Virus NS2B(H)-NS3pro Protease with Fluorogenic Model Peptide Substrates
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Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system

Ignatovica, Vita; Megnis, Kaspars; Lapins, Maris; Schiöth, Helgi B et al.

Part of The FEBS Journal, p. 180-191, 2012

• DOI for Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system

Linking the Resource Description Framework to cheminformatics and proteochemometrics

Willighagen, Egon; Alvarsson, Jonathan; Andersson, Annsofie; Eklund, Martin et al.

Part of Journal of Biomedical Semantics, p. 6, 2011

• DOI for Linking the Resource Description Framework to cheminformatics and proteochemometrics

Services for prediction of drug susceptibility for HIV proteases and reverse transcriptases at the HIV Drug Research Centre

Spjuth, Ola; Eklund, Martin; Lapins, Maris; Junaid, Muhammad et al.

Part of Bioinformatics, p. 1719-1720, 2011

• DOI for Services for prediction of drug susceptibility for HIV proteases and reverse transcriptases at the HIV Drug Research Centre

Towards proteome-wide interaction models using the proteochemometrics approach

Strömbergsson, Helena; Lapins, Maris; Kleywegt, Gerard J.; Wikberg, Jarl E. S.

Part of Molecular Informatics, p. 499-508, 2010

• DOI for Towards proteome-wide interaction models using the proteochemometrics approach

Proteochemometric Modeling of the Susceptibility of Mutated Variants of the HIV-1 Virus to Reverse Transcriptase Inhibitors

Junaid, Muhammad; Lapins, Maris; Eklund, Martin; Spjuth, Ola et al.

Part of PLoS ONE, 2010

• DOI for Proteochemometric Modeling of the Susceptibility of Mutated Variants of the HIV-1 Virus to Reverse Transcriptase Inhibitors

Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear and non-linear data analysis techniques

Lapins, Maris; Wikberg, Jarl E. S.

Part of BMC Bioinformatics, p. 339, 2010

• DOI for Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear and non-linear data analysis techniques

Proteochemometric Modeling of Drug Resistance over the Mutational Space for Multiple HIV Protease Variants and Multiple Protease Inhibitors

Lapins, Maris; Wikberg, Jarl E. S

Part of Journal of chemical information and modeling, p. 1202-1210, 2009

• DOI for Proteochemometric Modeling of Drug Resistance over the Mutational Space for Multiple HIV Protease Variants and Multiple Protease Inhibitors

Proteochemometric modeling of HIV protease susceptibility

Lapins, Maris; Eklund, Martin; Spjuth, Ola; Prusis, Peteris et al.

Part of BMC Bioinformatics, p. 181, 2008

• DOI for Proteochemometric modeling of HIV protease susceptibility

Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases

Prusis, Peteris; Lapins, Maris; Yahorava, Sviatlana; Petrovska, Ramona et al.

Part of Bioorganic & Medicinal Chemistry, p. 9369-9377, 2008

• DOI for Proteochemometrics analysis of substrate interactions with dengue virus NS3 proteases

Proteochemometric modeling reveals the interaction site for Trp9 modified alpha-MSH peptides in melanocortin receptors

Lapinsh, Maris; Prusis, Peteris; Petrovska, Ramona; Uhlén, Staffan et al.

Part of Proteins, p. 653-660, 2007

• DOI for Proteochemometric modeling reveals the interaction site for Trp9 modified alpha-MSH peptides in melanocortin receptors

Introduction to Pharmaceutical Bioinformatics

Wikberg, Jarl; Eklund, Martin; Willighagen, Egon; Spjuth, Ola et al.

Oakleaf Academic, 2010

Chemoinformatics taking Biology into Account: Proteochemometrics

Wikberg, Jarl; Spjuth, Ola; Eklund, Martin; Lapins, Maris

Part of Computational Approaches in Cheminformatics and Bioinformatics, John Wiley & Sons, 2012

• DOI for Chemoinformatics taking Biology into Account: Proteochemometrics

Design and Evaluation of Substrate-based Octapeptide and Nonsubstrate-based Tetrapeptide Inhibitors of Dengue Virus NS2B/NS3 Proteases

Prusis, Peteris; Junaid, Muhammad; Petrovska, Ramona; Yahorava, Sviatlana et al.

Design and Evaluation of Dengue NS3 Protease Peptide Inhibitors

Junaid, Muhammad; Lapins, Maris; Katzenmeier, Gerd; Cui, Taian et al.

AROS: Open Source Lab Automation Enables Fully Automated CellPainting

Dahlö, Martin; Larsson, Anders; Rosén, Dan; Francisco Rodríguez, María Andreína et al.

Novel anti-cancer agents targeting NAT2 loss in colorectal cancer

Rameika, Natallia; Tsiara, Ioanna; Haberek, Wawrzyniec; Akcan, Ece et al.

A Systematic Host-Centric Approach to Identifying Repurposed Drugs for Viral Infections

Asp, Elin; Rietdijk, Jonne; Tampere, Marianna; Axelsson, Hanna et al.