Femke Heindryckx

Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients

Arendt, Nathalie; Payo-Serafin, Tania; Kolosenko, Anna; Kopsida, Maria et al.

Part of Therapeutic Advances in Medical Oncology, 2026

• DOI for Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients
• Download full text (pdf) of Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients

CombiCTx: screening diffusion gradients of anti-cancer drug combinations

Stelzl, Christina; Clavero, Ada Lerma; Camenisch, Selina; Simon, Benoit et al.

Part of Lab on a Chip, p. 695-710, 2026

• DOI for CombiCTx: screening diffusion gradients of anti-cancer drug combinations
• Download full text (pdf) of CombiCTx: screening diffusion gradients of anti-cancer drug combinations

A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma

Lerma-Clavero, Ada; Kopsida, Maria; Arendt, Nathalie; Lennernäs, Hans et al.

Part of Biomedicine and Pharmacotherapy, 2025

• DOI for A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma
• Download full text (pdf) of A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma

Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients

Arendt, Nathalie; Kopsida, Maria; Khaled, Jaafar; Sjöblom, Markus et al.

Part of Therapeutic Advances in Medical Oncology, p. 1-30, 2025

• DOI for Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients
• Download full text (pdf) of Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients

Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives

Arendt, Nathalie; Kopsida, Maria; Lennernäs, Hans; Sjöblom, Markus et al.

Part of European Journal of Pharmacology, 2025

• DOI for Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives
• Download full text (pdf) of Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives

Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients

Arendt, Nathalie; Payo-Serafin, Tania; Kolosenko, Anna; Kopsida, Maria et al.

Part of Therapeutic Advances in Medical Oncology, 2026

• DOI for Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients
• Download full text (pdf) of Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients

CombiCTx: screening diffusion gradients of anti-cancer drug combinations

Stelzl, Christina; Clavero, Ada Lerma; Camenisch, Selina; Simon, Benoit et al.

Part of Lab on a Chip, p. 695-710, 2026

• DOI for CombiCTx: screening diffusion gradients of anti-cancer drug combinations
• Download full text (pdf) of CombiCTx: screening diffusion gradients of anti-cancer drug combinations

A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma

Lerma-Clavero, Ada; Kopsida, Maria; Arendt, Nathalie; Lennernäs, Hans et al.

Part of Biomedicine and Pharmacotherapy, 2025

• DOI for A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma
• Download full text (pdf) of A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma

Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients

Arendt, Nathalie; Kopsida, Maria; Khaled, Jaafar; Sjöblom, Markus et al.

Part of Therapeutic Advances in Medical Oncology, p. 1-30, 2025

• DOI for Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients
• Download full text (pdf) of Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients

Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives

Arendt, Nathalie; Kopsida, Maria; Lennernäs, Hans; Sjöblom, Markus et al.

Part of European Journal of Pharmacology, 2025

• DOI for Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives
• Download full text (pdf) of Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives

Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.

Kopsida, Maria; Regtop, Lotta; Lennernäs, Hans; Hedeland, Mikael et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, p. 117012, 2025

• DOI for Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.
• Download full text (pdf) of Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.

Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Part of Molecular Metabolism, 2024

• DOI for Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
• Download full text (pdf) of Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Peters, Karsten; Clavero, Ada Lerma; Kullenberg, Fredrik; Kopsida, Maria et al.

Part of PLOS ONE, 2024

• DOI for Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
• Download full text (pdf) of Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids

Nilsson, Jenny M.; Balgoma, David; Pettersson, Curt; Lennernäs, Hans et al.

Part of Analytica Chimica Acta, 2024

• DOI for Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids
• Download full text (pdf) of Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids

Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Degerstedt, Oliver; O'Callaghan, Paul; Clavero, Ada Lerma; Gråsjö, Johan et al.

Part of Drug Delivery and Translational Research, p. 970-983, 2023

• DOI for Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
• Download full text (pdf) of Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Part of Scientific Reports, 2023

• DOI for Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma
• Download full text (pdf) of Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

The progression of doxorubicin-induced intestinal mucositis in rats

Kullenberg, Fredrik; Peters, Karsten; Luna-Marco, C.; Salomonsson, A. et al.

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. 247-260, 2023

• DOI for The progression of doxorubicin-induced intestinal mucositis in rats
• Download full text (pdf) of The progression of doxorubicin-induced intestinal mucositis in rats

Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats

Kullenberg, Fredrik; Peters, Karsten; Sjöblom, Markus; Heindryckx, Femke et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 507-516, 2023

• DOI for Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats
• Download full text (pdf) of Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats

Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Part of BMJ Open, 2022

• DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
• Download full text (pdf) of Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Khaled, Jaafar; Kopsida, Maria; Lennernäs, Hans; Heindryckx, Femke

Part of Cells, 2022

• DOI for Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma
• Download full text (pdf) of Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Balgoma, David; Kullenberg, Fredrik; Peters, Karsten; Dahlgren, David et al.

Part of Metabolites, 2022

• DOI for Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
• Download full text (pdf) of Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Balgoma, David; Kullenberg, Fredrik; Calitz, Carlemi; Kopsida, Maria et al.

Part of Cells, 2021

• DOI for Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
• Download full text (pdf) of Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

Part of Cells, 2021

• DOI for In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
• Download full text (pdf) of In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Exploring the Role of Endoplasmic Reticulum Stress in Hepatocellular Carcinoma through mining of the Human Protein Atlas

Pavlovic, Natasa; Heindryckx, Femke

Part of Biology, 2021

• DOI for Exploring the Role of Endoplasmic Reticulum Stress in Hepatocellular Carcinoma through mining of the Human Protein Atlas
• Download full text (pdf) of Exploring the Role of Endoplasmic Reticulum Stress in Hepatocellular Carcinoma through mining of the Human Protein Atlas

Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment

Pavlovic, Natasa; Kopsida, Maria; Gerwins, Pär; Heindryckx, Femke

Part of Life Sciences, 2021

• DOI for Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment
• Download full text (pdf) of Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Calitz, Carlemi; Pavlovic, Natasa; Rosenquist, Jenny; Zagami, Claudia et al.

Part of Journal of Visualized Experiments, 2020

• DOI for A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype

Pavlović, Natasa; Kopsida, Maria; Gerwins, Pär; Heindryckx, Femke

Part of International Journal of Molecular Sciences, 2020

• DOI for Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype
• Download full text (pdf) of Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype

Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

Pavlovic, Natasa; Calitz, Carlemi; Thanapirom, Kess; Mazza, Guiseppe et al.

Part of eLIFE, 2020

• DOI for Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma
• Download full text (pdf) of Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Öhman Fuchs, Peder; Calitz, Carlemi; Pavlovic, Natasa; Binet, Francois et al.

Part of Cellular Signalling, 2020

• DOI for Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
• Download full text (pdf) of Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik et al.

Part of Cancers, 2019

• DOI for Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
• Download full text (pdf) of Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies

Best, Jan; Verhulst, Stefaan; Syn, Wing-Kin; Lagaisse, Kimberly et al.

Part of PLOS ONE, 2016

• DOI for Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies
• Download full text (pdf) of Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies

Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing

Heindryckx, Femke; Binet, Francois; Ponticos, Markella; Rombouts, Krista et al.

Part of EMBO Molecular Medicine, p. 729-744, 2016

• DOI for Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing
• Download full text (pdf) of Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing

Targeting the tumor stroma in hepatocellular carcinoma

Heindryckx, Femke; Gerwins, Pär

Part of World Journal of Hepatology, p. 165-176, 2015

• DOI for Targeting the tumor stroma in hepatocellular carcinoma

ER Stress Enhances Liver Fibrosis Through MIR-150 Degradation and XBP-1 Splicing

Heindryckx, Femke; Binet, F.; Kreuger, Johan; Gerwins, Pär

Part of Journal of Hepatology, 2015

Effect Of Extracellular Matrix On Cancer Stem Cells

Heindryckx, Femke; Rauer, D.; Bogaerts, E.; Gerwins, Pär et al.

Part of Journal of Hepatology, 2015

Time-Dependent Effect of Hypoxia on Tumor Progression and Liver Progenitor Cell Markers in Primary Liver Tumors

Bogaerts, Eliene; Heindryckx, Femke; Devisscher, Lindsey; Paridaens, Annelies et al.

Part of PLOS ONE, 2015

• DOI for Time-Dependent Effect of Hypoxia on Tumor Progression and Liver Progenitor Cell Markers in Primary Liver Tumors
• Download full text (pdf) of Time-Dependent Effect of Hypoxia on Tumor Progression and Liver Progenitor Cell Markers in Primary Liver Tumors

The need for transparency and good practices in the qPCR literature

Bustin, Stephen A.; Benes, Vladimir; Garson, Jeremy; Hellemans, Jan et al.

Part of Nature Methods, p. 1063-1067, 2013

• DOI for The need for transparency and good practices in the qPCR literature

MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Kasza, Zsolt; Fredlund Fuchs, Peder; Tamm, Christoffer; Eriksson, Anna S. et al.

Part of Journal of Biological Chemistry, p. 25956-25963, 2013

• DOI for MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Endoplasmic reticulum stress in the pathogenesis of chemotherapy-induced mucositis: Physiological mechanisms and therapeutic implications

Heindryckx, Femke; Sjöblom, Markus

Part of Acta Physiologica, 2024

• DOI for Endoplasmic reticulum stress in the pathogenesis of chemotherapy-induced mucositis: Physiological mechanisms and therapeutic implications
• Download full text (pdf) of Endoplasmic reticulum stress in the pathogenesis of chemotherapy-induced mucositis: Physiological mechanisms and therapeutic implications

Endoplasmic Reticulum Stress and Metabolism in Hepatocellular Carcinoma

Luna-Marco, Clara; Ubink, Anna; Kopsida, Maria; Heindryckx, Femke

Part of American Journal of Pathology, p. 1377-1388, 2023

• DOI for Endoplasmic Reticulum Stress and Metabolism in Hepatocellular Carcinoma

Targeting ER stress in the hepatic tumor microenvironment

Pavlović, Natasa; Heindryckx, Femke

Part of The FEBS Journal, p. 7163-7176, 2022

• DOI for Targeting ER stress in the hepatic tumor microenvironment
• Download full text (pdf) of Targeting ER stress in the hepatic tumor microenvironment

Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma

Ebeling Barbier, Charlotte; Heindryckx, Femke; Lennernäs, Hans

Part of International Journal of Molecular Sciences, 2021

• DOI for Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma
• Download full text (pdf) of Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma

Platelets as Key Factors in Hepatocellular Carcinoma

Pavlovic, Natasa; Rani, Bhavna; Gerwins, Pär; Heindryckx, Femke

Part of Cancers, 2019

• DOI for Platelets as Key Factors in Hepatocellular Carcinoma
• Download full text (pdf) of Platelets as Key Factors in Hepatocellular Carcinoma

Role of proteoglycans in neuro-inflammation and central nervous system fibrosis

Heindryckx, Femke; Li, Jin-Ping

Part of Matrix Biology, p. 589-601, 2018

• DOI for Role of proteoglycans in neuro-inflammation and central nervous system fibrosis

Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis

Yuksel, Muhammed; Laukens, Debby; Heindryckx, Femke; Van Vlierberghe, Hans et al.

Part of International journal of experimental pathology (Print), p. 309-320, 2014

• DOI for Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis

The roles of transforming growth factor- similar to, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours ( Review)

Bogaerts, Eliene; Heindryckx, Femke; Vandewynckel, Yves-Paul; Van Grunsven, Leo A. et al.

Part of International Journal of Oncology, p. 1015-1022, 2014

• DOI for The roles of transforming growth factor- similar to, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours ( Review)

The Paradox of the Unfolded Protein Response in Cancer

Vandewyncicel, Yves-Paul; Laukens, Debby; Geerts, Anja; Bogaerts, Eliene et al.

Part of Anticancer Research, p. 4683-4694, 2013

Pharmacological inhibition of PERK during early carcinogenesis restrains tumor progression and remodels the tumor microenvironment in hepatocellular carcinoma

Khaled, Jaafar; Kopsida, Maria; Payo Serafín, Tania; Sennefelt Nyman, Sofi et al.

Treatment with tauroursodeoxycholic acid reduces tumor burden during early hepatocarcinogenesis in a mouse model for HCC

Khaled, Jaafar; Kopsida, Maria; Heindryckx, Femke

Characterization of hepatocellular carcinoma patient-derived organoids receiving transarterial chemoembolization as a preclinical model for drug response assessment

Khaled, Jaafar; Sennefelt Nyman, Sofi; Rorsman, Fredrik; Lennernäs, Hans et al.