Marcel den Hoed

Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease

Jamialahmadi, Oveis; Mujica, Endrina; Morris, Lowri; Mancina, Rosellina Margherita et al.

Part of Clinical and Molecular Hepatology, p. 1252-1268, 2025

• DOI for Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease
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Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD

Bentanachs, Roger; Ramirez-Carrasco, Patricia; Braster, Bianca; Emmanouilidou, Anastasia et al.

Part of Pharmacological Research, 2025

• DOI for Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD
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A functional genomic framework to elucidate novel causal metabolic dysfunction-associated fatty liver disease genes

Saliba-Gustafsson, Peter; Justesen, Johanne M.; Ranta, Amanda; Sharma, Disha et al.

Part of Hepatology, p. 165-183, 2025

• DOI for A functional genomic framework to elucidate novel causal metabolic dysfunction-associated fatty liver disease genes
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Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning.

Mazzaferro, Eugenia; Mujica, Endrina; Zhang, Hanqing; Emmanouilidou, Anastasia et al.

Part of Scientific Reports, p. 5408, 2025

• DOI for Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning.
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Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Mathieson, Iain; Day, Felix R.; Barban, Nicola; Tropf, Felix C. et al.

Part of Nature Human Behaviour, p. 790-801, 2023

• DOI for Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease

Jamialahmadi, Oveis; Mujica, Endrina; Morris, Lowri; Mancina, Rosellina Margherita et al.

Part of Clinical and Molecular Hepatology, p. 1252-1268, 2025

• DOI for Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease
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Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD

Bentanachs, Roger; Ramirez-Carrasco, Patricia; Braster, Bianca; Emmanouilidou, Anastasia et al.

Part of Pharmacological Research, 2025

• DOI for Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD
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A functional genomic framework to elucidate novel causal metabolic dysfunction-associated fatty liver disease genes

Saliba-Gustafsson, Peter; Justesen, Johanne M.; Ranta, Amanda; Sharma, Disha et al.

Part of Hepatology, p. 165-183, 2025

• DOI for A functional genomic framework to elucidate novel causal metabolic dysfunction-associated fatty liver disease genes
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Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning.

Mazzaferro, Eugenia; Mujica, Endrina; Zhang, Hanqing; Emmanouilidou, Anastasia et al.

Part of Scientific Reports, p. 5408, 2025

• DOI for Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning.
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Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Mathieson, Iain; Day, Felix R.; Barban, Nicola; Tropf, Felix C. et al.

Part of Nature Human Behaviour, p. 790-801, 2023

• DOI for Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila et al.

Part of Nature Genetics, p. 1448-+, 2023

• DOI for GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
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Genetic insights into resting heart rate and its role in cardiovascular disease

van de Vegte, Yordi; Eppinga, Ruben P.; van der Ende, M. Yldau; Hagemeijer, Yanick et al.

Part of Nature Communications, 2023

• DOI for Genetic insights into resting heart rate and its role in cardiovascular disease
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Distilling causality between physical activity traits and obesity via Mendelian randomization

Wang, Zhe; Davey Smith, George; Loos, Ruth J. F.; den Hoed, Marcel

Part of Communications Medicine, 2023

• DOI for Distilling causality between physical activity traits and obesity via Mendelian randomization
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Investigating the role of lipid genes in liver disease using models of steatotic liver disease in zebrafish (Danio rerio)

Mujica, Endrina; den Hoed, Marcel

Part of Liver international, p. 2348-2350, 2023

• DOI for Investigating the role of lipid genes in liver disease using models of steatotic liver disease in zebrafish (Danio rerio)

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

Mattis, Katia K; Krentz, Nicole A J; Metzendorf, Christoph; Abaitua, Fernando et al.

Part of Diabetologia, p. 674-694, 2023

• DOI for Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
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CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations

Höijer, Ida; Emmanouilidou, Anastasia; Östlund, Rebecka; van Schendel, Robin et al.

Part of Nature Communications, 2022

• DOI for CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations
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Stroke genetics informs drug discovery and risk prediction across ancestries

Mishra, Aniket; den Hoed, Marcel; Gustafsson, Stefan; Ingelsson, Erik et al.

Part of Nature, p. 115-+, 2022

• DOI for Stroke genetics informs drug discovery and risk prediction across ancestries
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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J; Moore, Tim et al.

Part of Nature Genetics, p. 1332-1344, 2022

• DOI for Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
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Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

Pellegrinelli, V; Rodriguez-Cuenca, S.; Rouault, C.; Figueroa-Juarez, E. et al.

Part of Nature Metabolism, p. 476-+, 2022

• DOI for Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Mills, Melinda C.; Tropf, Felix C.; Brazel, David M.; van Zuydam, Natalie et al.

Part of Nature Human Behaviour, p. 1717-1730, 2021

• DOI for Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities

Huang, Lam O.; Rauch, Alexander; Mazzaferro, Eugenia; Preuss, Michael et al.

Part of Nature Metabolism, p. 228-243, 2021

• DOI for Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities

Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity

Höijer, Ida; Johansson, Josefin; Gudmundsson, Sanna; Chin, Chen-Shan et al.

Part of Genome Biology, 2020

• DOI for Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity
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Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach

von der Heyde, Benedikt; Emmanouilidou, Anastasia; Mazzaferro, Eugenia; Vicenzi, Silvia et al.

Part of Scientific Reports, 2020

• DOI for Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach
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Test-retest variability of VO_2max using total-capture indirect calorimetry reveals linear relationship of VO₂ and Power

Schoffelen, Paul F. M.; den Hoed, Marcel; van Breda, Eric; Plasqui, Guy

Part of Scandinavian Journal of Medicine and Science in Sports, p. 213-222, 2019

• DOI for Test-retest variability of VO_2max using total-capture indirect calorimetry reveals linear relationship of VO₂ and Power
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PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

van Setten, Jessica; Brody, Jennifer A.; Jamshidi, Yalda; Swenson, Brenton R. et al.

Part of Nature Communications, 2018

• DOI for PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Malik, Rainer; Chauhan, Ganesh; Traylor, Matthew; Sargurupremraj, Muralidharan et al.

Part of Nature Genetics, p. 524-537, 2018

• DOI for Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Strawbridge, Rona J.; Silveira, Angela; den Hoed, Marcel; Gustafsson, Stefan et al.

Part of Atherosclerosis, p. 196-204, 2017

• DOI for Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
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Genome-wide physical activity interactions in adiposity: A meta-analysis of 200,452 adults.

Graff, Mariaelisa; Scott, Robert A; Justice, Anne E; Young, Kristin L et al.

Part of PLOS Genetics, 2017

• DOI for Genome-wide physical activity interactions in adiposity: A meta-analysis of 200,452 adults.
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Maternal diabetes and incidence of childhood cancer: a nationwide cohort study and exploratory genetic analysis

Deleskog, Anna; den Hoed, Marcel; Tettamanti, Giorgio; Carlsson, Sofia et al.

Part of Clinical Epidemiology, p. 633-642, 2017

• DOI for Maternal diabetes and incidence of childhood cancer: a nationwide cohort study and exploratory genetic analysis
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Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Nolte, Ilja M.; Munoz, M. Loretto; Tragante, Vinicius; Amare, Azmeraw T. et al.

Part of Nature Communications, 2017

• DOI for Genetic loci associated with heart rate variability and their effects on cardiac disease risk
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Extensive Type II Muscle Fiber Atrophy in Elderly Female Hip Fracture Patients

Kramer, Irene Fleur; Snijders, Tim; Smeets, Joey S. J.; Leenders, Marika et al.

Part of The journals of gerontology. Series A, Biological sciences and medical sciences, p. 1369-1375, 2017

• DOI for Extensive Type II Muscle Fiber Atrophy in Elderly Female Hip Fracture Patients

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Barban, Nicola; Jansen, Rick; de Vlaming, Ronald; Vaez, Ahmad et al.

Part of Nature Genetics, p. 1462-1472, 2016

• DOI for Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.

den Hoed, Marcel

Part of Lancet Neurology, p. 695-707, 2016

• DOI for Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Scott, Robert A.; Freitag, Daniel F.; Li, Li; Chu, Audrey Y. et al.

Part of Science Translational Medicine, 2016

• DOI for A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb

den Hoed, Marcel; Strawbridge, Rona J; Almgren, Peter; Gustafsson, Stefan et al.

Part of Atherosclerosis, p. 304-310, 2015

• DOI for GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb

Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis

Richmond, Rebecca C.; Smith, George Davey; Ness, Andy R.; den Hoed, Marcel et al.

Part of PLoS Medicine, 2014

• DOI for Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis
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Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

den Hoed, Marcel; Eijgelsheim, Mark; Esko, Tonu; Brundel, Bianca J. J. M. et al.

Part of Nature Genetics, p. 621-+, 2013

• DOI for Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Heritability of objectively assessed daily physical activity and sedentary behavior

den Hoed, Marcel; Brage, Soren; Zhao, Jing Hua; Westgate, Kate et al.

Part of American Journal of Clinical Nutrition, p. 1317-1325, 2013

• DOI for Heritability of objectively assessed daily physical activity and sedentary behavior

Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals

van Vliet-Ostaptchouk, J. V.; den Hoed, Marcel; Luan, J.; Zhao, J. et al.

Part of Diabetologia, 2013

Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals

van Vliet-Ostaptchouk, J. V.; den Hoed, Marcel; Luan, J.; Zhao, J. H. et al.

Part of Diabetologia, p. 2134-2146, 2013

• DOI for Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals

Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.

den Hoed, Marcel

Part of Diabetes, p. 2980-8, 2010

• DOI for Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.

Biological/Genetic Regulation of Physical Activity Level: Consensus From Genbiopac

Lightfoot, J. Timothy; De Geus, Eco J. C.; Booth, Frank W.; Bray, Molly S. et al.

Part of Medicine & Science in Sports & Exercise, p. 863-873, 2018

• DOI for Biological/Genetic Regulation of Physical Activity Level: Consensus From Genbiopac

Image-based, in vivo characterization of cardiometabolic consequences of mutations in pcsk9

Bandaru, Manoj Kumar; Mazzaferro, Eugenia; Emmanouilidou, Anastasia; Larsson, Anders et al.

Apoc2 mutant zebrafish: a model for hypertriglyceridemia and early-stage atherosclerosis

Bandaru, Manoj Kumar; Emmanouilidou, Anastasia; Larsson, Anders; Erik, Ingelsson et al.

Kita crispants for systematic image-based genetic screens of complex traits in zebrafish larvae

Mazzaferro, Eugenia; Metzendorf, Christoph; Zhang, Hanqing; Mujica, Endrina et al.

Characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning

Mazzaferro, Eugenia; Mujica, Endrina; Zhang, Hanqing; Emmanouilidou, Anastasia et al.

Characterizing candidate genes in GWAS-identified loci that may uncouple excess adiposity from its comorbidities

Mazzaferro, Eugenia; Zhang, Hanqing; Mujica, Endrina; Azizah, Isyatul et al.